Product References
AR-A014418 regulates intronic polyadenylation and transcription of PD-L1 through inhibiting CDK12 and CDK13 in tumor cells.
Journal for immunotherapy of cancer
Zhang G,Lan B,Zhang X,Lin M,Liu Y,Chen J,Guo F
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Mon May 01 00:00:00 EDT 2023
Sustained release of therapeutic gene by injectable hydrogel for hepatocellular carcinoma.
International journal of pharmaceutics: X
Xu S,Cai J,Cheng H,Wang W
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Fri Dec 15 00:00:00 EST 2023
Contribution of Mesenchymal Stem Cells from Obese Adipose Tissue to PD-L1 Over-Expression and Breast Cancer Progression through Pathogenic Th17 Cell Activation.
Cancers
Blangero F,Robert M,Andraud T,Dumontet C,Vidal H,Eljaafari A
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Mon May 29 00:00:00 EDT 2023
BRAF D594A mutation defines a unique biological and immuno-modulatory subgroup associated with functional CD8+ T cell infiltration in colorectal cancer.
Journal of translational medicine
Li W,Zhao C,Li W,Gong Y,Ma K,Lu Y,Liu X,Zhang L,Guo F
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Wed Oct 18 00:00:00 EDT 2023
PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation.
Nature communications
Linnerbauer M,Beyer T,Nirschl L,Farrenkopf D,Lößlein L,Vandrey O,Peter A,Tsaktanis T,Kebir H,Laplaud D,Oellinger R,Engleitner T,Alvarez JI,Rad R,Korn T,Hemmer B,Quintana FJ,Rothhammer V
12-5982-82 was used in Flow cytometry/Cell sorting to suggest the glial PD-L1/PD-1 axis as a potential therapeutic target for both acute and progressive MS stages.
Sat Sep 09 00:00:00 EDT 2023
β3-adrenergic receptor on tumor-infiltrating lymphocytes sustains IFN-γ-dependent PD-L1 expression and impairs anti-tumor immunity in neuroblastoma.
Cancer gene therapy
Bruno G,Nastasi N,Subbiani A,Boaretto A,Ciullini Mannurita S,Mattei G,Nardini P,Della Bella C,Magi A,Pini A,De Marco E,Tondo A,Favre C,Calvani M
12-5982-82 was used in Flow cytometry/Cell sorting to indicate that β3-AR in NB TME is able to modulate the interaction between tumor and host immune system, and that its antagonism hits multiple pro-tumoral signaling pathways.
Thu Jun 01 00:00:00 EDT 2023
Combined PARP and WEE1 inhibition triggers anti-tumor immune response in BRCA1/2 wildtype triple-negative breast cancer.
NPJ breast cancer
Teo ZL,O'Connor MJ,Versaci S,Clarke KA,Brown ER,Percy LW,Kuykhoven K,Mintoff CP,Savas P,Virassamy B,Luen SJ,Byrne A,Sant S,Lindeman GJ,Darcy PK,Loi S
12-5982-82 was used in Flow cytometry/Cell sorting to identify baseline tumour-infiltrating lymphocyte (TIL) levels as a potential predictive biomarker of response to PARPi, WEE1i and immunotherapies in BRCA1/2 wild-type TNBC.
Tue Aug 15 00:00:00 EDT 2023
Regulatory T cells suppress the motility of cytotoxic T cells in Friend retrovirus-infected mice.
JCI insight
Mittermüller D,Otto L,Long Z,Kraus A,Beer A,Hasenberg A,Zelinskyy G,Westmeier J,Hasenkrug KJ,Dittmer U,Gunzer M
12-5982-82 was used in Flow cytometry/Cell sorting to identify an effect of Tregs on cytotoxic T lymphocytes motility as part of their mechanism of functional impairment in chronic viral infections.
Mon Jul 10 00:00:00 EDT 2023
Physachenolide C induces complete regression of established murine melanoma tumors via apoptosis and cell cycle arrest.
Translational oncology
Adams AC,Macy AM,Kang P,Castro-Ochoa KF,Wijeratne EMK,Xu YM,Liu MX,Charos A,Bosenberg MW,Gunatilaka AAL,Sertil AR,Hastings KT
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Sat Jan 01 00:00:00 EST 2022
Modification of PLAC8 by UFM1 affects tumorous proliferation and immune response by impacting PD-L1 levels in triple-negative breast cancer.
Journal for immunotherapy of cancer
Mao M,Chen Y,Yang J,Cheng Y,Xu L,Ji F,Zhou J,Zhang X,Li Z,Chen C,Ju S,Zhang J,Wang L
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2022
Heterogeneity of tyrosine-based melanin anabolism regulates pulmonary and cerebral organotropic colonization microenvironment of melanoma cells.
Theranostics
Wang X,Chen Y,Lan B,Wang Y,Lin W,Jiang X,Ye J,Shang B,Feng C,Liu J,Zhai J,Xu M,Li Q,Lin L,Hu M,Zheng F,Chen L,Shao C,Wang Y,Shi Y
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Thu Apr 21 00:00:00 EDT 2022
CD4+ CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.
Aging and disease
Shen S,Li Y,Jin M,Fan D,Pan R,Lin A,Chen Y,Xiang L,Zhao RC,Shao J
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2022
5-Azacytidine-Mediated Modulation of the Immune Microenvironment in Murine Acute Myeloid Leukemia.
Cancers
Ebelt ND,Manuel ER
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Sun Dec 25 00:00:00 EST 2022
Isotope tracing reveals distinct substrate preference in murine melanoma subtypes with differing anti-tumor immunity.
Cancer & metabolism
Zhang X,Halberstam AA,Zhu W,Leitner BP,Thakral D,Bosenberg MW,Perry RJ
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2022
Isotope tracing reveals distinct substrate preference in murine melanoma subtypes with differing anti-tumor immunity.
Cancer & metabolism
Zhang X,Halberstam AA,Zhu W,Leitner BP,Thakral D,Bosenberg MW,Perry RJ
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2022
Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer.
eLife
Wang Y,Yang H,Jia A,Wang Y,Yang Q,Dong Y,Hou Y,Cao Y,Dong L,Bi Y,Liu G
12-5982-82 was used in Flow cytometry/Cell sorting to demonstrate the role of the dendritic cells-based mechanical regulation of immunopathology in directing T cell lineage commitment in tumor microenvironments.
Mon Aug 22 00:00:00 EDT 2022
Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity.
Nature communications
Wiernicki B,Maschalidi S,Pinney J,Adjemian S,Vanden Berghe T,Ravichandran KS,Vandenabeele P
12-5982-82 was used in Flow cytometry/Cell sorting to show that ferroptosis negatively impacts antigen presenting cells and hence the adaptive immune response, which might hinder therapeutic applications of ferroptosis induction.
Mon Jun 27 00:00:00 EDT 2022
Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents.
Journal of nanobiotechnology
Hagemans IM,Wierstra PJ,Steuten K,Molkenboer-Kuenen JDM,van Dalen D,Ter Beest M,van der Schoot JMS,Ilina O,Gotthardt M,Figdor CG,Scheeren FA,Heskamp S,Verdoes M
12-5982-82 was used in Flow Cytometry to demonstrate that PD-L1 co-localized with the fluorescent and autoradiographic signal.
Wed Feb 02 00:00:00 EST 2022
Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents.
Journal of nanobiotechnology
Hagemans IM,Wierstra PJ,Steuten K,Molkenboer-Kuenen JDM,van Dalen D,Ter Beest M,van der Schoot JMS,Ilina O,Gotthardt M,Figdor CG,Scheeren FA,Heskamp S,Verdoes M
12-5982-82 was used in Flow Cytometry to demonstrate that PD-L1 co-localized with the fluorescent and autoradiographic signal.
Wed Feb 02 00:00:00 EST 2022
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
12-5982-82 was used in immunohistochemistry (frozen) immunofluorescence to better understand the roles of intestinal epithelial cells.
Mon Apr 05 00:00:00 EDT 2021
Lymphatic PD-L1 Expression Restricts Tumor-Specific CD8+ T-cell Responses.
Cancer research
Cousin N,Cap S,Dihr M,Tacconi C,Detmar M,Dieterich LC
12-5982-82 was used in Flow Cytometry to present a new lymphatic-specific PD-L1 knockout mouse model reveals that lymphatic endothelial PD-L1 expression reduces tumor immunity, inducing apoptosis in tumor-specific CD8+ central memory cells in tumor-draining lymph nodes.
Sun Aug 01 00:00:00 EDT 2021
Radiation-induced abscopal effect and its enhancement by programmed cell death 1 blockade in the hepatocellular carcinoma: A murine model study.
Clinical and molecular hepatology
Yoo GS,Ahn WG,Kim SY,Kang W,Choi C,Park HC
12-5982 was used in Flow cytometry/Cell sorting to elucidate the immunological mechanisms underlying the abscopal effect induced by the combination of irradiation and immunotherapy in a murine HCC model.
Fri Jan 01 00:00:00 EST 2021
Radiation-induced abscopal effect and its enhancement by programmed cell death 1 blockade in the hepatocellular carcinoma: A murine model study.
Clinical and molecular hepatology
Yoo GS,Ahn WG,Kim SY,Kang W,Choi C,Park HC
12-5982 was used in Flow cytometry/Cell sorting to elucidate the immunological mechanisms underlying the abscopal effect induced by the combination of irradiation and immunotherapy in a murine HCC model.
Fri Jan 01 00:00:00 EST 2021
Extracellular acidity in tumor tissue upregulates programmed cell death protein 1 expression on tumor cells via proton-sensing G protein-coupled receptors.
International journal of cancer
Mori D,Tsujikawa T,Sugiyama Y,Kotani SI,Fuse S,Ohmura G,Arai A,Kawaguchi T,Hirano S,Mazda O,Kishida T
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Wed Dec 15 00:00:00 EST 2021
Extracellular acidity in tumor tissue upregulates programmed cell death protein 1 expression on tumor cells via proton-sensing G protein-coupled receptors.
International journal of cancer
Mori D,Tsujikawa T,Sugiyama Y,Kotani SI,Fuse S,Ohmura G,Arai A,Kawaguchi T,Hirano S,Mazda O,Kishida T
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Wed Dec 15 00:00:00 EST 2021
Oncolytic herpes simplex virus HF10 (canerpaturev) promotes accumulation of CD8+ PD-1- tumor-infiltrating T cells in PD-L1-enriched tumor microenvironment.
International journal of cancer
Eissa IR,Mukoyama N,Abdelmoneim M,Naoe Y,Matsumura S,Bustos-Villalobos I,Ichinose T,Miyajima N,Morimoto D,Tanaka M,Fujimoto Y,Sone M,Kodera Y,Kasuya H
12-5982-82 was used in Flow cytometry/Cell sorting to reveal mechanisms that allow OVs to trigger an antitumor immune response, irrespective of a PD-L1-enriched tumor microenvironment, by recruitment of CD8+ PD-1- TILs.
Thu Jul 01 00:00:00 EDT 2021
Oncolytic herpes simplex virus HF10 (canerpaturev) promotes accumulation of CD8+ PD-1- tumor-infiltrating T cells in PD-L1-enriched tumor microenvironment.
International journal of cancer
Eissa IR,Mukoyama N,Abdelmoneim M,Naoe Y,Matsumura S,Bustos-Villalobos I,Ichinose T,Miyajima N,Morimoto D,Tanaka M,Fujimoto Y,Sone M,Kodera Y,Kasuya H
12-5982-82 was used in Flow cytometry/Cell sorting to reveal mechanisms that allow OVs to trigger an antitumor immune response, irrespective of a PD-L1-enriched tumor microenvironment, by recruitment of CD8+ PD-1- TILs.
Thu Jul 01 00:00:00 EDT 2021
Collagenase-Expressing Salmonella Targets Major Collagens in Pancreatic Cancer Leading to Reductions in Immunosuppressive Subsets and Tumor Growth.
Cancers
Ebelt ND,Zamloot V,Zuniga E,Passi KB,Sobocinski LJ,Young CA,Blazar BR,Manuel ER
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Fri Jul 16 00:00:00 EDT 2021
Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade.
JCI insight
Ferrere G,Tidjani Alou M,Liu P,Goubet AG,Fidelle M,Kepp O,Durand S,Iebba V,Fluckiger A,Daillère R,Thelemaque C,Grajeda-Iglesias C,Alves Costa Silva C,Aprahamian F,Lefevre D,Zhao L,Ryffel B,Colomba E,Arnedos M,Drubay D,Rauber C,Raoult D,Asnicar F,Spector T,Segata N,Derosa L,Kroemer G,Zitvogel L
12-5982-82 was used in Flow Cytometry to se preclinical tumor models to address the functional impact of a ketogenic diet on the host immune system and tumor immunosurveillance.
Mon Jan 25 00:00:00 EST 2021
Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade.
JCI insight
Ferrere G,Tidjani Alou M,Liu P,Goubet AG,Fidelle M,Kepp O,Durand S,Iebba V,Fluckiger A,Daillère R,Thelemaque C,Grajeda-Iglesias C,Alves Costa Silva C,Aprahamian F,Lefevre D,Zhao L,Ryffel B,Colomba E,Arnedos M,Drubay D,Rauber C,Raoult D,Asnicar F,Spector T,Segata N,Derosa L,Kroemer G,Zitvogel L
12-5982-82 was used in Flow Cytometry to se preclinical tumor models to address the functional impact of a ketogenic diet on the host immune system and tumor immunosurveillance.
Mon Jan 25 00:00:00 EST 2021
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Nature communications
Yang Z,Xu G,Wang B,Liu Y,Zhang L,Jing T,Tang M,Xu X,Jiao K,Xiang L,Fu Y,Tang D,Zhang X,Jin W,Zhuang G,Zhao X,Liu Y
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Wed Aug 11 00:00:00 EDT 2021
Human and mouse PD-L1: similar molecular structure, but different druggability profiles.
iScience
Magiera-Mularz K,Kocik J,Musielak B,Plewka J,Sala D,Machula M,Grudnik P,Hajduk M,Czepiel M,Siedlar M,Holak TA,Skalniak L
12-5982-82 was used in Flow cytometry/Cell sorting to indicate that while the amino acid sequence is well conserved between the hPD-L1 and mPD-L1 and overall structures are almost identical, crucial differences determine the interaction with anti-PD-L1 agents, that cannot be easily predicted in silico.
Fri Jan 22 00:00:00 EST 2021
Antigen-Capturing Mesoporous Silica Nanoparticles Enhance the Radiation-Induced Abscopal Effect in Murine Hepatocellular Carcinoma Hepa1-6 Models.
Pharmaceutics
Yang K,Choi C,Cho H,Ahn WG,Kim SY,Shin SW,Kim Y,Jang T,Lee N,Park HC
12-5982-82 was used in Flow Cytometry to suggest that MSNs can be applied as an adjuvant for in situ cancer vaccines with RT.
Fri Oct 29 00:00:00 EDT 2021
Antigen-Capturing Mesoporous Silica Nanoparticles Enhance the Radiation-Induced Abscopal Effect in Murine Hepatocellular Carcinoma Hepa1-6 Models.
Pharmaceutics
Yang K,Choi C,Cho H,Ahn WG,Kim SY,Shin SW,Kim Y,Jang T,Lee N,Park HC
12-5982-82 was used in Flow Cytometry to suggest that MSNs can be applied as an adjuvant for in situ cancer vaccines with RT.
Fri Oct 29 00:00:00 EDT 2021
Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors.
EMBO molecular medicine
Fan Z,Tian Y,Chen Z,Liu L,Zhou Q,He J,Coleman J,Dong C,Li N,Huang J,Xu C,Zhang Z,Gao S,Zhou P,Ding K,Chen L
12-5982 was used in Flow cytometry/Cell sorting to determine steps within PD-1 signalling pathway that can be targeted in anticancer drugs.
Mon Jun 08 00:00:00 EDT 2020
Induction of autophagy through CLEC4E in combination with TLR4: an innovative strategy to restrict the survival of Mycobacterium tuberculosis.
Autophagy
Pahari S,Negi S,Aqdas M,Arnett E,Schlesinger LS,Agrewala JN
12-5982-82 was used in Flow Cytometry to invesigate if a unique immunotherapeutic approach involving CLEC4E in conjunction with TLR4 to restrict the survival of mycobacterium tuberculosis through autophagy exists.
Mon Jun 01 00:00:00 EDT 2020
Enzalutamide, an Androgen Receptor Antagonist, Enhances Myeloid Cell-Mediated Immune Suppression and Tumor Progression.
Cancer immunology research
Consiglio CR,Udartseva O,Ramsey KD,Bush C,Gollnick SO
12-5982 was used in Flow cytometry/Cell sorting to investigate how AR antagonism affects myeloid cell function and metabolism in an AR-independent murine colon tumor model.
Tue Sep 01 00:00:00 EDT 2020
Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis.
Science signaling
Lovisa S,Fletcher-Sananikone E,Sugimoto H,Hensel J,Lahiri S,Hertig A,Taduri G,Lawson E,Dewar R,Revuelta I,Kato N,Wu CJ,Bassett RL,Putluri N,Zeisberg M,Zeisberg EM,LeBleu VS,Kalluri R
12-5982 was used in Flow cytometry/Cell sorting to demonstrate a functional role for EndMT in the response to kidney capillary endothelial injury and highlight the contribution of endothelial-epithelial cross-talk in the development of kidney fibrosis with a potential for therapeutic intervention.
Tue Jun 09 00:00:00 EDT 2020
Downregulation of PD-L1 via amide analogues of brefelamide: Alternatives to antibody-based cancer immunotherapy.
Experimental and therapeutic medicine
Zhang J,Yamada O,Kida S,Murase S,Hattori T,Oshima Y,Kikuchi H
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Genetic ablation of adipocyte PD-L1 reduces tumor growth but accentuates obesity-associated inflammation.
Journal for immunotherapy of cancer
Wu B,Chiang HC,Sun X,Yuan B,Mitra P,Hu Y,Curiel TJ,Li R
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2020
Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms.
Journal for immunotherapy of cancer
Neuwelt AJ,Kimball AK,Johnson AM,Arnold BW,Bullock BL,Kaspar RE,Kleczko EK,Kwak JW,Wu MH,Heasley LE,Doebele RC,Li HY,Nemenoff RA,Clambey ET
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy.
Journal for immunotherapy of cancer
Gao H,Wu Y,Shi J,Zhang X,Liu T,Hu B,Jia B,Wan Y,Liu Z,Wang F
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2020
Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy.
Journal for immunotherapy of cancer
Gao H,Wu Y,Shi J,Zhang X,Liu T,Hu B,Jia B,Wan Y,Liu Z,Wang F
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2020
Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.
Cell reports
Blagih J,Zani F,Chakravarty P,Hennequart M,Pilley S,Hobor S,Hock AK,Walton JB,Morton JP,Gronroos E,Mason S,Yang M,McNeish I,Swanton C,Blyth K,Vousden KH
12-5982 was used in Flow cytometry/Cell sorting to show suppressive regulatory T cells accumulate in tumour cells in the absence of p53 indicating a pathway in which cancer cells circumvent immune destruction.
Tue Jan 14 00:00:00 EST 2020
Epigenetically modulated FOXM1 suppresses dendritic cell maturation in pancreatic cancer and colon cancer.
Molecular oncology
Zhou Z,Chen H,Xie R,Wang H,Li S,Xu Q,Xu N,Cheng Q,Qian Y,Huang R,Shao Z,Xiang M
12-5982 was used in Flow cytometry/Cell sorting to show that upregulation of FOXM1 by H3K79me2 in pancreatic cancer and colon cancer significantly inhibits maturation phenotypes and function of bone marrow dendritic cells (BMDCs) through the Wnt5a signaling pathway, and thus provide novel insights into FOXM1-based antitumor immunotherapy.
Mon Apr 01 00:00:00 EDT 2019
Epigenetically modulated FOXM1 suppresses dendritic cell maturation in pancreatic cancer and colon cancer.
Molecular oncology
Zhou Z,Chen H,Xie R,Wang H,Li S,Xu Q,Xu N,Cheng Q,Qian Y,Huang R,Shao Z,Xiang M
12-5982 was used in Flow cytometry/Cell sorting to show that upregulation of FOXM1 by H3K79me2 in pancreatic cancer and colon cancer significantly inhibits maturation phenotypes and function of bone marrow dendritic cells (BMDCs) through the Wnt5a signaling pathway, and thus provide novel insights into FOXM1-based antitumor immunotherapy.
Mon Apr 01 00:00:00 EDT 2019
Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti-PD-1 response in NSCLC.
Life science alliance
Bullock BL,Kimball AK,Poczobutt JM,Neuwelt AJ,Li HY,Johnson AM,Kwak JW,Kleczko EK,Kaspar RE,Wagner EK,Hopp K,Schenk EL,Weiser-Evans MC,Clambey ET,Nemenoff RA
12-5982-82 was used in Flow Cytometry to demonstrate that targeted enhancement of tumor-intrinsic IFNγ signaling can induce a cascade of changes associated with increased therapeutic vulnerability.
Sat Jun 01 00:00:00 EDT 2019
Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors.
Immunity
Sharma MD,Rodriguez PC,Koehn BH,Baban B,Cui Y,Guo G,Shimoda M,Pacholczyk R,Shi H,Lee EJ,Xu H,Johnson TS,He Y,Mergoub T,Venable C,Bronte V,Wolchok JD,Blazar BR,Munn DH
12-5982 was used in Flow cytometry/Cell sorting to show that during immunotherapy large numbers of cells expressing CD103 arose in murine tumours via direct differentiation of Ly6c+ monocytic precursors.
Tue Jan 16 00:00:00 EST 2018
CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine.
Cell stem cell
Hirata Y,Furuhashi K,Ishii H,Li HW,Pinho S,Ding L,Robson SC,Frenette PS,Fujisaki J
12-5982-82 was used in Flow Cytometry to describe a Treg subpopulation that controls hematopoietic stem cell (HSC) quiescence and engraftment.
Thu Mar 01 00:00:00 EST 2018
Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell-Mediated Tumor Immunity.
Cancer research
Büll C,Boltje TJ,Balneger N,Weischer SM,Wassink M,van Gemst JJ,Bloemendal VR,Boon L,van der Vlag J,Heise T,den Brok MH,Adema GJ
12-5982 was used in Flow cytometry/Cell sorting to show that sialic acid sugars function as important modulators of the immunosuppressive tumor microenvironment that limit potent antitumor immunity.
Sun Jul 01 00:00:00 EDT 2018
Lenalidomide and Programmed Death-1 Blockade Synergistically Enhances the Effects of Dendritic Cell Vaccination in a Model of Murine Myeloma.
Frontiers in immunology
Vo MC,Jung SH,Chu TH,Lee HJ,Lakshmi TJ,Park HS,Kim HJ,Rhee JH,Lee JJ
12-5982 was used in Flow cytometry/Cell sorting to investigate the efficacy of dendritic cell vaccination in combination with lenalidomide and PD-1 blockade in a model of murine myeloma.
Sun Jan 03 00:00:00 EST 2021
The antitumor effects of entinostat in ovarian cancer require adaptive immunity.
Cancer
Smith HJ,McCaw TR,Londono AI,Katre AA,Meza-Perez S,Yang ES,Forero A,Buchsbaum DJ,Randall TD,Straughn JM,Norian LA,Arend RC
12-5982-82 was used in Flow Cytometry to evaluate whether entinostat treatment and resultant MHCII expression would enhance beneficial immune responses and impair tumor growth in mice with ovarian cancer.
Sat Dec 15 00:00:00 EST 2018
Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.
Nature communications
Sun C,Lan P,Han Q,Huang M,Zhang Z,Xu G,Song J,Wang J,Wei H,Zhang J,Sun R,Zhang C,Tian Z
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Wed Mar 28 00:00:00 EDT 2018
Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.
Nature communications
Sun C,Lan P,Han Q,Huang M,Zhang Z,Xu G,Song J,Wang J,Wei H,Zhang J,Sun R,Zhang C,Tian Z
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Wed Mar 28 00:00:00 EDT 2018
Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA.
Immunity
Coelho MA,de Carné Trécesson S,Rana S,Zecchin D,Moore C,Molina-Arcas M,East P,Spencer-Dene B,Nye E,Barnouin K,Snijders AP,Lai WS,Blackshear PJ,Downward J
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Tue Dec 19 00:00:00 EST 2017
Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression.
Immunity
Zhu Y,Herndon JM,Sojka DK,Kim KW,Knolhoff BL,Zuo C,Cullinan DR,Luo J,Bearden AR,Lavine KJ,Yokoyama WM,Hawkins WG,Fields RC,Randolph GJ,DeNardo DG
12-5982 was used in Flow cytometry/Cell sorting to uncover the heterogeneity of TAM origin and functions and could provide therapeutic insight for PDAC treatment.
Tue Aug 15 00:00:00 EDT 2017
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction.
Immunity
Wu J,Zhang H,Shi X,Xiao X,Fan Y,Minze LJ,Wang J,Ghobrial RM,Xia J,Sciammas R,Li XC,Chen W
12-5982-82 was used in Flow Cytometry to demonstrate that interferon regulatory factor 4 was a key transcriptional determinant controlling T cell responses during transplantation.
Tue Dec 19 00:00:00 EST 2017
Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity.
Cell metabolism
Westerterp M,Gautier EL,Ganda A,Molusky MM,Wang W,Fotakis P,Wang N,Randolph GJ,D'Agati VD,Yvan-Charvet L,Tall AR
12-5982 was used in Flow cytometry/Cell sorting to identify an essential role of DC cholesterol efflux pathways in maintaining immune tolerance.
Tue Jun 06 00:00:00 EDT 2017
Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.
Cell host & microbe
Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y
12-5982 was used in Flow cytometry/Cell sorting to demonstrate that autoreactive T-cells and chronic fungal infection, fostered by inflammation and epithelial injury, promote esophageal squamous cell carcinoma development.
Wed Apr 12 00:00:00 EDT 2017
The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2.
Molecular cell
Hartwig T,Montinaro A,von Karstedt S,Sevko A,Surinova S,Chakravarthy A,Taraborrelli L,Draber P,Lafont E,Arce Vargas F,El-Bahrawy MA,Quezada SA,Walczak H
12598282 was used in flow cytometry to test if TRAIL/TRAIL-R signaling in cancer cells alters the immune microenvironment
Thu Feb 16 00:00:00 EST 2017
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
The Journal of experimental medicine
Schwartz C,Khan AR,Floudas A,Saunders SP,Hams E,Rodewald HR,McKenzie ANJ,Fallon PG
12-5982 was used in Flow cytometry/Cell sorting to study how group 2 innate lymphoid cells regulate adaptive Th2 cell functions.
Mon Sep 04 00:00:00 EDT 2017
Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors.
Frontiers in immunology
Palsson-McDermott EM,Dyck L,Zasłona Z,Menon D,McGettrick AF,Mills KHG,O'Neill LA
12-5982 was used in Flow cytometry/Cell sorting to study how pyruvate kinase isoform M2 contributes to tumour progression.
Fri Sep 24 00:00:00 EDT 2021
Tumor-Associated Lymphatic Vessels Upregulate PDL1 to Inhibit T-Cell Activation.
Frontiers in immunology
Dieterich LC,Ikenberg K,Cetintas T,Kapaklikaya K,Hutmacher C,Detmar M
Wed Nov 20 00:00:00 EST 2019
Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells.
Journal of neuroimmunology
Benedek G,Zhang J,Nguyen H,Kent G,Seifert HA,Davin S,Stauffer P,Vandenbark AA,Karstens L,Asquith M,Offner H
Fri Sep 15 00:00:00 EDT 2017
Armored CAR T cells enhance antitumor efficacy and overcome the tumor microenvironment.
Scientific reports
Yeku OO,Purdon TJ,Koneru M,Spriggs D,Brentjens RJ
12-5982 was used in Flow cytometry/Cell sorting to develop an armoured chimeric antigen receptor T cell capable of constitutive secretion of IL-12, and delineate the mechanism by which these cells overcome a hostile tumour microenvironment.
Tue Sep 05 00:00:00 EDT 2017
Priming is key to effective incorporation of image-guided thermal ablation into immunotherapy protocols.
JCI insight
Silvestrini MT,Ingham ES,Mahakian LM,Kheirolomoom A,Liu Y,Fite BZ,Tam SM,Tucci ST,Watson KD,Wong AW,Monjazeb AM,Hubbard NE,Murphy WJ,Borowsky AD,Ferrara KW
12-5982 was used in Flow cytometry/Cell sorting to examine the importance of priming before pairing image-guided thermal ablation with immunotherapy protocols in the treatment of cancer.
Thu Mar 23 00:00:00 EDT 2017
Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission.
Immunity
Tian Y,Kuo CF,Akbari O,Ou JH
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Tue May 17 00:00:00 EDT 2016
Recruited monocytes modulate malaria-induced lung injury through CD36-mediated clearance of sequestered infected erythrocytes.
Journal of leukocyte biology
Lagassé HA,Anidi IU,Craig JM,Limjunyawong N,Poupore AK,Mitzner W,Scott AL
Sun May 01 00:00:00 EDT 2016
SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors.
Oncotarget
Xue W,Brentville VA,Symonds P,Cook KW,Yagita H,Metheringham RL,Durrant LG
12-5982 was used in Flow cytometry/Cell sorting to investigate the anti-tumour effect of a huIgG1 antibody DNA vaccine and PD-1 blockade.
Tue Dec 13 00:00:00 EST 2016
MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment.
Nature communications
Wilson R,Espinosa-Diez C,Kanner N,Chatterjee N,Ruhl R,Hipfinger C,Advani SJ,Li J,Khan OF,Franovic A,Weis SM,Kumar S,Coussens LM,Anderson DG,Chen CC,Cheresh DA,Anand S
12-5982 was used in Flow cytometry/Cell sorting to demonstrate a unique mechanism by which ectopic microRNA-103 can manipulate tumour-associated endothelial cells to enhance tumour cell death.
Fri Nov 25 00:00:00 EST 2016
Impact of myeloid-derived suppressor cell on Kupffer cells from mouse livers with hepatocellular carcinoma.
Oncoimmunology
Lacotte S,Slits F,Orci LA,Meyer J,Oldani G,Delaune V,Gonelle-Gispert C,Morel P,Toso C
12-5982 was used in Flow cytometry/Cell sorting to investigate the function of the myeloid-derived suppressor cell subsets, and their impact on Kupffer cell phenotype and function.
Tue Jan 12 00:00:00 EST 2021
Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis.
Nature immunology
Kim MS,Yan J,Wu W,Zhang G,Zhang Y,Cai D
12-5982 was used in Flow cytometry/Cell sorting to investigate the role of the brain in innate immunological signals, showing rapid linkage of innate signals and adaptive immunity by the brain-fat axis.
Fri May 01 00:00:00 EDT 2015
PD-L1 expression in melanocytic lesions does not correlate with the BRAF V600E mutation.
Cancer immunology research
Rodić N,Anders RA,Eshleman JR,Lin MT,Xu H,Kim JH,Beierl K,Chen S,Luber BS,Wang H,Topalian SL,Pardoll DM,Taube JM
12-5982 was used in Flow cytometry/Cell sorting to phenotypically assess melanocytic lesions for multiple traits to identify possible interactions and correlations.
Sun Feb 01 00:00:00 EST 2015
Haploinsufficiency for Stard7 is associated with enhanced allergic responses in lung and skin.
Journal of immunology (Baltimore, Md. : 1950)
Yang L,Lewkowich I,Apsley K,Fritz JM,Wills-Karp M,Weaver TE
12-5982 was used in Flow cytometry/Cell sorting to determine whether loss of Stard7 expression promotes allergic responses, showing that haploinsufficiency for Stard7 is associated with enhanced allergic responses.
Mon Jun 15 00:00:00 EDT 2015
TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses.
Nature communications
Okamura T,Sumitomo S,Morita K,Iwasaki Y,Inoue M,Nakachi S,Komai T,Shoda H,Miyazaki J,Fujio K,Yamamoto K
12-5982 was used in Flow cytometry/Cell sorting to investigate the role of GF-β3-expressing CD4+CD25(-)LAG3+ Tregs in humoral immune responses.
Thu Feb 19 00:00:00 EST 2015
Lignin-rich enzyme lignin (LREL), a cellulase-treated lignin-carbohydrate derived from plants, activates myeloid dendritic cells via Toll-like receptor 4 (TLR4).
The Journal of biological chemistry
Tsuji R,Koizumi H,Aoki D,Watanabe Y,Sugihara Y,Matsushita Y,Fukushima K,Fujiwara D
12-5982 was used in Flow cytometry/Cell sorting to investigate the role of lignin-rich enzyme lignin in dendritic cells.
Fri Feb 13 00:00:00 EST 2015
HIV-1 Tat protein induces PD-L1 (B7-H1) expression on dendritic cells through tumor necrosis factor alpha- and toll-like receptor 4-mediated mechanisms.
Journal of virology
Planès R,BenMohamed L,Leghmari K,Delobel P,Izopet J,Bahraoui E
12-5982 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which HIV-1 induces upregulation of coinhibitory molecules, showing that the HIV-1 Tat protein induces PD-L1 expression on dendritic cells.
Sun Jun 01 00:00:00 EDT 2014
Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness.
Laboratory investigation; a journal of technical methods and pathology
Wang Y,Jin TH,Farhana A,Freeman J,Estell K,Zmijewski JW,Gaggar A,Thannickal VJ,Schwiebert LM,Steyn AJ,Deshane JS
12-5982 was used in Flow cytometry/Cell sorting to assess the effects of exposing myeloid-derived regulatory cells to cigarette smoke on the production of nitric oxide.
Mon Dec 01 00:00:00 EST 2014
The NF-κB regulator Bcl-3 governs dendritic cell antigen presentation functions in adaptive immunity.
Journal of immunology (Baltimore, Md. : 1950)
Tassi I,Claudio E,Wang H,Tang W,Ha HL,Saret S,Ramaswamy M,Siegel R,Siebenlist U
12-5982 was used in Flow cytometry/Cell sorting to study the role of Bcl-3 in dendritic cell survival and the generation of adaptive immunity.
Sat Nov 01 00:00:00 EDT 2014
Oxidized lipids block antigen cross-presentation by dendritic cells in cancer.
Journal of immunology (Baltimore, Md. : 1950)
Ramakrishnan R,Tyurin VA,Veglia F,Condamine T,Amoscato A,Mohammadyani D,Johnson JJ,Zhang LM,Klein-Seetharaman J,Celis E,Kagan VE,Gabrilovich DI
12-5982 was used in Flow cytometry/Cell sorting to reveal a novel role for oxidised lipids in the regulation of cross-presentation.
Sat Mar 15 00:00:00 EDT 2014
Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease.
Virology
Wolf AI,Strauman MC,Mozdzanowska K,Williams KL,Osborne LC,Shen H,Liu Q,Garlick D,Artis D,Hensley SE,Caton AJ,Weiser JN,Erikson J
12-5982-82 was used in Flow Cytometry to investigate severity of influenza virus response with respiratory microbe presence.
Fri Aug 01 00:00:00 EDT 2014
Differential potency of regulatory T cell-mediated immunosuppression in kidney tumors compared to subcutaneous tumors.
Oncoimmunology
Devaud C,Westwood JA,Teng MW,John LB,Yong CS,Duong CP,Smyth MJ,Darcy PK,Kershaw MH
12-5982 was used in Flow cytometry/Cell sorting to provide insights into the immunosuppressive nature of the immune response generated in the kidney microenvironment.
Sat Nov 01 00:00:00 EDT 2014
Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs.
Journal of translational medicine
Lu L,Xu X,Zhang B,Zhang R,Ji H,Wang X
12-5982 was used in Flow cytometry/Cell sorting to evaluate the antitumor effects and mechanisms of combined PD-1 blockade and GITR triggering in a murine ID8 ovarian cancer model.
Fri Feb 07 00:00:00 EST 2014
Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity.
Molecular therapy. Nucleic acids
Dolina JS,Sung SS,Novobrantseva TI,Nguyen TM,Hahn YS
12-5982 was used in Flow cytometry/Cell sorting to demonstrate that PD-L1 knockdown on KCs is central in determining the outcome of liver viral infections, and they represent a new class of gene therapy.
Tue Feb 19 00:00:00 EST 2013
PD-L1 expression by neurons nearby tumors indicates better prognosis in glioblastoma patients.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Liu Y,Carlsson R,Ambjørn M,Hasan M,Badn W,Darabi A,Siesjö P,Issazadeh-Navikas S
12-5982 was used in Flow cytometry/Cell sorting to study the relationship between program death-ligand expression and clinical outcome in glioblastoma multiforme patients.
Wed Aug 28 00:00:00 EDT 2013
Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1.
Journal of leukocyte biology
Hutchins NA,Wang F,Wang Y,Chung CS,Ayala A
12-5982 was used in Flow cytometry/Cell sorting to study Kupffer cell-mediated potentiation of liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1.
Fri Nov 01 00:00:00 EDT 2013
PD-L1/B7-H1 regulates the survival but not the function of CD8+ T cells in herpes simplex virus type 1 latently infected trigeminal ganglia.
Journal of immunology (Baltimore, Md. : 1950)
Jeon S,St Leger AJ,Cherpes TL,Sheridan BS,Hendricks RL
12-5982 was used in Flow cytometry/Cell sorting to investigate the role of PD-L1/B7-H1 in herpes simplex virus type 1 infection, showing it regulates survival but not the function of CD8+ T cells.
Sat Jun 15 00:00:00 EDT 2013
Human and mouse macrophages collaborate with neutrophils to kill larval Strongyloides stercoralis.
Infection and immunity
Bonne-Année S,Kerepesi LA,Hess JA,O'Connell AE,Lok JB,Nolan TJ,Abraham D
12-5982 was used in Flow cytometry/Cell sorting to demonstrate a novel function by which alternatively activated macrophages control large extracellular parasites.
Sun Sep 01 00:00:00 EDT 2013
Thymic stromal lymphopoietin attenuates the development of atherosclerosis in ApoE-/- mice.
Journal of the American Heart Association
Yu K,Zhu P,Dong Q,Zhong Y,Zhu Z,Lin Y,Huang Y,Meng K,Ji Q,Yi G,Zhang W,Wu B,Mao Y,Cheng P,Zhao X,Mao X,Zeng Q
12-5982 was used in Flow cytometry/Cell sorting to examine the phenotype of TSLP-conditioned bone marrow dendritic cells of apolipoprotein E-deficient mice and their capacity to induce the differentiation of Tregs.
Wed Aug 28 00:00:00 EDT 2013
Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis.
Nature biotechnology
Getts DR,Martin AJ,McCarthy DP,Terry RL,Hunter ZN,Yap WT,Getts MT,Pleiss M,Luo X,King NJ,Shea LD,Miller SD
12-5982 was used in Flow cytometry/Cell sorting to highlight the potential for using microparticles to target natural apoptotic clearance pathways to inactivate pathogenic T cells in autoimmunity.
Sat Dec 01 00:00:00 EST 2012
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.
The Journal of experimental medicine
Yokosuka T,Takamatsu M,Kobayashi-Imanishi W,Hashimoto-Tane A,Azuma M,Saito T
12-5982 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms of PD-1-mediated suppression of T cell activation, showing that it inhibits T cell receptor signalling via SHP2.
Mon Jun 04 00:00:00 EDT 2012
Mechanisms of indirect acute lung injury: a novel role for the coinhibitory receptor, programmed death-1.
Annals of surgery
Monaghan SF,Thakkar RK,Heffernan DS,Huang X,Chung CS,Lomas-Neira J,Cioffi WG,Ayala A
12-5982 was used in Flow cytometry/Cell sorting to investigate how PD-1 expression contributes to mortality after the induction of indirect-acute lung injury.
Sun Jan 01 00:00:00 EST 2012
Nonviral delivery of small interfering RNA into pancreas-associated immune cells prevents autoimmune diabetes.
Molecular therapy : the journal of the American Society of Gene Therapy
Leconet W,Petit P,Peraldi-Roux S,Bresson D
12-5982 was used in Flow cytometry/Cell sorting to provide new insights into the development of siRNA-based therapeutics for the treatment of T1D.
Sat Dec 01 00:00:00 EST 2012
Regulatory T cells stimulate B7-H1 expression in myeloid-derived suppressor cells in ret melanomas.
The Journal of investigative dermatology
Fujimura T,Ring S,Umansky V,Mahnke K,Enk AH
12-5982 was used in Flow cytometry/Cell sorting to suggest the existence of a cross-talk between regulatory T-cells and myeloid-derived suppressor cells.
Sun Apr 01 00:00:00 EDT 2012
OX40 ligand and programmed cell death 1 ligand 2 expression on inflammatory dendritic cells regulates CD4 T cell cytokine production in the lung during viral disease.
Journal of immunology (Baltimore, Md. : 1950)
Wythe SE,Dodd JS,Openshaw PJ,Schwarze J
12-5982 was used in Flow cytometry/Cell sorting to study the regulation of CD4 T cell cytokine release during viral lung disease, by OX40 and PD-L2 expression on inflammatory dendritic cells.
Wed Feb 15 00:00:00 EST 2012
Midkine inhibits inducible regulatory T cell differentiation by suppressing the development of tolerogenic dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Sonobe Y,Li H,Jin S,Kishida S,Kadomatsu K,Takeuchi H,Mizuno T,Suzumura A
12-5982 was used in Flow cytometry/Cell sorting to suggest that midkine aggravates experimental autoimmune encephalomyelitis by suppressing tolerogenic dendritic cell development, thereby impairing regulatory T-cell differentiation.
Thu Mar 15 00:00:00 EDT 2012
Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function.
European journal of microbiology & immunology
Autengruber A,Gereke M,Hansen G,Hennig C,Bruder D
12-5982 was used in Flow cytometry/Cell sorting to indicate that enzymatic tissue disintegration can have profound effects on the expression of a variety of cell-surface molecules.
Fri Jun 01 00:00:00 EDT 2012
Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation.
Cell stem cell
Zheng J,Umikawa M,Zhang S,Huynh H,Silvany R,Chen BP,Chen L,Zhang CC
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Fri Aug 05 00:00:00 EDT 2011
Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance.
The Journal of pharmacology and experimental therapeutics
Yang W,Yamada M,Tamura Y,Chang K,Mao J,Zou L,Feng Y,Kida K,Scherrer-Crosbie M,Chao W,Ichinose F,Yu YM,Fischman AJ,Tompkins RG,Yao S,Kaneki M
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 12-5982-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2011
The expression of PD-1 ligands and their involvement in regulation of T cell functions in acute and chronic woodchuck hepatitis virus infection.
PloS one
Zhang E,Zhang X,Liu J,Wang B,Tian Y,Kosinska AD,Ma Z,Xu Y,Dittmer U,Roggendorf M,Yang D,Lu M
12-5982 was used in Flow cytometry/Cell sorting to demonstrate that wPD-1/wPD-L1 expression in hepatocytes and PBMCs can be induced by different inflammatory stimuli and is up-regulated mainly on PBMCs during WHV infection.
Fri Feb 17 00:00:00 EST 2012
PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction.
Critical care (London, England)
Zhang Y,Zhou Y,Lou J,Li J,Bo L,Zhu K,Wan X,Deng X,Cai Z
12-5982 was used in Flow cytometry/Cell sorting to investigate the function and mechanism of action of PD-L1 in experimental sepsis in mice.
Thu Jan 26 00:00:00 EST 2012
Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway.
Aging cell
Lages CS,Lewkowich I,Sproles A,Wills-Karp M,Chougnet C
12-5982 was used in Flow cytometry/Cell sorting to suggest that blockade of the PD-1/PD-L1 is not likely to be efficient at restoring exhausted T-cell responses in aged hosts.
Fri Oct 01 00:00:00 EDT 2010
PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions.
Mucosal immunology
Akbari O,Stock P,Singh AK,Lombardi V,Lee WL,Freeman GJ,Sharpe AH,Umetsu DT,Dekruyff RH
12-5982 was used in Flow cytometry/Cell sorting to investigate the roles of PD-L1 and PD-L2 in regulating invariant natural killer T cell mediated airway hyperreactivity in a mouse model of asthma.
Fri Jan 01 00:00:00 EST 2010
Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis.
Journal of immunology (Baltimore, Md. : 1950)
Ishiwata K,Watanabe N,Guo M,Tomihara K,Brumlik MJ,Yagita H,Pardoll D,Chen L,Shin T
12-5982 was used in Flow cytometry/Cell sorting to demonstrate that the inhibition of Th2 responses by B7-DC occurs independently of programmed death 1 but conceivably acts through an as yet unknown alternative receptor that enhances Th1 responses.
Mon Feb 15 00:00:00 EST 2010
Antigen-specific immunity and cross-priming by epithelial ovarian carcinoma-induced CD11b(+)Gr-1(+) cells.
Journal of immunology (Baltimore, Md. : 1950)
Tomihara K,Guo M,Shin T,Sun X,Ludwig SM,Brumlik MJ,Zhang B,Curiel TJ,Shin T
12-5982 was used in Flow cytometry/Cell sorting to investigate CD11b(+)Gr-1(+) cells found in epithelial ovarian cancer-bearing mice, which are induced by ovarian cancer cells and undergo antigen-specific immunity and cross-priming.
Tue Jun 01 00:00:00 EDT 2010
The herbal medicine compound falcarindiol from Notopterygii Rhizoma suppresses dendritic cell maturation.
The Journal of pharmacology and experimental therapeutics
Mitsui S,Torii K,Fukui H,Tsujimura K,Maeda A,Nose M,Nagatsu A,Mizukami H,Morita A
12-5982 was used in Flow cytometry/Cell sorting to study the effects of falcarindiol on dendritic cell function.
Tue Jun 01 00:00:00 EDT 2010
CD4 T-cell suppression by cells from Toxoplasma gondii-infected retinas is mediated by surface protein PD-L1.
Infection and immunity
Charles E,Joshi S,Ash JD,Fox BA,Farris AD,Bzik DJ,Lang ML,Blader IJ
12-5982 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which the retina protects itself from CD4 T-cell-mediated immune damage in retinal immune responses.
Sun Aug 01 00:00:00 EDT 2010
PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model.
Blood
Zhang L,Gajewski TF,Kline J
12-5982 was used in Flow cytometry/Cell sorting to indicate the importance of the PD-1/PD-L1 pathway in immune evasion by a hematologic malignancy, providing a rationale for clinical trials targeting this pathway in leukemia patients.
Thu Aug 20 00:00:00 EDT 2009
The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies.
Cancer research
Ozao-Choy J,Ma G,Kao J,Wang GX,Meseck M,Sung M,Schwartz M,Divino CM,Pan PY,Chen SH
12-5982 was used in Flow cytometry/Cell sorting to suggest that sunitinib can be used to reverse immune suppression and as a potentially useful adjunct for enhancing the efficacy of immune-based cancer therapy for advanced malignancies.
Sun Mar 15 00:00:00 EDT 2009
Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70.
Journal of immunology (Baltimore, Md. : 1950)
Zietara N,Łyszkiewicz M,Gekara N,Puchałka J,Dos Santos VA,Hunt CR,Pandita TK,Lienenklaus S,Weiss S
12-5982 was used in Flow cytometry/Cell sorting to investigate the role of low level production of IFN, showing that its absence impairs antigen presentation capacity of splenic dendritic cells.
Wed Jul 15 00:00:00 EDT 2009
Maternal PD-1 regulates accumulation of fetal antigen-specific CD8+ T cells in pregnancy.
Journal of reproductive immunology
Taglauer ES,Yankee TM,Petroff MG
12-5982 was used in Flow cytometry/Cell sorting to investigate the role of the PD-1/B7-H1 pathway in maternal tolerance of the fetus.
Mon Jun 01 00:00:00 EDT 2009
Allostimulatory activity of bone marrow-derived plasmacytoid dendritic cells is independent of indoleamine dioxygenase but regulated by inducible costimulator ligand expression.
Human immunology
Colvin BL,Sumpter TL,Tokita D,Salati J,Mellor AL,Thomson AW
12-5982 was used in Flow cytometry/Cell sorting to implicate inducible costimulator ligand-induced IL-10 in the regulation of bone marrow-derived plasmacytoid dendritic cell function.
Fri May 01 00:00:00 EDT 2009
A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1.
Cell research
Sheng H,Wang Y,Jin Y,Zhang Q,Zhang Y,Wang L,Shen B,Yin S,Liu W,Cui L,Li N
Fri Aug 01 00:00:00 EDT 2008
Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity.
Blood
Movahedi K,Guilliams M,Van den Bossche J,Van den Bergh R,Gysemans C,Beschin A,De Baetselier P,Van Ginderachter JA
12-5982 was used in Flow cytometry/Cell sorting to identify 2 distinct MDSC subfractions with clear morphologic, molecular, and functional differences.
Tue Apr 15 00:00:00 EDT 2008
Neo-organoid of marrow mesenchymal stromal cells secreting interleukin-12 for breast cancer therapy.
Cancer research
Eliopoulos N,Francois M,Boivin MN,Martineau D,Galipeau J
12-5982 was used in Flow cytometry/Cell sorting to establish the feasibility of using gene-enhanced MSCs in a cell-based neo-organoid approach for cancer treatment.
Sun Jun 15 00:00:00 EDT 2008
Dynamics of lung macrophage activation in response to helminth infection.
Journal of leukocyte biology
Siracusa MC,Reece JJ,Urban JF,Scott AL
12-5982 was used in Flow cytometry/Cell sorting to study the dynamics of lung macrophage activation in response to helminth infection.
Mon Dec 01 00:00:00 EST 2008
Blockade of PD-1/B7-H1 interaction restores effector CD8+ T cell responses in a hepatitis C virus core murine model.
Journal of immunology (Baltimore, Md. : 1950)
Lukens JR,Cruise MW,Lassen MG,Hahn YS
12-5982 was used in Flow cytometry/Cell sorting to study the blockade of PD-1/B7-H1 interaction to restore effector CD8+ T cell responses in a hepatitis C virus core murine model.
Tue Apr 01 00:00:00 EDT 2008
Mast cells are crucial for early inflammation, migration of Langerhans cells, and CTL responses following topical application of TLR7 ligand in mice.
Blood
Heib V,Becker M,Warger T,Rechtsteiner G,Tertilt C,Klein M,Bopp T,Taube C,Schild H,Schmitt E,Stassen M
12-5982 was used in Flow cytometry/Cell sorting to demonstrate the potent versatility of alternatively activated mast cells at the interface of innate and adaptive immunity.
Wed Aug 01 00:00:00 EDT 2007
Ethanol affects the generation, cosignaling molecule expression, and function of plasmacytoid and myeloid dendritic cell subsets in vitro and in vivo.
Journal of leukocyte biology
Lau AH,Abe M,Thomson AW
12-5982 was used in Flow cytometry/Cell sorting to show results that indicate a potential mechanism by which alcohol consumption is associated with immunosuppression.
Mon May 01 00:00:00 EDT 2006
Migratory Langerhans cells in mouse lymph nodes in steady state and inflammation.
The Journal of investigative dermatology
Stoitzner P,Tripp CH,Douillard P,Saeland S,Romani N
12-5982 was used in Flow cytometry/Cell sorting to determine that the overall phenotype of Langerhans cells is not an indicator for their immunogenic or tolerogenic potential.
Fri Jul 01 00:00:00 EDT 2005
Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen.
The Journal of experimental medicine
de Heer HJ,Hammad H,Soullié T,Hijdra D,Vos N,Willart MA,Hoogsteden HC,Lambrecht BN
12-5982 was used in Flow cytometry/Cell sorting to investigate the role of lung plasmacytoid dendritic cells in atopic asthma.
Mon Jul 05 00:00:00 EDT 2004
