Product References
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity.
Nature communications
Read KA,Jones DM,Pokhrel S,Hales EDS,Varkey A,Tuazon JA,Eisele CD,Abdouni O,Saadey A,Leonard MR,Warren RT,Powell MD,Boss JM,Hemann EA,Yount JS,Xin G,Ghoneim HE,Lio CJ,Freud AG,Collins PL,Oestreich KJ
25-4875-82 was used in Flow cytometry/Cell sorting to identify Aiolos as a pivotal regulator of CD4-CTL and TFH programming and highlight its potential as a target for manipulating CD4+ T cell responses.
Fri Mar 24 00:00:00 EDT 2023
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity.
Nature communications
Read KA,Jones DM,Pokhrel S,Hales EDS,Varkey A,Tuazon JA,Eisele CD,Abdouni O,Saadey A,Leonard MR,Warren RT,Powell MD,Boss JM,Hemann EA,Yount JS,Xin G,Ghoneim HE,Lio CJ,Freud AG,Collins PL,Oestreich KJ
25-4875-82 was used in Flow cytometry/Cell sorting to identify Aiolos as a pivotal regulator of CD4-CTL and TFH programming and highlight its potential as a target for manipulating CD4+ T cell responses.
Fri Mar 24 00:00:00 EDT 2023
Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells.
Nature communications
Rožmanić C,Lisnić B,Pribanić Matešić M,Mihalić A,Hiršl L,Park E,Lesac Brizić A,Indenbirken D,Viduka I,Šantić M,Adler B,Yokoyama WM,Krmpotić A,Juranić Lisnić V,Jonjić S,Brizić I
Published figure using EOMES monoclonal antibody (Product # 25-4875-82) in Flow Cytometry
Thu Oct 12 00:00:00 EDT 2023
Multiparametric flow cytometry to characterize vaccine-induced polyfunctional T cell responses and T cell/NK cell exhaustion and memory phenotypes in mouse immuno-oncology models.
Frontiers in immunology
Moi D,Zeng B,Minnie SA,Bhatt R,Wood J,Sester DP,Mazzieri R,Dolcetti R
25-4875-82 was used in Flow cytometry/Cell sorting to report the development and application of two 21-color flow cytometry panels allowing a comprehensive characterization of T cell and natural killer cell exhaustion and memory phenotypes in mice with a particular focus on preclinical cancer models.
Tue Apr 25 00:00:00 EDT 2023
PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor Immunity.
Cancer discovery
Wiede F,Lu KH,Du X,Zeissig MN,Xu R,Goh PK,Xirouchaki CE,Hogarth SJ,Greatorex S,Sek K,Daly RJ,Beavis PA,Darcy PK,Tonks NK,Tiganis T
Published figure using EOMES monoclonal antibody (Product # 25-4875-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2022
Whole-genome profiling of DNA methylation and hydroxymethylation identifies distinct regulatory programs among innate lymphocytes.
Nature immunology
Peng V,Xing X,Bando JK,Trsan T,Di Luccia B,Collins PL,Li D,Wang WL,Lee HJ,Oltz EM,Wang T,Colonna M
25-4875-82 was used in Flow cytometry/Cell sorting to provide a powerful resource for studying innate lymphocyte epigenetic regulation and decode the regulatory logic governing their identity.
Fri Apr 01 00:00:00 EDT 2022
Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation.
Immunity
McFarland AP,Yalin A,Wang SY,Cortez VS,Landsberger T,Sudan R,Peng V,Miller HL,Ricci B,David E,Faccio R,Amit I,Colonna M
25-4875-82 was used in Flow cytometry/Cell sorting to identify gene expression programs of tissue-specific ILC1s, tissue-specific NK cells, and non-tissue-specific populations in blood, spleen, and other tissues largely corresponding to circulating cells.
Tue Jun 08 00:00:00 EDT 2021
BATF regulates progenitor to cytolytic effector CD8+ T cell transition during chronic viral infection.
Nature immunology
Chen Y,Zander RA,Wu X,Schauder DM,Kasmani MY,Shen J,Zheng S,Burns R,Taparowsky EJ,Cui W
25-4875-82 was used in Flow cytometry/Cell sorting to show that these mechanistic insights can potentially be harnessed to overcome T cell exhaustion during chronic infection and cancer.
Sun Aug 01 00:00:00 EDT 2021
CD8+ T cells specific for cryptic apoptosis-associated epitopes exacerbate experimental autoimmune encephalomyelitis.
Cell death & disease
Feizi N,Focaccetti C,Pacella I,Tucci G,Rossi A,Costanza M,Pedotti R,Sidney J,Sette A,La Rocca C,Procaccini C,Matarese G,Barnaba V,Piconese S
Published figure using EOMES monoclonal antibody (Product # 25-4875-82) in Flow Cytometry
Fri Oct 29 00:00:00 EDT 2021
B cells promote CD8 T cell primary and memory responses to subunit vaccines.
Cell reports
Klarquist J,Cross EW,Thompson SB,Willett B,Aldridge DL,Caffrey-Carr AK,Xu Z,Hunter CA,Getahun A,Kedl RM
25-4875-82 was used in Flow Cytometry to show that interleukin-27 production by B cells contributes to their impact on primary, but not memory, CD8 responses.
Tue Aug 24 00:00:00 EDT 2021
B cells promote CD8 T cell primary and memory responses to subunit vaccines.
Cell reports
Klarquist J,Cross EW,Thompson SB,Willett B,Aldridge DL,Caffrey-Carr AK,Xu Z,Hunter CA,Getahun A,Kedl RM
25-4875-82 was used in Flow Cytometry to show that interleukin-27 production by B cells contributes to their impact on primary, but not memory, CD8 responses.
Tue Aug 24 00:00:00 EDT 2021
Interferon Lambda Regulates Cellular and Humoral Immunity in Pristane-Induced Lupus.
International journal of molecular sciences
Aschman T,Schaffer S,Biniaris Georgallis SI,Triantafyllopoulou A,Staeheli P,Voll RE
Published figure using EOMES monoclonal antibody (Product # 25-4875-82) in Flow Cytometry
Fri Oct 29 00:00:00 EDT 2021
Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation.
JCI insight
Hope HC,Brownlie RJ,Fife CM,Steele L,Lorger M,Salmond RJ
Published figure using EOMES monoclonal antibody (Product # 25-4875-82) in Flow Cytometry
Mon May 10 00:00:00 EDT 2021
A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy.
The Journal of experimental medicine
Oda SK,Anderson KG,Ravikumar P,Bonson P,Garcia NM,Jenkins CM,Zhuang S,Daman AW,Chiu EY,Bates BM,Greenberg PD
Published figure using EOMES monoclonal antibody (Product # 25-4875-82) in Flow Cytometry
Mon Dec 07 00:00:00 EST 2020
Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants.
Cell reports. Medicine
Marinaik CB,Kingstad-Bakke B,Lee W,Hatta M,Sonsalla M,Larsen A,Neldner B,Gasper DJ,Kedl RM,Kawaoka Y,Suresh M
Published figure using EOMES monoclonal antibody (Product # 25-4875-82) in Flow Cytometry
Tue Sep 22 00:00:00 EDT 2020
Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.
Cell
Ponzetta A,Carriero R,Carnevale S,Barbagallo M,Molgora M,Perucchini C,Magrini E,Gianni F,Kunderfranco P,Polentarutti N,Pasqualini F,Di Marco S,Supino D,Peano C,Cananzi F,Colombo P,Pilotti S,Alomar SY,Bonavita E,Galdiero MR,Garlanda C,Mantovani A,Jaillon S
Published figure using EOMES monoclonal antibody (Product # 25-4875-82) in Flow Cytometry
Thu Jul 11 00:00:00 EDT 2019
CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset that Protects against Chronic Infection and Cancer.
Immunity
Zander R,Schauder D,Xin G,Nguyen C,Wu X,Zajac A,Cui W
25-4875 was used in Flow cytometry/Cell sorting to use single-cell RNA sequencing, we show that CD8+ T cells responding to chronic infection were more heterogeneous than previously appreciated.
Tue Dec 17 00:00:00 EST 2019
EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming.
Nature communications
Istaces N,Splittgerber M,Lima Silva V,Nguyen M,Thomas S,Le A,Achouri Y,Calonne E,Defrance M,Fuks F,Goriely S,Azouz A
Published figure using EOMES monoclonal antibody (Product # 25-4875-82) in Flow Cytometry
Wed Jul 24 00:00:00 EDT 2019
mTOR Modulates CD8+ T Cell Differentiation in Mice with Invasive Pulmonary Aspergillosis.
Open life sciences
Wang H,Xiao Y,Su L,Cui N,Liu D
Published figure using EOMES monoclonal antibody (Product # 25-4875-82) in Flow Cytometry
Mon Jan 01 00:00:00 EST 2018
Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection.
Nature communications
Rolot M,Dougall AM,Chetty A,Javaux J,Chen T,Xiao X,Machiels B,Selkirk ME,Maizels RM,Hokke C,Denis O,Brombacher F,Vanderplasschen A,Gillet L,Horsnell WGC,Dewals BG
Published figure using EOMES monoclonal antibody (Product # 25-4875-82) in Flow Cytometry
Tue Oct 30 00:00:00 EDT 2018
Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming.
Cell reports
Simula L,Pacella I,Colamatteo A,Procaccini C,Cancila V,Bordi M,Tregnago C,Corrado M,Pigazzi M,Barnaba V,Tripodo C,Matarese G,Piconese S,Campello S
25-4875 was used in Flow cytometry/Cell sorting to describe the crucial role of the mitochondrial protein Drp1 in T cell development and regulation of lymphocyte immune-surveillance.
Tue Dec 11 00:00:00 EST 2018
Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function.
Nature communications
Wang F,Meng M,Mo B,Yang Y,Ji Y,Huang P,Lai W,Pan X,You T,Luo H,Guan X,Deng Y,Yuan S,Chu J,Namaka M,Hughes T,Ye L,Yu J,Li X,Deng Y
25-4875 was used in Flow cytometry/Cell sorting to elucidate the crosstalk between Raptor (mTORC1) and Rictor (mTORC2) to variegate cytokine signalling in controlling natural killer cell maturation and effector function.
Mon Nov 19 00:00:00 EST 2018
De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation.
Cell
Ghoneim HE,Fan Y,Moustaki A,Abdelsamed HA,Dash P,Dogra P,Carter R,Awad W,Neale G,Thomas PG,Youngblood B
25-4875 was used in Flow cytometry to study the role of de novo DNA-methylation programming as a regulator of T cell exhaustion and barrier of immune checkpoint blockade-mediated T cell rejuvenation.
Thu Jun 29 00:00:00 EDT 2017
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
25-4875 was used in Flow cytometry/Cell sorting to identify a regulatory subpopulation of innate lymphoid cells that exists in the gut, and harbour a unique gene identity.
Thu Sep 21 00:00:00 EDT 2017
IL-12 Influence mTOR to Modulate CD8+ T Cells Differentiation through T-bet and Eomesodermin in Response to Invasive Pulmonary Aspergillosis.
International journal of medical sciences
Wang H,Li J,Han Q,Yang F,Xiao Y,Xiao M,Xu Y,Su L,Cui N,Liu D
Published figure using EOMES monoclonal antibody (Product # 25-4875-82) in Flow Cytometry
Mon May 21 00:00:00 EDT 2018
Conventional NK cells and ILC1 are partially ablated in the livers of Ncr1 iCreTbx21 fl/fl mice.
Wellcome open research
Cuff AO,Male V
25-4875 was used in Flow cytometry/Cell sorting to examine the role of Tbet-dependent type I innate lymphoid cells in the murine liver.
Sat Jan 09 00:00:00 EST 2021
Autophagy is a critical regulator of memory CD8(+) T cell formation.
eLife
Puleston DJ,Zhang H,Powell TJ,Lipina E,Sims S,Panse I,Watson AS,Cerundolo V,Townsend AR,Klenerman P,Simon AK
25-4875 was used in Flow cytometry/Cell sorting to show that mice lacking the autophagy gene Atg7 in T cells failed to establish CD8(+) T cell memory to influenza and MCMV infection.
Tue Nov 11 00:00:00 EST 2014
CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Qui HZ,Hagymasi AT,Bandyopadhyay S,St Rose MC,Ramanarasimhaiah R,Ménoret A,Mittler RS,Gordon SM,Reiner SL,Vella AT,Adler AJ
Published figure using EOMES monoclonal antibody (Product # 25-4875-82) in Flow Cytometry
Sat Oct 01 00:00:00 EDT 2011
IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions.
Journal of immunology (Baltimore, Md. : 1950)
Marshall HD,Prince AL,Berg LJ,Welsh RM
Sun Aug 01 00:00:00 EDT 2010