Product References
Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation.
Cancer discovery
Chen S,Vedula RS,Cuevas-Navarro A,Lu B,Hogg SJ,Wang E,Benbarche S,Knorr K,Kim WJ,Stanley RF,Cho H,Erickson C,Singer M,Cui D,Tittley S,Durham BH,Pavletich TS,Fiala E,Walsh MF,Inoue D,Monette S,Taylor J,Rosen N,McCormick F,Lindsley RC,Castel P,Abdel-Wahab O
56-0161-82 was used in Flow cytometry/Cell sorting to reveal proteolysis of non-canonical RAS proteins as novel regulators of HSC self-renewal, define the function of RIT1 and LZTR1 mutations in leukemia, and identify means to overcome drug resistance due to LZTR1 downregulation.
Wed Oct 05 00:00:00 EDT 2022
Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis.
Cell
Weindel CG,Martinez EL,Zhao X,Mabry CJ,Bell SL,Vail KJ,Coleman AK,VanPortfliet JJ,Zhao B,Wagner AR,Azam S,Scott HM,Li P,West AP,Karpac J,Patrick KL,Watson RO
56-0161-82 was used in Flow Cytometry to provide insights into how LRRK2 mutations manifest or exacerbate human diseases and identifies GSDMD-dependent necroptosis as a potential target to limit Lrrk2G2019S-mediated immunopathology.
Thu Aug 18 00:00:00 EDT 2022
Adiponectin receptors sustain haematopoietic stem cells throughout adulthood by protecting them from inflammation.
Nature cell biology
Meacham CE,Jeffery EC,Burgess RJ,Sivakumar CD,Arora MA,Stanley AM,Colby EM,Crane GM,Zhao Z,Morrison SJ
56-0161-82 was used in Flow cytometry/Cell sorting to find that adiponectin receptors are non-cell-autonomously required in haematopoietic cells to promote HSC quiescence and self-renewal.
Sun May 01 00:00:00 EDT 2022
Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection.
Science advances
Eislmayr K,Bestehorn A,Morelli L,Borroni M,Vande Walle L,Lamkanfi M,Kovarik P
Published figure using CD16/CD32 monoclonal antibody (Product # 56-0161-82) in Flow Cytometry
Fri Mar 04 00:00:00 EST 2022
A somatic mutation in moesin drives progression into acute myeloid leukemia.
Science advances
Yuan O,Ugale A,de Marchi T,Anthonydhason V,Konturek-Ciesla A,Wan H,Eldeeb M,Drabe C,Jassinskaja M,Hansson J,Hidalgo I,Velasco-Hernandez T,Cammenga J,Magee JA,Niméus E,Bryder D
56-0161-82 was used in Flow cytometry/Cell sorting to demonstrate a critical role of ERM proteins in AML, with implications also for human cancer.
Fri Apr 22 00:00:00 EDT 2022
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Published figure using CD16/CD32 monoclonal antibody (Product # 56-0161-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
Retinoic Acid Induces Functionally Suppressive Foxp3+RORγt+ T Cells In Vitro.
Frontiers in immunology
Martínez-Blanco M,Lozano-Ojalvo D,Pérez-Rodríguez L,Benedé S,Molina E,López-Fandiño R
56-0161-82 was used in Flow Cytometry to show that under the influence of IL-2 and TGF-β, suppressive Foxp3+RORγt+ T cells that express and secrete IL-17 can be produced in vitro and RA further contributes to stabilize this phenotype.
Thu Oct 21 00:00:00 EDT 2021
TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling.
Cell reports
Agarwal P,Li H,Choi K,Hueneman K,He J,Welner RS,Starczynowski DT,Bhatia R
56-0161-82 was used in Flow Cytometry to find that TNF-α-mediated alterations in CML BM stromal niches enhance support of LSC maintenance and growth via CXCL1-CXCR2 signaling and that CXCR2 inhibition effectively depletes CML LSCs.
Tue Jul 13 00:00:00 EDT 2021
C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.
Cancer cell
Di Genua C,Valletta S,Buono M,Stoilova B,Sweeney C,Rodriguez-Meira A,Grover A,Drissen R,Meng Y,Beveridge R,Aboukhalil Z,Karamitros D,Belderbos ME,Bystrykh L,Thongjuea S,Vyas P,Nerlov C
Published figure using CD16/CD32 monoclonal antibody (Product # 56-0161-82) in Flow Cytometry
Mon May 11 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using CD16/CD32 monoclonal antibody (Product # 56-0161-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.
Proceedings of the National Academy of Sciences of the United States of America
Kitchen GB,Cunningham PS,Poolman TM,Iqbal M,Maidstone R,Baxter M,Bagnall J,Begley N,Saer B,Hussell T,Matthews LC,Dockrell DH,Durrington HJ,Gibbs JE,Blaikley JF,Loudon AS,Ray DW
Published figure using CD16/CD32 monoclonal antibody (Product # 56-0161-82) in Flow Cytometry
Tue Jan 21 00:00:00 EST 2020
Japanese Kampo Medicine Juzentaihoto Enhances Antitumor Immunity in CD1d-/- Mice Lacking NKT Cells.
Integrative cancer therapies
Takaku S,Shimizu M,Takahashi H
Published figure using CD16/CD32 monoclonal antibody (Product # 56-0161-82) in Flow Cytometry
Mon Mar 23 00:00:00 EDT 2020
Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis.
Nature
Yoshimi A,Lin KT,Wiseman DH,Rahman MA,Pastore A,Wang B,Lee SC,Micol JB,Zhang XJ,de Botton S,Penard-Lacronique V,Stein EM,Cho H,Miles RE,Inoue D,Albrecht TR,Somervaille TCP,Batta K,Amaral F,Simeoni F,Wilks DP,Cargo C,Intlekofer AM,Levine RL,Dvinge H,Bradley RK,Wagner EJ,Krainer AR,Abdel-Wahab O
56-0161 was used in Flow cytometry/Cell sorting to study the mutations in IDH2 and SRSF2 that together promote leukaemogenesis through coordinated effects on the epigenome and RNA splicing.
Tue Oct 01 00:00:00 EDT 2019
Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells.
Cell stem cell
Agarwal P,Isringhausen S,Li H,Paterson AJ,He J,Gomariz Á,Nagasawa T,Nombela-Arrieta C,Bhatia R
56-0161-82 was used in Flow Cytometry to highlight a critical role of niche-specific effects of Cxcl12 expression in maintaining quiescence of TKI-resistant LSC populations.
Thu May 02 00:00:00 EDT 2019
SIRT1 regulates metabolism and leukemogenic potential in CML stem cells.
The Journal of clinical investigation
Abraham A,Qiu S,Chacko BK,Li H,Paterson A,He J,Agarwal P,Shah M,Welner R,Darley-Usmar VM,Bhatia R
56-0161 was used in Flow cytometry/Cell sorting to demonstrate an important role for SIRT1 in leukemia development.
Mon Jun 10 00:00:00 EDT 2019
Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis.
Haematologica
Zhang Z,Huang Z,Ong B,Sahu C,Zeng H,Ruan HB
Published figure using CD16/CD32 monoclonal antibody (Product # 56-0161-82) in Flow Cytometry
Sun Sep 01 00:00:00 EDT 2019
C-Reactive Protein Promotes the Expansion of Myeloid Derived Cells With Suppressor Functions.
Frontiers in immunology
Jimenez RV,Kuznetsova V,Connelly AN,Hel Z,Szalai AJ
Published figure using CD16/CD32 monoclonal antibody (Product # 56-0161-82) in Neutralization
Tue Nov 10 00:00:00 EST 2020
NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis.
Nature communications
Ershaid N,Sharon Y,Doron H,Raz Y,Shani O,Cohen N,Monteran L,Leider-Trejo L,Ben-Shmuel A,Yassin M,Gerlic M,Ben-Baruch A,Pasmanik-Chor M,Apte R,Erez N
Published figure using CD16/CD32 monoclonal antibody (Product # 56-0161-82) in Flow Cytometry
Thu Sep 26 00:00:00 EDT 2019
Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.
Cancer cell
Lee SC,North K,Kim E,Jang E,Obeng E,Lu SX,Liu B,Inoue D,Yoshimi A,Ki M,Yeo M,Zhang XJ,Kim MK,Cho H,Chung YR,Taylor J,Durham BH,Kim YJ,Pastore A,Monette S,Palacino J,Seiler M,Buonamici S,Smith PG,Ebert BL,Bradley RK,Abdel-Wahab O
56-0161 was used in Flow cytometry/Cell sorting to identify shared consequences of splicing-factor mutations and the basis for their mutual exclusivity.
Mon Aug 13 00:00:00 EDT 2018
miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling.
Nature communications
Lam J,van den Bosch M,Wegrzyn J,Parker J,Ibrahim R,Slowski K,Chang L,Martinez-Høyer S,Condorelli G,Boldin M,Deng Y,Umlandt P,Fuller M,Karsan A
Published figure using CD16/CD32 monoclonal antibody (Product # 56-0161-82) in Flow Cytometry
Wed Jun 20 00:00:00 EDT 2018
Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.
Nature communications
Grinenko T,Eugster A,Thielecke L,Ramasz B,Krüger A,Dietz S,Glauche I,Gerbaulet A,von Bonin M,Basak O,Clevers H,Chavakis T,Wielockx B
56-0161 was used in Flow cytometry/Cell sorting to study the mechanisms that control fate decision in adult haematopoietic stem cells.s.
Tue May 15 00:00:00 EDT 2018
Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow.
Nature communications
Xu C,Gao X,Wei Q,Nakahara F,Zimmerman SE,Mar J,Frenette PS
56-0161 was used in Flow cytometry/Cell sorting to characterise the expression signature that distinguishes arterial endothelial cells from sinusoidal endothelial cells.
Fri Jun 22 00:00:00 EDT 2018
Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.
Nature
Hérault A,Binnewies M,Leong S,Calero-Nieto FJ,Zhang SY,Kang YA,Wang X,Pietras EM,Chu SH,Barry-Holson K,Armstrong S,Göttgens B,Passegué E
Published figure using CD16/CD32 monoclonal antibody (Product # 56-0161-82) in Flow Cytometry
Thu Apr 06 00:00:00 EDT 2017
Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy.
Nature communications
Liu Z,Ravindranathan R,Kalinski P,Guo ZS,Bartlett DL
Published figure using CD16/CD32 monoclonal antibody (Product # 56-0161-82) in Flow Cytometry
Mon Mar 27 00:00:00 EDT 2017
Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5-Trisphosphate Homeostasis.
mBio
Schlam D,Canton J,Carreño M,Kopinski H,Freeman SA,Grinstein S,Fairn GD
Published figure using CD16/CD32 monoclonal antibody (Product # 56-0161-82) in Immunofluorescence
Tue Apr 05 00:00:00 EDT 2016
Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5-Trisphosphate Homeostasis.
mBio
Schlam D,Canton J,Carreño M,Kopinski H,Freeman SA,Grinstein S,Fairn GD
Published figure using CD16/CD32 monoclonal antibody (Product # 56-0161-82) in Immunofluorescence
Tue Apr 05 00:00:00 EDT 2016
Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.
Journal for immunotherapy of cancer
Patel MA,Kim JE,Theodros D,Tam A,Velarde E,Kochel CM,Francica B,Nirschl TR,Ghasemzadeh A,Mathios D,Harris-Bookman S,Jackson CC,Jackson C,Ye X,Tran PT,Tyler B,Coric V,Selby M,Brem H,Drake CG,Pardoll DM,Lim M
Published figure using CD16/CD32 monoclonal antibody (Product # 56-0161-82) in Flow Cytometry
Wed May 18 00:00:00 EDT 2016
Angiogenic activity mediates bone repair from human pluripotent stem cell-derived osteogenic cells.
Scientific reports
Zou L,Chen Q,Quanbeck Z,Bechtold JE,Kaufman DS
56-0161 was used in Immunocytochemistry to explore the role of the pro-angiogenic potential of transplanted osteogenic cells for effective cell-mediated bone repair.
Wed Mar 16 00:00:00 EDT 2016
Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton.
eLife
Yue R,Shen B,Morrison SJ
56-0161 was used in Flow cytometry/Cell sorting to study how Clec11a/Osteolectin maintains the adult skeleton by promoting the differentiation of mesenchymal progenitors into mature osteoblasts.
Tue Dec 13 00:00:00 EST 2016
Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity.
PloS one
Jonas BA,Johnson C,Gratzinger D,Majeti R
56-0161 was used in Flow cytometry/Cell sorting to report several new t-AML/MDS mouse models that could potentially be used to further define disease pathogenesis and test novel therapeutics.
Wed Jul 26 00:00:00 EDT 2017
Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling.
The Journal of clinical investigation
Menéndez-Gutiérrez MP,Rőszer T,Fuentes L,Núñez V,Escolano A,Redondo JM,De Clerck N,Metzger D,Valledor AF,Ricote M
56-0161 was used in Flow cytometry/Cell sorting to reveal that retinoid X receptor signalling mediates bone homeostasis.
Sun Feb 01 00:00:00 EST 2015
A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.
Nature medicine
Herranz D,Ambesi-Impiombato A,Palomero T,Schnell SA,Belver L,Wendorff AA,Xu L,Castillo-Martin M,Llobet-Navás D,Cordon-Cardo C,Clappier E,Soulier J,Ferrando AA
56-0161 was used in Flow cytometry/Cell sorting to identify N-Me as a long-range oncogenic enhancer implicated directly in the pathogenesis of human leukaemia.
Wed Oct 01 00:00:00 EDT 2014
Flow cytometry analysis of murine hematopoietic stem cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Mayle A,Luo M,Jeong M,Goodell MA
56-0161 was used in Flow cytometry/Cell sorting to discuss methods for rapid flow cytometric analysis of peripheral blood cell types and novel strategies for working with rare cell populations such as hematopoietic stem cells in the analysis of cell cycle status by BrdU, Ki-67, and Pyronin Y staining.
Tue Jan 01 00:00:00 EST 2013
Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.
The Journal of experimental medicine
Austin WR,Armijo AL,Campbell DO,Singh AS,Hsieh T,Nathanson D,Herschman HR,Phelps ME,Witte ON,Czernin J,Radu CG
56-0161 was used in Flow cytometry/Cell sorting to investigate a functional link between nucleotide deficiency, replication stress, and two enzymes of the nucleoside salvage pathway: deoxycytidine kinase and thymidine kinase.
Mon Nov 19 00:00:00 EST 2012
Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac-1-, and p38 MAPK-dependent mechanisms.
The American journal of pathology
Ninković J,Roy S
Published figure using CD16/CD32 monoclonal antibody (Product # 56-0161-82) in Flow Cytometry
Thu Mar 01 00:00:00 EST 2012
Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac-1-, and p38 MAPK-dependent mechanisms.
The American journal of pathology
Ninković J,Roy S
Published figure using CD16/CD32 monoclonal antibody (Product # 56-0161-82) in Flow Cytometry
Thu Mar 01 00:00:00 EST 2012
In vivo inhibition of c-MYC in myeloid cells impairs tumor-associated macrophage maturation and pro-tumoral activities.
PloS one
Pello OM,Chèvre R,Laoui D,De Juan A,Lolo F,Andrés-Manzano MJ,Serrano M,Van Ginderachter JA,Andrés V
Published figure using CD16/CD32 monoclonal antibody (Product # 56-0161-82) in Flow Cytometry
Mon Feb 25 00:00:00 EST 2013