Product References
Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria.
The Journal of experimental medicine
Melo-Gonzalez F,Kammoun H,Evren E,Dutton EE,Papadopoulou M,Bradford BM,Tanes C,Fardus-Reid F,Swann JR,Bittinger K,Mabbott NA,Vallance BA,Willinger T,Withers DR,Hepworth MR
16-5874-81 was used in Flow Cytometry to study the mechanisms that modulate the magnitude and quality of T cell-dependent IgA responses.
Mon Apr 01 00:00:00 EDT 2019
The Imbalance of FOXP3/GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients.
Journal of immunology research
Chen T,Hou X,Ni Y,Du W,Han H,Yu Y,Shi G
16-5874 was used in Flow cytometry/Cell sorting to study the impaired immunosupression function in asthmatic patients in regard to T cell phenotype.
Wed Nov 14 00:00:00 EST 2018
The transcription factor musculin promotes the unidirectional development of peripheral Treg cells by suppressing the TH2 transcriptional program.
Nature immunology
Wu C,Chen Z,Dardalhon V,Xiao S,Thalhamer T,Liao M,Madi A,Franca RF,Han T,Oukka M,Kuchroo V
16-5874 was used in Flow cytometry/Cell sorting to identify the TF Musculin (MSC) as critical for iTreg development by repression of TH2 transcriptional program, using Transforming growth factor-β (TGF-β) induced regulatory T cell (iTreg) system.
Wed Mar 01 00:00:00 EST 2017
Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling.
The Journal of clinical investigation
Ansa-Addo EA,Zhang Y,Yang Y,Hussey GS,Howley BV,Salem M,Riesenberg B,Sun S,Rockey DC,Karvar S,Howe PH,Liu B,Li Z
16-5874 was used in Flow cytometry/Cell sorting to investigate whether moesin plays a role during the generation of TGF-β-induced Tregs, showing that it controls Treg differentiation and antitumor immunity.
Mon Apr 03 00:00:00 EDT 2017
Intratumoral delivery of tumor antigen-loaded DC and tumor-primed CD4+ T cells combined with agonist α-GITR mAb promotes durable CD8+ T-cell-dependent antitumor immunity.
Oncoimmunology
Liu Z,Hao X,Zhang Y,Zhang J,Carey CD,Falo LD,Storkus WJ,You Z
16-5874 was used in a functional assay to develop novel therapeutic strategies that can transform the tumour microenvironment into a pro-inflammatory niche that recruits and sustains protective immune cell populations.
Tue Jan 12 00:00:00 EST 2021
Regulatory T Cells Control Th2-Dominant Murine Autoimmune Gastritis.
Journal of immunology (Baltimore, Md. : 1950)
Harakal J,Rival C,Qiao H,Tung KS
16-5874-81 was used in Flow Cytometry to suggest that Tregs maintain physiological tolerance to clinically relevant gastric autoantigens, and Th2 responses can be a pathogenic mechanism in AIG.
Fri Jul 01 00:00:00 EDT 2016
Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.
The Journal of biological chemistry
Li X,Acuff NV,Peeks AR,Kirkland R,Wyatt KD,Nagy T,Watford WT
16-5874-81 was used in Flow Cytometry to demonstrate that the serine/threonine kinase tumour progression locus 2 constrains the development of inducible regulatory T cells.
Fri Aug 05 00:00:00 EDT 2016
Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance.
Journal of immunology (Baltimore, Md. : 1950)
O'Hagan KL,Choi J,Pryshchep O,Chernoff J,Phee H
16-5874 was used in Flow cytometry/Cell sorting to show a novel role for the actin cytoskeletal remodeling protein, p21-activated kinase 2, in Treg development and homeostasis.
Sat Aug 15 00:00:00 EDT 2015
Regulatory T cells require TCR signaling for their suppressive function.
Journal of immunology (Baltimore, Md. : 1950)
Schmidt AM,Lu W,Sindhava VJ,Huang Y,Burkhardt JK,Yang E,Riese MJ,Maltzman JS,Jordan MS,Kambayashi T
16-5874 was used in in vivo experiments to reveal that T cell receptor-mediated PLCγ activation is required for Tregs to inhibit Tconv proliferation.
Fri May 01 00:00:00 EDT 2015
Cellular size as a means of tracking mTOR activity and cell fate of CD4+ T cells upon antigen recognition.
PloS one
Pollizzi KN,Waickman AT,Patel CH,Sun IH,Powell JD
16-5874 was used in Flow cytometry/Cell sorting to characterise the metabolism and immunologic functions of distinct clonal populations of activated T cells.
Fri Mar 25 00:00:00 EDT 2016
Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.
Nature immunology
Mahmud SA,Manlove LS,Schmitz HM,Xing Y,Wang Y,Owen DL,Schenkel JM,Boomer JS,Green JM,Yagita H,Chi H,Hogquist KA,Farrar MA
16-5874 was used in Flow cytometry/Cell sorting to study the role of TNF receptors in the thymic development of Treg cells..
Thu May 01 00:00:00 EDT 2014
The acute phase of Trypanosoma cruzi infection is attenuated in 5-lipoxygenase-deficient mice.
Mediators of inflammation
Canavaci AM,Sorgi CA,Martins VP,Morais FR,de Sousa ÉV,Trindade BC,Cunha FQ,Rossi MA,Aronoff DM,Faccioli LH,Nomizo A
16-5874 was used in Flow cytometry/Cell sorting to provide evidence that 5-lipoxygenase-derived mediators negatively affect host survival during the acute phase of T. cruzi infection.
Fri May 15 00:00:00 EDT 2015
In vitro induced regulatory T cells are unique from endogenous regulatory T cells and effective at suppressing late stages of ongoing autoimmunity.
PloS one
Nguyen TL,Makhlouf NT,Anthony BA,Teague RM,DiPaolo RJ
16-5874 was used in Flow cytometry/Cell sorting to evaluate the ability of TGF-β-induced Tregs specific for the major self-antigen in autoimmune gastritis to suppress the established disease.
Mon May 11 00:00:00 EDT 2015
Diacylglycerol kinase ζ limits the generation of natural regulatory T cells.
Science signaling
Schmidt AM,Zou T,Joshi RP,Leichner TM,Pimentel MA,Sommers CL,Kambayashi T
16-5874 was used in Flow cytometry/Cell sorting to identify critical signal events in nT(reg) cell development, showing that diacylglycerol kinase ζ limits the generation of nT(reg) cells.
Tue Nov 26 00:00:00 EST 2013
Comparison of induced versus natural regulatory T cells of the same TCR specificity for induction of tolerance to an environmental antigen.
Journal of immunology (Baltimore, Md. : 1950)
Huang H,Ma Y,Dawicki W,Zhang X,Gordon JR
16-5874 was used in Flow cytometry/Cell sorting to compare abilities of nTreg and iTreg cells to mediate tolerance in OVA-asthmatic C57BL/6 mice.
Thu Aug 01 00:00:00 EDT 2013
Alterations of peripheral CD4+CD25+Foxp3+ T regulatory cells in mice with STZ-induced diabetes.
Cellular & molecular immunology
Zhen Y,Sun L,Liu H,Duan K,Zeng C,Zhang L,Jin D,Peng J,Ding W,Zhao Y
16-5874 was used in Flow cytometry/Cell sorting to investigate the effect of hyperglycemia on CD4+CD25+Tregs, showing alterations of peripheral CD4+CD25+Foxp3+ Tregs in STZ-induced diabetes.
Sun Jan 01 00:00:00 EST 2012
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
The Journal of experimental medicine
Billiard F,Lobry C,Darrasse-Jèze G,Waite J,Liu X,Mouquet H,DaNave A,Tait M,Idoyaga J,Leboeuf M,Kyratsous CA,Burton J,Kalter J,Klinakis A,Zhang W,Thurston G,Merad M,Steinman RM,Murphy AJ,Yancopoulos GD,Aifantis I,Skokos D
16-5874 was used in Flow cytometry/Cell sorting to investigate how Dll4-Notch signaling affects pro-T cell fate and thymic DC development, showing that it is a novel Flt3-independent pathway for DC development and autoimmunity.
Mon May 07 00:00:00 EDT 2012
Glucocorticoid-induced TNF receptor-triggered T cells are key modulators for survival/death of neural stem/progenitor cells induced by ischemic stroke.
Cell death and differentiation
Takata M,Nakagomi T,Kashiwamura S,Nakano-Doi A,Saino O,Nakagomi N,Okamura H,Mimura O,Taguchi A,Matsuyama T
16-5874 was used in Flow cytometry/Cell sorting to elucidate the mechanisms underlying the modulation of neurogenesis by CD4(+)T cells after stroke.
Tue May 01 00:00:00 EDT 2012
Controlled release formulations of IL-2, TGF-β1 and rapamycin for the induction of regulatory T cells.
Journal of controlled release : official journal of the Controlled Release Society
Jhunjhunwala S,Balmert SC,Raimondi G,Dons E,Nichols EE,Thomson AW,Little SR
16-5874 was used in Flow cytometry/Cell sorting to investigate alternative strategies to achieve an in situ increase in regulatory T cell abundance.
Tue Apr 10 00:00:00 EDT 2012
HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo.
PLoS pathogens
Satou Y,Yasunaga J,Zhao T,Yoshida M,Miyazato P,Takai K,Shimizu K,Ohshima K,Green PL,Ohkura N,Yamaguchi T,Ono M,Sakaguchi S,Matsuoka M
16-5874 was used in Western Blotting to investigate the effect of expression of HTLV-1 bZIP factor in CD4+ T cells.
Thu Feb 10 00:00:00 EST 2011
Reduced Treg frequency in LFA-1-deficient mice allows enhanced T effector differentiation and pathology in EAE.
European journal of immunology
Gültner S,Kuhlmann T,Hesse A,Weber JP,Riemer C,Baier M,Hutloff A
16-5874 was used in Flow cytometry/Cell sorting to suggest a substantial role of LFA-1 in Treg generation and subsequent expansion of effector T cells and highlight the importance of Treg in limiting EAE.
Wed Dec 01 00:00:00 EST 2010
Expression of costimulatory TNFR2 induces resistance of CD4+FoxP3- conventional T cells to suppression by CD4+FoxP3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Chen X,Hamano R,Subleski JJ,Hurwitz AA,Howard OM,Oppenheim JJ
16-5874 was used in Flow cytometry/Cell sorting to investigate the role of TNFR2 signalling in the function of conventional T cells.
Thu Jul 01 00:00:00 EDT 2010
GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo.
Journal of immunology (Baltimore, Md. : 1950)
van Olffen RW,Koning N,van Gisbergen KP,Wensveen FM,Hoek RM,Boon L,Hamann J,van Lier RA,Nolte MA
16-5874 was used in Flow cytometry/Cell sorting to study the role of glucocorticoid-induced TNF receptor family-related protein on activated and regulatory T cells.
Mon Jun 15 00:00:00 EDT 2009
Functional characterization and gene expression analysis of CD4+ CD25+ regulatory T cells generated in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Journal of immunology (Baltimore, Md. : 1950)
Marshall NB,Vorachek WR,Steppan LB,Mourich DV,Kerkvliet NI
16-5874 was used in Flow cytometry/Cell sorting to further characterise TCDD-CD4(+) cells by comparison with CD4(+) T-regs and vehicle-treated cells.
Fri Aug 15 00:00:00 EDT 2008
Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950)
Chen X,Subleski JJ,Kopf H,Howard OM,Männel DN,Oppenheim JJ
16-5874 was used in Flow cytometry/Cell sorting to characterise the phenotype and function of TNFR2(+) Tregs in peripheral lymphoid tissues, showing that expression defines a suppressive subset of Tregs that accumulate intratumourally.
Thu May 15 00:00:00 EDT 2008
Activation of tumor-specific CD8+ T Cells after intratumoral Ad5-TRAIL/CpG oligodeoxynucleotide combination therapy.
Cancer research
VanOosten RL,Griffith TS
16-5874 was used in in vivo experiments to show that local treatment with Ad5-mTRAIL and CpG ODN can augment tumor antigen cross-presentation.
Sat Dec 15 00:00:00 EST 2007
