Product References
Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses.
Mucosal immunology
Wittner J,Schulz SR,Steinmetz TD,Berges J,Hauke M,Channell WM,Cunningham AF,Hauser AE,Hutloff A,Mielenz D,Jäck HM,Schuh W
12-0232-82 was used in Flow cytometry/Cell sorting to conclude that KLF2 not only orchestrates the localization of IgA plasma cells by fine-tuning chemokine receptors and adhesion molecules but also controls IgA responses to Salmonella flagellin.
Fri Apr 01 00:00:00 EDT 2022
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Nature immunology
Rivas MA,Meydan C,Chin CR,Challman MF,Kim D,Bhinder B,Kloetgen A,Viny AD,Teater MR,McNally DR,Doane AS,Béguelin W,Fernández MTC,Shen H,Wang X,Levine RL,Chen Z,Tsirigos A,Elemento O,Mason CE,Melnick AM
Published figure using CD23 monoclonal antibody (Product # 12-0232-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Peptidylprolyl isomerase C (Ppic) regulates invariant Natural Killer T cell (iNKT) differentiation in mice.
European journal of immunology
Paiva RS,Ramos CV,Azenha SR,Alves C,Basto AP,Graca L,Martins VC
12-0232-82 was used in Flow Cytometry to show that Ppic is dispensable for myeloid cells, platelets, erythrocytes, αβ and γδ T lymphocytes in vivo in the steady state, while being involved in B and iNKT cell differentiation.
Sun Aug 01 00:00:00 EDT 2021
Dependence on Autophagy for Autoreactive Memory B Cells in the Development of Pristane-Induced Lupus.
Frontiers in immunology
Jang A,Sharp R,Wang JM,Feng Y,Wang J,Chen M
12-0232-82 was used in flow cytometry to suggest that autophagy is important for the persistence of autoreactive memory B cells, maintenance of autoantibody production, and sustained glomerulonephritis in pristane-induced lupus.
Fri Dec 10 00:00:00 EST 2021
Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity.
Cancer cell
Yu X,Chan HTC,Fisher H,Penfold CA,Kim J,Inzhelevskaya T,Mockridge CI,French RR,Duriez PJ,Douglas LR,English V,Verbeek JS,White AL,Tews I,Glennie MJ,Cragg MS
12-0232 was used in Flow cytometry/Cell sorting to show that clinically relevant antagonists used for treating autoimmune conditions can be converted into potent FcγR-independent agonists with remarkable antitumor activity by isotype switching to hIgG2.
Mon Jun 08 00:00:00 EDT 2020
Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity.
Cancer cell
Yu X,Chan HTC,Fisher H,Penfold CA,Kim J,Inzhelevskaya T,Mockridge CI,French RR,Duriez PJ,Douglas LR,English V,Verbeek JS,White AL,Tews I,Glennie MJ,Cragg MS
12-0232 was used in Flow cytometry/Cell sorting to show that clinically relevant antagonists used for treating autoimmune conditions can be converted into potent FcγR-independent agonists with remarkable antitumor activity by isotype switching to hIgG2.
Mon Jun 08 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using CD23 monoclonal antibody (Product # 12-0232-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production.
The Journal of experimental medicine
Lau A,Avery DT,Jackson K,Lenthall H,Volpi S,Brigden H,Russell AJ,Bier J,Reed JH,Smart JM,Cole T,Choo S,Gray PE,Berglund LJ,Hsu P,Wong M,O'Sullivan M,Boztug K,Meyts I,Uzel G,Notarangelo LD,Brink R,Goodnow CC,Tangye SG,Deenick EK
Published figure using CD23 monoclonal antibody (Product # 12-0232-82) in Flow Cytometry
Mon Feb 03 00:00:00 EST 2020
CD83 expression regulates antibody production in response to influenza A virus infection.
Virology journal
Akauliya M,Gautam A,Maharjan S,Park BK,Kim J,Kwon HJ
12-0232 was used in Flow cytometry/Cell sorting to investigate the role of CD83 using C57BL/6J wild type mice and CD83 knockout (KO) mice after intraperitoneal administration of the influenza A/WSN/1933 virus.
Thu Dec 10 00:00:00 EST 2020
CD83 expression regulates antibody production in response to influenza A virus infection.
Virology journal
Akauliya M,Gautam A,Maharjan S,Park BK,Kim J,Kwon HJ
12-0232 was used in Flow cytometry/Cell sorting to investigate the role of CD83 using C57BL/6J wild type mice and CD83 knockout (KO) mice after intraperitoneal administration of the influenza A/WSN/1933 virus.
Thu Dec 10 00:00:00 EST 2020
Estrogen Receptor Alpha Signaling Is Responsible for the Female Sex Bias in the Loss of Tolerance and Immune Cell Activation Induced by the Lupus Susceptibility Locus Sle1b.
Frontiers in immunology
Graham JH,Yoachim SD,Gould KA
Published figure using CD23 monoclonal antibody (Product # 12-0232-82) in Flow Cytometry
Tue Jun 22 00:00:00 EDT 2021
Liver Is a Generative Site for the B Cell Response to Ehrlichia muris.
Immunity
Trivedi N,Weisel F,Smita S,Joachim S,Kader M,Radhakrishnan A,Clouser C,Rosenfeld AM,Chikina M,Vigneault F,Hershberg U,Ismail N,Shlomchik MJ
12-0232-82 was used in Flow Cytometry to investigate the nature of liver B cell and spleen response to Ehrlichia muris.
Tue Dec 17 00:00:00 EST 2019
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.
Cell metabolism
Camell CD,Günther P,Lee A,Goldberg EL,Spadaro O,Youm YH,Bartke A,Hubbard GB,Ikeno Y,Ruddle NH,Schultze J,Dixit VD
12-0232 was used in Flow cytometry/Cell sorting to study the role of ageing within alterations of adipose tissue.
Tue Dec 03 00:00:00 EST 2019
Peritoneal Cells Mediate Immune Responses and Cross-Protection Against Influenza A Virus.
Frontiers in immunology
Gautam A,Park BK,Kim TH,Akauliya M,Kim D,Maharjan S,Park J,Kim J,Lee H,Park MS,Lee Y,Kwon HJ
Published figure using CD23 monoclonal antibody (Product # 12-0232-82) in Flow Cytometry
Mon Aug 17 00:00:00 EDT 2020
Activated Peyer's patch B cells sample antigen directly from M cells in the subepithelial dome.
Nature communications
Komban RJ,Strömberg A,Biram A,Cervin J,Lebrero-Fernández C,Mabbott N,Yrlid U,Shulman Z,Bemark M,Lycke N
12-0232-82 was used in Flow Cytometry to report a M cell-B cell antigen-specific transporting pathway in PP that is independent of DC. We propose that this antigen transporting pathway has a critical role in gut IgA responses, and should be taken into account when developing mucosal vaccines.
Mon Jun 03 00:00:00 EDT 2019
Activated Peyer's patch B cells sample antigen directly from M cells in the subepithelial dome.
Nature communications
Komban RJ,Strömberg A,Biram A,Cervin J,Lebrero-Fernández C,Mabbott N,Yrlid U,Shulman Z,Bemark M,Lycke N
12-0232-82 was used in Flow Cytometry to report a M cell-B cell antigen-specific transporting pathway in PP that is independent of DC. We propose that this antigen transporting pathway has a critical role in gut IgA responses, and should be taken into account when developing mucosal vaccines.
Mon Jun 03 00:00:00 EDT 2019
Mutations in topoisomerase IIβ result in a B cell immunodeficiency.
Nature communications
Broderick L,Yost S,Li D,McGeough MD,Booshehri LM,Guaderrama M,Brydges SD,Kucharova K,Patel NC,Harr M,Hakonarson H,Zackai E,Cowell IG,Austin CA,Hügle B,Gebauer C,Zhang J,Xu X,Wang J,Croker BA,Frazer KA,Putnam CD,Hoffman HM
12-0232-82 was used in Flow Cytometry to identify mutations in type II topoisomerase as a driver of defective proliferation and survival of B2 cells, leading to a B cell immunodeficiency.
Tue Aug 13 00:00:00 EDT 2019
Gestational Hypothyroxinemia Affects Its Offspring With a Reduced Suppressive Capacity Impairing the Outcome of the Experimental Autoimmune Encephalomyelitis.
Frontiers in immunology
Haensgen H,Albornoz E,Opazo MC,Bugueño K,Jara Fernández EL,Binzberger R,Rivero-Castillo T,Venegas Salas LF,Simon F,Cabello-Verrugio C,Elorza AA,Kalergis AM,Bueno SM,Riedel CA
12-0232 was used in Flow cytometry/Cell sorting to analyse the immune response after experimental autoimmune encephalitis induction in the adult offspring gestated in hypothyroxinemia.
Tue Aug 20 00:00:00 EDT 2019
Targeting of the Yersinia pestis F1 capsular antigen by innate-like B1b cells mediates a rapid protective response against bubonic plague.
NPJ vaccines
Levy Y,Vagima Y,Tidhar A,Aftalion M,Gur D,Nili U,Chitlaru T,Zauberman A,Mamroud E
Thu Oct 01 00:00:00 EDT 2020
S1P Signalling Differentially Affects Migration of Peritoneal B Cell Populations In Vitro and Influences the Production of Intestinal IgA In Vivo.
International journal of molecular sciences
Kleinwort A,Lührs F,Heidecke CD,Lipp M,Schulze T
12-0232 was used in Flow cytometry/Cell sorting to study the function of S1P signalling in the third B cell lineage.
Mon Jan 29 00:00:00 EST 2018
Prolonged Deleterious Influences of Chemotherapeutic Agent CPT-11 on Resident Peritoneal Macrophages and B1 Cells.
Frontiers in immunology
Bai WJ,Li CG,Zhang CC,Xu LH,Zeng QZ,Hu B,Hong Z,He XH,Ouyang DY
Wed Nov 20 00:00:00 EST 2019
Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms.
Blood
Lykken JM,Horikawa M,Minard-Colin V,Kamata M,Miyagaki T,Poe JC,Tedder TF
12-0232 was used in Flow cytometry/Cell sorting to elucidate the mechanisms through which non-Hodgkin lymphomas initially resist or gain resistance to immunotherapy.
Thu Apr 14 00:00:00 EDT 2016
Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Song Y,Kumar V,Wei HX,Qiu J,Stanley P
12-0232 was used in Flow cytometry/Cell sorting to investigate the roles for maniac fringe (MFNG) and radical fringe (RFNG) in T cell development, RFNG in B cell development, and Fringes in T and B cell activation, showing that they promote T and B cell development.
Fri Jan 01 00:00:00 EST 2016
IgE-mediated enhancement of CD4(+) T cell responses requires antigen presentation by CD8α(-) conventional dendritic cells.
Scientific reports
Ding Z,Dahlin JS,Xu H,Heyman B
12-0232 was used in Flow cytometry/Cell sorting to elucidate the dendritic cell population involved in the presentation of IgE-Ag complexes during enhanced specific antibody and CD4+ T cell responses.
Thu Jun 16 00:00:00 EDT 2016
Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.
The Journal of experimental medicine
Fiala GJ,Janowska I,Prutek F,Hobeika E,Satapathy A,Sprenger A,Plum T,Seidl M,Dengjel J,Reth M,Cesca F,Brummer T,Minguet S,Schamel WW
12-0232 was used in Flow cytometry/Cell sorting to study Kidins220/ARMS binding to the B cell antigen receptor and its regulation of B cell development and activation.
Mon Sep 21 00:00:00 EDT 2015
BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.
The Journal of experimental medicine
Jacque E,Schweighoffer E,Tybulewicz VL,Ley SC
12-0232 was used in Flow cytometry/Cell sorting to reveal a potentially critical role for the MEK5-ERK5 MAP kinase signalling pathway in BAFF-induced mature B cell survival and homeostatic maintenance of B2 cell numbers.
Mon Jun 01 00:00:00 EDT 2015
Essential role for autophagy in the maintenance of immunological memory against influenza infection.
Nature medicine
Chen M,Hong MJ,Sun H,Wang L,Shi X,Gilbert BE,Corry DB,Kheradmand F,Wang J
12-0232 was used in Flow cytometry/Cell sorting to demonstrate autophagy is essential for the survival of virus-specific memory B cells and maintenance of protective antibody responses.
Thu May 01 00:00:00 EDT 2014
Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells.
Blood
Katz SG,Labelle JL,Meng H,Valeriano RP,Fisher JK,Sun H,Rodig SJ,Kleinstein SH,Walensky LD
Thu Feb 06 00:00:00 EST 2014
NIAM-deficient mice are predisposed to the development of proliferative lesions including B-cell lymphomas.
PloS one
Reed SM,Hagen J,Muniz VP,Rosean TR,Borcherding N,Sciegienka S,Goeken JA,Naumann PW,Zhang W,Tompkins VS,Janz S,Meyerholz DK,Quelle DE
12-0232 was used in Flow cytometry/Cell sorting to investigate the predicted role of the nuclear interactor of ARF and Mdm2 as a tumour suppressor.
Fri Jan 15 00:00:00 EST 2016
The defect of SFRP2 modulates an influx of extracellular calcium in B lymphocytes.
BMC research notes
Tokuda Y,Tanaka M,Yagi T,Tashiro K
12-0232 was used in Flow cytometry/Cell sorting to suggest that SFRP2 modulates the influx from extracellular calcium in the B cell receptor signaling pathway.
Tue Nov 04 00:00:00 EST 2014
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
Nature immunology
Satpathy AT,Briseño CG,Lee JS,Ng D,Manieri NA,Kc W,Wu X,Thomas SR,Lee WL,Turkoz M,McDonald KG,Meredith MM,Song C,Guidos CJ,Newberry RD,Ouyang W,Murphy TL,Stappenbeck TS,Gommerman JL,Nussenzweig MC,Colonna M,Kopan R,Murphy KM
12-0232 was used in Flow cytometry/Cell sorting to elucidate the cellular source of essential IL-23 production required for the mucosal response to attaching-and-effacing bacterial infection.
Sun Sep 01 00:00:00 EDT 2013
In senescence, age-associated B cells secrete TNFα and inhibit survival of B-cell precursors.
Aging cell
Ratliff M,Alter S,Frasca D,Blomberg BB,Riley RL
12-0232 was used in Flow cytometry/Cell sorting to elucidate the differential cytokine expression by old and young follicular splenic (FO) B cells, and the effects on age-associated B cells (ABCs).
Mon Apr 01 00:00:00 EDT 2013
Intrinsic T- and B-cell defects impair T-cell-dependent antibody responses in mice lacking the actin-bundling protein L-plastin.
European journal of immunology
Todd EM,Deady LE,Morley SC
12-0232 was used in Flow cytometry/Cell sorting to study the role of L-plastin in the modulation of both T- and B-cell immune responses.
Mon Jul 01 00:00:00 EDT 2013
B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates.
Journal of immunology (Baltimore, Md. : 1950)
Ota T,Doyle-Cooper C,Cooper AB,Doores KJ,Aoki-Ota M,Le K,Schief WR,Wyatt RT,Burton DR,Nemazee D
12-0232 was used in Flow cytometry/Cell sorting to demonstrate a new mouse model for testing vaccine candidates for the routine elicitation of broadly neutralising antibodies against HIV.
Sun Sep 15 00:00:00 EDT 2013
IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.
Blood
Balkhi MY,Willette-Brown J,Zhu F,Chen Z,Liu S,Guttridge DC,Karin M,Hu Y
12-0232-82 was used in Flow Cytometry to demonstrate that IKKα regulates B-lineage commitment via combined canonical and noncanonical NF-κB transcriptional activities to target Pax5 expression during hematopoiesis.
Thu Jun 07 00:00:00 EDT 2012
Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses.
Proceedings of the National Academy of Sciences of the United States of America
Purtha WE,Swiecki M,Colonna M,Diamond MS,Bhattacharya D
12-0232 was used in Flow cytometry/Cell sorting to study the functional role of interferon regulatory factor-5 in human autoimmune disease pathogenesis.
Tue Apr 10 00:00:00 EDT 2012
Critical role of B cell lymphoma 10 in BAFF-regulated NF-κB activation and survival of anergic B cells.
Journal of immunology (Baltimore, Md. : 1950)
Yu M,Chen Y,He Y,Podd A,Fu G,Wright JA,Kleiman E,Khan WN,Wen R,Wang D
12-0232 was used in Flow cytometry/Cell sorting to demonstrate the essential role of Bcl10 in ensuring efficacy of BAFF, responsible for regulating NF-κB activation and subsequent survival of anergic B cells.
Sat Dec 01 00:00:00 EST 2012
Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.
The Journal of experimental medicine
Ota T,Ota M,Duong BH,Gavin AL,Nemazee D
12-0232 was used in Flow cytometry/Cell sorting to postulate that clonal deletion is the major irreversible pathway of tolerance induction among peripheral B cells.
Mon Mar 14 00:00:00 EDT 2011
Cellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartments.
Journal of immunology (Baltimore, Md. : 1950)
Nikbakht N,Migone TS,Ward CP,Manser T
12-0232 was used in Flow cytometry/Cell sorting to investigate the role of the peripheral B cell pro-survival cytokine BAFF/BLyS in the regulation of immunological tolerance and autoreactive cells.
Fri Jul 01 00:00:00 EDT 2011
The actin-bundling protein L-plastin is essential for marginal zone B cell development.
Journal of immunology (Baltimore, Md. : 1950)
Todd EM,Deady LE,Morley SC
12-0232 was used in Flow cytometry/Cell sorting to study the role of the actin-bundling protein L-plastin in B cell chemotaxis.
Thu Sep 15 00:00:00 EDT 2011
AUF1 is involved in splenic follicular B cell maintenance.
BMC immunology
Sadri N,Lu JY,Badura ML,Schneider RJ
12-0232 was used in Flow cytometry/Cell sorting to investigate the role of AUF1 in the immune system, showing that it is involved in splenic follicular B cell maintenance.
Mon Jan 11 00:00:00 EST 2010
Diversifying selection and functional analysis of interleukin-4 suggests antagonism-driven evolution at receptor-binding interfaces.
BMC evolutionary biology
Koyanagi M,Kerns JA,Chung L,Zhang Y,Brown S,Moldoveanu T,Malik HS,Bix M
12-0232 was used in Flow cytometry/Cell sorting to investigate ligand/receptor co-evolution in IL-4 antagonism in helminth infections.
Thu Jul 22 00:00:00 EDT 2010
A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation.
Blood
Schuman J,Chen Y,Podd A,Yu M,Liu HH,Wen R,Chen ZJ,Wang D
Published figure using CD23 monoclonal antibody (Product # 12-0232-82) in Flow Cytometry
Thu May 07 00:00:00 EDT 2009
The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function.
Blood
Lee JJ,Rauter I,Garibyan L,Ozcan E,Sannikova T,Dillon SR,Cruz AC,Siegel RM,Bram R,Jabara H,Geha RS
12-0232 was used in Flow cytometry/Cell sorting to define the consequence of the A181E mutation on TACI function.
Thu Sep 10 00:00:00 EDT 2009
Differential regulation of splenic CD8- dendritic cells and marginal zone B cells by Notch ligands.
International immunology
Sekine C,Moriyama Y,Koyanagi A,Koyama N,Ogata H,Okumura K,Yagita H
12-0232 was used in Flow cytometry/Cell sorting to investigate the ligand responsible for Notch signalling-mediated maintenance of CD8- dendritic cells.
Sun Mar 01 00:00:00 EST 2009
Defining a transcriptional fingerprint of murine splenic B-cell development.
Genes and immunity
Debnath I,Roundy KM,Dunn DM,Weiss RB,Weis JJ,Weis JH
12-0232 was used in Flow cytometry/Cell sorting to identify key transcriptional regulatory proteins that control the expression of B cell-specific surface markers during B-cell maturation.
Mon Dec 01 00:00:00 EST 2008
Immunoregulatory role of Jalpha281 T cells in aged mice developing lupus-like nephritis.
European journal of immunology
Sireci G,Russo D,Dieli F,Porcelli SA,Taniguchi M,La Manna MP,Di Liberto D,Scarpa F,Salerno A
12-0232 was used in Flow cytometry/Cell sorting to study renal functions and autoantibody production in aged Ja281 KO mice lacking iNKT cells.
Thu Feb 01 00:00:00 EST 2007
Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth.
Proceedings of the National Academy of Sciences of the United States of America
Kikuchi K,Kondo M
12-0232 was used in Flow cytometry/Cell sorting to demonstrate how foetal haematopoietic stem cells may acquire adult characteristics between 1 and 2 weeks after birth in mouse bone marrow.
Tue Nov 21 00:00:00 EST 2006
