Product References
Tripartite-Motif 21 (TRIM21) Deficiency Results in a Modest Loss of Herpes Simplex Virus (HSV)-1 Surveillance in the Trigeminal Ganglia Following Cornea Infection.
Viruses
Berube A,Gmyrek GB,Royer DJ,Carr DJJ
16-0161-82 was used in Flow cytometry/Cell sorting to show that absence of TRIM21 results in a modest, but significant, increase in HSV-1 titers recovered from the TG of TRIM21 KO mice during acute infection.
Sat Mar 12 00:00:00 EST 2022
IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells.
Developmental cell
Zhang X,Luo S,Wang M,Huang Q,Fang W,Li J,Liu T,Zhang Y,Deng Z,Liu CL,Guan S,Ayala JE,Flavell RA,Kulkarni RN,Libby P,Guo J,Liu Z,Shi GP
16-0161-82 was used in Flow Cytometry to report that IL18 is expressed on islet α cells, NCC on β cells, and IL18r on acinar cells in human and mouse pancreases.
Mon Jun 20 00:00:00 EDT 2022
Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients.
Cell death and differentiation
Picard M,Yonekura S,Slowicka K,Petta I,Rauber C,Routy B,Richard C,Iebba V,Tidjani Alou M,Becharef S,Ly P,Pizzato E,Lehmann CHK,Amon L,Klein C,Opolon P,Gomperts Boneca I,Scoazec JY,Hollebecque A,Malka D,Ghiringhelli F,Dudziak D,Berx G,Vereecke L,van Loo G,Kroemer G,Zitvogel L,Roberti MP
16-0161 was used in Flow cytometry/Cell sorting to suggest that chemotherapy inversely shapes the immune profile of the ileum-tumor axis, influencing clinical outcome.
Sat May 01 00:00:00 EDT 2021
Splenic Capture and In Vivo Intracellular Biodegradation of Biological-Grade Graphene Oxide Sheets.
ACS nano
Newman L,Jasim DA,Prestat E,Lozano N,de Lazaro I,Nam Y,Assas BM,Pennock J,Haigh SJ,Bussy C,Kostarelos K
16-0161 was used in Flow cytometry/Cell sorting to interrogate the potential consequences of 2D graphene oxide (GO) nanosheets accumulation and the fate of the spleen-residing GO over a period of nine months.
Tue Aug 25 00:00:00 EDT 2020
Development of Capsular Fibrosis Beneath the Liver Surface in Humans and Mice.
Hepatology (Baltimore, Md.)
Balog S,Li Y,Ogawa T,Miki T,Saito T,French SW,Asahina K
16-0161 was used in Flow cytometry/Cell sorting to reveal that the structure of Glisson's capsule is different between human and mouse livers and that alcohol impairs the resolution of CF by changing the phenotype of Ly-6CLow/- monocytes.
Wed Jan 01 00:00:00 EST 2020
Isolation, culture, and downstream characterization of primary microglia and astrocytes from adult rodent brain and spinal cord.
Journal of neuroscience methods
Agalave NM,Lane BT,Mody PH,Szabo-Pardi TA,Burton MD
16-0161-82 was used in Flow Cytometry to show a novel, single protocol to isolate microglia and astrocytes from brain and spinal cord tissue, allowing for culturing and other downstream applications from the cells of animals of various ages, which will be useful for researchers investigating these two major glial cell types from the brain or spinal cord of the same rodent.
Wed Jul 01 00:00:00 EDT 2020
A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling.
Cell reports
Donado CA,Cao AB,Simmons DP,Croker BA,Brennan PJ,Brenner MB
16-0161 was used in Flow cytometry/Cell sorting to describe an alternative, two-cell model for IL-1β release where invariant natural killer T (iNKT) cells use the death receptor pathway to instruct antigen-presenting cells to secrete IL-1β.
Tue Apr 07 00:00:00 EDT 2020
GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance.
Cell
Luan HH,Wang A,Hilliard BK,Carvalho F,Rosen CE,Ahasic AM,Herzog EL,Kang I,Pisani MA,Yu S,Zhang C,Ring AM,Young LH,Medzhitov R
16-0161 was used in Flow cytometry/Cell sorting to show that GDF15 coordinates tolerance to inflammatory damage through regulation of triglyceride metabolism.
Thu Aug 22 00:00:00 EDT 2019
NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis.
Nature communications
Ershaid N,Sharon Y,Doron H,Raz Y,Shani O,Cohen N,Monteran L,Leider-Trejo L,Ben-Shmuel A,Yassin M,Gerlic M,Ben-Baruch A,Pasmanik-Chor M,Apte R,Erez N
16-0161-82 was used in Flow Cytometry to find that fibroblasts sense damage-associated molecular patterns (DAMPs), and in response activate the NLRP3 inflammasome pathway, resulting in instigation of pro-inflammatory signalling and secretion of IL-1β.
Thu Sep 26 00:00:00 EDT 2019
The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity.
Immunity
Metidji A,Omenetti S,Crotta S,Li Y,Nye E,Ross E,Li V,Maradana MR,Schiering C,Stockinger B
16-0161 was used in Flow cytometry/Cell sorting to study the role of the aryl hydrocarbon receptor pathway of intestinal epithelial cells in maintaining intestinal barrier integrity.
Tue Aug 21 00:00:00 EDT 2018
Myeloid p38α signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis.
EMBO molecular medicine
Youssif C,Cubillos-Rojas M,Comalada M,Llonch E,Perna C,Djouder N,Nebreda AR
16-0161-82 was used in Inhibition Assays to determine the role of myeloid insulin-like growth factor-1 downstream of p38α in colitis-associated tumourigenesis.
Sun Jul 01 00:00:00 EDT 2018
Protein Deiminase 4 and CR3 Regulate Aspergillus fumigatus and β-Glucan-Induced Neutrophil Extracellular Trap Formation, but Hyphal Killing Is Dependent Only on CR3.
Frontiers in immunology
Clark HL,Abbondante S,Minns MS,Greenberg EN,Sun Y,Pearlman E
16-0161 was used in Flow cytometry/Cell sorting to conclude that PAD4 together with CR3-mediated ROS production is required for NET formation in response to A. fumigatus.
Mon Aug 12 00:00:00 EDT 2019
Analysis of Runx1 Using Induced Gene Ablation Reveals Its Essential Role in Pre-liver HSC Development and Limitations of an In Vivo Approach.
Stem cell reports
Senserrich J,Batsivari A,Rybtsov S,Gordon-Keylock S,Souilhol C,Buchholz F,Hills D,Zhao S,Medvinsky A
16-0161 was used in Flow cytometry/Cell sorting to study tamoxifen-inducible Runx1 inactivation in vivo.
Tue Sep 11 00:00:00 EDT 2018
Staphylococcal serine protease-like proteins are pacemakers of allergic airway reactions to Staphylococcus aureus.
The Journal of allergy and clinical immunology
Stentzel S,Teufelberger A,Nordengrün M,Kolata J,Schmidt F,van Crombruggen K,Michalik S,Kumpfmüller J,Tischer S,Schweder T,Hecker M,Engelmann S,Völker U,Krysko O,Bachert C,Bröker BM
16-0161 was used in Flow cytometry/Cell sorting to identify Spls as triggering allergens released by S aureus, opening prospects for diagnosis and causal therapy of asthma.
Wed Feb 01 00:00:00 EST 2017
Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis.
Proceedings of the National Academy of Sciences of the United States of America
Schampel A,Volovitch O,Koeniger T,Scholz CJ,Jörg S,Linker RA,Wischmeyer E,Wunsch M,Hell JW,Ergün S,Kuerten S
16-0161 was used in Flow cytometry/Cell sorting to show that nimodipine application generates a favourable environment for regenerative processes and could be a treatment option for multiple sclerosis.
Tue Apr 18 00:00:00 EDT 2017
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.
Proceedings of the National Academy of Sciences of the United States of America
McEwan WA,Falcon B,Vaysburd M,Clift D,Oblak AL,Ghetti B,Goedert M,James LC
16-0161-82 was used in Functional Assay to show that when misfolded tau assemblies enter the cell, they can be detected and neutralized via a danger response mediated by tau-associated antibodies and the cytosolic Fc receptor tripartite motif protein 21 (TRIM21).
Tue Jan 17 00:00:00 EST 2017
Contribution of IL-1RI Signaling to Protection against Cryptococcus neoformans 52D in a Mouse Model of Infection.
Frontiers in immunology
Shourian M,Ralph B,Angers I,Sheppard DC,Qureshi ST
16-0161 was used in Flow cytometry/Cell sorting to determine the role of IL-1RI signalling in protection against cryptococcal infection.
Wed Nov 20 00:00:00 EST 2019
The common parasite Toxoplasma gondii induces prostatic inflammation and microglandular hyperplasia in a mouse model.
The Prostate
Colinot DL,Garbuz T,Bosland MC,Wang L,Rice SE,Sullivan WJ,Arrizabalaga G,Jerde TJ
16-0161-82 was used in Flow cytometry/Cell sorting to report that T. gondii chronically encysts and induces chronic inflammation within the prostate of any species.
Sat Jul 01 00:00:00 EDT 2017
Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction.
JCI insight
Tatin F,Renaud-Gabardos E,Godet AC,Hantelys F,Pujol F,Morfoisse F,Calise D,Viars F,Valet P,Masri B,Prats AC,Garmy-Susini B
16-0161-82 was used in Flow cytometry/Cell sorting to show that apelin plays a key role in lymphatic vessel maturation and stability in pathological settings.
Thu Jun 15 00:00:00 EDT 2017
Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.
Cell
Wang A,Huen SC,Luan HH,Yu S,Zhang C,Gallezot JD,Booth CJ,Medzhitov R
16-0161 was used in an ELISA assay to analyse the effects of anorxia in mouse models wih viral and bacterial infections.
Thu Sep 08 00:00:00 EDT 2016
In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer.
Nature nanotechnology
Lizotte PH,Wen AM,Sheen MR,Fields J,Rojanasopondist P,Steinmetz NF,Fiering S
16-0161 was used in Flow cytometry/Cell sorting to inhalation of self-assembling virus-like nanoparticles from Cowpea Mosaic Virus reduces established B16F10 lung melanoma.
Tue Mar 01 00:00:00 EST 2016
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
The Journal of clinical investigation
Cole CB,Verdoni AM,Ketkar S,Leight ER,Russler-Germain DA,Lamprecht TL,Demeter RT,Magrini V,Ley TJ
16016182 was used in blocking or activating experiment to study how DNMT3A is involved in the function of PML-RARA, RUNX1-RUNX1T1, and MLL-AF9
Fri Jan 01 00:00:00 EST 2016
Critical Role of the Disintegrin Metalloprotease ADAM-like Decysin-1 [ADAMDEC1] for Intestinal Immunity and Inflammation.
Journal of Crohn's & colitis
O'Shea NR,Chew TS,Dunne J,Marnane R,Nedjat-Shokouhi B,Smith PJ,Bloom SL,Smith AM,Segal AW
16-0161 was used in Flow cytometry/Cell sorting to investigate how reduced expression of the ADAMDEC1 peptidase protein may lead to decreased protection from bacterial and chemical insults, characteristic of Crohn's disease.
Thu Dec 01 00:00:00 EST 2016
Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits Extracellular Aspergillus fumigatus Hyphal Growth and Corneal Infection.
Journal of immunology (Baltimore, Md. : 1950)
Clark HL,Jhingran A,Sun Y,Vareechon C,de Jesus Carrion S,Skaar EP,Chazin WJ,Calera JA,Hohl TM,Pearlman E
16-0161 was used in Flow cytometry/Cell sorting to demonstrate a novel stage-specific susceptibility of Aspergillus fumigatus to zinc and manganese chelation by neutrophil-derived calprotectin.
Fri Jan 01 00:00:00 EST 2016
Myeloid cell expressed proprotein convertase FURIN attenuates inflammation.
Oncotarget
Cordova ZM,Grönholm A,Kytölä V,Taverniti V,Hämäläinen S,Aittomäki S,Niininen W,Junttila I,Ylipää A,Nykter M,Pesu M
16016182 was used in blocking or activating experiment to investigate the role of FURIN in LysM positive myeloid cells in vivo
Tue Aug 23 00:00:00 EDT 2016
In vitro Differentiation of Murine Innate Lymphoid Cells from Common Lymphoid Progenitor Cells.
Bio-protocol
Seehus C,Kaye J
16-0161 was used in Inhibition experiments to demonstrate how to differentiate murine innate lymphoid cells from in vivo common lymphoid progenitor cells grown in vitro.
Sun Mar 20 00:00:00 EDT 2016
Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP.
Nature communications
Karmakar M,Katsnelson MA,Dubyak GR,Pearlman E
16-0161 was used in Blocking experiments to investigate the role of extracellular ATP in activating inflammasome signalling in neutrophils.
Mon Feb 15 00:00:00 EST 2016
Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP.
Nature communications
Karmakar M,Katsnelson MA,Dubyak GR,Pearlman E
16-0161 was used in Blocking experiments to investigate the role of extracellular ATP in activating inflammasome signalling in neutrophils.
Mon Feb 15 00:00:00 EST 2016
Preparation of Single Cell Suspensions from Mouse Aorta.
Bio-protocol
Hu D,Yin C,Mohanta SK,Weber C,Habenicht AJ
16-0161 was used in Flow cytometry/Cell sorting to describe isolation of single cells from mouse aorta for fluorescence activated cell sorting and other analysis.
Sun Jun 05 00:00:00 EDT 2016
Lack of the ubiquitin-editing enzyme A20 results in loss of hematopoietic stem cell quiescence.
The Journal of experimental medicine
Nakagawa MM,Thummar K,Mandelbaum J,Pasqualucci L,Rathinam CV
16-0161 was used in Flow cytometry/Cell sorting to investigate the critical regulatory role of the ubiquitin-editing enzyme A20, and the impact of A20 deficiency in the hematopoietic system.
Mon Feb 09 00:00:00 EST 2015
Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus.
EMBO molecular medicine
Herbst S,Shah A,Mazon Moya M,Marzola V,Jensen B,Reed A,Birrell MA,Saijo S,Mostowy S,Shaunak S,Armstrong-James D
16016182 was used in blocking or activating experiment to explore a macrophage TLR9-BTK-calcineurin-NFAT signaling pathway involved in impair fungal immunity
Sun Mar 01 00:00:00 EST 2015
Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models.
Epilepsia
Benson MJ,Manzanero S,Borges K
16-0161 was used in Flow cytometry/Cell sorting to demonstrate that the microglial inflammatory response during epileptogenesis is complex, varies between models, and appears to correlate with chronic seizure frequency.
Mon Jun 01 00:00:00 EDT 2015
Assessment of antibody-dependent respiratory burst activity from mouse neutrophils on Plasmodium yoelii malaria challenge outcome.
Journal of leukocyte biology
Llewellyn D,de Cassan SC,Williams AR,Douglas AD,Forbes EK,Adame-Gallegos JR,Shi J,Pleass RJ,Draper SJ
16-0161 was used to characterise the functional interaction between antimalarial serum antibodies and FcRs on neutrophils.
Sat Feb 01 00:00:00 EST 2014
Evidence for a multipotent mammary progenitor with pregnancy-specific activity.
Breast cancer research : BCR
Kaanta AS,Virtanen C,Selfors LM,Brugge JS,Neel BG
16-0161 was used in Blocking experiments to provide data to show the existence of multi-potent mammary progenitor cells that have pregnancy-specific function.
Mon Dec 08 00:00:00 EST 2014
Correlates of immune protection following cutaneous immunization with an attenuated Burkholderia pseudomallei vaccine.
Infection and immunity
Silva EB,Goodyear A,Sutherland MD,Podnecky NL,Gonzalez-Juarrero M,Schweizer HP,Dow SW
16-0161 was used in Flow cytometry/Cell sorting to elucidate immune correlates of vaccine-induced protective immunity against acute Burkholderia pseudomallei infection.
Sun Dec 01 00:00:00 EST 2013
Interferon γ-induced intratumoral expression of CXCL9 alters the local distribution of T cells following immunotherapy with Listeria monocytogenes.
Oncoimmunology
Guirnalda P,Wood L,Goenka R,Crespo J,Paterson Y
16-0161-82 was used in Flow Cytometry to conclude that the administration of monocytogenes-based anticancer vaccines regulates TH1 chemokine responses.
Thu Aug 01 00:00:00 EDT 2013
Vaccination with immunotherapeutic Listeria monocytogenes induces IL-17(+) γδ T cells in a murine model for HPV associated cancer.
Oncoimmunology
Guirnalda PD,Paterson Y
16-0161 was used in Flow cytometry/Cell sorting to investigate the role of IL-17 in Listeria based immunotherapy.
Sat Sep 01 00:00:00 EDT 2012
Activation of the maternal immune system induces endocrine changes in the placenta via IL-6.
Brain, behavior, and immunity
Hsiao EY,Patterson PH
16-0161 was used in Flow cytometry/Cell sorting to investigate how the IL-6-mediated effects of MIA on the placenta represent an indirect mechanism by which MIA can alter fetal development.
Sun May 01 00:00:00 EDT 2011
Naive mouse macrophages become activated following recognition of L5178Y lymphoma cells via concurrent ligation of CD40, NKG2D, and CD18 molecules.
Journal of immunology (Baltimore, Md. : 1950)
Buhtoiarov IN,Rakhmilevich AL,Lanier LL,Ranheim EA,Sondel PM
16-0161 was used in Blocking experiments to investigate the mechanisms of tumour-macrophage interactions leading to macrophage activation, showing that activation follows ligation of CD40, NKG2D, and CD18 molecules.
Sun Feb 15 00:00:00 EST 2009