Product References
Gammaherpesvirus-mediated repression reveals EWSR1 to be a negative regulator of B cell responses.
Proceedings of the National Academy of Sciences of the United States of America
Wang Y,Feswick A,Apostolou V,Petkov PM,Moser EK,Tibbetts SA
Published figure using CD93 (AA4.1) monoclonal antibody (Product # 12-5892-82) in Flow Cytometry
Tue Aug 09 00:00:00 EDT 2022
Hyper-metabolic B cells in the spleens of old mice make antibodies with autoimmune specificities.
Immunity & ageing : I & A
Frasca D,Romero M,Garcia D,Diaz A,Blomberg BB
Published figure using CD93 (AA4.1) monoclonal antibody (Product # 12-5892-82) in Flow Cytometry
Sat Feb 27 00:00:00 EST 2021
Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production.
The Journal of experimental medicine
Lau A,Avery DT,Jackson K,Lenthall H,Volpi S,Brigden H,Russell AJ,Bier J,Reed JH,Smart JM,Cole T,Choo S,Gray PE,Berglund LJ,Hsu P,Wong M,O'Sullivan M,Boztug K,Meyts I,Uzel G,Notarangelo LD,Brink R,Goodnow CC,Tangye SG,Deenick EK
Published figure using CD93 (AA4.1) monoclonal antibody (Product # 12-5892-82) in Flow Cytometry
Mon Feb 03 00:00:00 EST 2020
Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production.
The Journal of experimental medicine
Lau A,Avery DT,Jackson K,Lenthall H,Volpi S,Brigden H,Russell AJ,Bier J,Reed JH,Smart JM,Cole T,Choo S,Gray PE,Berglund LJ,Hsu P,Wong M,O'Sullivan M,Boztug K,Meyts I,Uzel G,Notarangelo LD,Brink R,Goodnow CC,Tangye SG,Deenick EK
Published figure using CD93 (AA4.1) monoclonal antibody (Product # 12-5892-82) in Flow Cytometry
Mon Feb 03 00:00:00 EST 2020
Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models.
Proceedings of the National Academy of Sciences of the United States of America
Tian M,McGovern K,Cheng HL,Waddicor P,Rieble L,Dao M,Chen Y,Kimble MT,Cantor E,Manfredonia N,Judson R,Chapdelaine-Williams A,Cain DW,Haynes BF,Alt FW
12-5892 was used in Flow cytometry/Cell sorting to develop a new approach to test a vaccine which circumvents B cell developmental blocks.
Tue Apr 07 00:00:00 EDT 2020
Transformation of Accessible Chromatin and 3D Nucleome Underlies Lineage Commitment of Early T Cells.
Immunity
Hu G,Cui K,Fang D,Hirose S,Wang X,Wangsa D,Jin W,Ried T,Liu P,Zhu J,Rothenberg EV,Zhao K
12-5892 was used in Flow cytometry/Cell sorting to find that abrupt genome-wide changes at all three levels of chromatin organization occur during the transition from double-negative stage 2 (DN2) to DN3, accompanying the T lineage commitment.
Tue Feb 20 00:00:00 EST 2018
A protocol for generating induced T cells by reprogramming B cells in vivo.
Cell regeneration (London, England)
Weng Q,Hu F,Zhang M,Dong Y,Lv C,Wang Y,Liu X,Wang J
Published figure using CD93 (AA4.1) monoclonal antibody (Product # 12-5892-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants.
Clinical and translational gastroenterology
Kattah MG,Milush JM,Burt T,McCabe RP,Whang MI,Ma A,Mahadevan U
12-5892 was used in Flow cytometry/Cell sorting to hypothesize that the increased risk of infection is due to abnormal development of the newborn immune system.
Tue Apr 03 00:00:00 EDT 2018
The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining.
Nature communications
Li C,Irrazabal T,So CC,Berru M,Du L,Lam E,Ling AK,Gommerman JL,Pan-Hammarström Q,Martin A
12-5892 was used in Flow cytometry/Cell sorting to show that Usp22 is the first deubiquitinase reported to regulate both V(D)J recombination and CSR in vivo by facilitating c-NHEJ.
Thu Mar 08 00:00:00 EST 2018
Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development.
Scientific reports
Tsiantoulas D,Kiss M,Bartolini-Gritti B,Bergthaler A,Mallat Z,Jumaa H,Binder CJ
12-5892 was used in Flow cytometry/Cell sorting to identify secreted IgM as negative regulators of BCR signalling and suggest that they can act as decoy receptors for self-antigens that are recognised by membrane bound BCRs.
Wed Jun 14 00:00:00 EDT 2017
Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function.
Journal of immunology (Baltimore, Md. : 1950)
Levit-Zerdoun E,Becker M,Pohlmeyer R,Wilhelm I,Maity PC,Rajewsky K,Reth M,Hobeika E
12-5892 was used in Flow cytometry/Cell sorting to assess the importance of the expression of a functional B-cell receptor for B cell maintenance.
Tue Mar 01 00:00:00 EST 2016
Prolactin Rescues Immature B-Cells from Apoptosis Induced by B-Cell Receptor Cross-Linking.
Journal of immunology research
Flores-Fernández R,Blanco-Favela F,Fuentes-Pananá EM,Chávez-Sánchez L,Gorocica-Rosete P,Pizaña-Venegas A,Chávez-Rueda AK
12-5892 was used in Flow cytometry/Cell sorting to determine the effect of prolactin in an in vitro system of B-cell tolerance, showing that it rescues immature B-cells from apoptosis induced by B-cell receptor cross-linking.
Mon Mar 06 00:00:00 EST 2017
VprBP Is Required for Efficient Editing and Selection of Igκ+ B Cells, but Is Dispensable for Igλ+ and Marginal Zone B Cell Maturation and Selection.
Journal of immunology (Baltimore, Md. : 1950)
Palmer VL,Aziz-Seible R,Kassmeier MD,Rothermund M,Perry GA,Swanson PC
12-5892 was used in Flow cytometry/Cell sorting to determine the contribution of the protein, VprBP, to B cell development and selection.
Sat Aug 15 00:00:00 EDT 2015
Mir-17-92 regulates bone marrow homing of plasma cells and production of immunoglobulin G2c.
Nature communications
Xu S,Ou X,Huo J,Lim K,Huang Y,Chee S,Lam KP
12-5892 was used in Flow cytometry/Cell sorting to identify important roles for mir-17-92 in the regulation of peripheral B-cell function.
Fri Apr 17 00:00:00 EDT 2015
B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates.
Journal of immunology (Baltimore, Md. : 1950)
Ota T,Doyle-Cooper C,Cooper AB,Doores KJ,Aoki-Ota M,Le K,Schief WR,Wyatt RT,Burton DR,Nemazee D
12-5892 was used in Flow cytometry/Cell sorting to demonstrate a new mouse model for testing vaccine candidates for the routine elicitation of broadly neutralising antibodies against HIV.
Sun Sep 15 00:00:00 EDT 2013
Galectin 1 modulates plasma cell homeostasis and regulates the humoral immune response.
Journal of immunology (Baltimore, Md. : 1950)
Anginot A,Espeli M,Chasson L,Mancini SJ,Schiff C
12-5892 was used in Flow cytometry/Cell sorting to elucidate the pattern of GAL1 expression and the function of GAL1 in B cells.
Sat Jun 01 00:00:00 EDT 2013
A non-redundant function of cyclin E1 in hematopoietic stem cells.
Cell cycle (Georgetown, Tex.)
Campaner S,Viale A,De Fazio S,Doni M,De Franco F,D'Artista L,Sardella D,Pelicci PG,Amati B
12-5892 was used in Flow cytometry/Cell sorting to support a role for cyclin E1 in controlling the exit from quiescence in hematopoietic stem cells.
Sun Dec 01 00:00:00 EST 2013
Separation of plasmacytoid dendritic cells from B-cell-biased lymphoid progenitor (BLP) and Pre-pro B cells using PDCA-1.
PloS one
Medina KL,Tangen SN,Seaburg LM,Thapa P,Gwin KA,Shapiro VS
12-5892 was used in Flow cytometry/Cell sorting to demonstrate that there are PDCA-1(+)Siglec H(+) plasmacytoid dendritic cells that co-purify with B-cell-biased lymphoid progenitors and Pre-pro B cells.
Mon Feb 23 00:00:00 EST 2015
Ectopic Runx1 expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.
PloS one
Tornack J,Seiler K,Grützkau A,Grün JR,Onodera M,Melchers F,Tsuneto M
12-5892 was used in Flow cytometry/Cell sorting to suggest that Tal-1 expression is needed to express Runx1 in the mesoderm.
Thu Aug 21 00:00:00 EDT 2014
Prolactin levels correlate with abnormal B cell maturation in MRL and MRL/lpr mouse models of systemic lupus erythematosus-like disease.
Clinical & developmental immunology
Legorreta-Haquet MV,Flores-Fernández R,Blanco-Favela F,Fuentes-Pananá EM,Chávez-Sánchez L,Hernández-González R,Tesoro-Cruz E,Arriaga-Pizano L,Chávez-Rueda AK
12-5892 was used in Flow cytometry/Cell sorting to determine the level of PRL receptor expression during bone-marrow B-cell development and assess relevance in disease outcomes in lupus-prone murine models.
Mon Aug 04 00:00:00 EDT 2014
IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.
Blood
Balkhi MY,Willette-Brown J,Zhu F,Chen Z,Liu S,Guttridge DC,Karin M,Hu Y
12-5892-82 was used in Flow Cytometry to demonstrate that IKKα regulates B-lineage commitment via combined canonical and noncanonical NF-κB transcriptional activities to target Pax5 expression during hematopoiesis.
Thu Jun 07 00:00:00 EDT 2012
Type II NKT cells facilitate Alum-sensing and humoral immunity.
Journal of leukocyte biology
Shah HB,Devera TS,Rampuria P,Lang GA,Lang ML
12-5892 was used in Flow cytometry/Cell sorting to show that type II NKT cells function as part of the Alum-sensing apparatus and in a CD1d-dependent manner, facilitate T(H)2-driven humoral immunity.
Mon Oct 01 00:00:00 EDT 2012
Critical role of B cell lymphoma 10 in BAFF-regulated NF-κB activation and survival of anergic B cells.
Journal of immunology (Baltimore, Md. : 1950)
Yu M,Chen Y,He Y,Podd A,Fu G,Wright JA,Kleiman E,Khan WN,Wen R,Wang D
Published figure using CD93 (AA4.1) monoclonal antibody (Product # 12-5892-82) in Flow Cytometry
Sat Dec 01 00:00:00 EST 2012
The specialized unfolded protein response of B lymphocytes: ATF6α-independent development of antibody-secreting B cells.
Molecular immunology
Aragon IV,Barrington RA,Jackowski S,Mori K,Brewer JW
12-5892 was used in Flow cytometry/Cell sorting to demonstrate that a specialised B cell UPR relies exclusively on the IRE1-XBP1 pathway to remodel the ER and expand secretory capacity.
Sun Jul 01 00:00:00 EDT 2012
Increased levels of prolactin receptor expression correlate with the early onset of lupus symptoms and increased numbers of transitional-1 B cells after prolactin treatment.
BMC immunology
Ledesma-Soto Y,Blanco-Favela F,Fuentes-Pananá EM,Tesoro-Cruz E,Hernández-González R,Arriaga-Pizano L,Legorreta-Haquet MV,Montoya-Diaz E,Chávez-Sánchez L,Castro-Mussot ME,Chávez-Rueda AK
12-5892 was used in Flow cytometry/Cell sorting to determine if different splenic B cell subsets express the prolactin receptor and if the presence of prolactin influences these B cell subsets and correlates with development of lupus.
Fri Mar 09 00:00:00 EST 2012
Deletion of genes encoding PU.1 and Spi-B in B cells impairs differentiation and induces pre-B cell acute lymphoblastic leukemia.
Blood
Sokalski KM,Li SK,Welch I,Cadieux-Pitre HA,Gruca MR,DeKoter RP
12-5892 was used in Flow cytometry/Cell sorting to investigate the impairment of differentiation of B cells and induction of pre-B cell acute lymphoblastic leukemia through the deletion of genes encoding PU.1 and Spi-1 in B cells.
Thu Sep 08 00:00:00 EDT 2011
Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.
The Journal of experimental medicine
Ota T,Ota M,Duong BH,Gavin AL,Nemazee D
12-5892 was used in Flow cytometry/Cell sorting to postulate that clonal deletion is the major irreversible pathway of tolerance induction among peripheral B cells.
Mon Mar 14 00:00:00 EDT 2011
Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice.
EMBO molecular medicine
Ermakova O,Piszczek L,Luciani L,Cavalli FM,Ferreira T,Farley D,Rizzo S,Paolicelli RC,Al-Banchaabouchi M,Nerlov C,Moriggl R,Luscombe NM,Gross C
12-5892 was used in Flow cytometry/Cell sorting to validate sensitised phenotypic screening of segmental aneuploidy lines as a strategy for systematically identifying disease susceptibility genes in mice.
Sat Jan 01 00:00:00 EST 2011
T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis.
PLoS pathogens
Bockstal V,Guirnalda P,Caljon G,Goenka R,Telfer JC,Frenkel D,Radwanska M,Magez S,Black SJ
12-5892 was used in Flow cytometry/Cell sorting to study how infection-induced deletion of transitional B cells prevents replenishment of mature B cell compartments during T. brucei infection.
Wed Jun 01 00:00:00 EDT 2011
Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape.
Journal of immunology (Baltimore, Md. : 1950)
Duong BH,Ota T,Aoki-Ota M,Cooper AB,Ait-Azzouzene D,Vela JL,Gavin AL,Nemazee D
12-5892 was used in Flow cytometry/Cell sorting to demonstrate the usefulness of reconstituted IgM(b) superantigen hosts in revealing pathways involved in central tolerance.
Thu Dec 01 00:00:00 EST 2011
Cellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartments.
Journal of immunology (Baltimore, Md. : 1950)
Nikbakht N,Migone TS,Ward CP,Manser T
12-5892 was used in Flow cytometry/Cell sorting to investigate the role of the peripheral B cell pro-survival cytokine BAFF/BLyS in the regulation of immunological tolerance and autoreactive cells.
Fri Jul 01 00:00:00 EDT 2011
Membrane-associated CD93 regulates leukocyte migration and C1q-hemolytic activity during murine peritonitis.
Journal of immunology (Baltimore, Md. : 1950)
Greenlee-Wacker MC,Briseño C,Galvan M,Moriel G,Velázquez P,Bohlson SS
12-5892 was used in Flow cytometry/Cell sorting to demonstrate and understand a heightened susceptibility to thioglycollate-induced peritonitis in CD93(-/-) mice.
Thu Sep 15 00:00:00 EDT 2011
Membrane-associated CD93 regulates leukocyte migration and C1q-hemolytic activity during murine peritonitis.
Journal of immunology (Baltimore, Md. : 1950)
Greenlee-Wacker MC,Briseño C,Galvan M,Moriel G,Velázquez P,Bohlson SS
12-5892 was used in Flow cytometry/Cell sorting to demonstrate and understand a heightened susceptibility to thioglycollate-induced peritonitis in CD93(-/-) mice.
Thu Sep 15 00:00:00 EDT 2011
Acute Disruption of Bone Marrow B Lymphopoiesis and Apoptosis of Transitional and Marginal Zone B Cells in the Spleen following a Blood-Stage Plasmodium chabaudi Infection in Mice.
Journal of parasitology research
Bockstal V,Geurts N,Magez S
12-5892 was used in Flow cytometry/Cell sorting to investigate the effects of a blood-stage Plasmodium chabaudi infection in the spleen and bone marrow of mice.
Thu Jul 14 00:00:00 EDT 2011
Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen.
Journal of immunology (Baltimore, Md. : 1950)
Duong BH,Ota T,Aït-Azzouzene D,Aoki-Ota M,Vela JL,Huber C,Walsh K,Gavin AL,Nemazee D
12-5892 was used in Flow cytometry/Cell sorting to generate mice which ubiquitously expressed a membrane-bound IgD-superantigen, to provide a model which should facilitate studies of peripheral B cell tolerance in future.
Thu Apr 15 00:00:00 EDT 2010
Regulation of follicular B cell differentiation by the related E26 transformation-specific transcription factors PU.1, Spi-B, and Spi-C.
Journal of immunology (Baltimore, Md. : 1950)
DeKoter RP,Geadah M,Khoosal S,Xu LS,Thillainadesan G,Torchia J,Chin SS,Garrett-Sinha LA
12-5892 was used in Flow cytometry/Cell sorting to demonstrate the role of the E26 transformation-specific transcription factors PU.1, Spi-B, and Spi-C in follicular B cell development.
Wed Dec 15 00:00:00 EST 2010
Generation of B cell memory to the bacterial polysaccharide alpha-1,3 dextran.
Journal of immunology (Baltimore, Md. : 1950)
Foote JB,Kearney JF
12-5892 was used in Flow cytometry/Cell sorting to define B1b B cells as the principal reservoir for memory to bacterial-associated polysaccharide Ags.
Sun Nov 15 00:00:00 EST 2009
A role for cFLIP in B cell proliferation and stress MAPK regulation.
Journal of immunology (Baltimore, Md. : 1950)
Zhang H,Rosenberg S,Coffey FJ,He YW,Manser T,Hardy RR,Zhang J
12-5892 was used in Flow cytometry/Cell sorting to reveal the novel functions of cFLIP in B cells.
Thu Jan 01 00:00:00 EST 2009
Influence of Fas on the regulation of the response of an anti-nuclear antigen B cell clonotype to foreign antigen.
International immunology
Alabyev B,Vuyyuru R,Manser T
12-5892 was used in Flow cytometry/Cell sorting to determine whether an intrinsic Fas deficient could rescue the participation of a transgenic BCR clonotype in the germinal centre (GC) response.
Wed Oct 01 00:00:00 EDT 2008
Defining a transcriptional fingerprint of murine splenic B-cell development.
Genes and immunity
Debnath I,Roundy KM,Dunn DM,Weiss RB,Weis JJ,Weis JH
12-5892 was used in Flow cytometry/Cell sorting to identify key transcriptional regulatory proteins that control the expression of B cell-specific surface markers during B-cell maturation.
Mon Dec 01 00:00:00 EST 2008
Receptor editing in peripheral B cell tolerance.
Proceedings of the National Academy of Sciences of the United States of America
Rice JS,Newman J,Wang C,Michael DJ,Diamond B
12-5892 was used in Flow cytometry/Cell sorting to provide evidence for receptor editing occurring in a mature, antigen-activated B cell population.
Tue Feb 01 00:00:00 EST 2005
Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America
Takeuchi O,Fisher J,Suh H,Harada H,Malynn BA,Korsmeyer SJ
12-5892 was used in Flow cytometry/Cell sorting to show proapoptotic BAX and BAK are essential for regulating the B cell number at immature and mature developmental stages.
Tue Aug 09 00:00:00 EDT 2005
