Product References
Pairing of single-cell RNA analysis and T cell antigen receptor profiling indicates breakdown of T cell tolerance checkpoints in atherosclerosis.
Nature cardiovascular research
Wang Z,Zhang X,Lu S,Zhang C,Ma Z,Su R,Li Y,Sun T,Li Y,Hong M,Deng X,Monjezi MR,Hristov M,Steffens S,Santovito D,Dornmair K,Ley K,Weber C,Mohanta SK,Habenicht AJR,Yin C
14-0161-82 was used in Flow cytometry/Cell sorting to support the concept of atherosclerosis as a bona fide T cell autoimmune disease targeting the arterial wall.
Wed Mar 01 00:00:00 EST 2023
Hyaluronic acid-bilirubin nanomedicine-based combination chemoimmunotherapy.
Nature communications
Lee Y,Shinn J,Xu C,Dobson HE,Neamati N,Moon JJ
14-0161-82 was used in Flow cytometry/Cell sorting to demonstrate a therapeutic strategy based on coordinated ICD induction and TAMC modulation and highlights the potential of combination chemoimmunotherapy.
Tue Aug 08 00:00:00 EDT 2023
Immunization against Zika by entrapping live virus in a subcutaneous self-adjuvanting hydrogel.
Nature biomedical engineering
Hao H,Wu S,Lin J,Zheng Z,Zhou Y,Zhang Y,Guo Q,Tian F,Zhao M,Chen Y,Xu X,Hou L,Wang X,Tang R
14-0161-82 was used in Flow cytometry/Cell sorting to show that a subcutaneous vaccine consisting of live Zika virus electrostatically entrapped in a self-adjuvanting hydrogel recruited immune cells at the injection site and provided mice with effective protection against a lethal viral challenge.
Sat Jul 01 00:00:00 EDT 2023
Neutrophil inhibition improves acute inflammation in a murine model of viral myocarditis.
Cardiovascular research
Carai P,González LF,Van Bruggen S,Spalart V,De Giorgio D,Geuens N,Martinod K,Jones EAV,Heymans S
14-0161-82 was used in Flow Cytometry, Functional Assay, Neutralization to illustrate that repression of neutrophils and related NET response in acute phase of VM improves the pathological phenotype by reducing cardiac inflammation.
Wed Jan 18 00:00:00 EST 2023
Macrophagic AMPKα1 orchestrates regenerative inflammation induced by glucocorticoids.
EMBO reports
Caratti G,Desgeorges T,Juban G,Stifel U,Fessard A,Koenen M,Caratti B,Théret M,Skurk C,Chazaud B,Tuckermann JP,Mounier R
14-0161-82 was used in Flow cytometry/Cell sorting to show that the metabolic sensor AMP-activated protein kinase (AMPK) is required for Glucocorticoids to induce restorative macrophages.
Mon Feb 06 00:00:00 EST 2023
Glycosylated nanoparticle-based PfCSP vaccine confers long-lasting antibody responses and sterile protection in mouse malaria model.
NPJ vaccines
Ludwig J,Scally SW,Costa G,Hoffmann S,Murugan R,Lossin J,Prieto K,Obraztsova A,Lobeto N,Franke-Fayard B,Janse CJ,Lebas C,Collin N,Binter S,Kellam P,Levashina EA,Wardemann H,Julien JP
14-0161-82 was used in Flow cytometry/Cell sorting to highlight the power of rational vaccine design to generate a highly efficacious second-generation anti-infective malaria vaccine candidate and provides the basis for its further development.
Fri Apr 07 00:00:00 EDT 2023
Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling.
JCI insight
Ruan W,Li J,Choi S,Ma X,Liang Y,Nair R,Yuan X,Mills TW,Eltzschig HK
14-0161-82 was used in Flow cytometry/Cell sorting to reveal a previously unrecognized role for myocyte-specific ENT1 in cardioprotection by enhancing myeloid-dependent Adora2b signaling during reperfusion.
Thu Jun 08 00:00:00 EDT 2023
Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease.
Nature neuroscience
Schäffner E,Bosch-Queralt M,Edgar JM,Lehning M,Strauß J,Fleischer N,Kungl T,Wieghofer P,Berghoff SA,Reinert T,Krueger M,Morawski M,Möbius W,Barrantes-Freer A,Stieler J,Sun T,Saher G,Schwab MH,Wrede C,Frosch M,Prinz M,Reich DS,Flügel A,Stadelmann C,Fledrich R,Nave KA,Stassart RM
14-0161-82 was used in Flow cytometry/Cell sorting to demonstrate that myelin ensheathment itself becomes detrimental for axonal survival and increases the risk of axons degenerating in an autoimmune environment.
Sat Jul 01 00:00:00 EDT 2023
A 3D Ex Vivo Tumor-Immune Coculture System Mimicking In Vivo Tumor Environmental Stress on CD8+ T Cells Exhaustion.
Advanced biology
Meng Z,Niu X,Xia L,Chen Y,Wang Z,Wang H,Ji P,Cui W,Wang Y,Lu S
14-0161-82 was used in Flow Cytometry to establish that the 3D-HyGTIC system is not only inclined to mimic the early differentiation trajectories of tumor-infiltrating CD8+ T cells but also may facilitate an evaluation of the efficacy of IC blockades and guide the designing of combination immunotherapy.
Sat Jul 01 00:00:00 EDT 2023
Influenza A virus infection disrupts oligodendrocyte homeostasis and alters the myelin lipidome in the adult mouse.
Journal of neuroinflammation
Louie AY,Kim JS,Drnevich J,Dibaeinia P,Koito H,Sinha S,McKim DB,Soto-Diaz K,Nowak RA,Das A,Steelman AJ
14-0161-82 was used in Flow cytometry/Cell sorting to determine if microglia mediated infection-induced changes to oligodendrocytes homeostasis.
Sat Aug 19 00:00:00 EDT 2023
Involucrin Modulates Vitamin D Receptor Activity in the Epidermis.
The Journal of investigative dermatology
Schmidt AD,Miciano C,Zheng Q,Mathyer ME,Grice EA,de Guzman Strong C
14-0161-82 was used in Flow cytometry/Cell sorting to carry out our studies in Ivl -/- mice to identify a functional role for Involucrin to positively impact Vdr activity and suggest an emerging IVL/VDR paradigm for adaptation in the human epidermis.
Thu Jun 01 00:00:00 EDT 2023
TGFβ Inhibitor A83-01 Enhances Murine HSPC Expansion for Gene Therapy.
Cells
Fleischauer J,Bastone AL,Selich A,John-Neek P,Weisskoeppel L,Schaudien D,Schambach A,Rothe M
14-0161-82 was used in Flow cytometry/Cell sorting to develop cell culture conditions to maintain stemness and prevent differentiation during HSPC culture.
Mon Jul 31 00:00:00 EDT 2023
Thyroid hormone modulates hyperoxic neonatal lung injury and mitochondrial function.
JCI insight
Vamesu BM,Nicola T,Li R,Hazra S,Matalon S,Kaminski N,Ambalavanan N,Kandasamy J
14-0161-82 was used in Flow Cytometry, Functional Assay, Neutralization, Sample Prep to show that TH signaling and function may play a critical role in neonatal lung injury and inhaled T3 supplementation may be useful as a therapeutic strategy for BPD.
Mon Apr 24 00:00:00 EDT 2023
P. gingivalis Infection Upregulates PD-L1 Expression on Dendritic Cells, Suppresses CD8+ T-cell Responses, and Aggravates Oral Cancer.
Cancer immunology research
Ren J,Han X,Lohner H,Hoyle RG,Li J,Liang S,Wang H
14-0161-82 was used in Flow Cytometry to investigate the effects of Porphyromonas gingivalis infection on PD-L1 expression on dendritic cells and related immune consequences in the infection milieu of oral cancer.
Wed Mar 01 00:00:00 EST 2023
Gasdermin D inhibition ameliorates neutrophil mediated brain damage in acute ischemic stroke.
Cell death discovery
Hu R,Liang J,Ding L,Zhang W,Wang Y,Zhang Y,Zhang D,Pei L,Liu X,Xia Z,Xu Y,Song B
14-0161-82 was used in Flow cytometry/Cell sorting to provide a new viewpoint on the immunological modulation of neutrophils after MCAO and suggest that suppression of GSDMD may relieve the neuroinflammatory load, thereby providing a potential treatment strategy for stroke.
Wed Feb 08 00:00:00 EST 2023
Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury.
iScience
Gonzatti MB,Freire BM,Antunes MM,de Menezes GB,Talbot J,Peron JPS,Basso AS,Keller AC
14-0161-82 was used in Flow Cytometry to suggest that the modulation of the adrenergic signaling can be a complementary approach to αGC-based immunotherapy to mitigate iNKT-induced liver injury without compromising its antitumoral activity.
Fri Oct 20 00:00:00 EDT 2023
Piezo2 regulates colonic mechanical sensitivity in a sex specific manner in mice.
Nature communications
Madar J,Tiwari N,Smith C,Sharma D,Shen S,Elmahdi A,Qiao LY
14-0161-82 was used in Flow cytometry/Cell sorting to suggest that Piezo2 in nociceptive neurons mediates innocuous colonic mechanosensing in female mice and painful sensation in male mice, suggesting a sexual dimorphism of Piezo2 function in the colonic sensory system.
Sat Apr 15 00:00:00 EDT 2023
Gene-dosage effect of Pfkfb3 on monocyte/macrophage biology in atherosclerosis.
British journal of pharmacology
Guo S,Li A,Fu X,Li Z,Cao K,Song M,Huang S,Li Z,Yan J,Wang L,Dai X,Feng D,Wang Y,He J,Huo Y,Xu Y
14-0161-82 was used in Flow Cytometry to suggest the existence of a double-edged sword effect of myeloid PFKFB3 on the pathogenesis of atherosclerosis and highlight the need for caution in developing anti-atherosclerotic strategies that target PFKFB3.
Tue Nov 01 00:00:00 EDT 2022
Prevention of Tumor Growth and Dissemination by In Situ Vaccination with Mitochondria-Targeted Atovaquone.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Huang M,Xiong D,Pan J,Zhang Q,Wang Y,Myers CR,Johnson BD,Hardy M,Kalyanaraman B,You M
14-0161-82 was used in Flow cytometry/Cell sorting to implicate granulocytic-myeloid-derived suppressor cells and regulatory T cells as novel targets of mitochondria-targeted atovaquone that facilitate its antitumor efficacy.
Fri Apr 01 00:00:00 EDT 2022
Targeting Glutamine Metabolism to Enhance Immunoprevention of EGFR-Driven Lung Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Huang M,Xiong D,Pan J,Zhang Q,Sei S,Shoemaker RH,Lubet RA,Montuenga LM,Wang Y,Slusher BS,You M
14-0161-82 was used in Flow cytometry/Cell sorting to report that JHU083, an orally active glutamine antagonist prodrug designed to be preferentially activated in the tumor microenvironment, has potent anticancer effects on EGFR-driven mouse lung tumorigenesis.
Thu Sep 01 00:00:00 EDT 2022
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
Nature communications
Günes Günsel G,Conlon TM,Jeridi A,Kim R,Ertüz Z,Lang NJ,Ansari M,Novikova M,Jiang D,Strunz M,Gaianova M,Hollauer C,Gabriel C,Angelidis I,Doll S,Pestoni JC,Edelmann SL,Kohlhepp MS,Guillot A,Bassler K,Van Eeckhoutte HP,Kayalar Ö,Konyalilar N,Kanashova T,Rodius S,Ballester-López C,Genes Robles CM,Smirnova N,Rehberg M,Agarwal C,Krikki I,Piavaux B,Verleden SE,Vanaudenaerde B,Königshoff M,Dittmar G,Bracke KR,Schultze JL,Watz H,Eickelberg O,Stoeger T,Burgstaller G,Tacke F,Heissmeyer V,Rinkevich Y,Bayram H,Schiller HB,Conrad M,Schneider R,Yildirim AÖ
14-0161-82 was used in Flow Cytometry to show that in chronic obstructive pulmonary disease (COPD) patients, protein arginine methyltransferase 7 (PRMT7) expression is elevated in the lung tissue and localized to the macrophages.
Mon Mar 14 00:00:00 EDT 2022
Evidence for oligodendrocyte progenitor cell heterogeneity in the adult mouse brain.
Scientific reports
Beiter RM,Rivet-Noor C,Merchak AR,Bai R,Johanson DM,Slogar E,Sol-Church K,Overall CC,Gaultier A
14-0161-82 was used in Immunohistochemistry-immunofluorescence to investigate the exact mechanisms through which Oligodendrocyte progenitor cells might influence brain function.
Thu Jul 28 00:00:00 EDT 2022
Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis.
Nature communications
Fujimoto M,Yokoyama M,Kiuchi M,Hosokawa H,Nakayama A,Hashimoto N,Sakuma I,Nagano H,Yamagata K,Kudo F,Manabe I,Lee E,Hatano R,Onodera A,Hirahara K,Yokote K,Miki T,Nakayama T,Tanaka T
14-0161-82 was used in Flow cytometry/Cell sorting to identify a regulatory role and molecular mechanism by which liver ILC2s contribute to glucose homeostasis.
Thu Sep 15 00:00:00 EDT 2022
Transcellular biosynthesis of leukotriene B4 orchestrates neutrophil swarming to fungi.
iScience
Hopke A,Lin T,Scherer AK,Shay AE,Timmer KD,Wilson-Mifsud B,Mansour MK,Serhan CN,Irimia D,Hurley BP
14-0161-82 was used in Flow cytometry/Cell sorting to demonstrate that transcellular biosynthesis occurs among neutrophils to generate LTB4, presenting a sufficient resource for the purposes of orchestrating neutrophil swarming.
Fri Oct 21 00:00:00 EDT 2022
Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression.
Nature communications
Qi M,Xia Y,Wu Y,Zhang Z,Wang X,Lu L,Dai C,Song Y,Xu K,Ji W,Zhan L
14-0161-82 was used in Flow Cytometry to demonstrate that Lin28B promotes lung metastasis of breast cancer by building an immune-suppressive pre-metastatic niche.
Wed Feb 16 00:00:00 EST 2022
Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation.
Cell metabolism
Mills EL,Harmon C,Jedrychowski MP,Xiao H,Gruszczyk AV,Bradshaw GA,Tran N,Garrity R,Laznik-Bogoslavski D,Szpyt J,Prendeville H,Lynch L,Murphy MP,Gygi SP,Spiegelman BM,Chouchani ET
14-0161-82 was used in Flow cytometry/Cell sorting to establish the UCP1 C253 activation site as a regulator of acute thermogenesis and sex-dependent tissue inflammation.
Tue Jan 04 00:00:00 EST 2022
The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota.
Frontiers in immunology
Kou Y,Zheng X,Meng L,Liu M,Xu S,Jing Q,Zhang S,Wang H,Han J,Liu Z,Wei Y,Wang Y
14-0161-82 was used in Flow cytometry/Cell sorting to report that HVEM deficiency aggravated hepatobiliary damage and compromised liver repair after 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-induced injury.
Fri Apr 01 00:00:00 EDT 2022
Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses.
Mucosal immunology
Wittner J,Schulz SR,Steinmetz TD,Berges J,Hauke M,Channell WM,Cunningham AF,Hauser AE,Hutloff A,Mielenz D,Jäck HM,Schuh W
14-0161-82 was used in Flow cytometry/Cell sorting to conclude that KLF2 not only orchestrates the localization of IgA plasma cells by fine-tuning chemokine receptors and adhesion molecules but also controls IgA responses to Salmonella flagellin.
Fri Apr 01 00:00:00 EDT 2022
CSF1R-Mediated Myeloid Cell Depletion Prolongs Lifespan But Aggravates Distinct Motor Symptoms in a Model of Multiple System Atrophy.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Battis K,Florio JB,Mante M,Lana A,Naumann I,Gauer C,Lambrecht V,Müller SJ,Cobo I,Fixsen B,Kim HY,Masliah E,Glass CK,Schlachetzki JCM,Rissman RA,Winkler J,Hoffmann A
14-0161-82 was used in Flow cytometry/Cell sorting to analyze the gene expression profile of microglia in a mouse model of MSA (MBP29-hα-syn) and identified a disease-associated expression profile and upregulation of the colony-stimulating factor 1 (Csf1).
Wed Oct 05 00:00:00 EDT 2022
CpG-C ODN M362 as an immunoadjuvant for HBV therapeutic vaccine reverses the systemic tolerance against HBV.
International journal of biological sciences
Zhao H,Han Q,Yang A,Wang Y,Wang G,Lin A,Wang X,Yin C,Zhang J
14-0161-82 was used in Flow Cytometry to conclude that CpG M362 in combination with rHBVvac cleared persistent HBV and achieved long-term virological control, making it a promising candidate for treating CHB.
Mon Mar 28 00:00:00 EDT 2022
Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19.
Cell host & microbe
Guo Q,Zhao Y,Li J,Liu J,Yang X,Guo X,Kuang M,Xia H,Zhang Z,Cao L,Luo Y,Bao L,Wang X,Wei X,Deng W,Wang N,Chen L,Chen J,Zhu H,Gao R,Qin C,Wang X,You F
14-0161 was used in Flow cytometry/Cell sorting to characterize the nature of the early innate immune responses evoked in rhesus macaques and mice during SARS-CoV-2 infection.
Wed Feb 10 00:00:00 EST 2021
Sectm1a deficiency aggravates inflammation-triggered cardiac dysfunction through disruption of LXRα signalling in macrophages.
Cardiovascular research
Li Y,Deng S,Wang X,Huang W,Chen J,Robbins N,Mu X,Essandoh K,Peng T,Jegga AG,Rubinstein J,Adams DE,Wang Y,Peng J,Fan GC
14-0161 was used in Flow cytometry/Cell sorting to defines Sectm1a as a new regulator of inflammatory-induced cardiac dysfunction through modulation of LXRα signalling in macrophages.
Mon Feb 22 00:00:00 EST 2021
Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ.
Aging cell
Webb LMC,Fra-Bido S,Innocentin S,Matheson LS,Attaf N,Bignon A,Novarino J,Fazilleau N,Linterman MA
14-0161-82 was used in Flow Cytometry to show increased formation of Tfh precursors (pre-Tfh) but no associated increase in germinal centre (GC)-Tfh cells in aged mice, suggesting age-driven promotion of only early Tfh cell differentiation.
Fri Jan 01 00:00:00 EST 2021
Pseudomonas aeruginosa-induced nociceptor activation increases susceptibility to infection.
PLoS pathogens
Lin T,Quellier D,Lamb J,Voisin T,Baral P,Bock F,Schönberg A,Mirchev R,Pier G,Chiu I,Gadjeva M
14-0161-82 was used in Flow Cytometry to show that sensory neurons regulate corneal neutrophil responses in a tissue-specific matter affecting disease progression during P. aeruginosa keratitis.
Sat May 01 00:00:00 EDT 2021
Generation of a Novel Oncolytic Vaccinia Virus Using the IHD-W Strain.
Human gene therapy
Shin J,Hong SO,Kim M,Lee H,Choi H,Kim J,Hong J,Kang H,Lee E,Lee S,Kong B,Kim M,Choi H,Kim S
14-0161 was used in Flow cytometry/Cell sorting to develope a novel oncolytic vaccinia virus with high potency and a favorable safety profile.
Sat May 01 00:00:00 EDT 2021
A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice.
Med (New York, N.Y.)
Silva-Cayetano A,Foster WS,Innocentin S,Belij-Rammerstorfer S,Spencer AJ,Burton OT,Fra-Bidó S,Le Lee J,Thakur N,Conceicao C,Wright D,Barrett J,Evans-Bailey N,Noble C,Bailey D,Liston A,Gilbert SC,Lambe T,Linterman MA
14-0161-82 was used in Flow Cytometry to show that ChAdOx1 nCoV-19 induces both cellular and humoral immunity in adult and aged mice and suggest a prime-boost strategy is a rational approach to enhance immunogenicity in older persons.
Fri Mar 12 00:00:00 EST 2021
Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation.
Theranostics
Chen L,Chen H,Ye J,Ge Y,Wang H,Dai E,Ren J,Liu W,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
14-0161-82 was used in Flow Cytometry to explore the use of virally-delivered interleukin 23 as an anti-cancer treatment.
Wed Aug 04 00:00:00 EDT 2021
Adiponectin-expressing Treg facilitate T lymphocyte development in thymic nurse cell complexes.
Communications biology
Zhang Y,Cao H,Chen J,Li Y,Xu A,Wang Y
14-0161-82 was used in Inhibition Assays to demonstrate that adiponectin is expressed in a population of regulatory T-cells (Treg) resided within the thymic nurse cell (TNC) complexes.
Tue Mar 16 00:00:00 EDT 2021
Immunogenicity and protective efficacy of an intranasal live-attenuated vaccine against SARS-CoV-2.
iScience
Park JG,Oladunni FS,Rohaim MA,Whittingham-Dowd J,Tollitt J,Hodges MDJ,Fathallah N,Assas MB,Alhazmi W,Almilaibary A,Iqbal M,Chang P,Escalona R,Shivanna V,Torrelles JB,Worthington JJ,Jackson-Jones LH,Martinez-Sobrido L,Munir M
14-0161-82 was used in Flow Cytometry to evaluate a Newcastle disease virus (NDV)-based vectored-vaccine in mice and hamsters for its immunogenicity, safety and protective efficacy against SARS-CoV-2.
Fri Sep 24 00:00:00 EDT 2021
SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway.
bioRxiv : the preprint server for biology
Khan S,Shafiei MS,Longoria C,Schoggins J,Savani RC,Zaki H
14-0161-82 was used in Functional assay to reveal a mechanism for the cytokine storm during SARS-CoV-2 infection and suggest that TLR2 could be a potential therapeutic target for COVID-19.
Wed Mar 17 00:00:00 EDT 2021
Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity.
EMBO reports
Chauveau L,Bridgeman A,Tan TK,Beveridge R,Frost JN,Rijal P,Pedroza-Pacheco I,Partridge T,Gilbert-Jaramillo J,Knight ML,Liu X,Russell RA,Borrow P,Drakesmith H,Townsend AR,Rehwinkel J
14-0161-82 was used in flow cytometry to investigate whether inclusion of cGAMP within viral vaccine vectors enhances their immunogenicity.
Wed Aug 04 00:00:00 EDT 2021
Dissociation of microdissected mouse brain tissue for artifact free single-cell RNA sequencing.
STAR protocols
Liu L,Besson-Girard S,Ji H,Gehring K,Bulut B,Kaya T,Usifo F,Simons M,Gokce O
14-0161-82 was used in Flow Cytometry to describe an enzymatic dissociation method for mouse brain that prevents dissociation artifacts and lowers technical variations with standardized steps.
Fri Jun 18 00:00:00 EDT 2021
Evaluation of tumor immunity after administration of conditionally replicative adenoviral vector in canine osteosarcoma patients.
Heliyon
Agarwal P,Gammon EA,Sandey M,Lindley SS,Koehler JW,Matz BM,Smith AN,Kashentseva EA,Dmitriev IP,Curiel DT,Smith BF
14-0161-82 was used in Flow Cytometry to propose that OC-CAVE1 (CAV2 with the E1A promoter replaced with the osteocalcin promotor) may also enhance existing immunity against tumors by overcoming immune tolerance via exposure of new epitopes and cytokine signaling.
Mon Feb 01 00:00:00 EST 2021
Activin A Promotes Regulatory T-cell-Mediated Immunosuppression in Irradiated Breast Cancer.
Cancer immunology research
De Martino M,Daviaud C,Diamond JM,Kraynak J,Alard A,Formenti SC,Miller LD,Demaria S,Vanpouille-Box C
14-0161-82 was used in Flow Cytometry to shed light on an immune escape mechanism driven by activin A and suggest that dual targeting of activin A and TGFβ may be required to optimally unleash radiation-induced antitumor immunity against breast cancer.
Fri Jan 01 00:00:00 EST 2021
Electronic Cigarette Exposure Enhances Lung Inflammatory and Fibrotic Responses in COPD Mice.
Frontiers in pharmacology
Han H,Peng G,Meister M,Yao H,Yang JJ,Zou MH,Liu ZR,Ji X
14-0161-82 was used in Flow cytometry/Cell sorting to employ βENaC-overexpressing mice bearing COPD-like pulmonary abnormality, and exposed them to ENDS.
Sat Apr 02 00:00:00 EDT 2022
Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression.
Nature communications
Johann K,Bohn T,Shahneh F,Luther N,Birke A,Jaurich H,Helm M,Klein M,Raker VK,Bopp T,Barz M,Becker C
14-0161-82 was used in Flow cytometry/Cell sorting to show that the release of non-toxic concentrations of an adenylate cyclase (AC) inhibitor from poly(sarcosine)-block-poly(L-glutamic acid γ-benzyl ester) (polypept(o)id) copolymer micelles restores antitumor immunity.
Wed Oct 13 00:00:00 EDT 2021
IL-33/ST2 axis deficiency exacerbates neutrophil-dominant allergic airway inflammation.
Clinical & translational immunology
Ma Q,Qian Y,Jiang J,Wu J,Song M,Li X,Chen Z,Wang Z,Zhu R,Sun Z,Huang M,Ji N,Zhang M
14-0161-82 was used in Flow Cytometry to demonstrate that the IL-33/ST2 axis may play a protective role in neutrophil-dominant allergic airway inflammation.
Sun Apr 24 00:00:00 EDT 2022
Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice.
eLife
Kuhn JA,Vainchtein ID,Braz J,Hamel K,Bernstein M,Craik V,Dahlgren MW,Ortiz-Carpena J,Molofsky AB,Molofsky AV,Basbaum AI
14-0161-82 was used in Flow Cytometry to conclude that sexual dimorphism in the contribution of microglia to pain results from Treg-mediated suppression of microglial activation and pain hypersensitivity in female mice.
Fri Oct 15 00:00:00 EDT 2021
UCP1 governs liver extracellular succinate and inflammatory pathogenesis.
Nature metabolism
Mills EL,Harmon C,Jedrychowski MP,Xiao H,Garrity R,Tran NV,Bradshaw GA,Fu A,Szpyt J,Reddy A,Prendeville H,Danial NN,Gygi SP,Lynch L,Chouchani ET
14-0161-82 was used in Sample Preparation (FC/FACS) to show that, without UCP1, brown and beige fat exhibit a diminished capacity to clear succinate from the circulation.
Sat May 01 00:00:00 EDT 2021
Chitosan Nanovaccines as Efficient Carrier Adjuvant System for IL-12 with Enhanced Protection Against HBV.
International journal of nanomedicine
Zhao H,Wang H,Hu Y,Xu D,Yin C,Han Q,Zhang J
14-0161-82 was used in Flow Cytometry to further confirm the long-term protective immune response against HBV.
Thu Oct 14 00:00:00 EDT 2021
Analyses of the pericyte transcriptome in ischemic skeletal muscles.
Stem cell research & therapy
Teng YC,Porfírio-Sousa AL,Ribeiro GM,Arend MC,da Silva Meirelles L,Chen ES,Rosa DS,Han SW
14-0161 was used in Flow cytometry/Cell sorting to provide a database that will improve our understanding of skeletal muscle pericyte biology under ischemic conditions, which may be useful for the development of novel pericyte-based cell and gene therapies.
Tue Mar 16 00:00:00 EDT 2021
BCG Cell Wall Skeleton As a Vaccine Adjuvant Protects Both Infant and Old-Aged Mice from Influenza Virus Infection.
Biomedicines
Kim KH,Lee YT,Park Y,Ko EJ,Jung YJ,Kim YJ,Jo EK,Kang SM
14-0161-82 was used in Flow Cytometry to investigate the roles of Bacillus Calmette-Guerin (BCG) and the cell wall skeleton (CWS) derived from BCG as vaccine adjuvants.
Wed May 05 00:00:00 EDT 2021
Micellar Hyaluronidase and Spiperone as a Potential Treatment for Pulmonary Fibrosis.
International journal of molecular sciences
Skurikhin E,Madonov P,Pershina O,Ermakova N,Pakhomova A,Widera D,Pan E,Zhukova M,Sandrikina L,Artamonov A,Dygai A
14-0161-82 was used in Flow Cytometry to evaluate the effects of poloxamer hyaluronidase on bleomycin-induced alveolar damage, inflammation, and lung fibrosis in C57BL/6 mice in comparison with native hyaluronidase.
Tue May 25 00:00:00 EDT 2021
Obesity-Activated Lung Stromal Cells Promote Myeloid Lineage Cell Accumulation and Breast Cancer Metastasis.
Cancers
Hillers-Ziemer LE,Williams AE,Janquart A,Grogan C,Thompson V,Sanchez A,Arendt LM
14-0161-82 was used in Flow Cytometry to suggest that prior to tumor formation, obesity alters the lung microenvironment, creating niches conducive to metastatic growth.
Sun Feb 28 00:00:00 EST 2021
Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE-/- mice in the presence and absence of immunomodulation with fingolimod.
Data in brief
Diaz Diaz AC,Malone K,Shearer JA,Moore AC,Waeber C
14-0161-82 was used in Flow cytometry/Cell sorting to assess the sphingosine-1-phosphate receptor modulator fingolimod as a preclinical candidate for the treatment of acute ischaemic stroke according to the Stroke Therapy Academic Industry Roundtable (STAIR) preclinical recommendations.
Tue Jun 01 00:00:00 EDT 2021
Intravesical High Dose BCG Tokyo and Low Dose BCG Tokyo with GMCSF+IFN α Induce Systemic Immunity in a Murine Orthotopic Bladder Cancer Model.
Biomedicines
Tham SM,Rahmat JN,Chiong E,Wu Q,Esuvaranathan K,Mahendran R
14-0161-82 was used in Flow cytometry/Cell sorting to evaluate a short therapy schedule for bladder cancer using BCG Tokyo. BCG Tokyo was evaluated in vitro using bone marrow derived dendritic cells, neutrophils, RAW macrophages and the murine bladder cancer cell line, MB49PSA, and compared to other BCG strains.
Thu Nov 25 00:00:00 EST 2021
A macrophage-T cell coculture model for severe tissue injury-induced T cell death.
STAR protocols
Zhu J,Cao J,Liesz A,Roth S
14-0161-82 was used in Flow Cytometry to present an in vitro model for cell-cell interactions between innate (macrophages) and adaptive (T cells) immune cells.
Fri Dec 17 00:00:00 EST 2021
CD226 knockout alleviates high-fat diet induced obesity by suppressing proinflammatory macrophage phenotype.
Journal of translational medicine
Ma J,Hu W,Zhang D,Xie J,Duan C,Liu Y,Wang Y,Xu X,Cheng K,Jin B,Zhang Y,Zhuang R
14-0161-82 was used in Flow Cytometry to show that the costimulatory molecule CD226 was highly expressed on adipose tissue macrophages and knockout of CD226 alleviated obesity caused by high-fat diet.
Thu Nov 25 00:00:00 EST 2021
A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2.
Cell
Hassan AO,Kafai NM,Dmitriev IP,Fox JM,Smith BK,Harvey IB,Chen RE,Winkler ES,Wessel AW,Case JB,Kashentseva E,McCune BT,Bailey AL,Zhao H,VanBlargan LA,Dai YN,Ma M,Adams LJ,Shrihari S,Danis JE,Gralinski LE,Hou YJ,Schäfer A,Kim AS,Keeler SP,Weiskopf D,Baric RS,Holtzman MJ,Fremont DH,Curiel DT,Diamond MS
14-0161 was used in Flow cytometry/Cell sorting to establish that immunization with ChAd-SARS-CoV-2-S induces both neutralizing antibody and antigen-specific CD8+ T cell responses.
Thu Oct 01 00:00:00 EDT 2020
Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth.
Cell
Yao M,Ventura PB,Jiang Y,Rodriguez FJ,Wang L,Perry JSA,Yang Y,Wahl K,Crittenden RB,Bennett ML,Qi L,Gong CC,Li XN,Barres BA,Bender TP,Ravichandran KS,Janes KA,Eberhart CG,Zong H
14-0161 was used in Flow cytometry/Cell sorting to reveal an evolutionary process that produces a multi-lateral network within the TME of medulloblastoma: a fraction of tumor cells trans-differentiate into TuAstrocytes, which, in turn, produce IL-4 that stimulates microglia to produce IGF1 to promote tumor progression.
Thu Feb 06 00:00:00 EST 2020
Legionella-Infected Macrophages Engage the Alveolar Epithelium to Metabolically Reprogram Myeloid Cells and Promote Antibacterial Inflammation.
Cell host & microbe
Liu X,Boyer MA,Holmgren AM,Shin S
14-0161-82 was used in Flow Cytometry to reveal that alveolar macrophages engage alveolar epithelial signals to metabolically reprogram monocytes for antibacterial inflammation.
Wed Nov 11 00:00:00 EST 2020
Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-γ in NK cells.
The Journal of clinical investigation
Kim EY,Ner-Gaon H,Varon J,Cullen AM,Guo J,Choi J,Barragan-Bradford D,Higuera A,Pinilla-Vera M,Short SA,Arciniegas-Rubio A,Tamura T,Leaf DE,Baron RM,Shay T,Brenner MB
14-0161 was used in Flow cytometry/Cell sorting to show that in vivo iNKT cells activated mTORC1 in NK cells to produce IFN-γ, which worsened macrophage phagocytosis, clearance of secondary Candida infection, and mortality.
Mon Jun 01 00:00:00 EDT 2020
Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model.
The Journal of experimental medicine
Reed-Geaghan EG,Croxford AL,Becher B,Landreth GE
14-0161 was used in Flow cytometry/Cell sorting to genetically label different myeloid populations and unequivocally demonstrate that plaque-associated myeloid cells in the AD brain are derived exclusively from resident microglia.
Mon Apr 06 00:00:00 EDT 2020
Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction.
The EMBO journal
Konishi H,Okamoto T,Hara Y,Komine O,Tamada H,Maeda M,Osako F,Kobayashi M,Nishiyama A,Kataoka Y,Takai T,Udagawa N,Jung S,Ozato K,Tamura T,Tsuda M,Yamanaka K,Ogi T,Sato K,Kiyama H
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that astrocytes, rather than nonmicroglial mononuclear cells, readily phagocytose microglial debris in our microglia ablation model.
Mon Nov 16 00:00:00 EST 2020
FS222, a CD137/PD-L1 Tetravalent Bispecific Antibody, Exhibits Low Toxicity and Antitumor Activity in Colorectal Cancer Models.
Clinical cancer research : an official journal of the American Association for Cancer Research
Lakins MA,Koers A,Giambalvo R,Munoz-Olaya J,Hughes R,Goodman E,Marshall S,Wollerton F,Batey S,Gliddon D,Tuna M,Brewis N
14-0161 was used in Flow cytometry/Cell sorting to develop FS222, a bispecific tetravalent antibody targeting CD137 and PD-L1, to induce T-cell activation to eradicate tumors without the current toxicity and efficacy limitations seen in the clinic.
Sat Aug 01 00:00:00 EDT 2020
Induction of autophagy through CLEC4E in combination with TLR4: an innovative strategy to restrict the survival of Mycobacterium tuberculosis.
Autophagy
Pahari S,Negi S,Aqdas M,Arnett E,Schlesinger LS,Agrewala JN
14-0161-82 was used in Flow Cytometry to invesigate if a unique immunotherapeutic approach involving CLEC4E in conjunction with TLR4 to restrict the survival of mycobacterium tuberculosis through autophagy exists.
Mon Jun 01 00:00:00 EDT 2020
IgSF11 regulates osteoclast differentiation through association with the scaffold protein PSD-95.
Bone research
Kim H,Takegahara N,Walsh MC,Middleton SA,Yu J,Shirakawa J,Ueda J,Fujihara Y,Ikawa M,Ishii M,Kim J,Choi Y
14-0161-82 was used in Immunohistochemistry to reveal a critical role for IgSF11 during osteoclast differentiation and suggest a role for IgSF11 in a receptor- and signal transduction molecule-containing protein complex.
Thu Jun 10 00:00:00 EDT 2021
Targeting Obesity-Induced Macrophages during Preneoplastic Growth Promotes Mammary Epithelial Stem/Progenitor Activity, DNA Damage, and Tumor Formation.
Cancer research
Chamberlin T,Clack M,Silvers C,Kuziel G,Thompson V,Johnson H,Arendt LM
14-0161 was used in Flow cytometry/Cell sorting to examine preneoplastic changes associated with epithelial cell-specific loss of Trp53, using a high-fat diet to induce obesity,.
Thu Oct 15 00:00:00 EDT 2020
The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.
Proceedings of the National Academy of Sciences of the United States of America
Kitchen GB,Cunningham PS,Poolman TM,Iqbal M,Maidstone R,Baxter M,Bagnall J,Begley N,Saer B,Hussell T,Matthews LC,Dockrell DH,Durrington HJ,Gibbs JE,Blaikley JF,Loudon AS,Ray DW
14-0161-82 was used in Flow Cytometry to show that loss of the core clock protein BMAL1 in macrophages confers protection against pneumococcal pneumonia.
Tue Jan 21 00:00:00 EST 2020
RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis.
Cell death and differentiation
Chen H,Li Y,Wu J,Li G,Tao X,Lai K,Yuan Y,Zhang X,Zou Z,Xu Y
14-0161-82 was used in Inhibition Assays to demonstrate that RIPK3-mediated necroptosis and GSDMD-mediated pyroptosis collaborated to amply inflammatory signaling and enhance tissue injury in the process of sepsis, which may shed new light on two potential targets of combined therapeutic interventions for this highly lethal disorder.
Tue Sep 01 00:00:00 EDT 2020
A Genetic Screen to Identify Gain- and Loss-of-Function Modifications that Enhance T-cell Infiltration into Tumors.
Cancer immunology research
Rogers LM,Wang Z,Mott SL,Dupuy AJ,Weiner GJ
14-0161 was used in Flow cytometry/Cell sorting to describe an unbiased in vivo genetic screen approach utilizing the Sleeping Beauty mutagenesis system to identify candidate genes in T cells that might be modified to drive intratumoral T-cell accumulation.
Tue Sep 01 00:00:00 EDT 2020
Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2).
Cancer immunology research
Huetter J,Gritzan U,Gutcher I,Doecke WD,Luetke-Eversloh MV,Golfier S,Roider HG,Frisk AL,Hunter J,Pow A,Drake A,Levine Z,Levy O,Azulay M,Barbiro I,Cojocaru G,Vaknin I,Kreft B,Roese L
14-0161 was used in Flow cytometry/Cell sorting to show that BAY 1905254 is a potential drug candidate for cancer immunotherapy.
Wed Jul 01 00:00:00 EDT 2020
Intratumoral Delivery of a PD-1-Blocking scFv Encoded in Oncolytic HSV-1 Promotes Antitumor Immunity and Synergizes with TIGIT Blockade.
Cancer immunology research
Lin C,Ren W,Luo Y,Li S,Chang Y,Li L,Xiong D,Huang X,Xu Z,Yu Z,Wang Y,Zhang J,Huang C,Xia N
14-0161-86 was used in Flow Cytometry to show that locoregional oncolytic virotherapy upregulated the expression of PD-L1 in the TME, which was mediated by virus-induced type I and type II IFNs.
Fri May 01 00:00:00 EDT 2020
Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma.
Cancer immunology research
Spenlé C,Loustau T,Murdamoothoo D,Erne W,Beghelli-de la Forest Divonne S,Veber R,Petti L,Bourdely P,Mörgelin M,Brauchle EM,Cremel G,Randrianarisoa V,Camara A,Rekima S,Schaub S,Nouhen K,Imhof T,Hansen U,Paul N,Carapito R,Pythoud N,Hirschler A,Carapito C,Dumortier H,Mueller CG,Koch M,Schenke-Layland K,Kon S,Sudaka A,Anjuère F,Van Obberghen-Schilling E,Orend G
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that tenascin-C enforced an immune-suppressive lymphoid stroma via CCL21/CCR7 signaling, leading to increased metastatic tumors.
Tue Sep 01 00:00:00 EDT 2020
Microtubules control cellular shape and coherence in amoeboid migrating cells.
The Journal of cell biology
Kopf A,Renkawitz J,Hauschild R,Girkontaite I,Tedford K,Merrin J,Thorn-Seshold O,Trauner D,Häcker H,Fischer KD,Kiermaier E,Sixt M
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that spatially distinct microtubule dynamics regulate amoeboid cell migration by locally promoting the retraction of protrusions.
Mon Jun 01 00:00:00 EDT 2020
Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging.
The journals of gerontology. Series A, Biological sciences and medical sciences
Mau T,O'Brien M,Ghosh AK,Miller RA,Yung R
14-0161 was used in Flow cytometry/Cell sorting to study the effects of three drugs identified in the Interventions Testing Program on inflammation in gonadal white adipose tissue of HET3 mice.
Wed Jan 01 00:00:00 EST 2020
Brief exposure to hyperglycemia activates dendritic cells in vitro and in vivo.
Journal of cellular physiology
Thomas AM,Dong Y,Beskid NM,García AJ,Adams AB,Babensee JE
14-0161-82 was used in Flow Cytometry to show that expression of the costimulatory molecule CD86 was found to reliably increase when dendritic cells were exposed to hyperglycemia.
Mon Jun 01 00:00:00 EDT 2020
In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2.
Molecular therapy oncolytics
Liu W,Dai E,Liu Z,Ma C,Guo ZS,Bartlett DL
14-0161 was used in Flow cytometry/Cell sorting to establish in situ anticancer immunotherapy regimens.
Fri Jun 26 00:00:00 EDT 2020
Sympathetic Nerves Positively Regulate Eosinophil-Driven Allergic Conjunctivitis via α1-Adrenergic Receptor Signaling.
The American journal of pathology
Liu J,Huang S,Li F,Wu M,He J,Xue Y,Fu T,Yu R,Chen X,Wang Y,Li Z
14-0161-82 was used in Flow Cytometry to report that conjunctival eosinophils comprise two populations-Siglec-Fint and Siglec-Fhi-in different life stages.
Mon Jun 01 00:00:00 EDT 2020
Mycobacterial Trehalose 6,6'-Dimycolate-Induced M1-Type Inflammation.
The American journal of pathology
Nguyen TKT,d'Aigle J,Chinea L,Niaz Z,Hunter RL,Hwang SA,Actor JK
14-0161 was used in Flow cytometry/Cell sorting to investigate the role of trehalose 6,6'-dimycolate (TDM) in the early macrophages response during initiation of granulomas of primary pathology.
Sat Feb 01 00:00:00 EST 2020
MOSPD2 is a therapeutic target for the treatment of CNS inflammation.
Clinical and experimental immunology
Yacov N,Kafri P,Salem Y,Propheta-Meiran O,Feldman B,Breitbart E,Mendel I
14-0161 was used in Flow cytometry/Cell sorting to study the therapeutic potential of MOSPD2 in central nervous system disease.
Sat Aug 01 00:00:00 EDT 2020
CD38 in cancer-associated fibroblasts promotes pro-tumoral activity.
Laboratory investigation; a journal of technical methods and pathology
Ben Baruch B,Mantsur E,Franco-Barraza J,Blacher E,Cukierman E,Stein R
14-0161 was used in Flow cytometry/Cell sorting to investigate the role of CD38 in regulating cancer-associated fibroblasts pro-tumorigenic functions.
Tue Dec 01 00:00:00 EST 2020
Cancer Cell-Intrinsic Expression of MHC Class II Regulates the Immune Microenvironment and Response to Anti-PD-1 Therapy in Lung Adenocarcinoma.
Journal of immunology (Baltimore, Md. : 1950)
Johnson AM,Bullock BL,Neuwelt AJ,Poczobutt JM,Kaspar RE,Li HY,Kwak JW,Hopp K,Weiser-Evans MCM,Heasley LE,Schenk EL,Clambey ET,Nemenoff RA
14-0161 was used in Flow cytometry/Cell sorting to examine the effect of cancer cell-specific MHC class II (csMHCII) expression in lung adenocarcinoma on T cell recruitment to tumors and response to anti-PD-1 therapy using two orthotopic immunocompetent murine models of non-small cell lung cancer: CMT167 (CMT) and Lewis lung carcinoma (LLC).
Wed Apr 15 00:00:00 EDT 2020
MiR-1165-3p Suppresses Th2 Differentiation via Targeting IL-13 and PPM1A in a Mouse Model of Allergic Airway Inflammation.
Allergy, asthma & immunology research
Wang Z,Ji N,Chen Z,Sun Z,Wu C,Yu W,Hu F,Huang M,Zhang M
14-0161 was used in Flow cytometry/Cell sorting to investigate the associations between Th2 differentiation and miR-1165b-3p in asthma as well as the possible mechanisms.
Tue Sep 01 00:00:00 EDT 2020
Japanese Kampo Medicine Juzentaihoto Enhances Antitumor Immunity in CD1d-/- Mice Lacking NKT Cells.
Integrative cancer therapies
Takaku S,Shimizu M,Takahashi H
14-0161-82 was used in Flow cytometry/Cell sorting to indicate that in the absence of NKT cells, JTT augments antitumor immunity by CD8+ T cells, suggesting that this Kampo medicine is a promising anticancer adjuvant when negative immune regulation is partially relieved.
Mon Mar 23 00:00:00 EDT 2020
Increase in liver γδ T cells with concurrent augmentation of IFN-β production during the early stages of a mouse model of acute experimental hepatitis B virus infection.
Experimental and therapeutic medicine
Chang L,Wang L,Ling N,Peng H,Chen M
14-0161-82 was used in Flow Cytometry to suggest that during the early stages of acute HBV infection, significantly increased numbers of liver γδ T cells may be involved in the enhanced immune response to the increased expression of HBV markers in the liver.
Wed Jan 01 00:00:00 EST 2020
Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease.
Experimental and therapeutic medicine
Li W,Chen S,Luo Y,Xia Y,Ma Q,Yao Q,Wu J
14-0161 was used in Flow cytometry/Cell sorting to investigate the infiltration of T cells in lesions in the central nervous system, in patients with and without Parkinson's Disease.
Sat Aug 01 00:00:00 EDT 2020
Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage.
Stem cell research & therapy
Fan C,Feng J,Tang C,Zhang Z,Feng Y,Duan W,Zhai M,Yan Z,Zhu L,Feng L,Zhu H,Luo E
14-0161 was used in Flow cytometry/Cell sorting to explore whether cytoprotective melatonin relieves endoplasmic reticulum(ER) stress-mediated mitochondrial dysfunction through AMPK in bone marrow mesenchymal stem cells(BMSCs) after oxidative stress injury.
Thu Oct 15 00:00:00 EDT 2020
Near infrared photoimmunotherapy targeting DLL3 for small cell lung cancer.
EBioMedicine
Isobe Y,Sato K,Nishinaga Y,Takahashi K,Taki S,Yasui H,Shimizu M,Endo R,Koike C,Kuramoto N,Yukawa H,Nakamura S,Fukui T,Kawaguchi K,Chen-Yoshikawa TF,Baba Y,Hasegawa Y
14-0161 was used in Flow cytometry/Cell sorting to demonstrate DLL3-targeted NIR-PIT to develop a novel molecularly targeted treatment for SCLC.
Sat Feb 01 00:00:00 EST 2020
G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program.
Cell reports
Mabe NW,Garcia NMG,Wolery SE,Newcomb R,Meingasner RC,Vilona BA,Lupo R,Lin CC,Chi JT,Alvarez JV
14-0161 was used in Flow cytometry/Cell sorting to show that recurrent mammary tumors exhibit global changes in gene expression and histone modifications and acquire dependence on the G9a histone methyltransferase.
Tue Nov 03 00:00:00 EST 2020
Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas.
Nature communications
Aslan K,Turco V,Blobner J,Sonner JK,Liuzzi AR,Núñez NG,De Feo D,Kickingereder P,Fischer M,Green E,Sadik A,Friedrich M,Sanghvi K,Kilian M,Cichon F,Wolf L,Jähne K,von Landenberg A,Bunse L,Sahm F,Schrimpf D,Meyer J,Alexander A,Brugnara G,Röth R,Pfleiderer K,Niesler B,von Deimling A,Opitz C,Breckwoldt MO,Heiland S,Bendszus M,Wick W,Becher B,Platten M
14-0161-82 was used in Flow Cytometry to investigate resistance mechanisms to anti-PD-1 and anti-CTLA-4 therapy in syngeneic hypermutated experimental gliomas and show a clear dichotomy and acquired immune heterogeneity in ICB-responder and non-responder tumors.
Tue Feb 18 00:00:00 EST 2020
Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration.
Cell reports
Piao W,Xiong Y,Li L,Saxena V,Smith KD,Hippen KL,Paluskievicz C,Willsonshirkey M,Blazar BR,Abdi R,Bromberg JS
14-0161 was used in Flow cytometry/Cell sorting to demonstrate the role of regulatory T cells in enhancing leukocyte migration through endothelial barriers.
Tue Jan 28 00:00:00 EST 2020
Distinct Transcriptional Responses across Tissue-Resident Macrophages to Short-Term and Long-Term Metabolic Challenge.
Cell reports
Brykczynska U,Geigges M,Wiedemann SJ,Dror E,Böni-Schnetzler M,Hess C,Donath MY,Paro R
14-0161 was used in Flow cytometry/Cell sorting to provide a resource for assessing the impact of nutrition and over-nutrition on the spectrum of macrophages across tissues with a potential for identification of systemic responses.
Tue Feb 04 00:00:00 EST 2020
Tissue-resident macrophages promote extracellular matrix homeostasis in the mammary gland stroma of nulliparous mice.
eLife
Wang Y,Chaffee TS,LaRue RS,Huggins DN,Witschen PM,Ibrahim AM,Nelson AC,Machado HL,Schwertfeger KL
14-0161 was used in Flow cytometry/Cell sorting to identify stromal macrophage subpopulations within the mammory gland of nulliparous mice.
Mon Jun 01 00:00:00 EDT 2020
Lipin-1 Contributes to IL-4 Mediated Macrophage Polarization.
Frontiers in immunology
Chandran S,Schilke RM,Blackburn CMR,Yurochko A,Mirza R,Scott RS,Finck BN,Woolard MD
14-0161 was used in Flow cytometry/Cell sorting to provide evidence that lipin-1 transcriptional co-regulatory activity contributes to macrophage polarization and influences wound healing in vivo.
Mon Mar 29 00:00:00 EDT 2021
Overproduction of IL-2 by Cbl-b deficient CD4+ T cells provides resistance against regulatory T cells.
Oncoimmunology
Han S,Chung DC,St Paul M,Liu ZQ,Garcia-Batres C,Elford AR,Tran CW,Chapatte L,Ohashi PS
14-0161 was used in Flow cytometry/Cell sorting to investigate the role of Cbl-b, an E3 ubiquitin ligase, in establishing resistance to Treg-mediated suppression.
Wed Jul 28 00:00:00 EDT 2021
Stromal CCL2 Signaling Promotes Mammary Tumor Fibrosis through Recruitment of Myeloid-Lineage Cells.
Cancers
Kuziel G,Thompson V,D'Amato JV,Arendt LM
14-0161 was used in Flow cytometry/Cell sorting to suggest that chronic inflammation induced by CCL2 significantly enhances tumor growth and promotes the formation of a desmoplastic stroma through early recruitment of macrophages and fibrocytes into the tumor microenvironment.
Tue Jul 28 00:00:00 EDT 2020
MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling.
Journal of neuroinflammation
Mao M,Xu Y,Zhang XY,Yang L,An XB,Qu Y,Chai YN,Wang YR,Li TT,Ai J
14-0161 was used in Flow cytometry/Cell sorting to investigate the effect of CCCI on microglial polarization after chronic brain hypoperfusion (CBH) and explore the underlying molecular mechanisms.
Thu Aug 20 00:00:00 EDT 2020
Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety.
Journal for immunotherapy of cancer
Ge Y,Wang H,Ren J,Liu W,Chen L,Chen H,Ye J,Dai E,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
14-0161-82 was used in Flow Cytometry to show IL-12 tethered to oncolytic vaccinia virus leading to transformed, immunogenic tumors and improved survival.
Sun Mar 01 00:00:00 EST 2020
Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination.
eLife
Stebegg M,Bignon A,Hill DL,Silva-Cayetano A,Krueger C,Vanderleyden I,Innocentin S,Boon L,Wang J,Zand MS,Dooley J,Clark J,Liston A,Carr E,Linterman MA
14-0161-82 was used in Flow Cytometry to discover what underpins the poor Tfh cell response in ageing and whether it is possible to correct it.
Tue Mar 24 00:00:00 EDT 2020
Atypical chemokine receptor ACKR2-V41A has decreased CCL2 binding, scavenging, and activation, supporting sustained inflammation and increased Alzheimer's disease risk.
Scientific reports
Murcia JDG,Weinert A,Freitas CMT,Arens DK,Ferrel MN,Grose JH,Ridge PG,Wilson E,Kauwe JSK,Weber KS
14-0161 was used in Flow cytometry/Cell sorting to study CCL2 binding to an atypical chemokine receptor in the context of Alzheimer's disease.
Fri May 15 00:00:00 EDT 2020
Macrophage-Associated Lipin-1 Promotes β-Oxidation in Response to Proresolving Stimuli.
ImmunoHorizons
Schilke RM,Blackburn CMR,Rao S,Krzywanski DM,Finck BN,Woolard MD
14-0161 was used in Flow cytometry/Cell sorting to show that lipin-1 is required for increased oxidative phosphorylation in IL-4 stimulated mouse (Mus musculus) macrophages.
Mon Oct 19 00:00:00 EDT 2020
CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes.
Nature communications
Shimokawa C,Kato T,Takeuchi T,Ohshima N,Furuki T,Ohtsu Y,Suzue K,Imai T,Obi S,Olia A,Izumi T,Sakurai M,Arakawa H,Ohno H,Hisaeda H
14-0161 was used in Flow cytometry/Cell sorting to show that CD8+ regulatory T (Treg) cells prevent the onset of streptozotocin -induced diabetes by a rodent intestinal nematode.
Wed Apr 22 00:00:00 EDT 2020
TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic.
Oncotarget
Ralff MD,Jhaveri A,Ray JE,Zhou L,Lev A,Campbell KS,Dicker DT,Ross EA,El-Deiry WS
14-0161-82 was used in Flow Cytometry to investigate strategies to convert the response of breast cancers to ONC201 from anti-proliferative to apoptotic.
Tue Oct 20 00:00:00 EDT 2020
Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells.
JCI insight
Markworth JF,Brown LA,Lim E,Floyd C,Larouche J,Castor-Macias JA,Sugg KB,Sarver DC,Macpherson PC,Davis C,Aguilar CA,Maddipati KR,Brooks SV
14-0161 was used in Flow cytometry/Cell sorting to reveal the efficacy of immunoresolvents as a novel alternative to classical antiinflammatory interventions in the management of muscle injuries to modulate inflammation while stimulating tissue repair.
Thu Sep 17 00:00:00 EDT 2020
Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities.
Nature communications
Cho SX,Rudloff I,Lao JC,Pang MA,Goldberg R,Bui CB,McLean CA,Stock M,Klassert TE,Slevogt H,Mangan NE,Cheng W,Fischer D,Gfroerer S,Sandhu MK,Ngo D,Bujotzek A,Lariviere L,Schumacher F,Tiefenthaler G,Beker F,Collins C,Kamlin COF,König K,Malhotra A,Tan K,Theda C,Veldman A,Ellisdon AM,Whisstock JC,Berger PJ,Nold-Petry CA,Nold MF
14-0161 was used in Flow cytometry/Cell sorting to implicate type 3 cytokines, TLRs and IL-37 as potential targets for novel Necrotizing enterocolitis therapies.
Fri Nov 13 00:00:00 EST 2020
Use of Busulfan to Condition Mice for Bone Marrow Transplantation.
STAR protocols
Montecino-Rodriguez E,Dorshkind K
14-0161 was used in Flow cytometry/Cell sorting to describe a protocol for the use of busulfan to condition mice for bone marrow transplantation and several of the variables to consider for effective implementation.
Fri Dec 18 00:00:00 EST 2020
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.
Nature communications
Iske J,Seyda M,Heinbokel T,Maenosono R,Minami K,Nian Y,Quante M,Falk CS,Azuma H,Martin F,Passos JF,Niemann CU,Tchkonia T,Kirkland JL,Elkhal A,Tullius SG
14-0161 was used in Flow cytometry/Cell sorting to show that cell-free mitochondrial DNA (cf-mt-DNA) released by senescent cells accumulates with aging and augments immunogenicity.
Thu Aug 27 00:00:00 EDT 2020
Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis.
Cell reports
Kaya B,Doñas C,Wuggenig P,Diaz OE,Morales RA,Melhem H,Hernández PP,Kaymak T,Das S,Hruz P,Franc Y,Geier F,Ayata CK,Villablanca EJ,Niess JH
14-0161 was used in Inhibition assays to indicate that LPA signals through GPR35 in CX3CR1+ macrophages to maintain TNF-mediated intestinal homeostasis.
Tue Aug 04 00:00:00 EDT 2020
The miR-183/96/182 Cluster Regulates the Functions of Corneal Resident Macrophages.
ImmunoHorizons
Coku A,McClellan SA,Van Buren E,Back JB,Hazlett LD,Xu S
14-0161-82 was used in Flow Cytometry to provide direct evidence that the mouse corneal ResMφ constitutively produce both IL-17f and IL-10.
Wed Nov 18 00:00:00 EST 2020
LncGBP9/miR-34a axis drives macrophages toward a phenotype conducive for spinal cord injury repair via STAT1/STAT6 and SOCS3.
Journal of neuroinflammation
Zhou J,Li Z,Wu T,Zhao Q,Zhao Q,Cao Y
14-0161 was used in Immunohistochemistry-immunofluorescence to demonstrate a novel mechanism by which the lncGBP9/miR-34a axis modulates STAT1/ STAT6 to affect macrophage polarization via SOCS3.
Tue Apr 28 00:00:00 EDT 2020
Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.
Communications biology
Waaler J,Mygland L,Tveita A,Strand MF,Solberg NT,Olsen PA,Aizenshtadt A,Fauskanger M,Lund K,Brinch SA,Lycke M,Dybing E,Nygaard V,Bøe SL,Heintz KM,Hovig E,Hammarström C,Corthay A,Krauss S
14-0161 was used in Flow cytometry/Cell sorting to show that a specific small-molecule tankyrase inhibitor, G007-LK, decreases WNT/β-catenin and YAP signaling in the syngeneic murine B16-F10 and Clone M-3 melanoma models and sensitizes the tumors to anti-PD-1 immune checkpoint therapy.
Fri Apr 24 00:00:00 EDT 2020
Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma.
eLife
Lau AN,Li Z,Danai LV,Westermark AM,Darnell AM,Ferreira R,Gocheva V,Sivanand S,Lien EC,Sapp KM,Mayers JR,Biffi G,Chin CR,Davidson SM,Tuveson DA,Jacks T,Matheson NJ,Yilmaz O,Vander Heiden MG
14-0161 was used in Flow cytometry/Cell sorting to assess differences between cancer cell and fibroblast metabolism in murine pancreatic cancer organoid-fibroblast co-cultures and tumours.
Fri Jul 10 00:00:00 EDT 2020
Myh11+ microvascular mural cells and derived mesenchymal stem cells promote retinal fibrosis.
Scientific reports
Ray HC,Corliss BA,Bruce AC,Kesting S,Dey P,Mansour J,Seaman SA,Smolko CM,Mathews C,Dey BK,Owens GK,Peirce SM,Yates PA
14-0161 was used in Flow cytometry/Cell sorting to show that myofibroblast differentiation of mural cells contributes directly to retinal fibrosis.
Fri Sep 25 00:00:00 EDT 2020
Axenic Caenorhabditis elegans antigen protects against development of type-1 diabetes in NOD mice.
Journal of translational autoimmunity
Jackson-Thompson BM,Torrero M,Mitre BK,Long J,Packiam M,Mitre E
14-0161 was used in Flow cytometry/Cell sorting to investigate whether soluble antigens obtained from Caenorhabditis elegans can confer protection against inflammatory disease.
Mon Sep 28 00:00:00 EDT 2020
Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.
Cell
Jin C,Lagoudas GK,Zhao C,Bullman S,Bhutkar A,Hu B,Ameh S,Sandel D,Liang XS,Mazzilli S,Whary MT,Meyerson M,Germain R,Blainey PC,Fox JG,Jacks T
14-0161-82 was used in Flow Cytometry to link local microbiota-immune crosstalk to lung tumor development and thereby define key cellular and molecular mediators that may serve as effective targets in lung cancer intervention.
Thu Feb 21 00:00:00 EST 2019
Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection.
Cell
Amezcua Vesely MC,Pallis P,Bielecki P,Low JS,Zhao J,Harman CCD,Kroehling L,Jackson R,Bailis W,Licona-Limón P,Xu H,Iijima N,Pillai PS,Kaplan DH,Weaver CT,Kluger Y,Kowalczyk MS,Iwasaki A,Pereira JP,Esplugues E,Gagliani N,Flavell RA
14-0161-82 was used in immunohistochemistry (frozen) immunofluorescence to delineate the origin and function of airway CD4 TRM cells during bacterial infection.
Thu Aug 22 00:00:00 EDT 2019
A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves.
Immunity
Kolter J,Feuerstein R,Zeis P,Hagemeyer N,Paterson N,d'Errico P,Baasch S,Amann L,Masuda T,Lösslein A,Gharun K,Meyer-Luehmann M,Waskow C,Franzke CW,Grün D,Lämmermann T,Prinz M,Henneke P
14-0161 was used in Flow cytometry/Cell sorting to delineate the postnatal development of dermal macrophages and their differentiation into subsets by adapting single-cell transcriptomics, fate mapping, and imaging.
Tue Jun 18 00:00:00 EDT 2019
Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice.
Gut
Hendrikx T,Duan Y,Wang Y,Oh JH,Alexander LM,Huang W,Stärkel P,Ho SB,Gao B,Fiehn O,Emond P,Sokol H,van Pijkeren JP,Schnabl B
14-0161 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms underlying REG3G suppression that occurs during alcoholic liver disease.
Thu Aug 01 00:00:00 EDT 2019
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.
Cell metabolism
Camell CD,Günther P,Lee A,Goldberg EL,Spadaro O,Youm YH,Bartke A,Hubbard GB,Ikeno Y,Ruddle NH,Schultze J,Dixit VD
14-0161 was used in Flow cytometry/Cell sorting to study the role of ageing within alterations of adipose tissue.
Tue Dec 03 00:00:00 EST 2019
Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding.
Cell metabolism
Kim JD,Yoon NA,Jin S,Diano S
14-0161 was used in Flow cytometry/Cell sorting to point to a fuel-availability-driven mitochondrial mechanism as a major player of microglia activation in the central regulation of DIO.
Tue Nov 05 00:00:00 EST 2019
CD8+ T cells induce cachexia during chronic viral infection.
Nature immunology
Baazim H,Schweiger M,Moschinger M,Xu H,Scherer T,Popa A,Gallage S,Ali A,Khamina K,Kosack L,Vilagos B,Smyth M,Lercher A,Friske J,Merkler D,Aderem A,Helbich TH,Heikenwälder M,Lang PA,Zechner R,Bergthaler A
14-0161-82 was used in Flow Cytometry to identify the role for CD8+ T cells in infection-associated cachexia.
Sat Jun 01 00:00:00 EDT 2019
FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias.
Blood
Esnault C,Rahmé R,Rice KL,Berthier C,Gaillard C,Quentin S,Maubert AL,Kogan S,de Thé H
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that FLT3-ITD severely blunts ATRA response.
Thu Mar 28 00:00:00 EDT 2019
A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis.
The Journal of clinical investigation
Han YH,Shin KO,Kim JY,Khadka DB,Kim HJ,Lee YM,Cho WJ,Cha JY,Lee BJ,Lee MO
14-0161 was used in Flow cytometry/Cell sorting to study the hepatic microenvironments that support the function of RORa as a polarity regulator.
Mon Mar 11 00:00:00 EDT 2019
Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223.
The Journal of clinical investigation
Calvente CJ,Tameda M,Johnson CD,Del Pilar H,Lin YC,Adronikou N,De Mollerat Du Jeu X,Llorente C,Boyer J,Feldstein AE
14-0161 was used in Flow cytometry/Cell sorting to identify a novel role for neutrophils as key contributors to resolving the inflammatory response in the liver.
Thu Jul 11 00:00:00 EDT 2019
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.
Molecular cell
Zhang H,Alsaleh G,Feltham J,Sun Y,Napolitano G,Riffelmacher T,Charles P,Frau L,Hublitz P,Yu Z,Mohammed S,Ballabio A,Balabanov S,Mellor J,Simon AK
14-0161 was used in Flow cytometry/Cell sorting to reveal an unexpected autophagy regulatory mechanism mediated by eIF5A at the translational level, which can be harnessed to reverse immune senescence in humans.
Thu Oct 03 00:00:00 EDT 2019
EDA fibronectin-TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis.
The Journal of experimental medicine
Malara A,Gruppi C,Abbonante V,Cattaneo D,De Marco L,Massa M,Iurlo A,Gianelli U,Balduini CL,Tira ME,Muro AF,Chauhan AK,Rosti V,Barosi G,Balduini A
14-0161 was used in Flow cytometry/Cell sorting to find that the EDA FN is increased in plasma and BM biopsies of PMF patients as compared with healthy controls, correlating with fibrotic phase.
Mon Mar 04 00:00:00 EST 2019
Negative Regulation of p53-Induced Senescence by N-WASP Is Crucial for DMBA/TPA-Induced Skin Tumor Formation.
Cancer research
Li H,Petersen S,Garcia Mariscal A,Brakebusch C
14-0161 was used in Flow cytometry/Cell sorting to study how mice with a keratinocyte-restricted deletion of the actin-polymerization promoting molecule N-WASP display cyclic hair loss and skin inflammation.
Wed May 01 00:00:00 EDT 2019
Tumor Lymphatic Function Regulates Tumor Inflammatory and Immunosuppressive Microenvironments.
Cancer immunology research
Kataru RP,Ly CL,Shin J,Park HJ,Baik JE,Rehal S,Ortega S,Lyden D,Mehrara BJ
14-0161 was used in Flow cytometry/Cell sorting to suggest that lymphatic dysfunction plays a role in regulating tumor microenvironments and may be therapeutically targeted in combination with immunotherapy to prevent tumor growth and progression.
Thu Aug 01 00:00:00 EDT 2019
Low-Dose Apatinib Optimizes Tumor Microenvironment and Potentiates Antitumor Effect of PD-1/PD-L1 Blockade in Lung Cancer.
Cancer immunology research
Zhao S,Ren S,Jiang T,Zhu B,Li X,Zhao C,Jia Y,Shi J,Zhang L,Liu X,Qiao M,Chen X,Su C,Yu H,Zhou C,Zhang J,Camidge DR,Hirsch FR
14-0161 was used in Flow cytometry/Cell sorting to analyze the impact of apatinib, a smallmolecule VEGFR2-TKI, on the TME in murine Lewis lung carcinoma (LLC) models at different doses alone and in combination with an anti–PD-L1.
Mon Apr 01 00:00:00 EDT 2019
Inflammation via myeloid differentiation primary response gene 88 signaling mediates the fibrotic response to implantable synthetic poly(ethylene glycol) hydrogels.
Acta biomaterialia
Amer LD,Saleh LS,Walker C,Thomas S,Janssen WJ,Alper S,Bryant SJ
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that MyD88-mediated inflammation is responsible in part for the formation of the fibrous capsule of the FBR.
Sun Dec 01 00:00:00 EST 2019
Fibroblast activation protein restrains adipogenic differentiation and regulates matrix-mediated mTOR signaling.
Matrix biology : journal of the International Society for Matrix Biology
Blomberg R,Beiting DP,Wabitsch M,Puré E
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that loss of FAP results in increased adiposity due, at least in part, to enhanced adipogenic differentiation and matrix-induced adipocyte hypertrophy via mTOR signaling.
Tue Oct 01 00:00:00 EDT 2019
T helper 2 differentiation is necessary for development of lymphedema.
Translational research : the journal of laboratory and clinical medicine
Ly CL,Nores GDG,Kataru RP,Mehrara BJ
14-0161 was used in Flow cytometry/Cell sorting to analyse the effect of lymphatic injury in transgenic mice with mutations that cause defects in Th1 and Th2 cell generation (T-bet knockout or T-betKO and STAT6 knockout or STAT6KO mice, respectively).
Mon Apr 01 00:00:00 EDT 2019
Antibiotic treatment ameliorates Ten-eleven translocation 2 (TET2) loss-of-function associated hematological malignancies.
Cancer letters
Zeng H,He H,Guo L,Li J,Lee M,Han W,Guzman AG,Zang S,Zhou Y,Zhang X,Goodell MA,King KY,Sun D,Huang Y
14-0161 was used in Flow cytometry/Cell sorting to establish the feasibility of targeting pro-inflammatory pathways to curtail TET2 inactivation-associated hematological malignancies.
Sat Dec 28 00:00:00 EST 2019
Inhibition of phosphodiesterase-4 attenuates murine ulcerative colitis through interference with mucosal immunity.
British journal of pharmacology
Li H,Fan C,Feng C,Wu Y,Lu H,He P,Yang X,Zhu F,Qi Q,Gao Y,Zuo J,Tang W
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that inhibition of PDE4 by apremilast protected against ulcerative colitis, by interfering with mucosal immunity in mice.
Mon Jul 01 00:00:00 EDT 2019
Myc-dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor-2.
EMBO reports
Testini C,Smith RO,Jin Y,Martinsson P,Sun Y,Hedlund M,Sáinz-Jaspeado M,Shibuya M,Hellström M,Claesson-Welsh L
14-0161-82 was used in Flow Cytometry to show vascular endothelial growth factor receptor-2 phosphotyrosine 1212 signalling activates ERK1/2 and Akt pathways for endothelial proliferation mediated by c-Myc.
Tue Nov 05 00:00:00 EST 2019
CD73 Promotes Glioblastoma Pathogenesis and Enhances Its Chemoresistance via A2B Adenosine Receptor Signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Yan A,Joachims ML,Thompson LF,Miller AD,Canoll PD,Bynoe MS
14-0161-82 was used in Flow Cytometry to indicate that blockade or inhibition of CD73 and the A2B AR are prime targets for future GB therapy.
Wed May 29 00:00:00 EDT 2019
Enhanced Therapeutic Efficacy of a Novel Oncolytic Herpes Simplex Virus Type 2 Encoding an Antibody Against Programmed Cell Death 1.
Molecular therapy oncolytics
Zhu Y,Hu X,Feng L,Yang Z,Zhou L,Duan X,Cheng S,Zhang W,Liu B,Zhang K
14-0161-82 was used in Flow Cytometry to develop a novel oncolytic herpes simplex virus 2 (HSV2) encoding an anti-human programmed cell death 1 (PD-1) monoclonal antibody (oHSV2-aPD1) and demostrate its therapeutic efficacy.
Fri Dec 20 00:00:00 EST 2019
Therapeutic efficacy of different routes of mesenchymal stem cell administration in corneal injury.
The ocular surface
Shukla S,Mittal SK,Foulsham W,Elbasiony E,Singhania D,Sahu SK,Chauhan SK
14-0161-82 was used in Immunohistochemistry to evaluate the efficacies of different modes of mesenchymal stem cells delivery (topical, subconjunctival, intraperitoneal [IP] and intravenous [IV]) to promote tissue repair and restore corneal transparency in a murine model of corneal injury.
Tue Oct 01 00:00:00 EDT 2019
Aging impairs mouse skeletal muscle macrophage polarization and muscle-specific abundance during recovery from disuse.
American journal of physiology. Endocrinology and metabolism
Reidy PT,McKenzie AI,Mahmassani ZS,Petrocelli JJ,Nelson DB,Lindsay CC,Gardner JE,Morrow VR,Keefe AC,Huffaker TB,Stoddard GJ,Kardon G,O'Connell RM,Drummond MJ
14-0161 was used in Flow cytometry/Cell sorting to investigate if dysregulated macrophage phenotype patterns in aged muscle during recovery from disuse may be related to impaired muscle growth.
Mon Jul 01 00:00:00 EDT 2019
Extracellular RNAs from lung cancer cells activate epithelial cells and induce neutrophil extracellular traps.
International journal of oncology
Li Y,Yang Y,Gan T,Zhou J,Hu F,Hao N,Yuan B,Chen Y,Zhang M
14-0161 was used in Flow cytometry/Cell sorting to investigate the cross‚talk of tumor exRNAs and neutrophil extracellular traps in lung cancer.
Mon Jul 01 00:00:00 EDT 2019
HPRT and Purine Salvaging Are Critical for Hematopoietic Stem Cell Function.
Stem cells (Dayton, Ohio)
Vogel M,Moehrle B,Brown A,Eiwen K,Sakk V,Geiger H
14-0161-82 was used in Immunohistochemistry to imply a unique and important role of hypocanthine guanine phosphoribosyl transferase and the purine salvage pathway for hematopoietic stem cell function.
Sun Dec 01 00:00:00 EST 2019
Genome-wide effect of pulmonary airway epithelial cell-specific Bmal1 deletion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhang Z,Hunter L,Wu G,Maidstone R,Mizoro Y,Vonslow R,Fife M,Hopwood T,Begley N,Saer B,Wang P,Cunningham P,Baxter M,Durrington H,Blaikley JF,Hussell T,Rattray M,Hogenesch JB,Gibbs J,Ray DW,Loudon ASI
14-0161-82 was used in Flow Cytometry to find that metabolic cues dictate phasing of the pulmonary clock and circadian responses to immunologic challenges.
Wed May 01 00:00:00 EDT 2019
Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Garcia-Agudo LF,Janova H,Sendler LE,Arinrad S,Steixner AA,Hassouna I,Balmuth E,Ronnenberg A,Schopf N,van der Flier FJ,Begemann M,Martens H,Weber MS,Boretius S,Nave KA,Ehrenreich H
14-0161 was used in Flow cytometry/Cell sorting to conclude that even though microglia depletion is temporarily beneficial and worth pursuing, complementary treatment strategies are needed for full and lasting recovery.
Mon Jul 01 00:00:00 EDT 2019
Podoplanin Positive Myeloid Cells Promote Glioma Development by Immune Suppression.
Frontiers in oncology
Eisemann T,Costa B,Peterziel H,Angel P
14-0161 was used in Flow cytometry/Cell sorting to identify the role of podoplanin positive myeloid cells in immune suppression and thus their potential as a target for immune mediated tumour elimination.
Wed Sep 30 00:00:00 EDT 2020
Cytochrome P450 26A1 modulates uterine dendritic cells in mice early pregnancy.
Journal of cellular and molecular medicine
Gu AQ,Li DD,Wei DP,Liu YQ,Ji WH,Yang Y,Lin HY,Peng JP
14-0161 was used in Flow cytometry/Cell sorting to study the relationship between cytochrome P450 26A1 and immune cells during the peri-implantation period in mice.
Thu Aug 01 00:00:00 EDT 2019
Single Dose of a Polyanhydride Particle-Based Vaccine Generates Potent Antigen-Specific Antitumor Immune Responses.
The Journal of pharmacology and experimental therapeutics
Wafa EI,Geary SM,Ross KA,Goodman JT,Narasimhan B,Salem AK
14-0161 was used in Flow cytometry/Cell sorting to indicate that the requirement for a booster dose using these particles appears unnecessary for the generation of effective cellular immunity, and furthermore, that the generation of a strong IgG response to a tumor antigen not expressed on the tumor cell surface may not be important for antitumor potency.
Sun Sep 01 00:00:00 EDT 2019
Characterization of abscopal effects of intratumoral electroporation-mediated IL-12 gene therapy.
Gene therapy
Mukhopadhyay A,Wright J,Shirley S,Canton DA,Burkart C,Connolly RJ,Campbell JS,Pierce RH
14-0161-82 was used in Flow Cytometry to analyze the immunological changes induced with the new IT-pIL12/EP platform in both electroporated and distant, non-electroporated lesions.
Fri Feb 01 00:00:00 EST 2019
Multi-walled carbon nanotube oxidation dependent keratinocyte cytotoxicity and skin inflammation.
Particle and fibre toxicology
Palmer BC,Phelan-Dickenson SJ,DeLouise LA
14-0161 was used in Flow cytometry/Cell sorting to examine the role of carboxylation in multi-walled carbon nanotube skin toxicity.
Tue Jan 08 00:00:00 EST 2019
C-Reactive Protein Promotes the Expansion of Myeloid Derived Cells With Suppressor Functions.
Frontiers in immunology
Jimenez RV,Kuznetsova V,Connelly AN,Hel Z,Szalai AJ
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that CRP dose-dependently increases the generation of MDSC from wild type mouse bone marrow progenitors and enhances MDSC production of intracellular reactive oxygen species (iROS).
Tue Nov 10 00:00:00 EST 2020
Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.
Cell stem cell
McKenzie MD,Ghisi M,Oxley EP,Ngo S,Cimmino L,Esnault C,Liu R,Salmon JM,Bell CC,Ahmed N,Erlichster M,Witkowski MT,Liu GJ,Chopin M,Dakic A,Simankowicz E,Pomilio G,Vu T,Krsmanovic P,Su S,Tian L,Baldwin TM,Zalcenstein DA,DiRago L,Wang S,Metcalf D,Johnstone RW,Croker BA,Lancaster GI,Murphy AJ,Naik SH,Nutt SL,Pospisil V,Schroeder T,Wall M,Dawson MA,Wei AH,de Thé H,Ritchie ME,Zuber J,Dickins RA
14-0161 was used in Flow cytometry/Cell sorting to investigate cancer stem cell plasticity in acute myeloid leukemia.
Thu Aug 01 00:00:00 EDT 2019
DC3 is a method for deconvolution and coupled clustering from bulk and single-cell genomics data.
Nature communications
Zeng W,Chen X,Duren Z,Wang Y,Jiang R,Wong WH
14-0161-82 was used in Flow cytometry/Cell sorting to show that the subpopulation-specific profiles of gene expression, chromatin accessibility and enhancer-promoter contact obtained by DC3 provide a comprehensive characterization of the gene regulatory system in each subpopulation.
Thu Oct 10 00:00:00 EDT 2019
Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation.
Science advances
Lee YS,Riopel M,Cabrales P,Bandyopadhyay GK
14-0161-82 was used in Flow Cytometry to understand obesity-induced changes in liver oxygen homeostasis and find that liver HIF-1α expression was increased mainly by soluble factors released from obese adipocytes, leading to decreased incretin effects.
Mon Jul 01 00:00:00 EDT 2019
Mast Cells Are Mediators of Fibrosis and Effector Cell Recruitment in Dermal Chronic Graft-vs.-Host Disease.
Frontiers in immunology
Strattan E,Palaniyandi S,Kumari R,Du J,Hakim N,Huang T,Kesler MV,Jennings CD,Sturgill JL,Hildebrandt GC
14-0161-82 was used in Flow cytometry/Cell sorting to show for the first time a role for mast cells in skin chronic graft-vs-host disease that may be targetable for preventive and therapeutic intervention in this disease.
Tue Nov 17 00:00:00 EST 2020
Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti-PD-1 response in NSCLC.
Life science alliance
Bullock BL,Kimball AK,Poczobutt JM,Neuwelt AJ,Li HY,Johnson AM,Kwak JW,Kleczko EK,Kaspar RE,Wagner EK,Hopp K,Schenk EL,Weiser-Evans MC,Clambey ET,Nemenoff RA
14-0161-82 was used in Flow Cytometry to demonstrate that targeted enhancement of tumor-intrinsic IFNγ signaling can induce a cascade of changes associated with increased therapeutic vulnerability.
Sat Jun 01 00:00:00 EDT 2019
PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells.
Cell reports
Tan DQ,Li Y,Yang C,Li J,Tan SH,Chin DWL,Nakamura-Ishizu A,Yang H,Suda T
14-0161 was used in Flow cytometry/Cell sorting to establish the importance of cell-intrinsic protein arginine methyltransferase 5 activity in hematopoietic stem cells.
Tue Feb 26 00:00:00 EST 2019
Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1.
Cell reports
Gawish R,Bulat T,Biaggio M,Lassnig C,Bago-Horvath Z,Macho-Maschler S,Poelzl A,Simonović N,Prchal-Murphy M,Rom R,Amenitsch L,Ferrarese L,Kornhoff J,Lederer T,Svinka J,Eferl R,Bosmann M,Kalinke U,Stoiber D,Sexl V,Krmpotić A,Jonjić S,Müller M,Strobl B
14-0161 was used in Flow cytometry/Cell sorting to provide genetic evidence that signaling through STAT1 in myeloid cells is required to restrict MCMV at early time points post-infection and to induce compensatory hematopoiesis in the spleen.
Tue Feb 26 00:00:00 EST 2019
The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells.
Cell reports
Araujo LP,Maricato JT,Guereschi MG,Takenaka MC,Nascimento VM,de Melo FM,Quintana FJ,Brum PC,Basso AS
14-0161-82 was used in Flow Cytometry to uncover a suppressive role for the SNS in CNS autoimmunity while they identify potential targets for therapeutic intervention.
Tue Sep 17 00:00:00 EDT 2019
Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression.
Nature communications
Bae J,Choi SP,Isono K,Lee JY,Park SW,Choi CY,Han J,Kim SH,Lee HH,Park K,Jin HY,Lee SJ,Park CG,Koseki H,Lee YS,Chun T
14-0161-82 was used in Flow cytometry/Cell sorting to determine the role of PHc2 in controlling the mobilisation of hematopoietic stem and progenitor cells.
Fri Aug 02 00:00:00 EDT 2019
LPA1/3 overactivation induces neonatal posthemorrhagic hydrocephalus through ependymal loss and ciliary dysfunction.
Science advances
Lummis NC,Sánchez-Pavón P,Kennedy G,Frantz AJ,Kihara Y,Blaho VA,Chun J
14-0161 was used in Flow cytometry/Cell sorting to show neonatal posthemorrhagic hydrocephalus can be induced by ependymal loss and ciliary dysfunction as a consequence of lysophosphatidic acid overactivation.
Tue Oct 01 00:00:00 EDT 2019
Trained immunity modulates inflammation-induced fibrosis.
Nature communications
Jeljeli M,Riccio LGC,Doridot L,Chêne C,Nicco C,Chouzenoux S,Deletang Q,Allanore Y,Kavian N,Batteux F
14-0161 was used in Flow cytometry/Cell sorting to show the effect of BCG or low-dose LPS stimulation on macrophage phenotype, cytokine production, chromatin and metabolic modifications.
Wed Dec 11 00:00:00 EST 2019
Sex Differences in Mouse Popliteal Lymph Nodes.
Scientific reports
Dill-Garlow R,Chen KE,Walker AM
14-0161 was used in Flow cytometry/Cell sorting to investigate the underlying sex differences that may contribute to differential footpad delayed-type hypersensitivity responses using wildtype and four core genotypes mice and popliteal lymphnode cellularity and gene expression.
Wed Jan 30 00:00:00 EST 2019
Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells.
JCI insight
Dawson NA,Lamarche C,Hoeppli RE,Bergqvist P,Fung VC,McIver E,Huang Q,Gillies J,Speck M,Orban PC,Bush JW,Mojibian M,Levings MK
14-0161 was used in Flow cytometry/Cell sorting to characterise and test alloantigen-specific chimeric antigen receptors in regulatory T cells.
Thu Mar 21 00:00:00 EDT 2019
c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism.
Acta neuropathologica communications
Merve A,Zhang X,Pomella N,Acquati S,Hoeck JD,Dumas A,Rosser G,Li Y,Jeyapalan J,Vicenzi S,Fan Q,Yang ZJ,Sabò A,Sheer D,Behrens A,Marino S
14-0161-82 was used in Flow Cytometry to show here that c-MYC overexpression in the choroid plexus epithelium induces T-cell inflammation-dependent choroid plexus papillomas in a mouse model.
Wed May 29 00:00:00 EDT 2019
Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity.
Nature metabolism
Seo JB,Riopel M,Cabrales P,Huh JY,Bandyopadhyay GK,Andreyev AY,Murphy AN,Beeman SC,Smith GI,Klein S,Lee YS,Olefsky JM
14-0161-82 was used in Flow Cytometry to demonstrate that increased adipocyte O2 demand, mediated by ANT2 activity, is the dominant cause of adipocyte hypoxia.
Tue Jan 01 00:00:00 EST 2019
Dietary calories and lipids synergistically shape adipose tissue cellularity during postnatal growth.
Molecular metabolism
Meln I,Wolff G,Gajek T,Koddebusch J,Lerch S,Harbrecht L,Hong W,Bayindir-Buchhalter I,Krunic D,Augustin HG,Vegiopoulos A
14-0161 was used in Flow cytometry/Cell sorting to show that dietary lipids and calories differentially and synergistically drive adipose tissue proliferative growth and the programming of the metabolic syndrome in childhood.
Sat Jun 01 00:00:00 EDT 2019
Characterization of Plaque-Sized Variants of Daniel's (DA) Strain in Theiler's Virus-Induced Epilepsy.
Scientific reports
Bijalwan M,Young CR,Tingling J,Zhou XJ,Rimmelin AR,Leibowitz JL,Welsh CJ
14-0161 was used in Flow cytometry/Cell sorting to investigate the neuropathogenesis of large (DA-CL) and small (DA-DS) plaque-size variants of Daniel's (DA) strain of Theiler's murine encephalomyelitis virus (TMEV)-induced seizures.
Tue Mar 05 00:00:00 EST 2019
Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors.
Nature communications
Duan X,Chan C,Han W,Guo N,Weichselbaum RR,Lin W
14-0161 was used in Flow cytometry/Cell sorting to conclude that the intrinsically biodegradable, well tolerated, and systemically available immunostimulatory NCP promises to enter clinical testing as an immunotherapy against colorectal cancer.
Tue Apr 23 00:00:00 EDT 2019
Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells.
Cell death & disease
Vig S,Buitinga M,Rondas D,Crèvecoeur I,van Zandvoort M,Waelkens E,Eizirik DL,Gysemans C,Baatsen P,Mathieu C,Overbergh L
14-0161-82 was used in Flow Cytometry to study the translocation of 78-kDa glucose-regulated protein to the surface of human EndoC-βH1 cells and primary human islets upon cytokine exposure.
Fri Apr 05 00:00:00 EDT 2019
Traceless aptamer-mediated isolation of CD8+ T cells for chimeric antigen receptor T-cell therapy.
Nature biomedical engineering
Kacherovsky N,Cardle II,Cheng EL,Yu JL,Baldwin ML,Salipante SJ,Jensen MC,Pun SH
14-0161 was used in Flow cytometry/Cell sorting to show that DNA aptamers (generated with a modified cell-SELEX procedure to display low-nanomolar affinity for the T-cell marker CD8) enable the traceless isolation of pure CD8+ T cells at low cost and high yield.
Tue Oct 01 00:00:00 EDT 2019
Mouse models of Loa loa.
Nature communications
Pionnier NP,Sjoberg H,Chunda VC,Fombad FF,Chounna PW,Njouendou AJ,Metuge HM,Ndzeshang BL,Gandjui NV,Akumtoh DN,Tayong DB,Taylor MJ,Wanji S,Turner JD
14-0161 was used in Flow cytometry/Cell sorting to provide validation of murine research models to identify loiasis biomarkers, to counter-screen candidate river blindness cures and to interrogate the inflammatory etiology of loiasis ivermectin-associated adverse reactions.
Fri Mar 29 00:00:00 EDT 2019
The nuclear variant of bone morphogenetic protein 2 (nBMP2) is expressed in macrophages and alters calcium response.
Scientific reports
Tellez Freitas CM,Burrell HR,Valdoz JC,Hamblin GJ,Raymond CM,Cox TD,Johnson DK,Andersen JL,Weber KS,Bridgewater LC
14-0161-82 was used in Flow Cytometry to show that nBMP2 plays a role in Ca2+ response.
Wed Jan 30 00:00:00 EST 2019
Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra.
Nature microbiology
Ji DX,Yamashiro LH,Chen KJ,Mukaida N,Kramnik I,Darwin KH,Vance RE
14-0161 was used in Flow cytometry/Cell sorting to show that enhanced production of type I IFNs was responsible for the susceptibility of B6.Sst1S mice to Mycobacterium tuberculosis (Mtb).
Sun Dec 01 00:00:00 EST 2019
Amorphous silicon dioxide nanoparticles modulate immune responses in a model of allergic contact dermatitis.
Scientific reports
Palmer BC,Jatana S,Phelan-Dickinson SJ,DeLouise LA
14-0161 was used in Flow cytometry/Cell sorting to show amorphous silicon dioxide nanoparticles have an immunomodulatory effect in a model of allergic contact dermatitis.
Mon Mar 25 00:00:00 EDT 2019
Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue.
Cell reports
Li B,Li L,Li M,Lam SM,Wang G,Wu Y,Zhang H,Niu C,Zhang X,Liu X,Hambly C,Jin W,Shui G,Speakman JR
14-0161-82 was used in Flow Cytometry to indicate that gut microbiota contributes to upregulated thermogenesis in the cold environment and that this may be partially mediated via butyrate.
Tue Mar 05 00:00:00 EST 2019
Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection.
Cell death discovery
Wang N,Yang X,Sun J,Sun Z,Ma Q,Wang Z,Chen Z,Wang Z,Hu F,Wang H,Zhou L,Zhang M,Xu J
14-0161-82 was used in Flow Cytometry to identify a direct role of VP1 in EV71-induced pulmonary edema and demonstrate that NETs may be both harmful and beneficial in EV71 infection.
Wed Sep 30 00:00:00 EDT 2020
Acute tobacco smoke exposure exacerbates the inflammatory response to corneal wounds in mice via the sympathetic nervous system.
Communications biology
Xiao C,Wu M,Liu J,Gu J,Jiao X,Lu D,He J,Lin C,Xue Y,Fu T,Wang H,Wang G,Yang X,Li Z
14-0161-82 was used in Flow Cytometry to highlight that the SNS may represent a major molecular sensor and mediator of ATSE-induced inflammation.
Thu Apr 02 00:00:00 EDT 2020
The CARD9-Associated C-Type Lectin, Mincle, Recognizes La Crosse Virus (LACV) but Plays a Limited Role in Early Antiviral Responses against LACV.
Viruses
Monteiro JT,Schön K,Ebbecke T,Goethe R,Ruland J,Baumgärtner W,Becker SC,Lepenies B
14-0161-82 was used in Flow Cytometry to investigate the role of additional C-type lectin receptors/La Crosse virus interactions.
Tue Mar 26 00:00:00 EDT 2019
TLR2 Promotes Monocyte/Macrophage Recruitment Into the Liver and Microabscess Formation to Limit the Spread of Listeria Monocytogenes.
Frontiers in immunology
Wang G,Zhao H,Zheng B,Li D,Yuan Y,Han Q,Tian Z,Zhang J
14-0161-82 was used in Flow Cytometry to provide insight into the intrinsic mechanisms of TLR2-induced Mo/MΦ migration and mobility, as well as the interaction between macrophages and hepatocytes in resistance to Lm infection.
Thu Oct 15 00:00:00 EDT 2020
Circuit Design Features of a Stable Two-Cell System.
Cell
Zhou X,Franklin RA,Adler M,Jacox JB,Bailis W,Shyer JA,Flavell RA,Mayo A,Alon U,Medzhitov R
14-0161 was used in Flow cytometry/Cell sorting to illustrate principles of cell circuit design and provide a quantitative perspective on cell interactions.
Thu Feb 08 00:00:00 EST 2018
Airway Epithelial Cell-Derived Colony Stimulating Factor-1 Promotes Allergen Sensitization.
Immunity
Moon HG,Kim SJ,Jeong JJ,Han SS,Jarjour NN,Lee H,Abboud-Werner SL,Chung S,Choi HS,Natarajan V,Ackerman SJ,Christman JW,Park GY
14-0161 was used in Flow cytometry/Cell sorting to describe the functional specification of CSF1-dependent DC subsets that link the innate and adaptive immune responses in T helper 2 (Th2) cell-mediated allergic lung inflammation.
Tue Aug 21 00:00:00 EDT 2018
γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.
Nature immunology
Kohlgruber AC,Gal-Oz ST,LaMarche NM,Shimazaki M,Duquette D,Koay HF,Nguyen HN,Mina AI,Paras T,Tavakkoli A,von Andrian U,Uldrich AP,Godfrey DI,Banks AS,Shay T,Brenner MB,Lynch L
14-0161-82 was used in Flow cytometry/Cell sorting to uncover important physiological roles for resident γδ T cells in adipose tissue immune homeostasis and body-temperature control.
Tue May 01 00:00:00 EDT 2018
Genetic Targeting of Organ-Specific Blood Vessels.
Circulation research
Pu W,He L,Han X,Tian X,Li Y,Zhang H,Liu Q,Huang X,Zhang L,Wang QD,Yu Z,Yang X,Smart N,Zhou B
14-0161 was used in Flow cytometry/Cell sorting to provide 2 examples to illustrate the use of intersectional genetics for more precise gene targeting in vivo, namely manipulation of genes in blood vessels of the heart and brain.
Fri Jun 22 00:00:00 EDT 2018
Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function.
The Journal of clinical investigation
Riopel M,Seo JB,Bandyopadhyay GK,Li P,Wollam J,Chung H,Jung SR,Murphy A,Wilson M,de Jong R,Patel S,Balakrishna D,Bilakovics J,Fanjul A,Plonowski A,Koh DS,Larson CJ,Olefsky JM,Lee YS
14-0161 was used in Flow cytometry/Cell sorting to raise the possibility of FKN-based therapy to improve type 2 diabetes by increasing both insulin secretion and insulin sensitivity.
Mon Apr 02 00:00:00 EDT 2018
Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis.
The Journal of clinical investigation
Szabady RL,Louissaint C,Lubben A,Xie B,Reeksting S,Tuohy C,Demma Z,Foley SE,Faherty CS,Llanos-Chea A,Olive AJ,Mrsny RJ,McCormick BA
14-0161 was used in Flow cytometry/Cell sorting to define a key role for epithelial cells in balancing the constitutive secretion of antiinflammatory lipids with the stimulated secretion of proinflammatory lipids in order to control neutrophil infiltration into the intestinal lumen and maintain homeostasis in the healthy intestine.
Fri Aug 31 00:00:00 EDT 2018
Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling.
The Journal of clinical investigation
Emmerson A,Trevelin SC,Mongue-Din H,Becker PD,Ortiz C,Smyth LA,Peng Q,Elgueta R,Sawyer G,Ivetic A,Lechler RI,Lombardi G,Shah AM
Mon Jul 02 00:00:00 EDT 2018
Endothelial cells in the innate response to allergens and initiation of atopic asthma.
The Journal of clinical investigation
Asosingh K,Weiss K,Queisser K,Wanner N,Yin M,Aronica M,Erzurum S
14-0161 was used in Flow cytometry/Cell sorting to identify that lung endothelium and proangiogenic haematopoietic progenitor cells in the airway sense allergen and elicit an angiogenic response that is central to the innate non-immune origins of Th2 inflammation.
Mon Jul 02 00:00:00 EDT 2018
Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.
Molecular cell
Annibaldi A,Wicky John S,Vanden Berghe T,Swatek KN,Ruan J,Liccardi G,Bianchi K,Elliott PR,Choi SM,Van Coillie S,Bertin J,Wu H,Komander D,Vandenabeele P,Silke J,Meier P
14-0161 was used in Flow cytometry/Cell sorting to reveal a direct role for cIAP-mediated ubiquitylation in controlling RIPK1 kinase activity and preventing TNF-mediated cytotoxicity.
Thu Feb 15 00:00:00 EST 2018
Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5.
The Journal of experimental medicine
Buxadé M,Huerga Encabo H,Riera-Borrull M,Quintana-Gallardo L,López-Cotarelo P,Tellechea M,Martínez-Martínez S,Redondo JM,Martín-Caballero J,Flores JM,Bosch E,Rodríguez-Fernández JL,Aramburu J,López-Rodríguez C
14-0161 was used in Flow cytometry/Cell sorting to study the requirement of NFAT5 for expression of Ciita and MHCII in macrophages, but not in dendritic cells and other antigen-presenting cells.
Mon Nov 05 00:00:00 EST 2018
The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.
The Journal of experimental medicine
Zhang W,Li Q,Li D,Li J,Aki D,Liu YC
14-0161 was used in Flow cytometry/Cell sorting to show VHL regulates alveolar macrophages and acts as a crucial egulatory factor in lung inflammation and fibrosis.
Mon Dec 03 00:00:00 EST 2018
Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney.
Journal of the American Society of Nephrology : JASN
Micanovic R,Khan S,Janosevic D,Lee ME,Hato T,Srour EF,Winfree S,Ghosh J,Tong Y,Rice SE,Dagher PC,Wu XR,El-Achkar TM
14-0161-82 was used in Flow Cytometry to suggest that interstitial THP positively regulates mononuclear phagocyte number, plasticity, and phagocytic activity.
Thu Mar 01 00:00:00 EST 2018
The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes.
The EMBO journal
Fletcher K,Ulferts R,Jacquin E,Veith T,Gammoh N,Arasteh JM,Mayer U,Carding SR,Wileman T,Beale R,Florey O
14-0161 was used in Flow cytometry/Cell sorting to demonstrate activation of non-canonical autophagy dependent on the WD40 CTD during influenza A virus infection.
Thu Feb 15 00:00:00 EST 2018
Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress.
PLoS biology
Mensurado S,Rei M,Lança T,Ioannou M,Gonçalves-Sousa N,Kubo H,Malissen M,Papayannopoulos V,Serre K,Silva-Santos B
14-0161 was used in Flow cytometry/Cell sorting to study the role of tumour-associated neutrophils in the regulation of γδ17 T-cell responses in the tumour microenvironment.
Tue May 01 00:00:00 EDT 2018
Experimental Stroke Differentially Affects Discrete Subpopulations of Splenic Macrophages.
Frontiers in immunology
McCulloch L,Alfieri A,McColl BW
14-0161 was used in Flow cytometry/Cell sorting to study the effects of experimental stroke on discrete splenic macrophage subpopulations.
Tue Jul 30 00:00:00 EDT 2019
Heterologous Prime-Boost Combinations Highlight the Crucial Role of Adjuvant in Priming the Immune System.
Frontiers in immunology
Ciabattini A,Pettini E,Fiorino F,Lucchesi S,Pastore G,Brunetti J,Santoro F,Andersen P,Bracci L,Pozzi G,Medaglini D
14-0161 was used in Flow cytometry/Cell sorting to investigate the impact of heterologous prime-boost approaches on the vaccine-specific cellular and humoral responses specific for a mycobacterial vaccine antigen on C57BL/6 mice.
Mon Apr 08 00:00:00 EDT 2019
A fully-virulent retargeted oncolytic HSV armed with IL-12 elicits local immunity and vaccine therapy towards distant tumors.
PLoS pathogens
Leoni V,Vannini A,Gatta V,Rambaldi J,Sanapo M,Barboni C,Zaghini A,Nanni P,Lollini PL,Casiraghi C,Campadelli-Fiume G
14-0161 was used in Flow cytometry/Cell sorting to analyse the efficacy of a fully-virulent HER2-retargeted oncolytic HSV, demonstrating its ability to elicit a local immune response and systemic therapy vaccine effects.
Wed Aug 01 00:00:00 EDT 2018
Low-Fat Diet With Caloric Restriction Reduces White Matter Microglia Activation During Aging.
Frontiers in molecular neuroscience
Yin Z,Raj DD,Schaafsma W,van der Heijden RA,Kooistra SM,Reijne AC,Zhang X,Moser J,Brouwer N,Heeringa P,Yi CX,van Dijk G,Laman JD,Boddeke EWGM,Eggen BJL
14-0161 was used in Immunohistochemistry on frozen tissues to study the impact of both high-fat and low-fat diets on the microglia of rats.
Wed Sep 30 00:00:00 EDT 2020
Constitutive Activation of NF-κB Pathway in Hematopoietic Stem Cells Causes Loss of Quiescence and Deregulated Transcription Factor Networks.
Frontiers in cell and developmental biology
Nakagawa MM,Chen H,Rathinam CV
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that aberrant activation of NF-κB signals impairs haematopoietic stem cells quiescence and functions, and alters the 'transcription factors networks' in HSCs.
Thu Oct 01 00:00:00 EDT 2020
Antibiotic-Induced Dysbiosis of Gut Microbiota Impairs Corneal Nerve Regeneration by Affecting CCR2-Negative Macrophage Distribution.
The American journal of pathology
Liu J,Wu M,He J,Xiao C,Xue Y,Fu T,Lin C,Dong D,Li Z
14-0161 was used in Flow cytometry/Cell sorting to study the relationship between dysbiosis of the gut microbiota induced by antibiotic treatment and impaired corneal nerve regeneration.
Sat Dec 01 00:00:00 EST 2018
MicroRNA 33 Regulates the Population of Peripheral Inflammatory Ly6Chigh Monocytes through Dual Pathways.
Molecular and cellular biology
Baba O,Horie T,Nakao T,Hakuno D,Nakashima Y,Nishi H,Kuwabara Y,Nishiga M,Nishino T,Ide Y,Nakazeki F,Koyama S,Kimura M,Hanada R,Kawahara M,Kimura T,Ono K
14-0161 was used in Flow cytometry/Cell sorting to indicate that miR-33 deficiency affects distribution of inflammatory monocytes through dual pathways.
Sun Jul 15 00:00:00 EDT 2018
Dysregulation of Kupffer Cells/Macrophages and Natural Killer T Cells in Steatohepatitis in LXRα Knockout Male Mice.
Endocrinology
Endo-Umeda K,Nakashima H,Umeda N,Seki S,Makishima M
Thu Mar 01 00:00:00 EST 2018
Quantification of airway fibrosis in asthma by flow cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Reichard A,Wanner N,Stuehr E,Alemagno M,Weiss K,Queisser K,Erzurum S,Asosingh K
14-0161 was used in Flow cytometry to develop a novel method to quantify myofibroblast collagen expression in asthmatic lungs.
Sun Jul 01 00:00:00 EDT 2018
Corticosterone Production during Repeated Social Defeat Causes Monocyte Mobilization from the Bone Marrow, Glucocorticoid Resistance, and Neurovascular Adhesion Molecule Expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Niraula A,Wang Y,Godbout JP,Sheridan JF
14-0161-82 was used in Flow cytometry/Cell sorting to delineate the role of HPA activation and corticosterone production in the immunological responses to stress in male C57BL/6 mice.
Wed Feb 28 00:00:00 EST 2018
CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema.
Nature communications
García Nores GD,Ly CL,Cuzzone DA,Kataru RP,Hespe GE,Torrisi JS,Huang JJ,Gardenier JC,Savetsky IL,Nitti MD,Yu JZ,Rehal S,Mehrara BJ
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that blocking T cell release from lymph nodes using a sphingosine-1-phosphate receptor modulator prevents lymphedema.
Thu May 17 00:00:00 EDT 2018
Long-Term Effects of Dietary Protein and Branched-Chain Amino Acids on Metabolism and Inflammation in Mice.
Nutrients
Mu WC,VanHoosier E,Elks CM,Grant RW
14-0161 was used in Flow cytometry/Cell sorting to investigate how dietary protein levels and branched-chain amino acid supplementation impact metabolism and immune profile in mice.
Wed Jul 18 00:00:00 EDT 2018
Dietary Supplementation of Selenoneine-Containing Tuna Dark Muscle Extract Effectively Reduces Pathology of Experimental Colorectal Cancers in Mice.
Nutrients
Masuda J,Umemura C,Yokozawa M,Yamauchi K,Seko T,Yamashita M,Yamashita Y
14-0161 was used in Flow cytometry/Cell sorting to suggest that dietary STDME may be an effective agent for reducing colorectal tumor progression.
Thu Sep 27 00:00:00 EDT 2018
Hyaluronidase inhibits reactive adipogenesis and inflammation of colon and skin.
JCI insight
Dokoshi T,Zhang LJ,Nakatsuji T,Adase CA,Sanford JA,Paladini RD,Tanaka H,Fujiya M,Gallo RL
14-0161 was used in Flow cytometry/Cell sorting to suggest hyaluronidase plays an important role in reactive adipogenesis and host defense after injury.
Fri Nov 02 00:00:00 EDT 2018
Meningeal whole mount preparation and characterization of neural cells by flow cytometry.
Current protocols in immunology
Louveau A,Filiano AJ,Kipnis J
14-0161 was used in Flow cytometry/Cell sorting to describe two protocols: analysis the meningeal compartment of rodents and the use flow cytometry to study the cells of the brain parenchyma.
Sun Apr 01 00:00:00 EDT 2018
Meningeal whole mount preparation and characterization of neural cells by flow cytometry.
Current protocols in immunology
Louveau A,Filiano AJ,Kipnis J
14-0161 was used in Flow cytometry/Cell sorting to describe two protocols: analysis the meningeal compartment of rodents and the use flow cytometry to study the cells of the brain parenchyma.
Sun Apr 01 00:00:00 EDT 2018
A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors.
Nature communications
Vigolo M,Chambers MG,Willen L,Chevalley D,Maskos K,Lammens A,Tardivel A,Das D,Kowalczyk-Quintas C,Schuepbach-Mallepell S,Smulski CR,Eslami M,Rolink A,Hummler E,Samy E,Fomekong Nanfack Y,Mackay F,Liao M,Hess H,Jiang X,Schneider P
14-0161 was used in Flow cytometry/Cell sorting to study TNSF13B/BAFF interactions in C57BL/6OlaHsd mice. TNSF13B/BAFF underwent flow cytometry to investigate if distint biological and clinical efficacies occur to the therapeutically relevant inhibitors.
Fri Mar 23 00:00:00 EDT 2018
Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling.
Nature communications
Piao W,Xiong Y,Famulski K,Brinkman CC,Li L,Toney N,Wagner C,Saxena V,Simon T,Bromberg JS
14-0161 was used in Flow cytometry/Cell sorting to demonstrate the importance of LTΒR signaling in leukocyte migration and LEC and lymphatic vessel function, and show that antagonist peptides may serve as lead compounds for therapeutic applications.
Wed Aug 01 00:00:00 EDT 2018
Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204.
NPJ vaccines
Lam LKM,Watson AM,Ryman KD,Klimstra WB
14-0161 was used in Flow cytometry/Cell sorting to determine the molecular mechanisms for attenuation of 17D in yellow fever pathogenesis.
Mon Sep 28 00:00:00 EDT 2020
Cytokine Expression and Macrophage Localization in Xenograft and Allograft Tumor Models Stimulated with Lipopolysaccharide.
International journal of molecular sciences
Masuda J,Shigehiro T,Matsumoto T,Satoh A,Mizutani A,Umemura C,Saito S,Kijihira M,Takayama E,Seno A,Murakami H,Seno M
14-0161 was used in Flow cytometry/Cell sorting to define the differences in the functions of macrophages and dendritic cells in the xenograft and the allograft.
Mon Apr 23 00:00:00 EDT 2018
Method for selective quantification of immune and inflammatory cells in the cornea using flow cytometry.
Journal of biological methods
Ogawa M,Inomata T,Shiang T,Tsubota K,Murakami A
14-0161 was used in Flow cytometry/Cell sorting to describe corneal preparation for flow cytometry to assess cells localized in the cornea.
Tue Sep 29 00:00:00 EDT 2020
Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge.
Nature communications
Yi S,Zhai J,Niu R,Zhu G,Wang M,Liu J,Huang H,Wang Y,Jing X,Kang L,Song W,Shi Y,Tang H
Mon Sep 24 00:00:00 EDT 2018
Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice.
Scientific reports
Nawaz A,Mehmood A,Kanatani Y,Kado T,Igarashi Y,Takikawa A,Yamamoto S,Okabe K,Nakagawa T,Yagi K,Fujisaka S,Tobe K
14-0161 was used in Flow cytometry/Cell sorting to suggest a novel role of SRT1720-induced Sirt1 activation in the induction of angiogenic genes in preadipocytes, promoting insulin sensitivity.
Fri Jul 27 00:00:00 EDT 2018
MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity.
JCI insight
Lee-Sherick AB,Jacobsen KM,Henry CJ,Huey MG,Parker RE,Page LS,Hill AA,Wang X,Frye SV,Earp HS,Jordan CT,DeRyckere D,Graham DK
14-0161 was used in Flow cytometry/Cell sorting to demonstrate both the direct therapeutic effects of MERTK inhibition on leukaemia cells and the induction of anti-leukaemia immunity via suppression of the coinhibitory PD-1 axis.
Fri Nov 02 00:00:00 EDT 2018
Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration.
Journal of neuroinflammation
Karlen SJ,Miller EB,Wang X,Levine ES,Zawadzki RJ,Burns ME
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that the immune response to photoreceptor degeneration includes both resident microglia and monocytes, even at very early times.
Sat Dec 15 00:00:00 EST 2018
Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen.
PloS one
Revathikumar P,Estelius J,Karmakar U,Le Maître E,Korotkova M,Jakobsson PJ,Lampa J
14-0161-82 was used in Flow cytometry/Cell sorting to suggest a possible link between cholinergic and PG system of CAP that may be of clinical significance in vagus nerve stimulation treatment.
Tue May 22 00:00:00 EDT 2018
Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages.
Nature communications
Yan J,Tie G,Wang S,Tutto A,DeMarco N,Khair L,Fazzio TG,Messina LM
14-0161 was used in Flow cytometry/Cell sorting to demonstrate for the first time that type 2 diabetes mellitus induces an haematopoietic stem cell-autonomous mechanism that causes impaired wound healing.
Tue Jan 02 00:00:00 EST 2018
Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program.
Nature communications
Frye M,Taddei A,Dierkes C,Martinez-Corral I,Fielden M,Ortsäter H,Kazenwadel J,Calado DP,Ostergaard P,Salminen M,He L,Harvey NL,Kiefer F,Mäkinen T
14-0161 was used in Flow cytometry/Cell sorting to study whether extracellular matrix stiffness impacts lymphatic vascular development.
Tue Apr 17 00:00:00 EDT 2018
Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury.
Respiratory research
Ni K,Gill A,Tseng V,Mikosz AM,Koike K,Beatman EL,Xu CY,Cao D,Gally F,Mould KJ,Serban KA,Schweitzer KS,March KL,Janssen WJ,Nozik-Grayck E,Garantziotis S,Petrache I
14-0161 was used in Flow cytometry/Cell sorting to show the covalent HC-HA binding, which is exclusively mediated by tumor necrosis factor α (TNFα)-stimulated-gene-6 (TSG-6), may play an important role in the onset or the resolution of lung inflammation in acute lung injury (ALI) induced by respiratory infection.
Thu May 31 00:00:00 EDT 2018
Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.
Nature communications
Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL
14-0161 was used in Flow cytometry/Cell sorting to explore a variety of IL-2 constructs expressed by a tumour-selective oncolytic vaccinia virus, designed to maintain IL-2 in the tumour microenvironment to reduce systemic toxicity.
Thu Nov 08 00:00:00 EST 2018
β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion.
Cell reports
Böni-Schnetzler M,Häuselmann SP,Dalmas E,Meier DT,Thienel C,Traub S,Schulze F,Steiger L,Dror E,Martin P,Herrera PL,Gabay C,Donath MY
14-0161 was used in Flow cytometry/Cell sorting to investigate the protective role of local Interleukin-1 receptor antagonist in pancreatic islet Β cell-specific versus myeloid-cell-specific IL-1Ra knockout mice.
Tue Feb 13 00:00:00 EST 2018
Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects.
Journal of experimental & clinical cancer research : CR
Xu L,Zhang Y,Tian K,Chen X,Zhang R,Mu X,Wu Y,Wang D,Wang S,Liu F,Wang T,Zhang J,Liu S,Zhang Y,Tu C,Liu H
14-0161 was used in Flow cytometry/Cell sorting to investigate the effects of the flavonoid apigenin on the PD-L1 expression and the tumourigenesis of melanoma.
Mon Oct 29 00:00:00 EDT 2018
Smooth muscle glucose metabolism promotes monocyte recruitment and atherosclerosis in a mouse model of metabolic syndrome.
JCI insight
Wall VZ,Barnhart S,Kanter JE,Kramer F,Shimizu-Albergine M,Adhikari N,Wight TN,Hall JL,Bornfeldt KE
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that arterial smooth muscle cell glucose metabolism markedly synergises with metabolic syndrome in accelerating atherosclerosis progression.
Thu Jun 07 00:00:00 EDT 2018
RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.
The Journal of biological chemistry
Ge J,Burnier L,Adamopoulou M,Kwa MQ,Schaks M,Rottner K,Brakebusch C
14-0161 was used in Flow cytometry/Cell sorting to provide molecular insights into the role of Rho GTPases in TGFβ signalling and understanding of mesenchymal stem cells in fibriosis.
Fri Jun 15 00:00:00 EDT 2018
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation.
Nature communications
Li H,Yao Q,Mariscal AG,Wu X,Hülse J,Pedersen E,Helin K,Waisman A,Vinkel C,Thomsen SF,Avgustinova A,Benitah SA,Lovato P,Norsgaard H,Mortensen MS,Veng L,Rozell B,Brakebusch C
14-0161 was used in Flow cytometry/Cell sorting to show that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation with an IL-17 profile in mice.
Thu Apr 12 00:00:00 EDT 2018
Partial depletion of CD206-positive M2-like macrophages induces proliferation of beige progenitors and enhances browning after cold stimulation.
Scientific reports
Igarashi Y,Nawaz A,Kado T,Bilal M,Kuwano T,Yamamoto S,Sasahara M,Jiuxiang X,Inujima A,Koizumi K,Imura J,Shibahara N,Usui I,Fujisaka S,Tobe K
Mon Oct 01 00:00:00 EDT 2018
Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.
Nature communications
Ackermann M,Kempf H,Hetzel M,Hesse C,Hashtchin AR,Brinkert K,Schott JW,Haake K,Kühnel MP,Glage S,Figueiredo C,Jonigk D,Sewald K,Schambach A,Wronski S,Moritz T,Martin U,Zweigerdt R,Munder A,Lachmann N
14-0161 was used in Flow cytometry/Cell sorting to develop a novel, cell-based treatment strategy to target bacterial airway infections.
Fri Nov 30 00:00:00 EST 2018
SPARC preserves endothelial glycocalyx integrity, and protects against adverse cardiac inflammation and injury during viral myocarditis.
Matrix biology : journal of the International Society for Matrix Biology
Rienks M,Carai P,van Teeffelen J,Eskens B,Verhesen W,Hemmeryckx B,Johnson DM,van Leeuwen R,Jones EA,Heymans S,Papageorgiou AP
14-0161-82 was used in Flow cytometry/Cell sorting to show that the secreted glycoprotein Secreted Protein Acidic and Rich in Cysteine (SPARC) protects against adverse cardiac inflammation and mortality by improving the glycocalyx function and resulting endothelial barrier function during viral myocarditis.
Sat Dec 01 00:00:00 EST 2018
Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease.
Nature medicine
Hahm E,Wei C,Fernandez I,Li J,Tardi NJ,Tracy M,Wadhwani S,Cao Y,Peev V,Zloza A,Lusciks J,Hayek SS,O'Connor C,Bitzer M,Gupta V,Sever S,Sykes DB,Scadden DT,Reiser J
14-0161 was used in Flow cytometry/Cell sorting to demonstrate a direct pathogenic role of suPAR as a circulating mediator of kidney disease, such as focal segmental glomerulosclerosis.
Sun Jan 01 00:00:00 EST 2017
Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism.
Nature
Pan Y,Tian T,Park CO,Lofftus SY,Mei S,Liu X,Luo C,O'Malley JT,Gehad A,Teague JE,Divito SJ,Fuhlbrigge R,Puigserver P,Krueger JG,Hotamisligil GS,Clark RA,Kupper TS
14-0161 was used in Inhibition experiments to suggest that FABP4 and FABP5 have a critical role in the maintenance, longevity and function of CD8+ TRM cells.
Thu Mar 09 00:00:00 EST 2017
A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.
Cell
Aguilar OA,Berry R,Rahim MMA,Reichel JJ,Popović B,Tanaka M,Fu Z,Balaji GR,Lau TNH,Tu MM,Kirkham CL,Mahmoud AB,Mesci A,Krmpotić A,Allan DSJ,Makrigiannis AP,Jonjić S,Rossjohn J,Carlyle JR
14-0161 was used in Flow cytometry/Cell sorting to identify a viral ligand for the inhibitory and activating NKR-P1 receptors.
Thu Mar 23 00:00:00 EDT 2017
Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.
Immunity
Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,Donath MY
14-0161 was used in Flow cytometry/Cell sorting to provide evidence that an immunometabolic crosstalk between islet-derived IL-33, ILC2s, and myeloid cells fosters insulin secretion.
Tue Nov 21 00:00:00 EST 2017
Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.
Cancer cell
Seaman S,Zhu Z,Saha S,Zhang XM,Yang MY,Hilton MB,Morris K,Szot C,Morris H,Swing DA,Tessarollo L,Smith SW,Degrado S,Borkin D,Jain N,Scheiermann J,Feng Y,Wang Y,Li J,Welsch D,DeCrescenzo G,Chaudhary A,Zudaire E,Klarmann KD,Keller JR,Dimitrov DS,St Croix B
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that the cell surface protein CD276/B7-H3 is broadly over-expressed by multiple tumour types on both cancer cells and tumour-infiltrating blood vessels, making it a potentially ideal dual-compartment therapeutic target.
Mon Apr 10 00:00:00 EDT 2017
Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis.
Gastroenterology
King A,Houlihan DD,Kavanagh D,Haldar D,Luu N,Owen A,Suresh S,Than NN,Reynolds G,Penny J,Sumption H,Ramachandran P,Henderson NC,Kalia N,Frampton J,Adams DH,Newsome PN
14-0161 was used in Flow cytometry/Cell sorting to investigate the role of sphingosine-1-phosphate in the response of hematopoietic stem cells to liver fibrosis in mice.
Sat Jul 01 00:00:00 EDT 2017
A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.
The Journal of clinical investigation
Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR
14-0161 was used in Flow cytometry/Cell sorting to determine the effect of CCR4 antagonism on human renal cell carcinoma.
Wed Mar 01 00:00:00 EST 2017
NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma.
The Journal of experimental medicine
Daley D,Mani VR,Mohan N,Akkad N,Pandian GSDB,Savadkar S,Lee KB,Torres-Hernandez A,Aykut B,Diskin B,Wang W,Farooq MS,Mahmud AI,Werba G,Morales EJ,Lall S,Wadowski BJ,Rubin AG,Berman ME,Narayanan R,Hundeyin M,Miller G
14-0161 was used for blocking in Flow cytometry/Cell sorting to suggest that targeting NLRP3 holds the promise for the immunotherapy of pancreatic ductal adenocarcinoma.
Mon Jun 05 00:00:00 EDT 2017
Splenic Ly6Chi monocytes contribute to adverse late post-ischemic left ventricular remodeling in heme oxygenase-1 deficient mice.
Basic research in cardiology
Tomczyk M,Kraszewska I,Szade K,Bukowska-Strakova K,Meloni M,Jozkowicz A,Dulak J,Jazwa A
14-0161 was used in Blocking experiments to determine the role of Hmox1 in the monocyte/macrophage-mediated cardiac remodelling in a mouse model of myocardial infarction.
Sat Jul 01 00:00:00 EDT 2017
CD73 regulates anti-inflammatory signaling between apoptotic cells and endotoxin-conditioned tissue macrophages.
Cell death and differentiation
Murphy PS,Wang J,Bhagwat SP,Munger JC,Janssen WJ,Wright TW,Elliott MR
14-0161 was used in Flow cytometry/Cell sorting to show that, in RAW264.7 cells, ectopic expression of both A2a and CD73 was required for TNF suppression by apoptotic cells.
Wed Mar 01 00:00:00 EST 2017
Role of Nuclear Factor (Erythroid-Derived 2)-Like 2 Signaling for Effects of Fumaric Acid Esters on Dendritic Cells.
Frontiers in immunology
Hammer A,Waschbisch A,Knippertz I,Zinser E,Berg J,Jörg S,Kuhbandner K,David C,Pi J,Bayas A,Lee DH,Haghikia A,Gold R,Steinkasserer A,Linker RA
14-0161 was used in Flow cytometry/Cell sorting to reveal, using treatment with fumaric acid esters as a model, the effects of Nrf2 activation and signalling on dendritic cells.
Wed Nov 20 00:00:00 EST 2019
The transcriptional repressor HIC1 regulates intestinal immune homeostasis.
Mucosal immunology
Burrows K,Antignano F,Bramhall M,Chenery A,Scheer S,Korinek V,Underhill TM,Zaph C
14-0161 was used in Flow cytometry/Cell sorting to identify a critical role for HIC1 in the regulation of T-cell function in the intestinal microenvironment under both homeostatic and inflammatory conditions.
Wed Nov 01 00:00:00 EDT 2017
CCR2- and CCR2+ corneal macrophages exhibit distinct characteristics and balance inflammatory responses after epithelial abrasion.
Mucosal immunology
Liu J,Xue Y,Dong D,Xiao C,Lin C,Wang H,Song F,Fu T,Wang Z,Chen J,Pan H,Li Y,Cai D,Li Z
14-0161 was used in Flow cytometry/Cell sorting to show how CCR2(-) and CCR2(+) corneal macrophages exhibit distinct characteristics and balance inflammatory responses after epithelial abrasion.
Fri Sep 01 00:00:00 EDT 2017
Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (≥C20)-acyl chains in macrophages.
Journal of lipid research
Wall VZ,Barnhart S,Kramer F,Kanter JE,Vivekanandan-Giri A,Pennathur S,Bolego C,Ellis JM,Gijón MA,Wolfgang MJ,Bornfeldt KE
Thu Jun 01 00:00:00 EDT 2017
Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis.
mAbs
Vicari AP,Schoepfer AM,Meresse B,Goffin L,Léger O,Josserand S,Guégan N,Yousefi S,Straumann A,Cerf-Bensussan N,Simon HU,Chvatchko Y
14-0161-82 was used in Flow Cytometry to identify and characterise a humanised antibody against IL-15.
Wed Nov 20 00:00:00 EST 2019
Rediscovering peritoneal macrophages in a murine endometriosis model.
Human reproduction (Oxford, England)
Yuan M,Li D,An M,Li Q,Zhang L,Wang G
14-0161 was used in Functional assays to study the role of large and small peritoneal macrophages in endometriosis.
Sun Jan 01 00:00:00 EST 2017
Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain.
Frontiers in molecular neuroscience
Raj D,Yin Z,Breur M,Doorduin J,Holtman IR,Olah M,Mantingh-Otter IJ,Van Dam D,De Deyn PP,den Dunnen W,Eggen BJL,Amor S,Boddeke E
14-0161 was used in Flow cytometry/Cell sorting to indicate that microglia-induced neuroinflammation is predominant in the white matter of aging mice and humans as well as in EOAD brains.
Thu Oct 01 00:00:00 EDT 2020
Evaluation of trained immunity by β-1, 3 (d)-glucan on murine monocytes in vitro and duration of response in vivo.
Immunology and cell biology
Garcia-Valtanen P,Guzman-Genuino RM,Williams DL,Hayball JD,Diener KR
14-0161-82 was used in Flow Cytometry to characterise the epigenetic changes induced in human monocytes by the β-1, 3 (d)-glucan present in the Candida albicans cell wall.
Tue Aug 01 00:00:00 EDT 2017
Local Group 2 Innate Lymphoid Cells Promote Corneal Regeneration after Epithelial Abrasion.
The American journal of pathology
Liu J,Xiao C,Wang H,Xue Y,Dong D,Lin C,Song F,Fu T,Wang Z,Chen J,Pan H,Li Y,Cai D,Li Z
Thu Jun 01 00:00:00 EDT 2017
Distribution and differentiation of myeloid-derived suppressor cells after fluid resuscitation in mice with hemorrhagic shock.
Journal of Zhejiang University. Science. B
Jiang JK,Fang W,Hong LJ,Lu YQ
14-0161 was used in Flow cytometry/Cell sorting to investigate the distribution and differentiation of myeloid-derived suppressor cells in hemorrhagic shock mice, which are resuscitated with various fluids.
Tue Jul 11 00:00:00 EDT 2017
Autophagy in Dendritic Cells and B Cells Is Critical for the Inflammatory State of TLR7-Mediated Autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Weindel CG,Richey LJ,Mehta AJ,Shah M,Huber BT
14-0161 was used in Flow cytometry/Cell sorting to identify that autophagy in B cells and dendritic cells are key to TLR7-mediated autoimmune disorders.
Wed Feb 01 00:00:00 EST 2017
Dipeptidyl Peptidase-4 Inhibition With Saxagliptin Ameliorates Angiotensin II-Induced Cardiac Diastolic Dysfunction in Male Mice.
Endocrinology
Brown SM,Smith CE,Meuth AI,Khan M,Aroor AR,Cleeton HM,Meininger GA,Sowers JR,DeMarco VG,Chandrasekar B,Nistala R,Bender SB
14-0161 was used in Flow cytometry/Cell sorting to examine whether dipeptidyl peptidase-4 inhibition with saxagliptin attenuates angiotensin II-induced cardiac diastolic dysfunction.
Sun Oct 01 00:00:00 EDT 2017
Impact of supplementation with a food-derived microbial community on obesity-associated inflammation and gut microbiota composition.
Genes & nutrition
Roselli M,Devirgiliis C,Zinno P,Guantario B,Finamore A,Rami R,Perozzi G
14-0161 was used in Flow cytometry/Cell sorting to study, using a mouse model, the effects of supplementary dietary microbes on obesity-associated inflammation and gut microbiota composition.
Thu Oct 01 00:00:00 EDT 2020
Tumor growth limited to subcutaneous site vs tumor growth in pulmonary site exhibit differential effects on systemic immunities.
Oncology reports
Masuda J,Takayama E,Strober W,Satoh A,Morimoto Y,Honjo Y,Ichinohe T,Tokuno SI,Ishizuka T,Nakata T,Mizutani A,Umemura N,Kitani A,Fuss IJ,Shigehiro T,Kawaki H,Mizuno-Kamiya M,Kondoh N,Seno M
14-0161 was used in Flow cytometry/Cell sorting to suggest that the mode of tumor development has differential effects on systemic immunity that may, in turn, influence approaches to treatment of cancer patients.
Sat Jul 01 00:00:00 EDT 2017
Upregulation of SOCS3 in lung CD4+ T cells in a mouse model of chronic PA lung infection and suppression of Th17‑mediated neutrophil recruitment in exogenous SOCS3 transfer in vitro.
Molecular medicine reports
Ding FM,Liao RM,Chen YQ,Xie GG,Zhang PY,Shao P,Zhang M
14-0161 was used in Blocking experiments to investigate the activation of the STAT3/Th17 signal pathway and the expression of SOCS3 in the lung CD4+ T cells in a mouse model of chronic PA lung infection.
Sat Jul 01 00:00:00 EDT 2017
Therapeutic potential of adipose-derived stem cells and macrophages for ischemic skeletal muscle repair.
Regenerative medicine
Rybalko V,Hsieh PL,Ricles LM,Chung E,Farrar RP,Suggs LJ
14-0161 was used in Flow cytometry/Cell sorting to assess the therapeutic potential of combined macrophage/adipose-derived stem cell therapy for ischaemic skeletal muscle repair.
Wed Mar 01 00:00:00 EST 2017
Japanese Kampo medicine ninjin'yoeito synergistically enhances tumor vaccine effects mediated by CD8+ T cells.
Oncology letters
Takaku S,Shimizu M,Takahashi H
14-0161 was used in Flow cytometry/Cell sorting to investigate the synergistic mechanisms by which ninjin'yoeito enhances cancer vaccine CD8 T cell mediated anti-tumour responses.
Mon May 01 00:00:00 EDT 2017
Role of Prolactin in Promotion of Immune Cell Migration into the Mammary Gland.
Journal of mammary gland biology and neoplasia
Dill R,Walker AM
14-0161 was used in Flow cytometry/Cell sorting to investigate the role of prolactin in immune cell recruitment.
Wed Mar 01 00:00:00 EST 2017
Novel phosphate-activated macrophages prevent ectopic calcification by increasing extracellular ATP and pyrophosphate.
PloS one
Villa-Bellosta R,Hamczyk MR,Andrés V
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that Pi alternatively activates unpolarized macrophages with anti-calcifying effects which may have protective functions in pathologic calcification.
Mon Aug 28 00:00:00 EDT 2017
Alveolar injury and regeneration following deletion of ABCA3.
JCI insight
Rindler TN,Stockman CA,Filuta AL,Brown KM,Snowball JM,Zhou W,Veldhuizen R,Zink EM,Dautel SE,Clair G,Ansong C,Xu Y,Bridges JP,Whitsett JA
14-0161 was used in Flow cytometry/Cell sorting to examine the effects of loss of ABCA3 in alveolar type 2 cells.
Thu Dec 21 00:00:00 EST 2017
Treatment of donor corneal tissue with immunomodulatory cytokines: a novel strategy to promote graft survival in high-risk corneal transplantation.
Scientific reports
Tahvildari M,Emami-Naeini P,Omoto M,Mashaghi A,Chauhan SK,Dana R
14-0161 was used in Neutralization experiments to provide a novel approach for tolAPC-based immunotherapy in transplantation by direct cytokine conditioning of the donor tissue.
Thu Apr 20 00:00:00 EDT 2017
Impact of the c-MybE308G mutation on mouse myelopoiesis and dendritic cell development.
PloS one
Papathanasiou P,Petvises S,Hey YY,Perkins AC,O'Neill HC
14-0161 was used in Flow cytometry/Cell sorting to reveal that mice with c-Myb308G point mutation have no disturbance of presence of L-DCs in spleen so not bone marrow-derived hematopoietic progenitors.
Thu Sep 07 00:00:00 EDT 2017
Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5.
Nature communications
Park S,Lee S,Lee CG,Park GY,Hong H,Lee JS,Kim YM,Lee SB,Hwang D,Choi YS,Fryer JD,Im SH,Lee SW,Lee Y
14-0161 was used in Blocking experiments to investigate the role of Capicua in autoimmunity.
Wed Jul 12 00:00:00 EDT 2017
Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy.
JCI insight
Yanagita T,Murata Y,Tanaka D,Motegi SI,Arai E,Daniwijaya EW,Hazama D,Washio K,Saito Y,Kotani T,Ohnishi H,Oldenborg PA,Garcia NV,Miyasaka M,Ishikawa O,Kanai Y,Komori T,Matozaki T
14-0161 was used in Flow cytometry/Cell sorting to show that SIRPα is highly expressed in human renal cell carcinoma and melanoma, and that anti-SIRPα antibody blocks the interaction with CD47, suppressing tumor formation by renal cell carcinoma or melanoma cells.
Thu Jan 12 00:00:00 EST 2017
IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice.
Scientific reports
Shintani Y,Ito T,Fields L,Shiraishi M,Ichihara Y,Sato N,Podaru M,Kainuma S,Tanaka H,Suzuki K
14-0161 was used in Flow cytometry/Cell sorting to show the proof-of-concept of efficacy of IL-4 treatment for acute myocardial infarction, encouraging its further development.
Mon Jul 31 00:00:00 EDT 2017
Fibroblast activation protein augments progression and metastasis of pancreatic ductal adenocarcinoma.
JCI insight
Lo A,Li CP,Buza EL,Blomberg R,Govindaraju P,Avery D,Monslow J,Hsiao M,Puré E
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that fibroblast activation protein overexpression in the tumour microenvironment correlates with poor overall and disease-free survival of pancreatic ductal adenocarcinoma patients.
Thu Oct 05 00:00:00 EDT 2017
Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury.
Scientific reports
Rossi M,Thierry A,Delbauve S,Preyat N,Soares MP,Roumeguère T,Leo O,Flamand V,Le Moine A,Hougardy JM
14-0161 was used in Flow cytometry/Cell sorting to determine the role of heme oxygenase-1 during renal ischemia-reperfusion injury.
Wed Mar 15 00:00:00 EDT 2017
Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.
Scientific reports
Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H
14-0161 was used in Blocking experiments to investigate the effect Paeoniflorin has on Th cells and dendritic cells in a mouse MS model.
Mon Feb 06 00:00:00 EST 2017
Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.
Scientific reports
Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H
14-0161 was used in Blocking experiments to investigate the effect Paeoniflorin has on Th cells and dendritic cells in a mouse MS model.
Mon Feb 06 00:00:00 EST 2017
The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models.
Clinical and translational allergy
Vonk MM,Wagenaar L,Pieters RHH,Knippels LMJ,Willemsen LEM,Smit JJ,van Esch BCAM,Garssen J
14-0161 was used in Flow cytometry/Cell sorting to compare oral immunotherapy and subcutaneous immunotherapy models for cows milk and peanut allergy.
Fri Apr 08 00:00:00 EDT 2022
TP53 Modulates Oxidative Stress in Gata1+ Erythroid Cells.
Stem cell reports
Kramer AC,Weber J,Zhang Y,Tolar J,Gibbens YY,Shevik M,Lund TC
14-0161 was used in Flow cytometry/Cell sorting to show that tp53, while classically a tumour suppressor and cell-cycle regulator, has additional roles in controlling cellular oxidative stress.
Tue Feb 14 00:00:00 EST 2017
Synthesis, Characterization and Immunological Evaluation of Self-Adjuvanting Group A Streptococcal Vaccine Candidates Bearing Various Lipidic Adjuvanting Moieties.
Chembiochem : a European journal of chemical biology
Fagan V,Hussein WM,Su M,Giddam AK,Batzloff MR,Good MF,Toth I,Simerska P
14-0161-82 was used in Flow cytometry/Cell sorting to prepare and characterize four group A streptococcal glycolipopeptide vaccine candidates with different lipidic adjuvanting moieties.
Thu Mar 16 00:00:00 EDT 2017
Ex vivo modulation of the Foxo1 phosphorylation state does not lead to dysfunction of T regulatory cells.
PloS one
Penberthy KK,Buckley MW,Arandjelovic S,Ravichandran K
14-0161 was used in Blocking experiments to study the effect of FoxO1 phosphorylation state on T regulatory cell function.
Fri Aug 25 00:00:00 EDT 2017
In vivo quantification of quantum dot systemic transport in C57BL/6 hairless mice following skin application post-ultraviolet radiation.
Particle and fibre toxicology
Jatana S,Palmer BC,Phelan SJ,Gelein R,DeLouise LA
14-0161 was used in Flow cytometry/Cell sorting to suggest that Langerhans cells can engulf quantum dots in skin, but lymph node transport is both cellular and non-cellular.
Fri Apr 14 00:00:00 EDT 2017
The introduction of mesenchymal stromal cells induces different immunological responses in the lungs of healthy and M. tuberculosis infected mice.
PloS one
Nenasheva T,Nikolaev A,Diykanov D,Sukhanova A,Tcyganov E,Panteleev A,Bocharova I,Serdyuk Y,Nezlin L,Radaeva T,Adrianov N,Rubtsov Y,Lyadova I
14-0161 was used in Flow cytometry/Cell sorting to emphasize the importance of the evaluation of MSC effects locally at the site of their predominant post-injection localization and question MSC usefulness as anti-TB treatment.
Tue Sep 19 00:00:00 EDT 2017
Control of metastatic niche formation by targeting APBA3/Mint3 in inflammatory monocytes.
Proceedings of the National Academy of Sciences of the United States of America
Hara T,Nakaoka HJ,Hayashi T,Mimura K,Hoshino D,Inoue M,Nagamura F,Murakami Y,Seiki M,Sakamoto T
14-0161-82 was used in Flow cytometry/Cell sorting to report that APBA3-deficient mice show reduced metastasis, with no apparent effect on primary tumor growth.
Tue May 30 00:00:00 EDT 2017
Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development.
Scientific reports
Tsiantoulas D,Kiss M,Bartolini-Gritti B,Bergthaler A,Mallat Z,Jumaa H,Binder CJ
14-0161 was used in Flow cytometry/Cell sorting to identify secreted IgM as negative regulators of BCR signalling and suggest that they can act as decoy receptors for self-antigens that are recognised by membrane bound BCRs.
Wed Jun 14 00:00:00 EDT 2017
Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Lindborg JA,Mack M,Zigmond RE
14-0161-82 was used in Flow cytometry/Cell sorting to characterize WD in male Ccr2-/- mice and identify a compensatory mechanism of WD that is facilitated primarily by neutrophils.
Wed Oct 25 00:00:00 EDT 2017
A hot spot on interferon α/β receptor subunit 1 (IFNAR1) underpins its interaction with interferon-β and dictates signaling.
The Journal of biological chemistry
de Weerd NA,Matthews AY,Pattie PR,Bourke NM,Lim SS,Vivian JP,Rossjohn J,Hertzog PJ
14-0161 was used in Inhibition experiments to elucidate an interface on the interferon α/Β receptor subunit-1-subdomain-3 that's differentially utilised by IFN-Β and IFN-α for signal transduction.
Fri May 05 00:00:00 EDT 2017
TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets.
Nature immunology
Muñoz-Ruiz M,Ribot JC,Grosso AR,Gonçalves-Sousa N,Pamplona A,Pennington DJ,Regueiro JR,Fernández-Malavé E,Silva-Santos B
14-0161 was used in Blocking experiments to determine the role of the T cell antigen receptor in the production of discrete γδ T cell subsets.
Wed Jun 01 00:00:00 EDT 2016
Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β.
Journal of hepatology
Ilyas G,Zhao E,Liu K,Lin Y,Tesfa L,Tanaka KE,Czaja MJ
14-0161 was used in Flow cytometry/Cell sorting to show that macrophage autophagy functions to limit acute toxin-induced liver injury and death by inhibiting the generation of inflammasome-dependent IL-1β.
Fri Jan 01 00:00:00 EST 2016
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
The Journal of clinical investigation
Cole CB,Verdoni AM,Ketkar S,Leight ER,Russler-Germain DA,Lamprecht TL,Demeter RT,Magrini V,Ley TJ
14016182 was used in blocking or activating experiment to study how DNMT3A is involved in the function of PML-RARA, RUNX1-RUNX1T1, and MLL-AF9
Fri Jan 01 00:00:00 EST 2016
Alternatively activated macrophages determine repair of the infarcted adult murine heart.
The Journal of clinical investigation
Shiraishi M,Shintani Y,Shintani Y,Ishida H,Saba R,Yamaguchi A,Adachi H,Yashiro K,Suzuki K
14-0161 was used in Blocking experiments to study repair of the infarcted adult murine heart determined by alternatively activated macrophages.
Wed Jun 01 00:00:00 EDT 2016
Alternatively activated macrophages determine repair of the infarcted adult murine heart.
The Journal of clinical investigation
Shiraishi M,Shintani Y,Shintani Y,Ishida H,Saba R,Yamaguchi A,Adachi H,Yashiro K,Suzuki K
14-0161 was used in Blocking experiments to study repair of the infarcted adult murine heart determined by alternatively activated macrophages.
Wed Jun 01 00:00:00 EDT 2016
NLRP2 controls age-associated maternal fertility.
The Journal of experimental medicine
Kuchmiy AA,D'Hont J,Hochepied T,Lamkanfi M
14-0161 was used in Flow cytometry/Cell sorting to identify Nlrp2 as a critical regulator of oocyte quality.
Mon Dec 12 00:00:00 EST 2016
Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis.
Autophagy
Lee HY,Kim J,Quan W,Lee JC,Kim MS,Kim SH,Bae JW,Hur KY,Lee MS
14-0161 was used in Flow cytometry/Cell sorting to investigate how autophagy of MΦs is important for the control of inflammasome activation in response to metabolic or extrinsic stress.
Tue Aug 02 00:00:00 EDT 2016
Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2.
Proceedings of the National Academy of Sciences of the United States of America
Schulze-Topphoff U,Varrin-Doyer M,Pekarek K,Spencer CM,Shetty A,Sagan SA,Cree BA,Sobel RA,Wipke BT,Steinman L,Scannevin RH,Zamvil SS
14-0161 was used in Blocking experiments to suggest that dimethyl fumarates antiinflammatory activity in treatment of MS patients may occur through Nrf2 independent pathways.
Tue Apr 26 00:00:00 EDT 2016
Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice.
Arteriosclerosis, thrombosis, and vascular biology
Srikakulapu P,Hu D,Yin C,Mohanta SK,Bontha SV,Peng L,Beer M,Weber C,McNamara CA,Grassia G,Maffia P,Manz RA,Habenicht AJ
14-0161 was used in Flow cytometry/Cell sorting to study how artery tertiary lymphoid organs can orchestrate B-cell responses in the diseased aorta.
Wed Jun 01 00:00:00 EDT 2016
Low-grade inflammatory polarization of monocytes impairs wound healing.
The Journal of pathology
Yuan R,Geng S,Chen K,Diao N,Chu HW,Li L
14-0161 was used in Blocking experiments to reveal the polarization of low-grade inflammatory monocytes by sustained endotoxin challenge, its underlying mechanisms and a potential intervention strategy.
Tue Mar 01 00:00:00 EST 2016
A subpopulation of itch-sensing neurons marked by Ret and somatostatin expression.
EMBO reports
Stantcheva KK,Iovino L,Dhandapani R,Martinez C,Castaldi L,Nocchi L,Perlas E,Portulano C,Pesaresi M,Shirlekar KS,de Castro Reis F,Paparountas T,Bilbao D,Heppenstall PA
14-0161 was used in Flow cytometry/Cell sorting to provide a molecular signature for a subpopulation of neurons activated by multiple pruritogens.
Fri Apr 01 00:00:00 EDT 2016
Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis.
Mucosal immunology
Borthwick LA,Barron L,Hart KM,Vannella KM,Thompson RW,Oland S,Cheever A,Sciurba J,Ramalingam TR,Fisher AJ,Wynn TA
14-0161 was used in Flow cytometry/Cell sorting to show that macrophages are required for the maintenance of type 2 immunity within affected tissues but not within secondary lymphoid organs.
Fri Jan 01 00:00:00 EST 2016
Norovirus antagonism of B-cell antigen presentation results in impaired control of acute infection.
Mucosal immunology
Zhu S,Jones MK,Hickman D,Han S,Reeves W,Karst SM
14-0161 was used in Flow cytometry/Cell sorting to determine the biological consequences of norovirus-mediated immune antagonism.
Tue Nov 01 00:00:00 EDT 2016
Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.
Immunology
Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H
14-0161 was used in Immunohistochemistry to identify a novel pathway of cross-talk between macrophages and dendritic cells.
Sat Oct 01 00:00:00 EDT 2016
Real-time in vivo imaging reveals the ability of neutrophils to remove Cryptococcus neoformans directly from the brain vasculature.
Journal of leukocyte biology
Zhang M,Sun D,Liu G,Wu H,Zhou H,Shi M
14-0161 was used in Flow cytometry/Cell sorting to demonstrate direct removal of Cryptococcus neoformans by neutrophils from its arrested site as a potential host defense mechanism.
Tue Mar 01 00:00:00 EST 2016
Collaborative Interferon-γ and Interleukin-17 Signaling Protects the Oral Mucosa from Staphylococcus aureus.
The American journal of pathology
Barin JG,Talor MV,Schaub JA,Diny NL,Hou X,Hoyer M,Archer NK,Gebremariam ES,Davis MF,Miller LS,Rose NR,Čiháková D
14016182 was used in blocking or activating experiment to study how IL-17 and IFN-gamma control Staphylococcus aureus infection
Thu Sep 01 00:00:00 EDT 2016
Colony-stimulating factor (CSF) 1 receptor blockade reduces inflammation in human and murine models of rheumatoid arthritis.
Arthritis research & therapy
Garcia S,Hartkamp LM,Malvar-Fernandez B,van Es IE,Lin H,Wong J,Long L,Zanghi JA,Rankin AL,Masteller EL,Wong BR,Radstake TR,Tak PP,Reedquist KA
14-0161 was used in Blocking experiments to show that inhibition of CSF1R interactions with CSF-1 and IL-34 suppresses inflammatory activation of rheumatoid arthritis synovial tissue.
Thu Mar 31 00:00:00 EDT 2016
Batf3-dependent CD103(+) dendritic cell accumulation is dispensable for mucosal and systemic antifungal host defense.
Virulence
Break TJ,Hoffman KW,Swamydas M,Lee CC,Lim JK,Lionakis MS
14-0161 was used in Flow cytometry/Cell sorting to demonstrate a number of critical roles played by Batf3 in the accumulation of CD103+ dendritic cells.
Sun Oct 02 00:00:00 EDT 2016
Mechanisms of Acute Toxicity in NKG2D Chimeric Antigen Receptor T Cell-Treated Mice.
Journal of immunology (Baltimore, Md. : 1950)
Sentman ML,Murad JM,Cook WJ,Wu MR,Reder J,Baumeister SH,Dranoff G,Fanger MW,Sentman CL
14-0161-82 was used in Flow Cytometry to examine the mechanisms of acute toxicity in NKG2D chimeric antigen receptor T cell-treated mice.
Thu Dec 15 00:00:00 EST 2016
CD137 Agonist Therapy Can Reprogram Regulatory T Cells into Cytotoxic CD4+ T Cells with Antitumor Activity.
Journal of immunology (Baltimore, Md. : 1950)
Akhmetzyanova I,Zelinskyy G,Littwitz-Salomon E,Malyshkina A,Dietze KK,Streeck H,Brandau S,Dittmer U
14-0161-82 was used in Flow Cytometry to study the mechanisms of immunological tumour control by CD4(+) T cells in the course of CD137 agonist immunotherapy in the absence of a CD8 T cell response.
Fri Jan 01 00:00:00 EST 2016
Cell cycle re-entry sensitizes podocytes to injury induced death.
Cell cycle (Georgetown, Tex.)
Hagen M,Pfister E,Kosel A,Shankland S,Pippin J,Amann K,Daniel C
14-0161 was used for blocking in immunofluorescence to develop an in vitro model for testing the consequences of re-entry into the cell cycle on podocyte survival.
Sun Jul 17 00:00:00 EDT 2016
CSF-1 receptor signalling is governed by pre-requisite EHD1 mediated receptor display on the macrophage cell surface.
Cellular signalling
Cypher LR,Bielecki TA,Huang L,An W,Iseka F,Tom E,Storck MD,Hoppe AD,Band V,Band H
14-0161 was used in Blocking experiments to investigate the mechanism underlying macrophage receptor trafficking.
Thu Sep 01 00:00:00 EDT 2016
Real-Time Imaging of Interactions of Neutrophils with Cryptococcus neoformans Demonstrates a Crucial Role of Complement C5a-C5aR Signaling.
Infection and immunity
Sun D,Zhang M,Liu G,Wu H,Zhu X,Zhou H,Shi M
14-0161 was used in Blocking experiments to characterise the dynamic interactions of neutrophils with C. neoformans, showing a crucial role of complement C5a-C5aR signalling.
Fri Jan 01 00:00:00 EST 2016
Development of a diet-induced murine model of diabetes featuring cardinal metabolic and pathophysiological abnormalities of type 2 diabetes.
Biology open
Morris JL,Bridson TL,Alim MA,Rush CM,Rudd DM,Govan BL,Ketheesan N
14-0161 was used in Flow cytometry/Cell sorting to develop a novel murine model, based on an energy-dense diet, which closely simulates the development of type 2 diabetes.
Mon Aug 15 00:00:00 EDT 2016
Pdgfrb-Cre targets lymphatic endothelial cells of both venous and non-venous origins.
Genesis (New York, N.Y. : 2000)
Ulvmar MH,Martinez-Corral I,Stanczuk L,Mäkinen T
14-0161 was used in Flow cytometry/Cell sorting to show that Pdgfrb-Cre does not target YS HemEC or YS-derived erythro-myeloid progenitors.
Wed Jun 01 00:00:00 EDT 2016
Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages.
eLife
Eichenfield DZ,Troutman TD,Link VM,Lam MT,Cho H,Gosselin D,Spann NJ,Lesch HP,Tao J,Muto J,Gallo RL,Evans RM,Glass CK
14-0161 was used in Blocking experiments to investigate the roles of Rev-erb nuclear receptors in regulating responses of mouse macrophages to complex tissue damage signals and wound repair.
Wed Jul 27 00:00:00 EDT 2016
A Toll-like receptor 2 agonist-fused antigen enhanced antitumor immunity by increasing antigen presentation and the CD8 memory T cells population.
Oncotarget
Wu CC,Liu SJ,Chen HW,Shen KY,Leng CH
14-0161 was used in Flow cytometry/Cell sorting to explore the use of TLR2 agonist-fused antigens for efficient cancer therapy.
Tue May 24 00:00:00 EDT 2016
Myeloid cell expressed proprotein convertase FURIN attenuates inflammation.
Oncotarget
Cordova ZM,Grönholm A,Kytölä V,Taverniti V,Hämäläinen S,Aittomäki S,Niininen W,Junttila I,Ylipää A,Nykter M,Pesu M
14016182 was used in blocking or activating experiment to investigate the role of FURIN in LysM positive myeloid cells in vivo
Tue Aug 23 00:00:00 EDT 2016
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation.
Nature communications
Yip KH,Kolesnikoff N,Hauschild N,Biggs L,Lopez AF,Galli SJ,Kumar S,Grimbaldeston MA
14-0161 was used in Flow cytometry/Cell sorting to reveal that Nedd4-2 and Ndfip1 have an important function in negatively regulating IgE-dependent mast cell activity in IgE-dependent allergic disorders.
Thu Oct 27 00:00:00 EDT 2016
Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.
Nature communications
Brinkman CC,Iwami D,Hritzo MK,Xiong Y,Ahmad S,Simon T,Hippen KL,Blazar BR,Bromberg JS
14-0161 was used in Blocking experiments to demonstrate a form of T-cell migration used only by Treg in tissues that serves an important role in their suppressive function.
Tue Jun 21 00:00:00 EDT 2016
IL-12 protects from psoriasiform skin inflammation.
Nature communications
Kulig P,Musiol S,Freiberger SN,Schreiner B,Gyülveszi G,Russo G,Pantelyushin S,Kishihara K,Alessandrini F,Kündig T,Sallusto F,Hofbauer GF,Haak S,Becher B
14-0161 was used in Flow cytometry/Cell sorting to investigate the individual contribution of IL-12 and IL-23 to the formation of psoriatic lesions and understand the effect of therapeutic co-targeting of these cytokines, showing that IL-12 protects from psoriasiform skin inflammation.
Mon Nov 28 00:00:00 EST 2016
CDDO-Me Redirects Activation of Breast Tumor Associated Macrophages.
PloS one
Ball MS,Shipman EP,Kim H,Liby KT,Pioli PA
14-0161 was used in Flow cytometry/Cell sorting to investigate the effect of CDDO-Me on the activation profile of tumour-associated macrophages, showing that it redirects activation from immune-suppressive to immune-stimulatory.
Thu Jul 21 00:00:00 EDT 2016
Sequencing and cloning of antigen-specific antibodies from mouse memory B cells.
Nature protocols
von Boehmer L,Liu C,Ackerman S,Gitlin AD,Wang Q,Gazumyan A,Nussenzweig MC
14-0161-82 was used in Flow cytometry/Cell sorting to sequence and clone the variable antibody region of single antigen-specific mouse memory B cells for antibody production.
Sat Oct 01 00:00:00 EDT 2016
Redefined clinical features and diagnostic criteria in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.
JCI insight
Ferre EM,Rose SR,Rosenzweig SD,Burbelo PD,Romito KR,Niemela JE,Rosen LB,Break TJ,Gu W,Hunsberger S,Browne SK,Hsu AP,Rampertaap S,Swamydas M,Collar AL,Kong HH,Lee CR,Chascsa D,Simcox T,Pham A,Bondici A,Natarajan M,Monsale J,Kleiner DE,Quezado M,Alevizos I,Moutsopoulos NM,Yockey L,Frein C,Soldatos A,Calvo KR,Adjemian J,Similuk MN,Lang DM,Stone KD,Uzel G,Kopp JB,Bishop RJ,Holland SM,Olivier KN,Fleisher TA,Heller T,Winer KK,Lionakis MS
14-0161 was used in Blocking experiments to examine the genetic, clinical, autoantibody and immunoglogical characteristics of patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.
Thu Aug 18 00:00:00 EDT 2016
Chronic spinal cord injury attenuates influenza virus-specific antiviral immunity.
Journal of neuroinflammation
Bracchi-Ricard V,Zha J,Smith A,Lopez-Rodriguez DM,Bethea JR,Andreansky S
14-0161 was used in Flow cytometry/Cell sorting to show that chronic SCI causes severe morbidity and mortality in mice infected with influenza A virus by compromising antibody and CD8+ T cell responses.
Tue May 31 00:00:00 EDT 2016
The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis.
PloS one
Braun J,Meixner A,Brachner A,Foisner R
14-0161 was used in Flow cytometry/Cell sorting to test whether ANKLE1 may contribute to Holliday junction resolution during DNA repair in mice.
Fri Aug 12 00:00:00 EDT 2016
Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity.
Scientific reports
Torrisi JS,Hespe GE,Cuzzone DA,Savetsky IL,Nitti MD,Gardenier JC,García Nores GD,Jowhar D,Kataru RP,Mehrara BJ
14-0161 was used in Flow cytometry/Cell sorting to study the cellular mechanisms regulating decreased lymphatic function found in obesity, showing that inhibition of inflammation and iNOS improves lymphatic function.
Fri Jan 22 00:00:00 EST 2016
Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity.
PLoS genetics
Fox BA,Sanders KL,Rommereim LM,Guevara RB,Bzik DJ
14-0161 was used in Blocking experiments to investigate the effect of rhoptry and dense granules on antitumour immunity.
Fri Jul 01 00:00:00 EDT 2016
Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition.
Oncoimmunology
Kleinpeter P,Fend L,Thioudellet C,Geist M,Sfrontato N,Koerper V,Fahrner C,Schmitt D,Gantzer M,Remy-Ziller C,Brandely R,Villeval D,Rittner K,Silvestre N,Erbs P,Zitvogel L,Quéméneur E,Préville X,Marchand JB
14-0161 was used in Flow cytometry/Cell sorting to develop a method to vectorise a hamster monoclonal IgG against murine PD-1 in Western Reserve oncolytic vaccina virus.
Tue Jan 12 00:00:00 EST 2021
Bifidobacterium animalis ssp. lactis CNCM-I2494 Restores Gut Barrier Permeability in Chronically Low-Grade Inflamed Mice.
Frontiers in microbiology
Martín R,Laval L,Chain F,Miquel S,Natividad J,Cherbuy C,Sokol H,Verdu EF,van Hylckama Vlieg J,Bermudez-Humaran LG,Smokvina T,Langella P
14-0161 was used in Blocking experiments to evaluate the effects of B. animalis ssp. lactis CNCM-I2494, a strain used in fermented dairy products, on murine intestinal epithelium barrier function.
Fri May 20 00:00:00 EDT 2016
Epithelium-Intrinsic MicroRNAs Contribute to Mucosal Immune Homeostasis by Promoting M-Cell Maturation.
PloS one
Nakato G,Hase K,Sato T,Kimura S,Sakakibara S,Sugiyama M,Obata Y,Hanazato M,Iwanaga T,Ohno H
14-0161 was used for blocking on paraffin embedded tissues to study the role of microRNAs in M cell differentiation and mucosal immune homeostasis.
Mon Jul 18 00:00:00 EDT 2016
Enrichment of IFN-γ producing cells in different murine adipose tissue depots upon infection with an apicomplexan parasite.
Scientific reports
Teixeira L,Marques RM,Ferreirinha P,Bezerra F,Melo J,Moreira J,Pinto A,Correia A,Ferreira PG,Vilanova M
14-0161 was used in Flow cytometry/Cell sorting to investigate the contribution of NK and T cells to the production of IFN-γ in the adipose tissue of Neospora caninum infected mice.
Tue Mar 22 00:00:00 EDT 2016
Restoration of Corneal Transparency by Mesenchymal Stem Cells.
Stem cell reports
Mittal SK,Omoto M,Amouzegar A,Sahu A,Rezazadeh A,Katikireddy KR,Shah DI,Sahu SK,Chauhan SK
14-0161 was used in Immunohistochemistry to demonstrate that mesenchymal stem cells can restore corneal transparency by secreting high levels of hepatocyte growth factor.
Tue Oct 11 00:00:00 EDT 2016
Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner.
PloS one
Watanabe N,Kaminuma O,Kitamura N,Hiroi T
14-0161 was used in Flow cytometry/Cell sorting to study whether Th17 and Tregs that promote and suppress inflammatory responses, respectively, work with or against each other in immune reactions, showing that cotransfer of Th17 and induced Tregs led to increased inflammation, and blockage of CTLA4 led to abrogation of this effect.
Mon Aug 01 00:00:00 EDT 2016
GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal.
Cell death & disease
Le Q,Yao W,Chen Y,Yan B,Liu C,Yuan M,Zhou Y,Ma L
14016182 was used in flow cytometry to use knockout mice to determine if GRK6 contributes to hematopoiesis
Thu Nov 24 00:00:00 EST 2016
Pro-inflammatory effect of a traditional Chinese medicine formula with potent anti-cancer activity in vitro impedes tumor inhibitory potential in vivo.
Molecular and clinical oncology
Xia L,Plachynta M,Liu T,Xiao X,Song J,Li X,Zhang M,Yao Y,Luo H,Hao X,Ben-David Y
14-0161 was used in Flow cytometry/Cell sorting to highlight the complexity of Chinese medicinal compounds and the need to thoroughly analyze their systemic effects at high concentrations in vivo.
Thu Dec 01 00:00:00 EST 2016
Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells.
Aging
Hall BM,Balan V,Gleiberman AS,Strom E,Krasnov P,Virtuoso LP,Rydkina E,Vujcic S,Balan K,Gitlin I,Leonova K,Polinsky A,Chernova OB,Gudkov AV
14-0161 was used in Flow cytometry/Cell sorting to investigate the role of p16(Ink4a)/β-gal(pH6)-positive macrophages in aging, which previously was attributed solely to senescent cells.
Fri Jul 01 00:00:00 EDT 2016
Stat3 modulates chloride channel accessory protein expression in normal and neoplastic mammary tissue.
Cell death & disease
Hughes K,Blanck M,Pensa S,Watson CJ
14-0161 was used in Blocking experiments to investigate Stat3-mediated regulation of expression of calcium-activated chloride channel regulator family proteins during involution and mammary carcinogenesis.
Thu Oct 06 00:00:00 EDT 2016
Ly6C(hi) Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis.
Cell reports
Möhle L,Mattei D,Heimesaat MM,Bereswill S,Fischer A,Alutis M,French T,Hambardzumyan D,Matzinger P,Dunay IR,Wolf SA
14-0161 was used in Blocking experiments to detect that treatment of adult mice with antibiotics decreases hippocampal neurogenesis and memory retention.
Tue May 31 00:00:00 EDT 2016
Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.
Immunity
Jha AK,Huang SC,Sergushichev A,Lampropoulou V,Ivanova Y,Loginicheva E,Chmielewski K,Stewart KM,Ashall J,Everts B,Pearce EJ,Driggers EM,Artyomov MN
14-0161 was used in Blocking experiments to provide a highly integrated picture of the physiological modules supporting macrophage polarization, identifying potential pharmacologic control points for both macrophage phenotypes.
Tue Mar 17 00:00:00 EDT 2015
Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes.
Nature genetics
Hobbs RP,DePianto DJ,Jacob JT,Han MC,Chung BM,Batazzi AS,Poll BG,Guo Y,Han J,Ong S,Zheng W,Taube JM,Čiháková D,Wan F,Coulombe PA
14-0161 was used in Flow cytometry/Cell sorting to provide new insight into keratin intermediate filament and Aire function, as well as a molecular basis for the K17-dependent amplification of inflammatory and immune responses in diseased epithelia.
Sat Aug 01 00:00:00 EDT 2015
The development of innate lymphoid cells requires TOX-dependent generation of a common innate lymphoid cell progenitor.
Nature immunology
Seehus CR,Aliahmad P,de la Torre B,Iliev ID,Spurka L,Funari VA,Kaye J
14-0161 was used in Blocking experiments to demonstrate that transcriptional regulator TOX is required for the in vivo differentiation of common lymphoid progenitors to ILC lineage-restricted cells.
Mon Jun 01 00:00:00 EDT 2015
Nonvenous origin of dermal lymphatic vasculature.
Circulation research
Martinez-Corral I,Ulvmar MH,Stanczuk L,Tatin F,Kizhatil K,John SW,Alitalo K,Ortega S,Makinen T
14-0161 was used in Flow cytometry/Cell sorting to investigate the origin of murine lymphatic vasculature, showing a significant contribution from nonvenous cells.
Fri May 08 00:00:00 EDT 2015
Type 1 interferon-induced IL-7 maintains CD8+ T-cell responses and homeostasis by suppressing PD-1 expression in viral hepatitis.
Cellular & molecular immunology
Hou L,Jie Z,Liang Y,Desai M,Soong L,Sun J
14-0161 was used in Blocking experiments to investigate the underlying mechanisms used by IFN-I to orchestrate antiviral immune responses in the liver.
Sun Mar 01 00:00:00 EST 2015
Chitinase 3-like-1 and its receptors in Hermansky-Pudlak syndrome-associated lung disease.
The Journal of clinical investigation
Zhou Y,He CH,Herzog EL,Peng X,Lee CM,Nguyen TH,Gulati M,Gochuico BR,Gahl WA,Slade ML,Lee CG,Elias JA
14-0161 was used in Immunohistochemistry to investigate the role of chitinase 3-like-1 in Hermansky-Pudlak syndrome.
Mon Aug 03 00:00:00 EDT 2015
Stress-associated erythropoiesis initiation is regulated by type 1 conventional dendritic cells.
The Journal of clinical investigation
Kim TS,Hanak M,Trampont PC,Braciale TJ
14-0161 was used in Blocking experiments to report that type 1 conventional dendritic cells, are critical for induction of erythropoiesis in response to stress.
Thu Oct 01 00:00:00 EDT 2015
Bcl11b is essential for group 2 innate lymphoid cell development.
The Journal of experimental medicine
Walker JA,Oliphant CJ,Englezakis A,Yu Y,Clare S,Rodewald HR,Belz G,Liu P,Fallon PG,McKenzie AN
14-0161 was used in Flow cytometry/Cell sorting to study the role of Bcl11b in the differentiation of group 2 innate lymphoid cells.
Mon Jun 01 00:00:00 EDT 2015
Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.
Brain : a journal of neurology
Natrajan MS,de la Fuente AG,Crawford AH,Linehan E,Nuñez V,Johnson KR,Wu T,Fitzgerald DC,Ricote M,Bielekova B,Franklin RJ
14-0161 was used in Flow cytometry/Cell sorting to reveal the retinoid X receptor pathway as a regulator of myelin debris clearance and age-related decline in remyelination.
Tue Dec 01 00:00:00 EST 2015
GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury.
Journal of the American Society of Nephrology : JASN
Huen SC,Huynh L,Marlier A,Lee Y,Moeckel GW,Cantley LG
14-0161 was used in Blocking experiments to study the reparative phenotype of macrophages, which is promoted in vitro by GM-CSF expression in tubular cells, and which leads to proliferation in these cells after sterile ischemic injury.
Mon Jun 01 00:00:00 EDT 2015
GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury.
Journal of the American Society of Nephrology : JASN
Huen SC,Huynh L,Marlier A,Lee Y,Moeckel GW,Cantley LG
14-0161 was used in Blocking experiments to study the reparative phenotype of macrophages, which is promoted in vitro by GM-CSF expression in tubular cells, and which leads to proliferation in these cells after sterile ischemic injury.
Mon Jun 01 00:00:00 EDT 2015
The macrophage mediates the renoprotective effects of endotoxin preconditioning.
Journal of the American Society of Nephrology : JASN
Hato T,Winfree S,Kalakeche R,Dube S,Kumar R,Yoshimoto M,Plotkin Z,Dagher PC
14-0161 was used in Blocking experiments to investigate the protective mechanisms of endotoxin preconditioning at the tissue level in organs.
Mon Jun 01 00:00:00 EDT 2015
Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis.
Journal of the American Society of Nephrology : JASN
Micanovic R,Chitteti BR,Dagher PC,Srour EF,Khan S,Hato T,Lyle A,Tong Y,Wu XR,El-Achkar TM
14-0161 was used in Blocking experiments to show that Tamm-Horsfall protein deficiency in mice causes systemic neutrophilia through enhanced granulopoiesis in the bone marrow.
Tue Sep 01 00:00:00 EDT 2015
Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus.
EMBO molecular medicine
Herbst S,Shah A,Mazon Moya M,Marzola V,Jensen B,Reed A,Birrell MA,Saijo S,Mostowy S,Shaunak S,Armstrong-James D
14-0161 was used in Blocking experiments to study how the inhibition of the TLR9-BTK-calcineurin-NFAT signalling pathway is a key immune defect that can lead to organ transplant-related aspergillosis.
Sun Mar 01 00:00:00 EST 2015
Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus.
EMBO molecular medicine
Herbst S,Shah A,Mazon Moya M,Marzola V,Jensen B,Reed A,Birrell MA,Saijo S,Mostowy S,Shaunak S,Armstrong-James D
14-0161 was used in Blocking experiments to study how the inhibition of the TLR9-BTK-calcineurin-NFAT signalling pathway is a key immune defect that can lead to organ transplant-related aspergillosis.
Sun Mar 01 00:00:00 EST 2015
B cell autophagy mediates TLR7-dependent autoimmunity and inflammation.
Autophagy
Weindel CG,Richey LJ,Bolland S,Mehta AJ,Kearney JF,Huber BT
14-0161 was used in Blocking experiments to demonstrate that autophagy plays an essential role in TLR7 activation of B cells for the induction of systemic lupus erythematosus.
Mon Apr 18 00:00:00 EDT 2016
Erythropoietin and IGF-1 signaling synchronize cell proliferation and maturation during erythropoiesis.
Genes & development
Kadri Z,Lefevre C,Goupille O,Penglong T,Granger-Locatelli M,Fucharoen S,Maouche-Chretien L,Leboulch P,Chretien S
14-0161 was used in Flow cytometry/Cell sorting to study how erythropoietin and IGF-1 signalling may synchronise cell proliferation and differentiation during erythropoiesis as components of GATA-1 pathways.
Tue Dec 15 00:00:00 EST 2015
Characterization of the Antigen-Specific CD4(+) T Cell Response Induced by Prime-Boost Strategies with CAF01 and CpG Adjuvants Administered by the Intranasal and Subcutaneous Routes.
Frontiers in immunology
Ciabattini A,Prota G,Christensen D,Andersen P,Pozzi G,Medaglini D
14-0161 was used in Blocking experiments to investigate different prime-boost combinations using the tuberculosis vaccine antigen H56 with CAF01 or CpG ODN 1826 adjuvants.
Fri Sep 18 00:00:00 EDT 2015
Control of murine cytomegalovirus infection by γδ T cells.
PLoS pathogens
Sell S,Dietz M,Schneider A,Holtappels R,Mach M,Winkler TH
14-0161 was used in Flow cytometry/Cell sorting to show that γδ T cells can provide an effective control mechanism of acute cytomegalovirus infections.
Sun Feb 01 00:00:00 EST 2015
Porphyromonas gingivalis gingipains selectively reduce CD14 expression, leading to macrophage hyporesponsiveness to bacterial infection.
Journal of innate immunity
Wilensky A,Tzach-Nahman R,Potempa J,Shapira L,Nussbaum G
14-0161 was used in Flow cytometry/Cell sorting to study how porphyromonas gingivalis gingipains can reduce CD14 expression without affecting expression of the bacterial-sensing TLRs.
Mon Dec 21 00:00:00 EST 2015
Splenic extrafollicular reactions and BM plasma cells sustain IgM response associated with hypercholesterolemia.
European journal of immunology
Khoo LH,Thiam CH,Soh SY,Angeli V
14-0161 was used in Flow cytometry/Cell sorting to elucidate the mechanism underlying the elevated IgM response observed in hypercholesterolaemia.
Fri May 01 00:00:00 EDT 2015
Complement C3 mediated targeting of liposomes to granulocytic myeloid derived suppressor cells.
Nanomedicine : nanotechnology, biology, and medicine
Kullberg M,Martinson H,Mann K,Anchordoquy TJ
14-0161 was used in Flow cytometry/Cell sorting to describe the development of a liposomal drug delivery system which targets immune suppressors.
Sat Aug 01 00:00:00 EDT 2015
Intratumoral INF-γ triggers an antiviral state in GL261 tumor cells: a major hurdle to overcome for oncolytic vaccinia virus therapy of cancer.
Molecular therapy oncolytics
Kober C,Weibel S,Rohn S,Kirscher L,Szalay AA
14-0161 was used in Flow cytometry/Cell sorting to identify microenvironmental factors, which may be decisive for failure or success of oncolytic VACV therapy.
Wed Apr 27 00:00:00 EDT 2016
Transcriptional Pathways in cPGI2-Induced Adipocyte Progenitor Activation for Browning.
Frontiers in endocrinology
Bayindir I,Babaeikelishomi R,Kocanova S,Sousa IS,Lerch S,Hardt O,Wild S,Bosio A,Bystricky K,Herzig S,Vegiopoulos A
14-0161 was used in Blocking experiments to develop models for the mechanistic investigation of progenitor-mediated beige/brite adipocyte differentiation.
Tue Sep 08 00:00:00 EDT 2015
Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model.
Antimicrobial agents and chemotherapy
Hilliard JJ,Datta V,Tkaczyk C,Hamilton M,Sadowska A,Jones-Nelson O,O'Day T,Weiss WJ,Szarka S,Nguyen V,Prokai L,Suzich J,Stover CK,Sellman BR
14-0161 was used in Blocking experiments to characterise MEDI4893* and its therapeutic activity in a dermonecrosis model, showing that MEDI4893* and antibiotic combination therapy improves disease outcome.
Thu Jan 01 00:00:00 EST 2015
Enhancing the Quality of Antibodies to HIV-1 Envelope by GagPol-Specific Th Cells.
Journal of immunology (Baltimore, Md. : 1950)
Storcksdieck genannt Bonsmann M,Niezold T,Temchura V,Pissani F,Ehrhardt K,Brown EP,Osei-Owusu NY,Hannaman D,Hengel H,Ackerman ME,Streeck H,Nabi G,Tenbusch M,Überla K
14-0161-82 was used in Flow Cytometry to enhance the quality of antibodies to HIV-1 envelope by GagPol-Specific T helper Cells.
Sun Nov 15 00:00:00 EST 2015
Eosinophils Contribute to Early Clearance of Pneumocystis murina Infection.
Journal of immunology (Baltimore, Md. : 1950)
Eddens T,Elsegeiny W,Nelson MP,Horne W,Campfield BT,Steele C,Kolls JK
14-0161 was used in Flow cytometry/Cell sorting to examine how CD4(+) T cells contribute to host defence against Pneumocystis.
Wed Jul 01 00:00:00 EDT 2015
Hydroxypropyl-β-cyclodextrin spikes local inflammation that induces Th2 cell and T follicular helper cell responses to the coadministered antigen.
Journal of immunology (Baltimore, Md. : 1950)
Onishi M,Ozasa K,Kobiyama K,Ohata K,Kitano M,Taniguchi K,Homma T,Kobayashi M,Sato A,Katakai Y,Yasutomi Y,Wijaya E,Igarashi Y,Nakatsu N,Ise W,Inoue T,Yamada H,Vandenbon A,Standley DM,Kurosaki T,Coban C,Aoshi T,Kuroda E,Ishii KJ
14-0161 was used in Blocking experiments to investigate the immunological properties of drug-delivery systems.
Sun Mar 15 00:00:00 EDT 2015
Loss of MyD88 alters neuroinflammatory response and attenuates early Purkinje cell loss in a spinocerebellar ataxia type 6 mouse model.
Human molecular genetics
Aikawa T,Mogushi K,Iijima-Tsutsui K,Ishikawa K,Sakurai M,Tanaka H,Mizusawa H,Watase K
14-0161 was used in Immunohistochemistry on paraffin embedded tissues to suggest that early neuroinflammatory response may play an important role in the pathogenesis of SCA6.
Tue Sep 01 00:00:00 EDT 2015
Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice.
Endocrinology
Schoiswohl G,Stefanovic-Racic M,Menke MN,Wills RC,Surlow BA,Basantani MK,Sitnick MT,Cai L,Yazbeck CF,Stolz DB,Pulinilkunnil T,O'Doherty RM,Kershaw EE
14-0161 was used in Flow cytometry/Cell sorting to study the effects of ATGL-mediated adipocyte lipolysis on immune cell infiltration, and the impact this has on obesity-related inflammation and insulin resistance.
Thu Oct 01 00:00:00 EDT 2015
Mitoquinone restores platelet production in irradiation-induced thrombocytopenia.
Platelets
Ramsey H,Zhang Q,Wu MX
14-0161 was used in Flow cytometry/Cell sorting to investigate whether increased ROS production in myelodysplastic syndromes is an instigator or a byproduct of the disease.
Tue Mar 08 00:00:00 EST 2016
Yersinia pestis targets neutrophils via complement receptor 3.
Cellular microbiology
Merritt PM,Nero T,Bohman L,Felek S,Krukonis ES,Marketon MM
14-0161 was used in Blocking experiments to identify the factors involved in the targeting of murine splenocytes by Yersinia pestis.
Fri May 01 00:00:00 EDT 2015
Outer surface protein OspC is an antiphagocytic factor that protects Borrelia burgdorferi from phagocytosis by macrophages.
Infection and immunity
Carrasco SE,Troxell B,Yang Y,Brandt SL,Li H,Sandusky GE,Condon KW,Serezani CH,Yang XF
14-0161 was used in Flow cytometry/Cell sorting to provide evidence that mononuclear phagocytes play a key role in clearance of the ospC mutant and that OspC promotes spirochetes'' evasion of macrophages during early Lyme borreliosis.
Tue Dec 01 00:00:00 EST 2015
The Cnes2 locus on mouse chromosome 17 regulates host defense against cryptococcal infection through pleiotropic effects on host immunity.
Infection and immunity
Shourian M,Flaczyk A,Angers I,Mindt BC,Fritz JH,Qureshi ST
14-0161 was used in Flow cytometry/Cell sorting to show that Cryptococcus neoformans infected lungs showed a significantly higher number of neutrophils, exudate macrophages, CD11b(+) dendritic cells, and CD4(+) cells in B6.CBA-Cnes2 than in C57BL/6 mice.
Tue Dec 01 00:00:00 EST 2015
Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation.
BioMed research international
Tejón G,Manríquez V,De Calisto J,Flores-Santibáñez F,Hidalgo Y,Crisóstomo N,Fernández D,Sauma D,Mora JR,Bono MR,Rosemblatt M
14-0161 was used in Flow cytometry/Cell sorting to study the contribution of different factors to the reprogramming of iTregs into IL-17-producing cells, showing that vitamin A impairs reprogramming during intestinal inflammation.
Fri Sep 02 00:00:00 EDT 2016
In vivo capture and label-free detection of early metastatic cells.
Nature communications
Azarin SM,Yi J,Gower RM,Aguado BA,Sullivan ME,Goodman AG,Jiang EJ,Rao SS,Ren Y,Tucker SL,Backman V,Jeruss JS,Shea LD
14-0161 was used in Blocking experiments to develop an in vivo capture and label-free detection method for early metastasis, showing potential to identify metastasis in patients at risk of recurrence.
Tue Sep 08 00:00:00 EDT 2015
Non-classical MHC I-E negatively regulates macrophage activation and Th17 cell development in NOD mice.
Scientific reports
Yang C,Guo N,Liu J,Yang J,Zhu K,Xiao H,Leng Q
14-0161 was used in Blocking experiments to investigate the role of I-E molecules.
Fri Aug 07 00:00:00 EDT 2015
Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model.
Oncotarget
Sorrentino C,Miele L,Porta A,Pinto A,Morello S
14-0161 was used in Blocking experiments to investigate the role of myeloid-derived suppressor cells in tumour vascularisation and progression.
Tue Sep 29 00:00:00 EDT 2015
Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion.
The Journal of biological chemistry
Pamir N,Liu NC,Irwin A,Becker L,Peng Y,Ronsein GE,Bornfeldt KE,Duffield JS,Heinecke JW
14-0161 was used in Flow cytometry/Cell sorting to investigate dendritic cells and show cells that are dependent on GM-CSF restrain lean adipose tissue expansion.
Fri Jun 05 00:00:00 EDT 2015
Inflammation-associated alterations to the intestinal microbiota reduce colonization resistance against non-typhoidal Salmonella during concurrent malaria parasite infection.
Scientific reports
Mooney JP,Lokken KL,Byndloss MX,George MD,Velazquez EM,Faber F,Butler BP,Walker GT,Ali MM,Potts R,Tiffany C,Ahmer BM,Luckhart S,Tsolis RM
14-0161 was used in Blocking experiments to investigate whether malaria affects resistance to intestinal colonisation with non-typhoidal Salmonella.
Mon Oct 05 00:00:00 EDT 2015
Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells.
Nature communications
Gao Y,Yang P,Shen H,Yu H,Song X,Zhang L,Zhang P,Cheng H,Xie Z,Hao S,Dong F,Ma S,Ji Q,Bartlow P,Ding Y,Wang L,Liu H,Li Y,Cheng H,Miao W,Yuan W,Yuan Y,Cheng T,Xie XQ
14-0161 was used in Flow cytometry/Cell sorting to investigate how putative small-molecule inhibitors for p18 protein are valuable for further dissecting the signalling pathways of stem cell self-renewal.
Wed Feb 18 00:00:00 EST 2015
Cd1d regulates B cell development but not B cell accumulation and IL10 production in mice with pathologic CD5(+) B cell expansion.
BMC immunology
Palmer VL,Nganga VK,Rothermund ME,Perry GA,Swanson PC
14-0161 was used in Flow cytometry/Cell sorting to investigate the effect of CD1d expression on CD5+ B cell accumulation, IL10 competence and antibody production in mice with pathologic CD5+ B cell expansion.
Wed Nov 04 00:00:00 EST 2015
Phagosomal Acidification Prevents Macrophage Inflammatory Cytokine Production to Malaria, and Dendritic Cells Are the Major Source at the Early Stages of Infection: IMPLICATION FOR MALARIA PROTECTIVE IMMUNITY DEVELOPMENT.
The Journal of biological chemistry
Wu X,Gowda NM,Gowda DC
14-0161 was used in Blocking experiments to demonstrate that monocytes and macrophages do not produce inflammatory cytokines to malaria parasites and that DCs are the primary source.
Fri Sep 18 00:00:00 EDT 2015
Plant virus particles carrying tumour antigen activate TLR7 and Induce high levels of protective antibody.
PloS one
Jobsri J,Allen A,Rajagopal D,Shipton M,Kanyuka K,Lomonossoff GP,Ottensmeier C,Diebold SS,Stevenson FK,Savelyeva N
14-0161 was used in Blocking experiments to assess the effectiveness of a plant viral particle conjugate vaccine against a murine B-cell malignancy.
Mon Jan 25 00:00:00 EST 2016
Interferon-γ from Brain Leukocytes Enhances Meningitis by Type 4 Streptococcus pneumoniae.
Frontiers in microbiology
Pettini E,Fiorino F,Cuppone AM,Iannelli F,Medaglini D,Pozzi G
14-0161 was used in Flow cytometry/Cell sorting to elucidate the role of IFN-γ in the neuroinflammatory response following type 4 Streptococcus pneumoniae-induced meningitis in mice.
Wed Dec 09 00:00:00 EST 2015
Metronomic cyclophosphamide eradicates large implanted GL261 gliomas by activating antitumor Cd8+ T-cell responses and immune memory.
Oncoimmunology
Wu J,Waxman DJ
14-0161 was used in Flow cytometry/Cell sorting to prove that single-agent chemotherapy can eradicate large, established tumours and induce long-term immune memory.
Wed Apr 01 00:00:00 EDT 2015
A Stochastic Model for CD4+ T Cell Proliferation and Dissemination Network in Primary Immune Response.
PloS one
Boianelli A,Pettini E,Prota G,Medaglini D,Vicino A
14-0161 was used in Flow cytometry/Cell sorting to construct a stochastic model based on branching process theory, for the dissemination network of antigen-specific CD4+ T cells.
Tue May 17 00:00:00 EDT 2016
The Polyunsaturated Fatty Acids Arachidonic Acid and Docosahexaenoic Acid Induce Mouse Dendritic Cells Maturation but Reduce T-Cell Responses In Vitro.
PloS one
Carlsson JA,Wold AE,Sandberg AS,Östman SM
14-0161 was used in Blocking experiments to measure the effects of omega-3, -6 and -9 fatty acids on the interaction between dendritic cells and naïve T cells.
Fri Jul 01 00:00:00 EDT 2016
Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors.
Oncotarget
Colbeck EJ,Hindley JP,Smart K,Jones E,Bloom A,Bridgeman H,McPherson RC,Turner DG,Ladell K,Price DA,O'Connor RA,Anderton SM,Godkin AJ,Gallimore AM
14-0161 was used in Flow cytometry/Cell sorting to study the enrichment of tumor-infiltrating Treg populations and assess the role of IL-2 in pertubation of Treg frequencies in tumors.
Tue Sep 22 00:00:00 EDT 2015
PD-L1hi B cells are critical regulators of humoral immunity.
Nature communications
Khan AR,Hams E,Floudas A,Sparwasser T,Weaver CT,Fallon PG
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that elevated PD-L1 expression on B cells is an important regulator of T follicular helper-cell activity, downstream antibody responses and autoimmune disease.
Thu Jan 22 00:00:00 EST 2015
Galectin-3 deficiency exacerbates hyperglycemia and the endothelial response to diabetes.
Cardiovascular diabetology
Darrow AL,Shohet RV
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that galectin-3 deficiency contributes both to the pathogenesis of diabetes and the associated vasculopathy.
Sat Jun 06 00:00:00 EDT 2015
Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties.
The Journal of biological chemistry
Schuepbach-Mallepell S,Das D,Willen L,Vigolo M,Tardivel A,Lebon L,Kowalczyk-Quintas C,Nys J,Smulski C,Zheng TS,Maskos K,Lammens A,Jiang X,Hess H,Tan SL,Schneider P
14-0161 was used in Flow cytometry/Cell sorting to study how BAFF-APRIL heteromers of different stoichiometries have distinct receptor-binding properties and activities.
Fri Jun 26 00:00:00 EDT 2015
The Divergent CD8+ T Cell Adjuvant Properties of LT-IIb and LT-IIc, Two Type II Heat-Labile Enterotoxins, Are Conferred by Their Ganglioside-Binding B Subunits.
PloS one
Hu JC,Greene CJ,King-Lyons ND,Connell TD
14-0161 was used in Blocking experiments to investigate the influence of the B subunits on the enhancement of immune responses by LT-IIb and LT-IIc.
Wed Jun 29 00:00:00 EDT 2016
Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model.
BMC cancer
Gillgrass AE,Chew MV,Krneta T,Ashkar AA
14-0161 was used in Flow cytometry/Cell sorting to investigate the potential role of IL-15 for metastatic reduction in breast cancer via effects on NK1.1+ cells.
Thu Apr 16 00:00:00 EDT 2015
IFN-γ modulates Ly-49 receptors on NK cells in IFN-γ-induced pregnancy failure.
Scientific reports
Li ZY,Song ZH,Meng CY,Yang DD,Yang Y,Peng JP
14-0161 was used in Blocking experiments to investigate the mechanism by which IFN-γ modulates Ly-49 receptors on natural killer cells during pregnancy failure.
Fri Dec 11 00:00:00 EST 2015
Poly(I:C) and CpG-ODN combined aerosolization to treat lung metastases and counter the immunosuppressive microenvironment.
Oncoimmunology
Le Noci V,Tortoreto M,Gulino A,Storti C,Bianchi F,Zaffaroni N,Tripodo C,Tagliabue E,Balsari A,Sfondrini L
14-0161 was used in Flow cytometry/Cell sorting to evaluated aerosol delivery CpG-ODN combined with Poly(I:C) in the treatment of B16 melanoma lung metastases in C57BL/6 mice.
Thu Oct 01 00:00:00 EDT 2015
The Development of Macrophage-Mediated Cell Therapy to Improve Skeletal Muscle Function after Injury.
PloS one
Rybalko V,Hsieh PL,Merscham-Banda M,Suggs LJ,Farrar RP
14-0161 was used in Flow cytometry/Cell sorting to show that delivery of M1 (LPS/IFNγ) macrophages early in regeneration improves skeletal muscle function after injury.
Sun Jun 26 00:00:00 EDT 2016
Eosinophils from Murine Lamina Propria Induce Differentiation of Naïve T Cells into Regulatory T Cells via TGF-β1 and Retinoic Acid.
PloS one
Chen HH,Sun AH,Ojcius DM,Hu WL,Ge YM,Lin X,Li LJ,Pan JP,Yan J
14-0161 was used in Blocking experiments to investigate mechanisms that induce Tregs, showing that eosinophils from murine lamina propria induce differentiation via TGF-β1 and retinoic acid.
Fri Jun 17 00:00:00 EDT 2016
Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance.
Nature communications
Kim AY,Park YJ,Pan X,Shin KC,Kwak SH,Bassas AF,Sallam RM,Park KS,Alfadda AA,Xu A,Kim JB
14-0161 was used in Flow cytometry/Cell sorting to study how obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance.
Fri Jul 03 00:00:00 EDT 2015
An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action.
Nature medicine
Gibbs J,Ince L,Matthews L,Mei J,Bell T,Yang N,Saer B,Begley N,Poolman T,Pariollaud M,Farrow S,DeMayo F,Hussell T,Worthen GS,Ray D,Loudon A
14-0161 was used in Blocking experiments to study the regulatory mechanism linking the circadian clock and glucocorticoid hormones, to control time-of-day variation and the magnitude of pulmonary inflammation.
Fri Aug 01 00:00:00 EDT 2014
RNA viruses can hijack vertebrate microRNAs to suppress innate immunity.
Nature
Trobaugh DW,Gardner CL,Sun C,Haddow AD,Wang E,Chapnik E,Mildner A,Weaver SC,Ryman KD,Klimstra WB
14-0161 was used in Flow Cytometry to study the mechanism by which haematopoietic-cell-specific miR-142-3p potently restricts the replication of the mosquito-borne North American eastern equine encephalitis virus in myeloid-lineage cells.
Thu Feb 13 00:00:00 EST 2014
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages.
Nature immunology
Huang SC,Everts B,Ivanova Y,O'Sullivan D,Nascimento M,Smith AM,Beatty W,Love-Gregory L,Lam WY,O'Neill CM,Yan C,Du H,Abumrad NA,Urban JF,Artyomov MN,Pearce EL,Pearce EJ
14-0161 was used in Blocking experiments to delineate a critical role for cell-intrinsic lysosomal lipolysis in M2 activation.
Mon Sep 01 00:00:00 EDT 2014
Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice.
Nature immunology
Watchmaker PB,Lahl K,Lee M,Baumjohann D,Morton J,Kim SJ,Zeng R,Dent A,Ansel KM,Diamond B,Hadeiba H,Butcher EC
14-0161 was used in Flow cytometry/Cell sorting to characterise human gut dendritic cell populations, and define their relationship to previously studied human and mouse dendritic cells.
Wed Jan 01 00:00:00 EST 2014
Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2.
Nature immunology
Taylor PR,Roy S,Leal SM,Sun Y,Howell SJ,Cobb BA,Li X,Pearlman E
14-0161 was used in Blocking experiments to identify a population of human and murine neutrophils that exhibit autocrine IL-17 activity.
Sat Feb 01 00:00:00 EST 2014
miR33 inhibition overcomes deleterious effects of diabetes mellitus on atherosclerosis plaque regression in mice.
Circulation research
Distel E,Barrett TJ,Chung K,Girgis NM,Parathath S,Essau CC,Murphy AJ,Moore KJ,Fisher EA
14-0161 was used in Blocking experiments to assess the effects of mir33 inhibition on atherosclerosis regression in diabetic mice.
Fri Oct 10 00:00:00 EDT 2014
Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation.
Science translational medicine
Beale J,Jayaraman A,Jackson DJ,Macintyre JDR,Edwards MR,Walton RP,Zhu J,Man Ching Y,Shamji B,Edwards M,Westwick J,Cousins DJ,Yi Hwang Y,McKenzie A,Johnston SL,Bartlett NW
14-0161 was used in Blocking experiments to demonstrate asthmatic epithelial cells have an increased intrinsic capacity for expression of a pro-type 2 cytokine in response to a viral infection.
Wed Oct 01 00:00:00 EDT 2014
Kinetic characteristics of euflammation: the induction of controlled inflammation without overt sickness behavior.
Brain, behavior, and immunity
Tarr AJ,Liu X,Reed NS,Quan N
14-0161 was used in Blocking experiments to characterise kinetic changes in the behaviour, immunological, and neuroendocrine aspects of euflammation.
Sat Nov 01 00:00:00 EDT 2014
Leukotriene B4 amplifies eosinophil accumulation in response to nematodes.
The Journal of experimental medicine
Patnode ML,Bando JK,Krummel MF,Locksley RM,Rosen SD
14-0161 was used in Blocking experiments to investigate the mechanisms of eosinophil recognition of parasitic worms.
Mon Jun 30 00:00:00 EDT 2014
The effect of combined IL10 siRNA and CpG ODN as pathogen-mimicking microparticles on Th1/Th2 cytokine balance in dendritic cells and protective immunity against B cell lymphoma.
Biomaterials
Pradhan P,Qin H,Leleux JA,Gwak D,Sakamaki I,Kwak LW,Roy K
14-0161 was used in Blocking experiments to investigate the effect of IL10 siRNA and CpG ODN on B cell lymphoma.
Tue Jul 01 00:00:00 EDT 2014
Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions.
EMBO molecular medicine
Hoeksema MA,Gijbels MJ,Van den Bossche J,van der Velden S,Sijm A,Neele AE,Seijkens T,Stöger JL,Meiler S,Boshuizen MC,Dallinga-Thie GM,Levels JH,Boon L,Mullican SE,Spann NJ,Cleutjens JP,Glass CK,Lazar MA,de Vries CJ,Biessen EA,Daemen MJ,Lutgens E,de Winther MP
14-0161 was used in Blocking experiments to investigate the role of the Histone deacetylase 3 in regulating the atherosclerotic phenotype of macrophages.
Mon Sep 01 00:00:00 EDT 2014
Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality.
Proceedings of the National Academy of Sciences of the United States of America
Wu J,Tian L,Yu X,Pattaradilokrat S,Li J,Wang M,Yu W,Qi Y,Zeituni AE,Nair SC,Crampton SP,Orandle MS,Bolland SM,Qi CF,Long CA,Myers TG,Coligan JE,Wang R,Su XZ
14-0161 was used in Blocking experiments to investigate the parasite ligands, host receptors, and the signalling pathways responsible for triggering host immune responses following malaria infection.
Tue Jan 28 00:00:00 EST 2014
Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Rei M,Gonçalves-Sousa N,Lança T,Thompson RG,Mensurado S,Balkwill FR,Kulbe H,Pennington DJ,Silva-Santos B
14-0161 was used in Flow cytometry/Cell sorting to characterise the role of tumour-associated γδ T cells on disease development using a model peritoneal/ovarian cancer cell line.
Tue Aug 26 00:00:00 EDT 2014
Signaling pathways activated by a protease allergen in basophils.
Proceedings of the National Academy of Sciences of the United States of America
Rosenstein RK,Bezbradica JS,Yu S,Medzhitov R
14-0161 was used in Blocking experiments to characterize the cellular response activated by papain in basophils.
Tue Nov 18 00:00:00 EST 2014
Signaling pathways activated by a protease allergen in basophils.
Proceedings of the National Academy of Sciences of the United States of America
Rosenstein RK,Bezbradica JS,Yu S,Medzhitov R
14-0161 was used in Blocking experiments to characterize the cellular response activated by papain in basophils.
Tue Nov 18 00:00:00 EST 2014
CD300b regulates the phagocytosis of apoptotic cells via phosphatidylserine recognition.
Cell death and differentiation
Murakami Y,Tian L,Voss OH,Margulies DH,Krzewski K,Coligan JE
14-0161 was used in Blocking experiments to investigate the mechanism of recognition of CD300b.
Sat Nov 01 00:00:00 EDT 2014
Intravenous injection of MVA virus targets CD8+ lymphocytes to tumors to control tumor growth upon combinatorial treatment with a TLR9 agonist.
Cancer immunology research
Fend L,Gatard-Scheikl T,Kintz J,Gantzer M,Schaedler E,Rittner K,Cochin S,Fournel S,Préville X
14-0161 was used in Blocking experiments to evaluate the impact of injection routes on therapeutic efficacy of a Modified Vaccinia virus Ankara viral vector expressing the human mucin 1 tumour-associated xeno-antigen.
Mon Dec 01 00:00:00 EST 2014
Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis.
Aging cell
Linehan E,Dombrowski Y,Snoddy R,Fallon PG,Kissenpfennig A,Fitzgerald DC
14-0161 was used in Flow cytometry/Cell sorting to determine that age-related defects in macrophage phagocytosis may be due to extrinsic factors in the tissue microenvironment.
Fri Aug 01 00:00:00 EDT 2014
A20-deficient mast cells exacerbate inflammatory responses in vivo.
PLoS biology
Heger K,Fierens K,Vahl JC,Aszodi A,Peschke K,Schenten D,Hammad H,Beyaert R,Saur D,van Loo G,Roers A,Lambrecht BN,Kool M,Schmidt-Supprian M
14-0161 was used in Blocking experiments to develop an in vivo model of hyperactive mast cells.
Wed Jan 01 00:00:00 EST 2014
A novel 1,2-benzenediamine derivative FC-99 suppresses TLR3 expression and ameliorates disease symptoms in a mouse model of sepsis.
British journal of pharmacology
Gong W,Hu E,Dou H,Song Y,Yang L,Ji J,Li E,Tan R,Hou Y
14-0161 was used in Flow cytometry/Cell sorting to explore a 1,2-benzenediamine derivative FC-99 as a therapeutic candidate for sepsis.
Sat Nov 01 00:00:00 EDT 2014
Distinct progenitor origin distinguishes a lineage of dendritic-like cells in spleen.
Frontiers in immunology
Petvises S,O'Neill HC
14-0161 was used in Blocking experiments to study how a lineage of dendritic-like cells in the spleen are distinguished by distinct progenitor origins.
Wed Jan 15 00:00:00 EST 2014
Secretion of IL-16 through TNFR1 and calpain-caspase signaling contributes to MRSA pneumonia.
Mucosal immunology
Ahn DS,Parker D,Planet PJ,Nieto PA,Bueno SM,Prince A
14-0161 was used in Flow cytometry/Cell sorting to study the role of IL-16 in disease progression of S. aureus pneumonia.
Sat Nov 01 00:00:00 EDT 2014
Dual oxidase 2 in lung epithelia is essential for hyperoxia-induced acute lung injury in mice.
Antioxidants & redox signaling
Kim MJ,Ryu JC,Kwon Y,Lee S,Bae YS,Yoon JH,Ryu JH
14-0161 was used in Functional assays to investigate the molecular mechanisms of ROS production in type II alveolar epithelial cells, showing that dual oxidase 2 is essential for hyperoxia-induced acute lung injury.
Sat Nov 01 00:00:00 EDT 2014
The Vi capsular polysaccharide enables Salmonella enterica serovar typhi to evade microbe-guided neutrophil chemotaxis.
PLoS pathogens
Wangdi T,Lee CY,Spees AM,Yu C,Kingsbury DD,Winter SE,Hastey CJ,Wilson RP,Heinrich V,Bäumler AJ
14-0161 was used in Flow cytometry/Cell sorting to study how the expression of the Vi capsular polysaccharide of S. Typhi obstructs bacterial-guided neutrophil chemotaxis.
Fri Aug 01 00:00:00 EDT 2014
Signal-regulatory protein α from the NOD mouse binds human CD47 with an exceptionally high affinity-- implications for engraftment of human cells.
Immunology
Kwong LS,Brown MH,Barclay AN,Hatherley D
14-0161 was used in Flow cytometry/Cell sorting to compare binding affinities of CD47 for different SIRPα mutants to assess the role of leucocyte surface protein interactions with tumours in cancer development.
Mon Sep 01 00:00:00 EDT 2014
Therapeutic effects of DZ2002, a reversible SAHH inhibitor, on lupus-prone NZB×NZW F1 mice via interference with TLR-mediated APC response.
Acta pharmacologica Sinica
He SJ,Lin ZM,Wu YW,Bai BX,Yang XQ,He PL,Zhu FH,Tang W,Zuo JP
14-0161 was used in Blocking experiments to demonstrate that DZ2002 effectively ameliorates lupus syndrome in NZB/W F1 mice by regulating TLR signaling-mediated APC responses.
Sat Feb 01 00:00:00 EST 2014
Orphan chemoattractant receptor GPR15 mediates dendritic epidermal T-cell recruitment to the skin.
European journal of immunology
Lahl K,Sweere J,Pan J,Butcher E
14-0161 was used in Blocking experiments to investigate the role of GRP15 in dendritic epidermal T cell recruitment to the skin.
Mon Sep 01 00:00:00 EDT 2014
Evidence that meningeal mast cells can worsen stroke pathology in mice.
The American journal of pathology
Arac A,Grimbaldeston MA,Nepomuceno AR,Olayiwola O,Pereira MP,Nishiyama Y,Tsykin A,Goodall GJ,Schlecht U,Vogel H,Tsai M,Galli SJ,Bliss TM,Steinberg GK
14-0161 was used in Blocking experiments to investigate the factors that promote inflammation during stroke.
Mon Sep 01 00:00:00 EDT 2014
Dynamic changes in macrophage activation and proliferation during the development and resolution of intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Little MC,Hurst RJ,Else KJ
14-0161 was used in Flow cytometry/Cell sorting to study intestinal inflammation and the dynamic changes in macrophage activation and proliferation that occur during this process.
Sat Nov 01 00:00:00 EDT 2014
An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
White AJ,Jenkinson WE,Cowan JE,Parnell SM,Bacon A,Jones ND,Jenkinson EJ,Anderson G
14-0161 was used in Flow cytometry/Cell sorting to investigate whether thymus microenvironments are required in iNKT cell development, showing that medullary thymic epithelial cells are essential for intrathymic development of iNKT cells.
Sat Mar 15 00:00:00 EDT 2014
Upregulation of GRAIL is associated with impaired CD4 T cell proliferation in sepsis.
Journal of immunology (Baltimore, Md. : 1950)
Aziz M,Yang WL,Matsuo S,Sharma A,Zhou M,Wang P
14-0161 was used in Blocking experiments to investigate the role of GRAIL in CD4 T cell proliferation during sepsis.
Sat Mar 01 00:00:00 EST 2014
A novel murine cytomegalovirus vaccine vector protects against Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950)
Beverley PC,Ruzsics Z,Hey A,Hutchings C,Boos S,Bolinger B,Marchi E,O'Hara G,Klenerman P,Koszinowski UH,Tchilian EZ
14-0161 was used in Blocking experiments to investigate the effect of a novel murine cytomegalovirus vaccine vector on Mycobacterium tuberculosis infection.
Mon Sep 01 00:00:00 EDT 2014
Involvement of the 4-1BB/4-1BBL pathway in control of monocyte numbers by invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
Cole SL,Benam KH,McMichael AJ,Ho LP
14-0161 was used in Flow cytometry/Cell sorting to show 4-1BB/L costimulation amplified monocyte-mediated proliferation of iNKT cells, indirectly providing a method for monocytes to control their own numbers during infection.
Tue Apr 15 00:00:00 EDT 2014
The thyroxine-containing thyroglobulin peptide (aa 2549-2560) is a target epitope in iodide-accelerated spontaneous autoimmune thyroiditis.
Journal of immunology (Baltimore, Md. : 1950)
Kolypetri P,Carayanniotis K,Rahman S,Georghiou PE,Magafa V,Cordopatis P,Carayanniotis G
14-0161 was used for neutralization to identify a thyroglobulin T cell epitope as a spontaneous target in iodide-accelerated spontaneous autoimmune thyroiditis.
Tue Jul 01 00:00:00 EDT 2014
Cytokine deposition alters leukocyte morphology and initial recruitment of monocytes and γδT cells after corneal injury.
Investigative ophthalmology & visual science
Pal-Ghosh S,Pajoohesh-Ganji A,Menko AS,Oh HY,Tadvalkar G,Saban DR,Stepp MA
14-0161 was used in Flow cytometry/Cell sorting to characterize differences in cytokine deposition and changes in leukocytes between 0 and 6 hours after dulled-blade and rotating-burr wounding.
Mon Apr 28 00:00:00 EDT 2014
Tumor-promoting role of TGFβ1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells.
Carcinogenesis
Ravindran A,Mohammed J,Gunderson AJ,Cui X,Glick AB
14-0161 was used in Flow cytometry/Cell sorting to study how TGFβ1 signalling has a tumour-promoting role in UVB-induced skin carcinogenesis, which is mediated in part through its role in UVB-induced migration of dDC and cutaneous inflammation.
Tue Apr 01 00:00:00 EDT 2014
Appropriate development of the liver Treg compartment is modulated by the microbiota and requires TGF-β and MyD88.
Journal of immunology research
Maria A,English KA,Gorham JD
14-0161 was used in Blocking experiments to investigate the development of liver Treg compartment and the factors that regulate development.
Tue May 12 00:00:00 EDT 2015
An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection.
Genes and immunity
Lafferty EI,Flaczyk A,Angers I,Homer R,d'Hennezel E,Malo D,Piccirillo CA,Vidal SM,Qureshi ST
14-0161 was used in Flow cytometry/Cell sorting to establish a role for Unc93b1 and endosomal TLRs in the activation of both myeloid and lymphoid cells during the innate immune response to influenza.
Fri Apr 10 00:00:00 EDT 2015
Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock.
Biochemical and biophysical research communications
Shimura E,Shibui A,Narushima S,Nambu A,Yamaguchi S,Akitsu A,Leonard WJ,Iwakura Y,Matsumoto K,Suto H,Okumura K,Sudo K,Nakae S
14-0161 was used in Blocking experiments to indicate that IL-17A, but not IL-17F or IL-25, is crucial for LPS-induced endotoxin shock.
Fri Oct 10 00:00:00 EDT 2014
Murine complement receptor 1 is required for germinal center B cell maintenance but not initiation.
Immunobiology
Donius LR,Weis JJ,Weis JH
14-0161 was used in Flow cytometry/Cell sorting to describe unique functions of Cr1 on the surface of both B cells and follicular dendritic cells.
Sun Jun 01 00:00:00 EDT 2014
Rhof promotes murine marginal zone B cell development.
Nagoya journal of medical science
Kishimoto M,Matsuda T,Yanase S,Katsumi A,Suzuki N,Ikejiri M,Takagi A,Ikawa M,Kojima T,Kunishima S,Kiyoi H,Naoe T,Matsushita T,Maruyama M
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that RhoF promotes MZ B cell development in the spleen.
Fri Aug 01 00:00:00 EDT 2014
Differential immune response associated to malaria outcome is detectable in peripheral blood following Plasmodium yoelii infection in mice.
PloS one
Azcárate IG,Marín-García P,Kamali AN,Pérez-Benavente S,Puyet A,Diez A,Bautista JM
14-0161 was used in Blocking experiments to investigate the effect of a heterogeneous course of Plasmodium yoelii lethal malaria infection in mice.
Tue Nov 11 00:00:00 EST 2014
Systemic CD8+ T cell-mediated tumoricidal effects by intratumoral treatment of oncolytic herpes simplex virus with the agonistic monoclonal antibody for murine glucocorticoid-induced tumor necrosis factor receptor.
PloS one
Ishihara M,Seo N,Mitsui J,Muraoka D,Tanaka M,Mineno J,Ikeda H,Shiku H
14-0161 was used in Blocking experiments to investigate the kinetics and immunological mechanisms of DTA-1 in HF10 infection.
Mon Dec 07 00:00:00 EST 2015
Autophagy is a critical regulator of memory CD8(+) T cell formation.
eLife
Puleston DJ,Zhang H,Powell TJ,Lipina E,Sims S,Panse I,Watson AS,Cerundolo V,Townsend AR,Klenerman P,Simon AK
14-0161 was used in Flow cytometry/Cell sorting to show that mice lacking the autophagy gene Atg7 in T cells failed to establish CD8(+) T cell memory to influenza and MCMV infection.
Tue Nov 11 00:00:00 EST 2014
Mice lacking natural killer T cells are more susceptible to metabolic alterations following high fat diet feeding.
PloS one
Martin-Murphy BV,You Q,Wang H,De La Houssaye BA,Reilly TP,Friedman JE,Ju C
14-0161 was used in Blocking experiments to investigate whether NKT cells exert pathogenic or suppressive functions in obesity.
Thu Dec 18 00:00:00 EST 2014
The mucosal adjuvant cyclic di-AMP exerts immune stimulatory effects on dendritic cells and macrophages.
PloS one
Škrnjug I,Rueckert C,Libanova R,Lienenklaus S,Weiss S,Guzmán CA
14-0161 was used in Flow cytometry/Cell sorting to assess changes in cell surface marker expression of dendritic cells and macrophages in response to c-di-AMP.
Wed Jan 14 00:00:00 EST 2015
Cyclic GMP-AMP displays mucosal adjuvant activity in mice.
PloS one
Škrnjug I,Guzmán CA,Rueckert C
14-0161 was used in Flow cytometry/Cell sorting to explore the efficacy of cGAMP as a mucosal adjuvant in mice.
Fri Oct 09 00:00:00 EDT 2015
Anti-tumor innate immunity activated by intermittent metronomic cyclophosphamide treatment of 9L brain tumor xenografts is preserved by anti-angiogenic drugs that spare VEGF receptor 2.
Molecular cancer
Doloff JC,Chen CS,Waxman DJ
14-0161 was used in Flow cytometry/Cell sorting to investigate the variation in immune response from different regimens of metronomic cyclophosphamide treatment.
Thu Jun 26 00:00:00 EDT 2014
Characterization of oligodendroglial populations in mouse demyelinating disease using flow cytometry: clues for MS pathogenesis.
PloS one
Robinson AP,Rodgers JM,Goings GE,Miller SD
14-0161 was used in Blocking experiments to characterise and enumerate cells of the oligodendrocyte lineage.
Mon Jun 22 00:00:00 EDT 2015
The macrophage A2B adenosine receptor regulates tissue insulin sensitivity.
PloS one
Johnston-Cox H,Eisenstein AS,Koupenova M,Carroll S,Ravid K
14-0161 was used in Flow cytometry/Cell sorting to determine a mechanism for high fat diet-induced tissue inflammation and insulin resistance.
Mon Jan 12 00:00:00 EST 2015
Elucidating immunologic mechanisms of PROSTVAC cancer immunotherapy.
Journal for immunotherapy of cancer
Mandl SJ,Rountree RB,Dela Cruz TB,Foy SP,Cote JJ,Gordon EJ,Trent E,Delcayre A,Franzusoff A
14-0161 was used in Blocking experiments to investigate the mechanism of action and immune signatures of anti-tumour efficacy with PROSTVAC immunotherapy.
Mon Oct 20 00:00:00 EDT 2014
An orally active immune adjuvant prepared from cones of Pinus sylvestris, enhances the proliferative phase of a primary T cell response.
BMC complementary and alternative medicine
Bradley WG,Holm KN,Tanaka A
14-0161 was used in Flow cytometry/Cell sorting to investigate the mechanism by which polyphenylpropanoid polysaccharide complex enhances the proliferative phase of a primary T cell response.
Thu May 22 00:00:00 EDT 2014
Hematopoietic stem and progenitor cell activation during chronic dermatitis provoked by constitutively active aryl-hydrocarbon receptor driven by Keratin 14 promoter.
Toxicological sciences : an official journal of the Society of Toxicology
Murakami S,Yamamoto M,Motohashi H
14-0161 was used in Flow cytometry/Cell sorting to analyse the bone marrow and spleen of transgenic mice to understand how aryl-hydrocarbon receptor-provoked allergy affects haematopoiesis.
Sat Mar 01 00:00:00 EST 2014
p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression.
Nature communications
Tian L,Choi SC,Murakami Y,Allen J,Morse HC,Qi CF,Krzewski K,Coligan JE
14-0161 was used in Flow cytometry/Cell sorting to identify the mechanism and role of mouse CD300f in apoptotic cell phagocytosis and the maintenance of immune homeostasis.
Mon Mar 07 00:00:00 EST 2016
Attenuated Listeria monocytogenes reprograms M2-polarized tumor-associated macrophages in ovarian cancer leading to iNOS-mediated tumor cell lysis.
Oncoimmunology
Lizotte PH,Baird JR,Stevens CA,Lauer P,Green WR,Brockstedt DG,Fiering SN
14-0161 was used in Flow cytometry/Cell sorting to investigate whether transformation of the suppressive ovarian cancer microenvironment could be achieved by introduction of the attenuated δactA/δinlB strain of Listeria monocytogenes.
Thu Oct 21 00:00:00 EDT 2021
"Glowing head" mice: a genetic tool enabling reliable preclinical image-based evaluation of cancers in immunocompetent allografts.
PloS one
Day CP,Carter J,Weaver Ohler Z,Bonomi C,El Meskini R,Martin P,Graff-Cherry C,Feigenbaum L,Tüting T,Van Dyke T,Hollingshead M,Merlino G
14-0161 was used in an ELISA assay to assess the value of reporter-tolerized GEMs as allograft recipients by targeting a luciferase-GFP fusion reporter to the anterior pituitary gland.
Wed Jul 01 00:00:00 EDT 2015
Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice.
Journal of neuroinflammation
Prajeeth CK,Beineke A,Iskandar CD,Gudi V,Herder V,Gerhauser I,Haist V,Teich R,Huehn J,Baumgärtner W,Stangel M
14-0161 was used in Blocking experiments to investigate the role of Tregs in regulating antiviral responses during acute encephalitis.
Thu Nov 13 00:00:00 EST 2014
Intraluminal containment of commensal outgrowth in the gut during infection-induced dysbiosis.
Cell host & microbe
Molloy MJ,Grainger JR,Bouladoux N,Hand TW,Koo LY,Naik S,Quinones M,Dzutsev AK,Gao JL,Trinchieri G,Murphy PM,Belkaid Y
14-0161 was used in Blocking experiments to investigate the mechanisms by which hosts rapidly contain commensal pathobiont outgrowth during infection.
Wed Sep 11 00:00:00 EDT 2013
The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging.
The Journal of clinical investigation
Montalvao F,Garcia Z,Celli S,Breart B,Deguine J,Van Rooijen N,Bousso P
14-0161 was used in Blocking experiments to investigate how anti-CD20 antibodies operate in vivo to mediate B cell depletion.
Sun Dec 01 00:00:00 EST 2013
Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment.
Cancer research
Baird JR,Fox BA,Sanders KL,Lizotte PH,Cubillos-Ruiz JR,Scarlett UK,Rutkowski MR,Conejo-Garcia JR,Fiering S,Bzik DJ
14-0161 was used in Flow cytometry/Cell sorting to establish that cps preferentially invades tumour-associated antigen-presenting cells and restores their ability to trigger potent anti-tumour CD8(+) T-cell responses.
Mon Jul 01 00:00:00 EDT 2013
SDF-1-CXCR4 differentially regulates autoimmune diabetogenic T cell adhesion through ROBO1-SLIT2 interactions in mice.
Diabetologia
Glawe JD,Mijalis EM,Davis WC,Barlow SC,Gungor N,McVie R,Kevil CG
14-0161 was used in Flow cytometry/Cell sorting to reveal a novel molecular pathway, which regulates diabetogenic T cell recruitment and may be useful in modulating autoimmune diabetes.
Tue Oct 01 00:00:00 EDT 2013
Role of NK cells in host defense against pulmonary type A Francisella tularensis infection.
Microbes and infection
Schmitt DM,O'Dee DM,Brown MJ,Horzempa J,Russo BC,Morel PA,Nau GJ
14-0161 was used in Blocking experiments to study the role of NK cells in host defence against acute respiratory infection with type A F. tularensis in vivo.
Fri Mar 01 00:00:00 EST 2013
Role of NK cells in host defense against pulmonary type A Francisella tularensis infection.
Microbes and infection
Schmitt DM,O'Dee DM,Brown MJ,Horzempa J,Russo BC,Morel PA,Nau GJ
14-0161 was used in Blocking experiments to study the role of NK cells in host defence against acute respiratory infection with type A F. tularensis in vivo.
Fri Mar 01 00:00:00 EST 2013
Prime-boost strategies in mucosal immunization affect local IgA production and the type of th response.
Frontiers in immunology
Fiorino F,Pettini E,Pozzi G,Medaglini D,Ciabattini A
14-0161 was used in Blocking experiments to investigate T cell clonal expansion.
Wed Jun 12 00:00:00 EDT 2013
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation.
eLife
Kerenyi MA,Shao Z,Hsu YJ,Guo G,Luc S,O'Brien K,Fujiwara Y,Peng C,Nguyen M,Orkin SH
14-0161 was used in Flow cytometry/Cell sorting to study how Lsd1-mediated concurrent repression of enhancer and promoter activity of stem and progenitor cell genes is a pivotal epigenetic mechanism required for proper hematopoietic maturation.
Tue Jun 18 00:00:00 EDT 2013
Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury.
Mucosal immunology
Koeppen M,McNamee EN,Brodsky KS,Aherne CM,Faigle M,Downey GP,Colgan SP,Evans CM,Schwartz DA,Eltzschig HK
14-0161 was used in Blocking experiments to investigate whether excessive mucus production could be detrimental during lung injury.
Mon Jul 01 00:00:00 EDT 2013
TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity.
The Journal of investigative dermatology
Mohammed J,Gunderson AJ,Khong HH,Koubek RD,Udey MC,Glick AB
14-0161 was used in Flow cytometry/Cell sorting to highlight a role for keratinocyte-derived TGFβ1 in dendritic cell trafficking and in the initiation of skin inflammation.
Tue Jan 01 00:00:00 EST 2013
Targeting iron acquisition blocks infection with the fungal pathogens Aspergillus fumigatus and Fusarium oxysporum.
PLoS pathogens
Leal SM,Roy S,Vareechon C,Carrion Sd,Clark H,Lopez-Berges MS,Di Pietro A,Schrettl M,Beckmann N,Redl B,Haas H,Pearlman E
14-0161 was used in Blocking experiments to investigate the effect of iron sequestering on fungal pathogen growth.
Tue Feb 18 00:00:00 EST 2014
Intrinsic T- and B-cell defects impair T-cell-dependent antibody responses in mice lacking the actin-bundling protein L-plastin.
European journal of immunology
Todd EM,Deady LE,Morley SC
14-0161 was used in Blocking experiments to study the role of L-plastin in the modulation of both T- and B-cell immune responses.
Mon Jul 01 00:00:00 EDT 2013
Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR.
European journal of immunology
Stanietsky N,Rovis TL,Glasner A,Seidel E,Tsukerman P,Yamin R,Enk J,Jonjic S,Mandelboim O
14-0161 was used in Blocking experiments to investigate whether mouse TIGIT inhibits mouse NK-cell cytotoxicity.
Thu Aug 01 00:00:00 EDT 2013
Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells.
Cancer immunology, immunotherapy : CII
Akhmetzyanova I,Zelinskyy G,Schimmer S,Brandau S,Altenhoff P,Sparwasser T,Dittmer U
14-0161 was used in Flow cytometry/Cell sorting to explore the role of effector CD4(+) T cells in the immune control of tumours.
Fri Feb 01 00:00:00 EST 2013
A comprehensive analysis of transfection-assisted delivery of iron oxide nanoparticles to dendritic cells.
Nanomedicine : nanotechnology, biology, and medicine
Toki S,Omary RA,Wilson K,Gore JC,Peebles RS,Pham W
14-0161 was used in Blocking experiments to investigate the effect of polylysine on dendritic cell toxicity and induction of cell maturation.
Fri Nov 01 00:00:00 EDT 2013
Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1.
Journal of leukocyte biology
Hutchins NA,Wang F,Wang Y,Chung CS,Ayala A
14-0161 was used in Flow cytometry/Cell sorting to study Kupffer cell-mediated potentiation of liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1.
Fri Nov 01 00:00:00 EDT 2013
KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing.
Glycobiology
Patnode ML,Yu SY,Cheng CW,Ho MY,Tegesjö L,Sakuma K,Uchimura K,Khoo KH,Kannagi R,Rosen SD
14-0161 was used in Flow cytometry/Cell sorting to investigate the functional significance of galactose-6-O-sulfate.
Fri Mar 01 00:00:00 EST 2013
Quantification of quantum dot murine skin penetration with UVR barrier impairment.
Nanotoxicology
Mortensen LJ,Jatana S,Gelein R,De Benedetto A,De Mesy Bentley KL,Beck LA,Elder A,Delouise LA
14-0161 was used in Blocking experiments to understand the effect of UVR on nanoparticle skin penetration and the potential for systemic translocation.
Sun Dec 01 00:00:00 EST 2013
Alcam regulates long-term hematopoietic stem cell engraftment and self-renewal.
Stem cells (Dayton, Ohio)
Jeannet R,Cai Q,Liu H,Vu H,Kuo YH
14-0161 was used in Flow cytometry/Cell sorting to investigate the role of activated leukocyte cell adhesion molecule in hematopoietic stem cell differentiation and self-renewal using an Alcam-null mouse model.
Fri Mar 01 00:00:00 EST 2013
Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age.
Journal of immunology (Baltimore, Md. : 1950)
Brubaker AL,Rendon JL,Ramirez L,Choudhry MA,Kovacs EJ
14-0161 was used in Flow cytometry/Cell sorting to deduce the contribution of reduced neutrophil chemotaxis and infiltration to the speed of wound infection healing.
Fri Feb 15 00:00:00 EST 2013
Mouse tumor vasculature expresses NKG2D ligands and can be targeted by chimeric NKG2D-modified T cells.
Journal of immunology (Baltimore, Md. : 1950)
Zhang T,Sentman CL
14-0161 was used in Blocking experiments to investigate the use of NKG2D-modified T cells for tumour therapy.
Fri Mar 01 00:00:00 EST 2013
GM-CSF produced by nonhematopoietic cells is required for early epithelial cell proliferation and repair of injured colonic mucosa.
Journal of immunology (Baltimore, Md. : 1950)
Egea L,McAllister CS,Lakhdari O,Minev I,Shenouda S,Kagnoff MF
14-0161 was used in Blocking experiments to investigate the functional role of endogenous host-produced GM-CSF in a colitis model induced after injury to the colon epithelium.
Fri Feb 15 00:00:00 EST 2013
Host b7x promotes pulmonary metastasis of breast cancer.
Journal of immunology (Baltimore, Md. : 1950)
Abadi YM,Jeon H,Ohaegbulam KC,Scandiuzzi L,Ghosh K,Hofmeyer KA,Lee JS,Ray A,Gravekamp C,Zang X
14-0161 was used in Flow cytometry/Cell sorting to uncover the metastasis-promoting properties of the inhibitory T cell co-stimulatory molecule, B7x, and suggest the therapeutic potential of targeting its pathway during cancer immunotherapy.
Mon Apr 01 00:00:00 EDT 2013
Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Liu B,Wang M,Wang X,Zhao D,Liu D,Liu J,Chen PJ,Yang D,He F,Tang L
14-0161 was used in Flow cytometry/Cell sorting to elucidate the role of LSECtin in pathogenesis of viral infection, showing that its absence led to increased frequency in intrahepatic CTLs, leading to accelerated liver adenovirus clearance.
Mon Apr 15 00:00:00 EDT 2013
Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1β release.
Journal of immunology (Baltimore, Md. : 1950)
Laudisi F,Spreafico R,Evrard M,Hughes TR,Mandriani B,Kandasamy M,Morgan BP,Sivasankar B,Mortellaro A
14-0161 was used in Blocking experiments to investigate the link between complement and IL-1β secretion.
Thu Aug 01 00:00:00 EDT 2013
Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3.
Journal of immunology (Baltimore, Md. : 1950)
Gambardella L,Anderson KE,Jakus Z,Kovács M,Voigt S,Hawkins PT,Stephens L,Mócsai A,Vermeren S
14-0161 was used in Blocking experiments to investigate the regulatory input of PI3K upstream of ARAP3.
Tue Jan 01 00:00:00 EST 2013
IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans.
Journal of immunology (Baltimore, Md. : 1950)
Flaczyk A,Duerr CU,Shourian M,Lafferty EI,Fritz JH,Qureshi ST
14-0161 was used in Flow cytometry/Cell sorting to study how allergic patterns of lung inflammation are mediated as a host response to Cryptococcus neoformans infection.
Sun Sep 01 00:00:00 EDT 2013
Mast cell-deficient Kit(W-sh) "Sash" mutant mice display aberrant myelopoiesis leading to the accumulation of splenocytes that act as myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Michel A,Schüler A,Friedrich P,Döner F,Bopp T,Radsak M,Hoffmann M,Relle M,Distler U,Kuharev J,Tenzer S,Feyerabend TB,Rodewald HR,Schild H,Schmitt E,Becker M,Stassen M
14-0161 was used in Blocking experiments to demonstrate the broad effects that the Kit(W-sh) mutation has on key steps in myelopoiesis.
Sat Jun 01 00:00:00 EDT 2013
Optimal germinal center B cell activation and T-dependent antibody responses require expression of the mouse complement receptor Cr1.
Journal of immunology (Baltimore, Md. : 1950)
Donius LR,Handy JM,Weis JJ,Weis JH
14-0161 was used in Immunohistochemistry to study differences in expression of protein isoforms from the Cr2 gene in B cells and follicular dendritic cells.
Mon Jul 01 00:00:00 EDT 2013
Ganciclovir prophylaxis improves late murine cytomegalovirus-induced renal allograft damage.
Transplantation
Shimamura M,Seleme MC,Guo L,Saunders U,Schoeb TR,George JF,Britt WJ
14-0161 was used in Flow cytometry/Cell sorting to examine the lasting effect of Ganciclovir treatment on renal allografts after the discontinuation of prophylaxis.
Tue Jan 15 00:00:00 EST 2013
FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation.
Molecular and cellular biology
Ren X,Shah TA,Ustiyan V,Zhang Y,Shinn J,Chen G,Whitsett JA,Kalin TV,Kalinichenko VV
14-0161 was used in Blocking experiments to investigate the role of transcriptional control of goblet cell differentiation and mucus hyperproduction, showing that FOXM1 promotes allergen-induced metaplasia and pulmonary inflammation.
Tue Jan 01 00:00:00 EST 2013
SAP modulates B cell functions in a genetic background-dependent manner.
Immunology letters
Detre C,Yigit B,Keszei M,Castro W,Magelky EM,Terhorst C
14-0161 was used in Flow cytometry/Cell sorting to investigate the mechanism by which SLAM-associated protein modulates B cell functions.
Sat Jun 01 00:00:00 EDT 2013
Proximal tubule PPARα attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction.
American journal of physiology. Renal physiology
Li S,Mariappan N,Megyesi J,Shank B,Kannan K,Theus S,Price PM,Duffield JS,Portilla D
14-0161 was used in Flow cytometry/Cell sorting to study how proximal tubule PPARα attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction.
Sun Sep 01 00:00:00 EDT 2013
Streptomycin-induced inflammation enhances Escherichia coli gut colonization through nitrate respiration.
mBio
Spees AM,Wangdi T,Lopez CA,Kingsbury DD,Xavier MN,Winter SE,Tsolis RM,Bäumler AJ
14-0161 was used in Blocking experiments to identify streptomycin-induced changes in the gut that lower resistance to colonisation by facultative anaerobic bacteria.
Tue Jul 02 00:00:00 EDT 2013
The absence of CCR7 results in dysregulated monocyte migration and immunosuppression facilitating chronic cutaneous leishmaniasis.
PloS one
Kling JC,Mack M,Körner H
14-0161 was used in Flow cytometry/Cell sorting to show that B6.CCR7(-/-) mice were unable to resolve cutaneous lesions and developed chronic cutaneous leishmaniasis.
Sat Feb 21 00:00:00 EST 2015
Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.
The Journal of biological chemistry
Steelman AJ,Smith R,Welsh CJ,Li J
14-0161 was used in Flow cytometry/Cell sorting to investigate the role of galectin-9 in the pathogenesis of multiple sclerosis.
Fri Aug 16 00:00:00 EDT 2013
Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue.
The Journal of biological chemistry
Patnode ML,Cheng CW,Chou CC,Singer MS,Elin MS,Uchimura K,Crocker PR,Khoo KH,Rosen SD
14-0161 was used in Blocking experiments to investigate whether keratan sulfate galactose 6-O-sulfotransferase and chondroitin 6-O-sulfotransferase 1 are required for the generation of endogenous Siglec-F ligands.
Fri Sep 13 00:00:00 EDT 2013
Liver accumulation of Plasmodium chabaudi-infected red blood cells and modulation of regulatory T cell and dendritic cell responses.
PloS one
Medeiros MM,da Silva HB,Reis AS,Barboza R,Thompson J,Lima MR,Marinho CR,Tadokoro CE
14-0161 was used in Flow cytometry/Cell sorting to determine that malaria parasite accumulation could be an escape mechanism to avoid sterile immunity sponsored by a tolerogenic environment.
Wed Dec 17 00:00:00 EST 2014
Inflammation and resolution are associated with upregulation of fatty acid β-oxidation in Zymosan-induced peritonitis.
PloS one
Fujieda Y,Manno A,Hayashi Y,Rhodes N,Guo L,Arita M,Bamba T,Fukusaki E
14-0161 was used in Blocking experiments to study how the resolution of inflammation, and inflammation itself, may be associated with the upregulation of fatty acid β-oxidation in Zymosan-induced peritonitis.
Thu Jan 16 00:00:00 EST 2014
Distinct Roles for CXCR6(+) and CXCR6(-) CD4(+) T Cells in the Pathogenesis of Chronic Colitis.
PloS one
Mandai Y,Takahashi D,Hase K,Obata Y,Furusawa Y,Ebisawa M,Nakagawa T,Sato T,Katsuno T,Saito Y,Shimaoka T,Yokosuka O,Yokote K,Ohno H
14-0161 was used in Flow cytometry/Cell sorting to elucidate the different roles of CD4(+) T cell subsets in the development of inflammatory bowel disease.
Tue Oct 31 00:00:00 EDT 2017
Ocular mucosal CD11b+ and CD103+ mouse dendritic cells under normal conditions and in allergic immune responses.
PloS one
Khandelwal P,Blanco-Mezquita T,Emami P,Lee HS,Reyes NJ,Mathew R,Huang R,Saban DR
14-0161 was used in Blocking experiments to investigate whether CD11b+ and CD103+ dendritic cells exist in ocular mucosa.
Mon Dec 30 00:00:00 EST 2013
CD36 contributes to malaria parasite-induced pro-inflammatory cytokine production and NK and T cell activation by dendritic cells.
PloS one
Gowda NM,Wu X,Kumar S,Febbraio M,Gowda DC
14-0161 was used in an ELISA assay to imply that the effect of CD36 on malaria immunity is imprinted early during infection when parasite load is low.
Tue Aug 05 00:00:00 EDT 2014
Mouse models and techniques for the isolation of the diabetic endothelium.
ISRN endocrinology
Darrow AL,Maresh JG,Shohet RV
14-0161 was used in Flow cytometry/Cell sorting to validate mouse models and endothelial isolation techniques for assessing diabetic endothelial dysfunction and vascular responses in vivo.
Wed Jul 10 00:00:00 EDT 2013
Interleukin-21 receptor signalling is important for innate immune protection against HSV-2 infections.
PloS one
Kratholm SK,Iversen MB,Reinert L,Jensen SK,Hokland M,Andersen T,Rankin A,Young D,Frische S,Paludan SR,Holm CK
14-0161 was used in Flow cytometry/Cell sorting to investigate the role of IL-21 and IL-21R in the innate immune response to viral infection.
Tue Sep 30 00:00:00 EDT 2014
Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner.
The Journal of biological chemistry
Åhsberg J,Ungerbäck J,Strid T,Welinder E,Stjernberg J,Larsson M,Qian H,Sigvardsson M
14-0161 was used in Blocking experiments to investigate the underlying mechanisms and consequences of reduced transcription factor levels on malignant B-lymphocyte development.
Fri Nov 15 00:00:00 EST 2013
A survey of ex vivo/in vitro transduction efficiency of mammalian primary cells and cell lines with Nine natural adeno-associated virus (AAV1-9) and one engineered adeno-associated virus serotype.
Virology journal
Ellis BL,Hirsch ML,Barker JC,Connelly JP,Steininger RJ,Porteus MH
14-0161 was used in Flow cytometry/Cell sorting to produce a comprehensive study of the transduction efficiency of viral vectors.
Wed Mar 06 00:00:00 EST 2013
New perspective on dextran sodium sulfate colitis: antigen-specific T cell development during intestinal inflammation.
PloS one
Morgan ME,Zheng B,Koelink PJ,van de Kant HJ,Haazen LC,van Roest M,Garssen J,Folkerts G,Kraneveld AD
14-0161 was used in Flow cytometry/Cell sorting to investigate the specificity of the immune cell response to colitis.
Wed Mar 05 00:00:00 EST 2014
In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation.
PloS one
Vink PM,Smout WM,Driessen-Engels LJ,de Bruin AM,Delsing D,Krajnc-Franken MA,Jansen AJ,Rovers EF,van Puijenbroek AA,Kaptein A,Nolte MA,Garritsen A,van Eenennaam H
14-0161 was used in Flow cytometry/Cell sorting to study the function of TAK1 protein in the adult immune system.
Fri Sep 06 00:00:00 EDT 2013
Transcription factor RORα is critical for nuocyte development.
Nature immunology
Wong SH,Walker JA,Jolin HE,Drynan LF,Hams E,Camelo A,Barlow JL,Neill DR,Panova V,Koch U,Radtke F,Hardman CS,Hwang YY,Fallon PG,McKenzie AN
14-0161 was used in Flow cytometry/Cell sorting to study how nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, indicating they are a distinct, previously unknown member of the lymphoid lineage.
Sun Jan 22 00:00:00 EST 2012
DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues.
Blood
Poulin LF,Reyal Y,Uronen-Hansson H,Schraml BU,Sancho D,Murphy KM,Håkansson UK,Moita LF,Agace WW,Bonnet D,Reis e Sousa C
14-0161 was used in Blocking experiments to investigate the presence of unique markers in human dendritic cells, showing that DNGR-1 is a specific marker of mouse and human dendritic cells in lymphoid and nonlymphoid tissues.
Thu Jun 21 00:00:00 EDT 2012
Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas.
Blood
Victora GD,Dominguez-Sola D,Holmes AB,Deroubaix S,Dalla-Favera R,Nussenzweig MC
14-0161 was used in Blocking experiments to investigate the differences between B cells in dark and light zones of germinal centers.
Thu Sep 13 00:00:00 EDT 2012
Enucleation of human erythroblasts involves non-muscle myosin IIB.
Blood
Ubukawa K,Guo YM,Takahashi M,Hirokawa M,Michishita Y,Nara M,Tagawa H,Takahashi N,Komatsuda A,Nunomura W,Takakuwa Y,Sawada K
14-0161 was used in Blocking experiments to investigate the effect of various cell-division inhibitors on cytokinesis and enucleation.
Thu Jan 26 00:00:00 EST 2012
Blood flukes exploit Peyer's Patch lymphoid tissue to facilitate transmission from the mammalian host.
PLoS pathogens
Turner JD,Narang P,Coles MC,Mountford AP
14-0161 was used in Blocking experiments to investigate how schistosomes eggs escape the vasculature to exit the host.
Sat Dec 01 00:00:00 EST 2012
Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice.
PLoS pathogens
Broadhurst MJ,Leung JM,Lim KC,Girgis NM,Gundra UM,Fallon PG,Premenko-Lanier M,McKerrow JH,McCune JM,Loke P
14-0161 was used in Blocking experiments to show that retinal dehydrogenases are induced during a retinoid-dependent type-2 immune response elicited by Schistosoma mansoni infection.
Mon Dec 17 00:00:00 EST 2012
Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections.
PLoS pathogens
Majer O,Bourgeois C,Zwolanek F,Lassnig C,Kerjaschki D,Mack M,Müller M,Kuchler K
14-0161 was used in Flow cytometry/Cell sorting to study how the reduction of monocytes and neutrophils observed by treating mice with pioglitazone could reduce renal immunopathology during Candida infection.
Tue Jan 29 00:00:00 EST 2013
The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis.
Cancer immunology, immunotherapy : CII
Garrison K,Hahn T,Lee WC,Ling LE,Weinberg AD,Akporiaye ET
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that combining a TGF-β signalling inhibitor with anti-OX40 is a viable approach for treating metastatic breast cancer.
Sun Apr 01 00:00:00 EDT 2012
Cellular and cytokine-dependent immunosuppressive mechanisms of grm1-transgenic murine melanoma.
Cancer immunology, immunotherapy : CII
Alb M,Sie C,Adam C,Chen S,Becker JC,Schrama D
14-0161 was used in Blocking experiments to investigate the cellular and cytokine-dependent immunosuppressive mechanisms in tumour-bearing grm1-transgenic mice.
Sat Dec 01 00:00:00 EST 2012
The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis.
The American journal of pathology
Piliponsky AM,Chen CC,Rios EJ,Treuting PM,Lahiri A,Abrink M,Pejler G,Tsai M,Galli SJ
14-0161 was used in Blocking experiments to investigate the role of chymase mouse mast cell protease 4 in a mouse model of sepsis.
Sat Sep 01 00:00:00 EDT 2012
TLR9 and MyD88 are crucial for the development of protective immunity to malaria.
Journal of immunology (Baltimore, Md. : 1950)
Gowda NM,Wu X,Gowda DC
14-0161 was used in Flow cytometry/Cell sorting to investigate TLR9 and MyD88 regulation of pro/anti-inflammatory cytokines in mice infected with Plasmodium yoelii.
Tue May 15 00:00:00 EDT 2012
Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Obata Y,Takahashi D,Ebisawa M,Kakiguchi K,Yonemura S,Jinnohara T,Kanaya T,Fujimura Y,Ohmae M,Hase K,Ohno H
14-0161 was used in Blocking experiments to demonstrate that mice with an IEC-specific deletion in a TF that mediates Notch signalling spontaneously develop colitis.
Thu Mar 01 00:00:00 EST 2012
Localized production of IL-10 suppresses early inflammatory cell infiltration and subsequent development of IFN-γ-mediated Lyme arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Sonderegger FL,Ma Y,Maylor-Hagan H,Brewster J,Huang X,Spangrude GJ,Zachary JF,Weis JH,Weis JJ
14-0161 was used in Flow cytometry/Cell sorting to highlight a critical difference in arthritis development between C3H and B6 IL-10-/- mice.
Wed Feb 01 00:00:00 EST 2012
Losartan inhibits conventional dendritic cell maturation and Th1 and Th17 polarization responses: Νovel mechanisms of preventive effects on lipopolysaccharide-induced acute lung injury.
International journal of molecular medicine
Liu J,Zhang PS,Yu Q,Liu L,Yang Y,Guo FM,Qiu HB
14-0161 was used in Blocking experiments to demonstrate that losartan suppresses conventional dendritic cell maturation and Th1 and Th17 polarization responses.
Wed Feb 01 00:00:00 EST 2012
Th2 type inflammation promotes the gradual progression of HPV-infected cervical cells to cervical carcinoma.
Gynecologic oncology
Feng Q,Wei H,Morihara J,Stern J,Yu M,Kiviat N,Hellstrom I,Hellstrom KE
14-0161 was used in Flow cytometry/Cell sorting to study the effect of Th2 inflammation upon the tumorigenesis of cervical cancer in human papillomavirus infected women.
Thu Nov 01 00:00:00 EDT 2012
MyD88-dependent recruitment of monocytes and dendritic cells required for protection from pulmonary Burkholderia mallei infection.
Infection and immunity
Goodyear A,Troyer R,Bielefeldt-Ohmann H,Dow S
14-0161 was used in Flow cytometry/Cell sorting to find that MyD88-/- mice were highly susceptible to pulmonary challenge with B. mallei and had significantly short survival times, increased bacterial burdens, and severe organ pathology compared to wild-type mice.
Sun Jan 01 00:00:00 EST 2012
Susceptibility to progressive Cryptococcus neoformans pulmonary infection is regulated by loci on mouse chromosomes 1 and 9.
Infection and immunity
Carroll SF,Lafferty EI,Flaczyk A,Fujiwara TM,Homer R,Morgan K,Loredo-Osti JC,Qureshi ST
14-0161 was used in Blocking experiments to reveal additional genetic complexity of the host response to C. neoformans that is associated with divergent patterns of pulmonary inflammation.
Sat Dec 01 00:00:00 EST 2012
Tumor necrosis factor expression is ameliorated after exposure to an acidic environment.
The Journal of surgical research
Grabowski J,Vazquez DE,Costantini T,Cauvi DM,Charles W,Bickler S,Talamini MA,Vega VL,Coimbra R,De Maio A
14-0161 was used in Blocking experiments to investigate the mechanisms responsible for the reduced inflammatory response after exposure to acidic environments, showing that TNF expression is ameliorated after acid exposure.
Thu Mar 01 00:00:00 EST 2012
Leukocyte compartments in the mouse lung: distinguishing between marginated, interstitial, and alveolar cells in response to injury.
Journal of immunological methods
Barletta KE,Cagnina RE,Wallace KL,Ramos SI,Mehrad B,Linden J
14-0161 was used in Blocking experiments to developed a flow cytometry-based assay to simultaneously quantify multiple leukocyte populations of the mouse lung.
Tue Jan 31 00:00:00 EST 2012
Interleukin-7 influences FOXP3+CD4+ regulatory T cells peripheral homeostasis.
PloS one
Simonetta F,Gestermann N,Martinet KZ,Boniotto M,Tissières P,Seddon B,Bourgeois C
14-0161 was used in Flow cytometry/Cell sorting to elucidate the mechanisms governing Treg cell survival and homeostasis.
Wed Sep 26 00:00:00 EDT 2012
Plasmodium yoelii blood-stage primes macrophage-mediated innate immune response through modulation of toll-like receptor signalling.
Malaria journal
Fu Y,Ding Y,Zhou T,Fu X,Xu W
14-0161 was used in Flow cytometry/Cell sorting to study the immune response following infection of a lethal or non-lethal strain of rodent malaria parasites.
Sun Apr 01 00:00:00 EDT 2012
Flt3L combined with rapamycin promotes cardiac allograft tolerance by inducing regulatory dendritic cells and allograft autophagy in mice.
PloS one
Xiong A,Duan L,Chen J,Fan Z,Zheng F,Tan Z,Gong F,Fang M
14-0161 was used in Blocking experiments to investigate the role of Flt3 and Flt3L in immune tolerance, showing that Flt3L combined with rapamycin promotes cardiac allograft tolerance via dendritic cell induction.
Tue Jun 11 00:00:00 EDT 2013
Interleukin-15 treatment induces weight loss independent of lymphocytes.
PloS one
Barra NG,Chew MV,Reid S,Ashkar AA
14-0161 was used in Flow cytometry/Cell sorting to determine if lymphocytes, particularly natural killer cells, play a role in Interleukin-15 mediated weight loss.
Tue Nov 27 00:00:00 EST 2012
Interleukin-15 treatment induces weight loss independent of lymphocytes.
PloS one
Barra NG,Chew MV,Reid S,Ashkar AA
14-0161 was used in Flow cytometry/Cell sorting to determine if lymphocytes, particularly natural killer cells, play a role in Interleukin-15 mediated weight loss.
Tue Nov 27 00:00:00 EST 2012
An abundant tissue macrophage population in the adult murine heart with a distinct alternatively-activated macrophage profile.
PloS one
Pinto AR,Paolicelli R,Salimova E,Gospocic J,Slonimsky E,Bilbao-Cortes D,Godwin JW,Rosenthal NA
14-0161 was used in Blocking experiments to characterise cardiac tissue macrophages.
Wed Sep 19 00:00:00 EDT 2012
RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.
Immunity
Powolny-Budnicka I,Riemann M,Tänzer S,Schmid RM,Hehlgans T,Weih F
14-0161 was used in Flow cytometry/Cell sorting to investigate the contribution of NF-κB to IL-17 production by T cells, showing that RelA and RelB in distinct thymocyte populations control lymphotoxin-dependent IL-17 production.
Fri Mar 25 00:00:00 EDT 2011
Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages.
Blood
Choi H,Lee RH,Bazhanov N,Oh JY,Prockop DJ
14-0161 was used in Blocking experiments to investigate the mechanisms by which hMSCs repair tissues and modulate immune systems, showing that secretion of TSG-6 attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling.
Thu Jul 14 00:00:00 EDT 2011
Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.
Blood
Welch JS,Klco JM,Varghese N,Nagarajan R,Ley TJ
14-0161 was used in Flow cytometry/Cell sorting to test the prediction that RARA (retinoic acid receptor alpha) haploinsufficiency would contribute to acute promyelocytic leukemia (APL) pathogenesis.
Thu Feb 24 00:00:00 EST 2011
Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.
Blood
Kharazi S,Mead AJ,Mansour A,Hultquist A,Böiers C,Luc S,Buza-Vidas N,Ma Z,Ferry H,Atkinson D,Reckzeh K,Masson K,Cammenga J,Rönnstrand L,Arai F,Suda T,Nerlov C,Sitnicka E,Jacobsen SE
14-0161 was used in Flow cytometry/Cell sorting to study the relationship between gene dosage and FLT3 production.
Thu Sep 29 00:00:00 EDT 2011
High-affinity memory B cells induced by conjugate vaccines against weak tumor antigens are vulnerable to nonconjugated antigen.
Blood
Savelyeva N,Shipton M,Suchacki A,Babbage G,Stevenson FK
14-0161 was used in Flow cytometry/Cell sorting to reveal a vulnerability in the immunity against weak tumour antigens conferred by conjugate vaccines.
Thu Jul 21 00:00:00 EDT 2011
PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice.
The Journal of clinical investigation
Welch JS,Yuan W,Ley TJ
14-0161 was used in Flow cytometry/Cell sorting to study a platform for more accurately dissecting the early events in acute promyelocytic leukemia pathogenesis.
Fri Apr 01 00:00:00 EDT 2011
Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region.
The Journal of experimental medicine
Ivanovs A,Rybtsov S,Welch L,Anderson RA,Turner ML,Medvinsky A
14-0161 was used in Blocking experiments to investigate the embryonic development of human hematopoietic stem cells.
Mon Nov 21 00:00:00 EST 2011
Distinct macrophage phenotypes contribute to kidney injury and repair.
Journal of the American Society of Nephrology : JASN
Lee S,Huen S,Nishio H,Nishio S,Lee HK,Choi BS,Ruhrberg C,Cantley LG
14-0161 was used in Blocking experiments to investigate the role of macrophages in ischemic kidney injury, showing that distinct macrophage phenotypes contribute to kidney injury and repair.
Tue Feb 01 00:00:00 EST 2011
An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity.
Mucosal immunology
Eri RD,Adams RJ,Tran TV,Tong H,Das I,Roche DK,Oancea I,Png CW,Jeffery PL,Radford-Smith GL,Cook MC,Florin TH,McGuckin MA
14-0161 was used in Flow cytometry/Cell sorting to characterise the immune response to the intestinal dysfunction caused by the Muc2 mutation carried by Winnie mice.
Sun May 01 00:00:00 EDT 2011
Fatal outcome of pandemic H1N1 2009 influenza virus infection is associated with immunopathology and impaired lung repair, not enhanced viral burden, in pregnant mice.
Journal of virology
Marcelin G,Aldridge JR,Duan S,Ghoneim HE,Rehg J,Marjuki H,Boon AC,McCullers JA,Webby RJ
14-0161 was used in Flow cytometry/Cell sorting to investigate the mechanisms that affect H1N1 influenza infection outcome in pregnant women.
Tue Nov 01 00:00:00 EDT 2011
Systemic low-dose UVB inhibits CD8 T cells and skin inflammation by alternative and novel mechanisms.
The American journal of pathology
Rana S,Rogers LJ,Halliday GM
14-0161 was used in Blocking experiments to investigate the effect of systematic low-dose UVB on T cells.
Wed Jun 01 00:00:00 EDT 2011
Endogenous galectin-1 and acute inflammation: emerging notion of a galectin-9 pro-resolving effect.
The American journal of pathology
Iqbal AJ,Sampaio AL,Maione F,Greco KV,Niki T,Hirashima M,Perretti M,Cooper D
14-0161 was used in Blocking experiments to show that the absence of endogenous Gal-1 results in an abrogated response during the second phase of the edema reaction.
Tue Mar 01 00:00:00 EST 2011
CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated Remodeling.
The American journal of pathology
Masterson JC,McNamee EN,Jedlicka P,Fillon S,Ruybal J,Hosford L,Rivera-Nieves J,Lee JJ,Furuta GT
14-0161 was used in Blocking experiments to demonstrate an association between ileitis progression and remodeling over the course of 40 weeks.
Tue Nov 01 00:00:00 EDT 2011
Cellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartments.
Journal of immunology (Baltimore, Md. : 1950)
Nikbakht N,Migone TS,Ward CP,Manser T
14-0161 was used in Flow cytometry/Cell sorting to investigate the role of the peripheral B cell pro-survival cytokine BAFF/BLyS in the regulation of immunological tolerance and autoreactive cells.
Fri Jul 01 00:00:00 EDT 2011
Absence of β2 integrins impairs regulatory T cells and exacerbates CD4+ T cell-dependent autoimmune carditis.
Journal of immunology (Baltimore, Md. : 1950)
Haasken S,Auger JL,Binstadt BA
14-0161 was used in Immunohistochemistry to investigate the contribution of CD4(+) T cells and β(2) integrins in the pathogenesis of autoimmune arthritis and endocarditis.
Thu Sep 01 00:00:00 EDT 2011
Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells.
Journal of immunology (Baltimore, Md. : 1950)
Hams E,McCarron MJ,Amu S,Yagita H,Azuma M,Chen L,Fallon PG
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that the coinhibitory B7-H1/programmed death 1 pathway can limit the expansion of T(FH) cells and constrain Ag-specific Ig responses.
Sun May 15 00:00:00 EDT 2011
CpG and non-CpG oligodeoxynucleotides directly costimulate mouse and human CD4+ T cells through a TLR9- and MyD88-independent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Landrigan A,Wong MT,Utz PJ
14-0161 was used in Flow cytometry/Cell sorting to study the ability of oligodeoxynucleotides to activate and polarise T cells.
Thu Sep 15 00:00:00 EDT 2011
Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950)
Chen YG,Scheuplein F,Driver JP,Hewes AA,Reifsnyder PC,Leiter EH,Serreze DV
14-0161 was used in Flow cytometry/Cell sorting to demonstrate the presence of a T1D resistance gene closely linked to the ablated Cd38 allele in the previously reported NOD stock also lacking ART2.
Fri Apr 01 00:00:00 EDT 2011
Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells.
Journal of cell science
Meziane el K,Randle SJ,Nelson DE,Lomonosov M,Laman H
14-0161 was used in Flow cytometry/Cell sorting to test the ability of Fbxo7 to transform haematopoietic pro-B cells.
Fri Jul 01 00:00:00 EDT 2011
Transcriptional analysis of the endothelial response to diabetes reveals a role for galectin-3.
Physiological genomics
Darrow AL,Shohet RV,Maresh JG
14-0161 was used in Flow cytometry/Cell sorting to survey transcriptional responses in the vascular endothelia of mice receiving a diabetogenic, high-fat diet.
Thu Oct 20 00:00:00 EDT 2011
Sertoli cell-specific deletion of the androgen receptor compromises testicular immune privilege in mice.
Biology of reproduction
Meng J,Greenlee AR,Taub CJ,Braun RE
14-0161 was used in Flow cytometry/Cell sorting to show that Sertoli cell-specific Ar ablation leads to defective tight junction ultrastructure and elevated IgG in mouse testes.
Mon Aug 01 00:00:00 EDT 2011
Toll-like receptor 9 is required for full host resistance to Mycobacterium avium infection but plays no role in induction of Th1 responses.
Infection and immunity
Carvalho NB,Oliveira FS,Durães FV,de Almeida LA,Flórido M,Prata LO,Caliari MV,Appelberg R,Oliveira SC
14-0161 was used in Flow cytometry/Cell sorting to investigate the role of Toll-like receptor 9 (TLR9) in innate immunity to Mycobacterium avium.
Fri Apr 01 00:00:00 EDT 2011
IL-17A increases ADP-induced platelet aggregation.
Biochemical and biophysical research communications
Maione F,Cicala C,Liverani E,Mascolo N,Perretti M,D'Acquisto F
14-0161 was used in Flow cytometry/Cell sorting to test whether IL-17A exerts pro-aggregant effects on both human and mouse platelets.
Fri May 20 00:00:00 EDT 2011
IL-17A increases ADP-induced platelet aggregation.
Biochemical and biophysical research communications
Maione F,Cicala C,Liverani E,Mascolo N,Perretti M,D'Acquisto F
14-0161 was used in Flow cytometry/Cell sorting to test whether IL-17A exerts pro-aggregant effects on both human and mouse platelets.
Fri May 20 00:00:00 EDT 2011
Expression of the Mycobacterium tuberculosis PPE37 protein in Mycobacterium smegmatis induces low tumour necrosis factor alpha and interleukin 6 production in murine macrophages.
Journal of medical microbiology
Daim S,Kawamura I,Tsuchiya K,Hara H,Kurenuma T,Shen Y,Dewamitta SR,Sakai S,Nomura T,Qu H,Mitsuyama M
14-0161 was used in Flow cytometry/Cell sorting to suggest a potential role of PPE37 in interfering with the pro-inflammatory cytokine response of infected macrophages.
Sun May 01 00:00:00 EDT 2011
Prevention of NKT cell activation accelerates cutaneous wound closure and alters local inflammatory signals.
The Journal of surgical research
Schneider DF,Palmer JL,Tulley JM,Kovacs EJ,Gamelli RL,Faunce DE
14-0161 was used in Flow cytometry/Cell sorting to explore the effects of purposefully inhibiting natural killer T cell activation on the response to injury.
Tue Nov 01 00:00:00 EDT 2011
Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection.
Parasite immunology
Svensson M,Bell L,Little MC,DeSchoolmeester M,Locksley RM,Else KJ
14-0161-82 was used in Flow Cytometry to study the accumulation of eosinophils in intestine-draining mesenteric lymph nodes following Trichuris muris infection.
Sat Jan 01 00:00:00 EST 2011
Pseudomonas aeruginosa elastase provides an escape from phagocytosis by degrading the pulmonary surfactant protein-A.
PloS one
Kuang Z,Hao Y,Walling BE,Jeffries JL,Ohman DE,Lau GW
14-0161 was used in Flow cytometry/Cell sorting to study how P. aeruginosa secretions grant protection against SP-A-mediated opsonisation.
Fri Mar 16 00:00:00 EDT 2012
Distribution of primed T cells and antigen-loaded antigen presenting cells following intranasal immunization in mice.
PloS one
Ciabattini A,Pettini E,Fiorino F,Prota G,Pozzi G,Medaglini D
14-0161 was used in Flow cytometry/Cell sorting to elucidate the trafficking of antigen-specific primed T cells to non-draining peripheral and mucosa-associated lymph nodes following nasal immunisation.
Fri Apr 29 00:00:00 EDT 2011
Critical role of TCF-1 in repression of the IL-17 gene.
PloS one
Ma J,Wang R,Fang X,Ding Y,Sun Z
14-0161 was used in Flow cytometry/Cell sorting to show that TCF-1 is a critical factor to repress the IL-17 gene by chromatin modifications during T cell development.
Tue Feb 28 00:00:00 EST 2012
Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation.
PloS one
Ohno T,Oboki K,Morita H,Kajiwara N,Arae K,Tanaka S,Ikeda M,Iikura M,Akiyama T,Inoue J,Matsumoto K,Sudo K,Azuma M,Okumura K,Kamradt T,Saito H,Nakae S
14-0161 was used in Flow cytometry/Cell sorting to show that exogenous IL-33 potentiates LPS-mediated cytokine production by macrophages.
Mon Apr 11 00:00:00 EDT 2011
Molecular mechanism for adiponectin-dependent M2 macrophage polarization: link between the metabolic and innate immune activity of full-length adiponectin.
The Journal of biological chemistry
Mandal P,Pratt BT,Barnes M,McMullen MR,Nagy LE
14-0161 was used in Blocking experiments to examine the differential mechanisms by which gAcrp and flAcrp suppress pro-inflammatory signaling in macrophages.
Fri Apr 15 00:00:00 EDT 2011
Suppression and regression of choroidal neovascularization in mice by a novel CCR2 antagonist, INCB3344.
PloS one
Xie P,Kamei M,Suzuki M,Matsumura N,Nishida K,Sakimoto S,Sakaguchi H,Nishida K
14-0161 was used in Flow cytometry/Cell sorting to investigate the effect of an intravitreally administered CCR2 antagonist, INCB3344, on a mouse model of choroidal neovascularisation.
Mon Apr 23 00:00:00 EDT 2012
CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells.
Blood
Guo YM,Ishii K,Hirokawa M,Tagawa H,Ohyagi H,Michishita Y,Ubukawa K,Yamashita J,Ohteki T,Onai N,Kawakami K,Xiao W,Sawada K
14-0161 was used in Blocking experiments to investigate the effect of CpG-ODN 2006 on erythroid growth derived from human CD34(+) cells.
Thu Jun 03 00:00:00 EDT 2010
Conditional TPM3-ALK and NPM-ALK transgenic mice develop reversible ALK-positive early B-cell lymphoma/leukemia.
Blood
Giuriato S,Foisseau M,Dejean E,Felsher DW,Al Saati T,Demur C,Ragab A,Kruczynski A,Schiff C,Delsol G,Meggetto F
14-0161 was used in Blocking experiments to develop conditional mouse models for anaplastic lymphoma kinase-induced lymphomagenesis.
Thu May 20 00:00:00 EDT 2010
The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS.
Blood
Lane SW,Sykes SM,Al-Shahrour F,Shterental S,Paktinat M,Lo Celso C,Jesneck JL,Ebert BL,Williams DA,Gilliland DG
14-0161 was used in Flow cytometry/Cell sorting to reveal that Wnt activation through haploinsufficiency of Apc causes insidious loss of HSC function.
Thu Apr 29 00:00:00 EDT 2010
High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis.
Hepatology (Baltimore, Md.)
Kohli R,Kirby M,Xanthakos SA,Softic S,Feldstein AE,Saxena V,Tang PH,Miles L,Miles MV,Balistreri WF,Woods SC,Seeley RJ
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that nongenetically modified mice maintained on an HFHC diet in addition to developing obesity have increased hepatic ROS and a NASH-like phenotype with significant fibrosis.
Wed Sep 01 00:00:00 EDT 2010
Minimally invasive assessment of tumor angiogenesis by fine needle aspiration and flow cytometry.
Angiogenesis
Sottnik JL,Guth AM,Mitchell LA,Dow SW
14-0161 was used in Flow cytometry/Cell sorting to develop an optimised method for studying tumour angiogenesis.
Wed Sep 01 00:00:00 EDT 2010
Complement independent antibody-mediated endarteritis and transplant arteriopathy in mice.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Hirohashi T,Uehara S,Chase CM,DellaPelle P,Madsen JC,Russell PS,Colvin RB
14-0161 was used in Immunofluorescence on frozen tissues to investigate whether complement was required for chronic transplant arteriopathy.
Mon Mar 01 00:00:00 EST 2010
Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties.
European journal of immunology
Hegde VL,Nagarkatti M,Nagarkatti PS
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that cannabinoid receptor signalling may play a crucial role in immune regulation via the induction of myeloid-derived suppressor cells.
Wed Dec 01 00:00:00 EST 2010
T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells.
European journal of immunology
Ma J,McCarl CA,Khalil S,Lüthy K,Feske S
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that the SOCE regulators STIM1 and STIM2 are required for the function of autoreactive T-cells and their ability to induce EAE in mice.
Mon Nov 01 00:00:00 EDT 2010
Interleukin-22 (IL-22) production by pulmonary Natural Killer cells and the potential role of IL-22 during primary influenza virus infection.
Journal of virology
Guo H,Topham DJ
14-0161 was used in Blocking experiments to test whether interleukin-22 (IL-22) is protective during influenza virus infection, showing that IL-22 plays a marginal role for protection, with a differential requirement of this cytokine for bacterial and viral infections.
Sun Aug 01 00:00:00 EDT 2010
Distinct roles of complement receptor 3, Dectin-1, and sialic acids in murine macrophage interaction with Histoplasma yeast.
Journal of leukocyte biology
Lin JS,Huang JH,Hung LY,Wu SY,Wu-Hsieh BA
14-0161 was used in Flow cytometry/Cell sorting to delineate the distinct roles of CR3, Dectin-1, and sialic acids in the interaction with Histoplasma.
Thu Jul 01 00:00:00 EDT 2010
Unique requirements for reactivation of virus-specific memory B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Weisel FJ,Appelt UK,Schneider AM,Horlitz JU,van Rooijen N,Korner H,Mach M,Winkler TH
14-0161 was used in Immunofluorescence on frozen tissues to study how the reactivation of memory B lymphocytes may occur inside lymphoid follicles, and how this activation has virus-specific requirements.
Fri Oct 01 00:00:00 EDT 2010
Critical protective role for MCP-1 in pneumonic Burkholderia mallei infection.
Journal of immunology (Baltimore, Md. : 1950)
Goodyear A,Jones A,Troyer R,Bielefeldt-Ohmann H,Dow S
14-0161 was used in Blocking experiments to assess the role of MCP-1 in immunity to acute pneumonia caused by gram-negative bacteria.
Mon Feb 01 00:00:00 EST 2010
Dysregulated macrophage-inflammatory protein-2 expression drives illness in bacterial superinfection of influenza.
Journal of immunology (Baltimore, Md. : 1950)
Zavitz CC,Bauer CM,Gaschler GJ,Fraser KM,Strieter RM,Hogaboam CM,Stampfli MR
14-0161 was used in Flow cytometry/Cell sorting to suggest that pulmonary inflammation is the key threat during bacterial superinfection of influenza.
Mon Feb 15 00:00:00 EST 2010
Antigen-specific immunity and cross-priming by epithelial ovarian carcinoma-induced CD11b(+)Gr-1(+) cells.
Journal of immunology (Baltimore, Md. : 1950)
Tomihara K,Guo M,Shin T,Sun X,Ludwig SM,Brumlik MJ,Zhang B,Curiel TJ,Shin T
14-0161 was used in Flow cytometry/Cell sorting to investigate CD11b(+)Gr-1(+) cells found in epithelial ovarian cancer-bearing mice, which are induced by ovarian cancer cells and undergo antigen-specific immunity and cross-priming.
Tue Jun 01 00:00:00 EDT 2010
Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection.
Journal of immunology (Baltimore, Md. : 1950)
McCarl CA,Khalil S,Ma J,Oh-hora M,Yamashita M,Roether J,Kawasaki T,Jairaman A,Sasaki Y,Prakriya M,Feske S
14-0161 was used in Flow cytometry/Cell sorting to reaffirm the critical role of ORAI1 for T cell function, and provide important insights into the in vivo functions of CRAC channels for T cell-mediated immunity.
Mon Nov 15 00:00:00 EST 2010
IL-1-induced inflammation promotes development of leishmaniasis in susceptible BALB/c mice.
International immunology
Voronov E,Dotan S,Gayvoronsky L,White RM,Cohen I,Krelin Y,Benchetrit F,Elkabets M,Huszar M,El-On J,Apte RN
14-0161 was used in Flow cytometry/Cell sorting to assess the role of host derived IL-1 on the course of Leishmania major infection in susceptible BLAB/c mice.
Thu Apr 01 00:00:00 EDT 2010
Forkhead box M1 transcription factor is required for macrophage recruitment during liver repair.
Molecular and cellular biology
Ren X,Zhang Y,Snyder J,Cross ER,Shah TA,Kalin TV,Kalinichenko VV
14-0161 was used in Flow cytometry/Cell sorting to study how Foxm1 is critical for liver repair and is required for the recruitment of monocytes to the injured liver.
Mon Nov 01 00:00:00 EDT 2010
Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine.
Gastroenterology
Shang L,Thirunarayanan N,Viejo-Borbolla A,Martin AP,Bogunovic M,Marchesi F,Unkeless JC,Ho Y,Furtado GC,Alcami A,Merad M,Mayer L,Lira SA
14-0161 was used in Blocking experiments to study the importance of the chemokine binding protein M3 in enabling distribution of leukocytes throughout the intestine.
Tue Sep 01 00:00:00 EDT 2009
Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine.
Gastroenterology
Shang L,Thirunarayanan N,Viejo-Borbolla A,Martin AP,Bogunovic M,Marchesi F,Unkeless JC,Ho Y,Furtado GC,Alcami A,Merad M,Mayer L,Lira SA
14-0161 was used in Blocking experiments to study the importance of the chemokine binding protein M3 in enabling distribution of leukocytes throughout the intestine.
Tue Sep 01 00:00:00 EDT 2009
Restraint stress modulates virus specific adaptive immunity during acute Theiler's virus infection.
Brain, behavior, and immunity
Steelman AJ,Dean DD,Young CR,Smith R,Prentice TW,Meagher MW,Welsh CJ
14-0161 was used in Blocking experiments to examine how stress during acute TMEV infection alters virus-specific cell mediated responses, showing that stress-induced immunosuppression enhances viral persistence.
Sat Aug 01 00:00:00 EDT 2009
Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice.
The Journal of experimental medicine
Gräbner R,Lötzer K,Döpping S,Hildner M,Radke D,Beer M,Spanbroek R,Lippert B,Reardon CA,Getz GS,Fu YX,Hehlgans T,Mebius RE,van der Wall M,Kruspe D,Englert C,Lovas A,Hu D,Randolph GJ,Weih F,Habenicht AJ
14-0161 was used in Flow cytometry/Cell sorting to investigate how the LTbetaR pathway has a major role in shaping the immunological characteristics and overall integrity of the arterial wall.
Fri Jan 16 00:00:00 EST 2009
Effect of polyI:C cotreatment on halothane-induced liver injury in mice.
Hepatology (Baltimore, Md.)
Cheng L,You Q,Yin H,Holt M,Franklin C,Ju C
14-0161 was used in Blocking experiments to investigate the effect of viral infection on halothane-induced hepatotoxicity in mice using a viral RNA mimetic.
Thu Jan 01 00:00:00 EST 2009
Enhanced immune recognition of cryptic glycan markers in human tumors.
Cancer research
Newsom-Davis TE,Wang D,Steinman L,Chen PF,Wang LX,Simon AK,Screaton GR
14-0161 was used in Blocking experiments to investigate methods to enhance recognition of cryptic glycan marker for tumour targeting.
Sun Mar 01 00:00:00 EST 2009
Naringenin: a potential immunomodulator for inhibiting lung fibrosis and metastasis.
Cancer research
Du G,Jin L,Han X,Song Z,Zhang H,Liang W
14-0161 was used in Flow cytometry/Cell sorting to determine whether mouse models of idiopathic pulmonary fibrosis have high incidence of lung cancer, showing that Naringenin could treat lung fibrosis and metastasis.
Wed Apr 01 00:00:00 EDT 2009
Viral infection induces de novo lesions of coronary allograft vasculopathy through a natural killer cell-dependent pathway.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Graham JA,Wilkinson RA,Hirohashi T,Chase CM,Colvin RB,Madsen JC,Fishman JA,Russell PS
14-0161 was used in Immunohistochemistry on frozen tissues to investigate the relationship between cytomegalovirus infections and de novo formation of coronary vascular lesions.
Sun Nov 01 00:00:00 EDT 2009
The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection.
PLoS pathogens
Shimada K,Chen S,Dempsey PW,Sorrentino R,Alsabeh R,Slepenkin AV,Peterson E,Doherty TM,Underhill D,Crother TR,Arditi M
14-0161 was used in Flow cytometry/Cell sorting to investigate the role of the Nod/Rip2 pathway in responses to Chlamydophila pneumoniae infection, showing that it is essential for host defences against pneumonia.
Wed Apr 01 00:00:00 EDT 2009
Toll-like receptor 4 deficiency increases disease and mortality after mouse hepatitis virus type 1 infection of susceptible C3H mice.
Journal of virology
Khanolkar A,Hartwig SM,Haag BA,Meyerholz DK,Harty JT,Varga SM
14-0161 was used in Blocking experiments to demonstrate that TLR4 plays an important role in respiratory CoV pathogenesis.
Tue Sep 01 00:00:00 EDT 2009
Adenosine A2B receptors are highly expressed on murine type II alveolar epithelial cells.
American journal of physiology. Lung cellular and molecular physiology
Cagnina RE,Ramos SI,Marshall MA,Wang G,Frazier CR,Linden J
14-0161 was used in Functional assays to determine the sites of expression of the A(2B) receptor in the mouse lung, showing that they are highly expressed on murine type II alveolar epithelial cells.
Tue Sep 01 00:00:00 EDT 2009
Allogeneic stromal cell implantation in brain tissue leads to robust microglial activation.
Immunology and cell biology
Tambuyzer BR,Bergwerf I,De Vocht N,Reekmans K,Daans J,Jorens PG,Goossens H,Ysebaert DK,Chatterjee S,Van Marck E,Berneman ZN,Ponsaerts P
14-0161 was used in Blocking experiments to describe the immunological mechanism leading to rejection of allogeneic BM-SCs after implantation in murine CNS.
Fri Jun 19 00:00:00 EDT 2009
Evaluation of the long-term reconstituting subset of hematopoietic stem cells with CD150.
Stem cells (Dayton, Ohio)
Papathanasiou P,Attema JL,Karsunky H,Xu J,Smale ST,Weissman IL
14-0161 was used in Flow cytometry/Cell sorting to identify cell surface markers that allow the isolation and characterisation of haematopoietic stem cells.
Thu Oct 01 00:00:00 EDT 2009
Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Huggins A,Paschalidis N,Flower RJ,Perretti M,D'Acquisto F
14-0161 was used in Flow cytometry/Cell sorting to suggest that the inhibition of Anx-A1 expression in dendritic cells may be useful to modulate the adaptive immune response in pathogen-induced immune diseases.
Wed Apr 01 00:00:00 EDT 2009
Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Ohno T,Oboki K,Kajiwara N,Morii E,Aozasa K,Flavell RA,Okumura K,Saito H,Nakae S
14-0161 was used in Magnetic cell separation to investigate the immune source of IL-33.
Tue Dec 15 00:00:00 EST 2009
Early life exposure to lipopolysaccharide suppresses experimental autoimmune encephalomyelitis by promoting tolerogenic dendritic cells and regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Ellestad KK,Tsutsui S,Noorbakhsh F,Warren KG,Yong VW,Pittman QJ,Power C
14-0161 was used in Blocking experiments to support the concept of early-life microbial exposure influencing the generation of neuroprotective regulatory T cells in relation to autoimmune diseases.
Wed Jul 01 00:00:00 EDT 2009
De novo recruitment of antigen-experienced and naive T cells contributes to the long-term maintenance of antiviral T cell populations in the persistently infected central nervous system.
Journal of immunology (Baltimore, Md. : 1950)
Zhao J,Zhao J,Perlman S
14-0161 was used in Flow cytometry/Cell sorting to establish the source of virus-specific CD4 and CD8 T cells at the site of hepatitis infection.
Thu Oct 15 00:00:00 EDT 2009
Enhanced susceptibility to Leishmania infection in resistant mice in the absence of immediate early response gene X-1.
Journal of immunology (Baltimore, Md. : 1950)
Akilov OE,Ustyugova IV,Zhi L,Hasan T,Wu MX
14-0161 was used in Immunohistochemistry on paraffin embedded tissues to explore a potential role for immediate early response gene X-1 in control of the susceptibility to Leishmania major infection.
Tue Dec 15 00:00:00 EST 2009
Transgenic inhibition of astroglial NF-kappa B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Brambilla R,Persaud T,Hu X,Karmally S,Shestopalov VI,Dvoriantchikova G,Ivanov D,Nathanson L,Barnum SR,Bethea JR
14-0161 was used in Flow cytometry/Cell sorting to display the potential neuroprotective benefits of transgenic inhibition of NF-kappaB following autoimmune encephalomyelitis.
Sun Mar 01 00:00:00 EST 2009
New approach for m-cell-specific molecules screening by comprehensive transcriptome analysis.
DNA research : an international journal for rapid publication of reports on genes and genomes
Nakato G,Fukuda S,Hase K,Goitsuka R,Cooper MD,Ohno H
14-0161 was used in Blocking experiments to investigate commonly expressed genes by M cells in mice and chickens.
Sat Aug 01 00:00:00 EDT 2009
Bacteroides induce higher IgA production than Lactobacillus by increasing activation-induced cytidine deaminase expression in B cells in murine Peyer's patches.
Bioscience, biotechnology, and biochemistry
Yanagibashi T,Hosono A,Oyama A,Tsuda M,Hachimura S,Takahashi Y,Itoh K,Hirayama K,Takahashi K,Kaminogawa S
14-0161 was used in Blocking experiments to investigate how intestinal commensal bacteria induce IgA production.
Sun Feb 01 00:00:00 EST 2009
Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis.
PloS one
Chan AS,Jensen KK,Skokos D,Doty S,Lederman HK,Kaplan RN,Rafii S,Rivella S,Lyden D
14-0161 was used in Flow cytometry/Cell sorting to identify Id1 as crucial for the dynamic cross-talk between bone and bone marrow haematopoietic cells.
Tue Nov 24 00:00:00 EST 2009
Modulation of experimental autoimmune encephalomyelitis by endogenous annexin A1.
Journal of neuroinflammation
Paschalidis N,Iqbal AJ,Maione F,Wood EG,Perretti M,Flower RJ,D'Acquisto F
14-0161 was used in Blocking experiments to investigate the potential modulatory role of Annexin A1 in the development of experimental autoimmune encephalomyelitis.
Fri Nov 13 00:00:00 EST 2009
Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells.
Immunity
Ng G,Sharma K,Ward SM,Desrosiers MD,Stephens LA,Schoel WM,Li T,Lowell CA,Ling CC,Amrein MW,Shi Y
14-0161 was used in Blocking experiments to suggest a mechanism of immune cell activation by solid structures via membrane lipid alteration without specific cell-surface receptor involvement.
Fri Nov 14 00:00:00 EST 2008
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-0161 was used in Blocking experiments to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 EDT 2008
Enhanced NK-cell development and function in BCAP-deficient mice.
Blood
MacFarlane AW,Yamazaki T,Fang M,Sigal LJ,Kurosaki T,Campbell KS
14-0161 was used in Flow cytometry/Cell sorting to show that the B-cell adaptor for phosphatidylinositol 3-kinase is strongly expressed in natural killer cells and plays an important role in their development.
Tue Jul 01 00:00:00 EDT 2008
GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival.
The Journal of experimental medicine
Sonderegger I,Iezzi G,Maier R,Schmitz N,Kurrer M,Kopf M
14-0161 was used in Blocking experiments to investigate how GM-CSF can promote generation and maintenance of Th17 cells by regulation of IL-6 and IL-23 in vivo.
Mon Sep 29 00:00:00 EDT 2008
Mechanism of NKT cell activation by intranasal coadministration of alpha-galactosylceramide, which can induce cross-protection against influenza viruses.
Mucosal immunology
Kamijuku H,Nagata Y,Jiang X,Ichinohe T,Tashiro T,Mori K,Taniguchi M,Hase K,Ohno H,Shimaoka T,Yonehara S,Odagiri T,Tashiro M,Sata T,Hasegawa H,Seino KI
14-0161 was used in Immunohistochemistry-Immunofluorescence to analyse the mechanism of natural killer T cell activation by intranasal coadministration of alpha-galactosylceramide.
Thu May 01 00:00:00 EDT 2008
Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS.
Glia
de Haas AH,Boddeke HW,Biber K
14-0161 was used in Flow cytometry/Cell sorting to evaluate the existence of distinct microglia phenotypes in various regions of the healthy, adult mouse central nervous system.
Sun Jun 01 00:00:00 EDT 2008
Regulation of cytokine production by virus-specific CD8 T cells in the lungs.
Journal of virology
Fulton RB,Olson MR,Varga SM
14-0161 was used in Flow cytometry/Cell sorting to show that both virus-induced inflammation and the host tissue environment influence the capacity of virus-specific T cells to produce cytokines.
Fri Aug 01 00:00:00 EDT 2008
Differential role of gamma interferon in inhibiting pulmonary eosinophilia and exacerbating systemic disease in fusion protein-immunized mice undergoing challenge infection with respiratory syncytial virus.
Journal of virology
Castilow EM,Olson MR,Meyerholz DK,Varga SM
14-0161 was used in Blocking experiments to compare the immune response elicited by the G versus F protein of the respiratory syncytial virus, showing a differential role of gamma interferon.
Sat Mar 01 00:00:00 EST 2008
Activation-induced NKT cell hyporesponsiveness protects from alpha-galactosylceramide hepatitis and is independent of active transregulatory factors.
Journal of leukocyte biology
Biburger M,Tiegs G
14-0161 was used in Flow cytometry/Cell sorting to investigate the use of alpha-GalCer as a regulator of natural killer T cell activation, with potential applications in cancer and hepatitis.
Tue Jul 01 00:00:00 EDT 2008
Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury.
Journal of leukocyte biology
Holt MP,Cheng L,Ju C
14-0161 was used in Blocking experiments to explore the role of the acetaminophen-induced macrophage in tissue repair following acetaminophen-induced liver injury.
Mon Dec 01 00:00:00 EST 2008
Expression of CXCL4 in microglia in vitro and in vivo and its possible signaling through CXCR3.
Journal of neurochemistry
de Jong EK,de Haas AH,Brouwer N,van Weering HR,Hensens M,Bechmann I,Pratley P,Wesseling E,Boddeke HW,Biber K
14-0161-82 was used in Flow Cytometry to propose that locally released CXCL4 may control microglia responses and signal via CXCR3.
Sun Jun 01 00:00:00 EDT 2008
Activated CD8 T cells redistribute to antigen-free lymph nodes and exhibit effector and memory characteristics.
Journal of immunology (Baltimore, Md. : 1950)
Brinkman CC,Sheasley-O'Neill SL,Ferguson AR,Engelhard VH
14-0161 was used in Blocking experiments to characterise the activation and differentiation of CD8 T cells in individual lymphoid compartments over time, and their migration between compartments.
Fri Aug 01 00:00:00 EDT 2008
Runx proteins are involved in regulation of CD122, Ly49 family and IFN-gamma expression during NK cell differentiation.
International immunology
Ohno S,Sato T,Kohu K,Takeda K,Okumura K,Satake M,Habu S
14-0161 was used in Flow cytometry/Cell sorting to investigate the role of Runx family proteins in NK cells, showing that they are involved in regulation of CD122, Ly49 family and IFN-gamma expression during differentiation.
Tue Jan 01 00:00:00 EST 2008
T cells help to amplify inflammatory responses induced by Salmonella enterica serotype Typhimurium in the intestinal mucosa.
Infection and immunity
Godinez I,Haneda T,Raffatellu M,George MD,Paixão TA,Rolán HG,Santos RL,Dandekar S,Tsolis RM,Bäumler AJ
14-0161 was used in Blocking experiments to investigate global changes in gene expression elicited by Salmonella enterica serotype Typhimurium in the cecal mucosa.
Thu May 01 00:00:00 EDT 2008
The isolation and characterization of murine macrophages.
Current protocols in immunology
Zhang X,Goncalves R,Mosser DM
14-0161 was used in Blocking experiments to study differences in the physiology of macrophages isolated from distinct environments.
Sat Nov 01 00:00:00 EDT 2008
Chimeric NKG2D modified T cells inhibit systemic T-cell lymphoma growth in a manner involving multiple cytokines and cytotoxic pathways.
Cancer research
Zhang T,Barber A,Sentman CL
14-0161 was used in Blocking experiments to investigate the efficiency and mechanisms by which chimeric NKG2D-modified T cells inhibit systemic T-cell lymphoma growth.
Thu Nov 15 00:00:00 EST 2007
IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals.
Journal of leukocyte biology
Ho LH,Ohno T,Oboki K,Kajiwara N,Suto H,Iikura M,Okayama Y,Akira S,Saito H,Galli SJ,Nakae S
14-0161 was used in Flow cytometry/Cell sorting to reveal potential roles for IL-33 in mast cell- and Th2 cytokine-associated immune responses and disorders.
Sat Dec 01 00:00:00 EST 2007
Exacerbated pathology of viral encephalitis in mice with central nervous system-specific autoantibodies.
The American journal of pathology
Burrer R,Buchmeier MJ,Wolfe T,Ting JP,Feuer R,Iglesias A,von Herrath MG
14-0161 was used in Blocking experiments to examine the outcome of viral encephalomyelitis in mice with autoantibodies to a central nervous system specific antigen, myelin oligodendrocyte glycoprotein, that usually develop no clinical disease.
Thu Feb 01 00:00:00 EST 2007
B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion.
The Journal of experimental medicine
Savitsky D,Calame K
14-0161 was used in Flow cytometry/Cell sorting to show that Blimp-1 is not necessary for the formation or self-renewal of B-1 B cells but that Blimp-1 is required for normal immunoglobulin (Ig) secretion by B-1 cells.
Mon Oct 02 00:00:00 EDT 2006
Arming tumor-reactive T cells with costimulator B7-1 enhances therapeutic efficacy of the T cells.
Cancer research
Zheng G,Liu S,Wang P,Xu Y,Chen A
14-0161 was used in Flow cytometry/Cell sorting to establish that producing tumour-reactive T cells that ectopically express a costimulator can enhance the antitumour response.
Sat Jul 01 00:00:00 EDT 2006
T/B lineage choice occurs prior to intrathymic Notch signaling.
Blood
Harman BC,Jenkinson WE,Parnell SM,Rossi SW,Jenkinson EJ,Anderson G
14-0161 was used in Blocking experiments to analyse the T-cell/B-cell lineage potential of precursors that have been recruited to the foetal mouse thymus, showing that lineage choice occurs prior to intrathymic Notch signaling.
Mon Aug 01 00:00:00 EDT 2005
Estrogen stimulates microglia and brain recovery from hypoxia-ischemia in normoglycemic but not diabetic female mice.
The Journal of clinical investigation
Zhang L,Nair A,Krady K,Corpe C,Bonneau RH,Simpson IA,Vannucci SJ
14-0161 was used in Flow cytometry/Cell sorting to describe antiapoptotic gene expression (bfl-1) in the brain with localization to microglia and macrophages.
Thu Jan 01 00:00:00 EST 2004
Defective macrophage function in neonates and its impact on unresponsiveness of neonates to polysaccharide antigens.
Journal of leukocyte biology
Chelvarajan RL,Collins SM,Doubinskaia IE,Goes S,Van Willigen J,Flanagan D,De Villiers WJ,Bryson JS,Bondada S
14-0161 was used in Flow cytometry/Cell sorting to investigate the impact of defective macrophage function in neonates on their unresponsiveness to antigens.
Tue Jun 01 00:00:00 EDT 2004
Mac1 positive cells are required for enhancement of splenocytes proliferation caused by bisphenol a.
Bioscience, biotechnology, and biochemistry
Goto M,Ono H,Takano-Ishikawa Y,Shinmoto H,Yoshida M
14-0161 was used in Flow cytometry/Cell sorting to demonstrate that bisphenol A upregulates the proliferation of murine splenocytes stimulated with Concanavalin A.
Thu Jan 01 00:00:00 EST 2004
A novel population of Gr-1+-activated macrophages induced during acute toxoplasmosis.
Journal of leukocyte biology
Mordue DG,Sibley LD
14-0161 was used in Flow cytometry/Cell sorting to demonstrate the mechanisms by which activated CD68+/Gr-1+ macrophages contribute to parasite control during infection.
Mon Dec 01 00:00:00 EST 2003
