Invitrogen

CD24 Monoclonal Antibody (SN3), PE-Alexa Fluor™ 610

6 References

View all (96) CD24 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Product Details

MHCD2422

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

Assay-Dependent

View 5 publications 5 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

SN3

Immunogen

Human CD24

Conjugate

PE-Alexa Fluor™ 610 PE-Alexa Fluor™ 610 PE-Alexa Fluor™ 610

Excitation/Emission Max

567/627 nm View spectra

Form

Liquid

Purification

purified

Storage buffer

PBS with BSA, 10% sucrose

Contains

0.1% sodium azide

Storage conditions

4° C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10375871

Product Specific Information

The R-phycoerythrin (PE)-Cy7® tandem conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a 488 nm laser without occupying traditional channels associated with FITC and PE.

Target Information

CD24 is a two-chain glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed at multiple stages of B-cell development, beginning with the bone marrow pro-B-cell compartment and continuing through mature, surface Ig positive B-cells. Plasma cell expression is very low or negative. CD24 is also expressed on the majority of B-lineage acute lymphoblastic leukemias, B-cell CCLs and B-cell non-Hodgkin's lymphomas. CD24 may play a role in regulation of B-cell proliferation and maturation, and control of autoimmunity.

Analyte Specific Reagent

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

Product References

Impaired IL-23-dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency.

The Journal of experimental medicine

Ogishi M,Arias AA,Yang R,Han JE,Zhang P,Rinchai D,Halpern J,Mulwa J,Keating N,Chrabieh M,Lainé C,Seeleuthner Y,Ramírez-Alejo N,Nekooie-Marnany N,Guennoun A,Muller-Fleckenstein I,Fleckenstein B,Kilic SS,Minegishi Y,Ehl S,Kaiser-Labusch P,Kendir-Demirkol Y,Rozenberg F,Errami A,Zhang SY,Zhang Q,Bohlen J,Philippot Q,Puel A,Jouanguy E,Pourmoghaddas Z,Bakhtiar S,Willasch AM,Horneff G,Llanora G,Shek LP,Chai LYA,Tay SH,Rahimi HH,Mahdaviani SA,Nepesov S,Bousfiha AA,Erdeniz EH,Karbuz A,Marr N,Navarrete C,Adeli M,Hammarstrom L,Abolhassani H,Parvaneh N,Al Muhsen S,Alosaimi MF,Alsohime F,Nourizadeh M,Moin M,Arnaout R,Alshareef S,El-Baghdadi J,Genel F,Sherkat R,Kiykim A,Yücel E,Keles S,Bustamante J,Abel L,Casanova JL,Boisson-Dupuis S

MHCD2422 was used in Flow cytometry/Cell sorting to show that partial TYK2 deficiency across signaling pathways, or rare or common partial TYK2 deficiency specific for IL-23 signaling.

Mon Oct 03 00:00:00 EDT 2022

The memory B cell response to influenza vaccination is impaired in older persons.

Cell reports

Burton AR,Guillaume SM,Foster WS,Wheatley AK,Hill DL,Carr EJ,Linterman MA

MHCD2422 was used in Flow cytometry/Cell sorting to show that the aged human GC reaction and memory B cell response following vaccination is defective.

Tue Nov 08 00:00:00 EST 2022

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.

Science immunology

Asano T,Boisson B,Onodi F,Matuozzo D,Moncada-Velez M,Maglorius Renkilaraj MRL,Zhang P,Meertens L,Bolze A,Materna M,Korniotis S,Gervais A,Talouarn E,Bigio B,Seeleuthner Y,Bilguvar K,Zhang Y,Neehus AL,Ogishi M,Pelham SJ,Le Voyer T,Rosain J,Philippot Q,Soler-Palacín P,Colobran R,Martin-Nalda A,Rivière JG,Tandjaoui-Lambiotte Y,Chaïbi K,Shahrooei M,Darazam IA,Olyaei NA,Mansouri D,Hatipoğlu N,Palabiyik F,Ozcelik T,Novelli G,Novelli A,Casari G,Aiuti A,Carrera P,Bondesan S,Barzaghi F,Rovere-Querini P,Tresoldi C,Franco JL,Rojas J,Reyes LF,Bustos IG,Arias AA,Morelle G,Christèle K,Troya J,Planas-Serra L,Schlüter A,Gut M,Pujol A,Allende LM,Rodriguez-Gallego C,Flores C,Cabrera-Marante O,Pleguezuelo DE,de Diego RP,Keles S,Aytekin G,Akcan OM,Bryceson YT,Bergman P,Brodin P,Smole D,Smith CIE,Norlin AC,Campbell TM,Covill LE,Hammarström L,Pan-Hammarström Q,Abolhassani H,Mane S,Marr N,Ata M,Al Ali F,Khan T,Spaan AN,Dalgard CL,Bonfanti P,Biondi A,Tubiana S,Burdet C,Nussbaum R,Kahn-Kirby A,Snow AL,Bustamante J,Puel A,Boisson-Dupuis S,Zhang SY,Béziat V,Lifton RP,Bastard P,Notarangelo LD,Abel L,Su HC,Jouanguy E,Amara A,Soumelis V,Cobat A,Zhang Q,Casanova JL

MHCD2422 was used in Flow Cytometry to report very rare, biochemically deleterious X-linked TLR7 variants in 16 unrelated male individuals with unexplained critical COVID-19 pneumonia.

Thu Aug 19 00:00:00 EDT 2021

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.

Science immunology

MHCD2422 was used in Flow Cytometry to report very rare, biochemically deleterious X-linked TLR7 variants in 16 unrelated male individuals with unexplained critical COVID-19 pneumonia.

Thu Aug 19 00:00:00 EDT 2021

Asporin Is a Fibroblast-Derived TGF-β1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer.

PLoS medicine

Maris P,Blomme A,Palacios AP,Costanza B,Bellahcène A,Bianchi E,Gofflot S,Drion P,Trombino GE,Di Valentin E,Cusumano PG,Maweja S,Jerusalem G,Delvenne P,Lifrange E,Castronovo V,Turtoi A

MHCD2422 was used in Flow cytometry/Cell sorting to show that asporin is a stroma-derived inhibitor of TGF-β1 and a tumor suppressor in breast cancer and indicate the direction of pre-clinical studies.

Tue Sep 01 00:00:00 EDT 2015

Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Newell KA,Asare A,Sanz I,Wei C,Rosenberg A,Gao Z,Kanaparthi S,Asare S,Lim N,Stahly M,Howell M,Knechtle S,Kirk A,Marks WH,Kawai T,Spitzer T,Tolkoff-Rubin N,Sykes M,Sachs DH,Cosimi AB,Burlingham WJ,Phippard D,Turka LA

MHCD2422 was used in flow cytometry to assess the role of B cells in tolerant kidney transplant recipients.

Sun Nov 01 00:00:00 EDT 2015

Profiling of normal and malignant breast tissue show CD44high/CD24low phenotype as a predominant stem/progenitor marker when used in combination with Ep-CAM/CD49f markers.

BMC cancer

Ghebeh H,Sleiman GM,Manogaran PS,Al-Mazrou A,Barhoush E,Al-Mohanna FH,Tulbah A,Al-Faqeeh K,Adra CN

MHCD2422 was used in Flow cytometry/Cell sorting to demonstrate that normal and malignant breast cells with CD44high/CD24low phenotypes have the highest stem/progenitor cell ability, with Ep-CAM/CD49f reference markers.

Fri Jun 14 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: CD24; CD24 antigen (small cell lung carcinoma cluster 4 antigen); FLJ22950; FLJ43543; MGC75043; Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen

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Gene Aliases: CD24; CD24A

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UniProt ID: (Human) P25063

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Entrez Gene ID: (Human) 100133941

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Function(s)

signal transducer activity protein binding protein kinase binding protein tyrosine kinase activator activity

Process(es)

response to hypoxia cell activation regulation of cytokine-mediated signaling pathway response to molecule of bacterial origin immune response-regulating cell surface receptor signaling pathway positive regulation of cytosolic calcium ion concentration Wnt signaling pathway single organismal cell-cell adhesion cell migration regulation of epithelial cell differentiation T cell costimulation B cell receptor transport into membrane raft chemokine receptor transport out of membrane raft negative regulation of transforming growth factor beta3 production positive regulation of activated T cell proliferation regulation of phosphorylation cholesterol homeostasis positive regulation of MAP kinase activity regulation of MAPK cascade response to estrogen respiratory burst positive regulation of protein tyrosine kinase activity glomerular visceral epithelial cell differentiation glomerular parietal epithelial cell differentiation intrinsic apoptotic signaling pathway positive regulation of nephron tubule epithelial cell differentiation

Performance Guarantee

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CD24 Monoclonal Antibody (SN3), PE-Alexa Fluor™ 610

Product Details

MHCD2422

Flow Cytometry (Flow)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Excitation/Emission Max

Form

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

Bioinformatics

Performance Guarantee

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