Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: MASPGKPGAD EAQEEEGELE GGSAGPRAAI LEQAEELFLL CDKEAKGFIT KHDLQGLQSD LPLTPEQLEA VFESLDQAHT GFLTAREFCL GLGMFVGVAS AQGANPCRTP EETFESGGLD VQGTAGSLDE EEEEEERFHT VLEQLGVAPV LGEQRAVRTL WARLQRERPE LLGSFEDVLI RASACLEEAA RERDGLEQAL RRRESEHERE VRALYEETEQ LREQSRRPPS QNFARGERRS RLELELQIRE QDLERAGLRQ RERRGRRLQE HAERESQPAT ATGAAQGAEY TAAG
EFCAB4A, also known as Calcium release-activated calcium channel regulator 2B, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation, but the detailed function is still under investigation. It is likely to play a similar role as the related protein EFCAB4B, which acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Ca2+ release-activated Ca2+ (CRAC) channel regulator 2B; Calcium release-activated calcium channel regulator 2B; Calcium release-activated channel regulator 2B; CRAC channel regulator 2B; CRAC regulator 2B; EF-hand calcium binding domain 4A; EF-hand calcium-binding domain-containing protein 4A
Gene Aliases: CRACR2B; EFCAB4A
UniProt ID: (Human) Q8N4Y2
Entrez Gene ID: (Human) 283229
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