Invitrogen

F4/80 Monoclonal Antibody (BM8), PE-Cyanine5, eBioscience™

FIGURE: 1 / 99

F4/80 Antibody (15-4801-82) in Flow

Staining of C57Bl/6 resident peritoneal exudate cells with Anti-Mouse CD11b APC (Product # 17-0112-82) and 0.125 µg of Rat IgG2a K Isotype Control PE-Cyanine5 (Product # 15-4321-80) (left) or 0.125 µg of Anti-Mouse F4/80 Antigen PE-Cyanine5 (right).Cells in the large scatter population were used for analysis.

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Product Details

15-4801-82

Applications

Tested Dilution

Publications

Western Blot (WB)

View 1 publication 1 publication

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

View 2 publications 2 publications

Flow Cytometry (Flow)

0.25 µg/test

View 221 publications 221 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Mouse

Published species

Hamster, Human, Mouse

Host/Isotype

Rat / IgG2a, kappa

Recommended Isotype Control

Rat IgG2a kappa Isotype Control (eBR2a), PE-Cyanine5, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

BM8

Conjugate

PE-Cyanine5 PE-Cyanine5 PE-Cyanine5

Excitation/Emission Max

568/666 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_468798

Product Specific Information

Description: The BM8 monoclonal antibody reacts with mouse F4/80 antigen, an approximately 160 kDa surface receptor. It belongs to the EGF-TM7 family of proteins. As such it contains seven EGF-like domains on its extracellular N-terminus, seven transmembrane spanning sequences, and an intracellular C-terminal domain showing homology to other TM7 superfamily members. The F4/80 antigen is expressed by a majority of mature macrophages and is one of the best markers for this population of cells. However, other cell types, such as peritoneal eosinophils, Langerhans cells, and some other dendritic cell subtypes, have been reported to express this antigen as well. Expression of F4/80 commences during early myeloid development in vivo and can be upregulated on BM cells stimulated in vitro with M-CSF. Some populations of macrophages, especially in the lymphoid microenvironment, may be devoid of F4/80.

Applications Reported: The BM8 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The BM8 antibody has been tested by flow cytometric analysis of mouse resident peritoneal exudate cells. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Light sensitivity: This tandem dye is sensitive photo-induced oxidation. Please protect this vial and stained samples from light.

Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-822-49) (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product # 00-5333-54) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.

Excitation: 488-561 nm; Emission: 667 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

F4/80 antigen is a 160 kDa cell surface glycoprotein that is a member of the EGF TM7 family of proteins and shares 68% overall amino acid identity with human EGF module containing mucin like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

YAP/STAT3 inhibited CD8⁺ T cells activity in the breast cancer immune microenvironment by inducing M2 polarization of tumor-associated macrophages.

Cancer medicine

Wang C,Shen N,Guo Q,Tan X,He S

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation.

Redox biology

Tomitsuka Y,Imaeda H,Ito H,Asou I,Ohbayashi M,Ishikawa F,Kuwata H,Hara S

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2023

Dipeptidyl peptidase 4 inhibitor reduces tumor-associated macrophages and enhances anti-PD-L1-mediated tumor suppression in non-small cell lung cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Zuo B,Li T,Liu X,Wang S,Cheng J,Liu X,Cui W,Shi H,Ling C

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Nov 01 00:00:00 EDT 2023

Platelet factors attenuate inflammation and rescue cognition in ageing.

Nature

Schroer AB,Ventura PB,Sucharov J,Misra R,Chui MKK,Bieri G,Horowitz AM,Smith LK,Encabo K,Tenggara I,Couthouis J,Gross JD,Chan JM,Luke A,Villeda SA

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury.

iScience

Gonzatti MB,Freire BM,Antunes MM,de Menezes GB,Talbot J,Peron JPS,Basso AS,Keller AC

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Oct 20 00:00:00 EDT 2023

HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.

eLife

Scinicariello S,Soderholm A,Schäfer M,Shulkina A,Schwartz I,Hacker K,Gogova R,Kalis R,Froussios K,Budroni V,Bestehorn A,Clausen T,Kovarik P,Zuber J,Versteeg GA

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Mar 24 00:00:00 EDT 2023

Differential requirement of neutralizing antibodies and T cells on protective immunity to SARS-CoV-2 variants of concern.

NPJ vaccines

Azevedo PO,Hojo-Souza NS,Faustino LP,Fumagalli MJ,Hirako IC,Oliveira ER,Figueiredo MM,Carvalho AF,Doro D,Benevides L,Durigon E,Fonseca F,Machado AM,Fernandes AP,Teixeira SR,Silva JS,Gazzinelli RT

15-4801-82 was used in Flow cytometry/Cell sorting to evaluate the efficacy of a Spike-based DNA vaccine (pCTV-WS) for protection against different VOCs using existing pre-clinical models of severe and moderate COVID-19.

Mon Feb 13 00:00:00 EST 2023

Role of low-intensity pulsed ultrasound in regulating macrophage polarization to accelerate tendon-bone interface repair.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Xu Z,Li S,Wan L,Hu J,Lu H,Zhang T

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2023

Inflammasome Coordinates Senescent Chronic Wound Induced by Thalassophryne nattereri Venom.

International journal of molecular sciences

Lima C,Andrade-Barros AI,Carvalho FF,Falcão MAP,Lopes-Ferreira M

15-4801-82 was used in Flow cytometry/Cell sorting to demonstrate in mouse paws injected with the venom the installation of γH2AX/p16Ink4a-dependent senescence with persistent neutrophilic inflammation in the proliferation and remodeling phases.

Mon May 08 00:00:00 EDT 2023

SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization.

Journal of advanced research

Lee JH,Lee SH,Lee EH,Cho JY,Song DK,Lee YJ,Kwon TK,Oh BC,Cho KW,Osborne TF,Jeon TI,Im SS

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

GPR84 regulates pulmonary inflammation by modulating neutrophil functions.

Acta pharmacologica Sinica

Wang SW,Zhang Q,Lu D,Fang YC,Yan XC,Chen J,Xia ZK,Yuan QT,Chen LH,Zhang YM,Nan FJ,Xie X

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

Reducing cell intrinsic immunity to mRNA vaccine alters adaptive immune responses in mice.

Molecular therapy. Nucleic acids

Wang Z,Jacobus EJ,Stirling DC,Krumm S,Flight KE,Cunliffe RF,Mottl J,Singh C,Mosscrop LG,Santiago LA,Vogel AB,Kariko K,Sahin U,Erbar S,Tregoning JS

15-4801-82 was used in Flow Cytometry to compare mRNA vaccines in mice against influenza virus using three different mRNA formats: uridine-containing mRNA (D1-uRNA), m1Ψ-modified mRNA (D1-modRNA), and D1-modRNA with a cap1 structure (cC1-modRNA).

Tue Dec 12 00:00:00 EST 2023

Overexpression of lipocalin 2 in PBX1-deficient decidual NK cells promotes inflammation at the maternal-fetal interface.

American journal of reproductive immunology (New York, N.Y. : 1989)

An X,Qin J,Hu X,Zhou Y,Fu B,Wei H

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Oxygen-carrying nanoplatform to reprogram tumor immunosuppressive microenvironment and enhance photothermal-immunotherapy.

Materials today. Bio

Huang J,Leng X,Jiang T,Xu L,Zheng J,Fang M,Wang J,Wang Z,Zhang L

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2023

Low-intensity pulsed ultrasound promotes skeletal muscle regeneration via modulating the inflammatory immune microenvironment.

International journal of biological sciences

Qin H,Luo Z,Sun Y,He Z,Qi B,Chen Y,Wang J,Li C,Lin W,Han Z,Zhu Y

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Mar 20 00:00:00 EDT 2023

Colchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins.

Archives of toxicology

Hassan R,Myllys M,Brackhagen L,Hobloss Z,González D,Seddek AL,Friebel A,Hoehme S,Marchan R,Trauner M,Hengstler JG,Ghallab A

15-4801-82 was used in Immunohistochemistry to show that the here-observed adverse effects on KC occurred at doses only slightly above those used clinically, and may be critical for patients with endotoxemia due to a leaky gut-blood barrier.

Tue Nov 01 00:00:00 EDT 2022

CD146 Associates with Gp130 to Control a Macrophage Pro-inflammatory Program That Regulates the Metabolic Response to Obesity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Duan H,Jing L,Xiang J,Ju C,Wu Z,Liu J,Ma X,Chen X,Liu Z,Feng J,Yan X

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2022

Role of circular RNA cdr1as in modulation of macrophage phenotype.

Life sciences

Gonzalez C,Cimini M,Cheng Z,Benedict C,Wang C,Trungcao M,Mallaredy V,Rajan S,Garikipati VNS,Kishore R

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Nov 15 00:00:00 EST 2022

Maternal-fetal conflict averted by progesterone- induced FOXP3+ regulatory T cells.

iScience

Severance AL,Kinder JM,Xin L,Burg AR,Shao TY,Pham G,Tilburgs T,Goodman WA,Mesiano S,Way SS

15-4801-82 was used in Flow cytometry/Cell sorting to show that the female reproductive hormone, progesterone, coordinates immune tolerance by stimulating expansion of FOXP3+ regulatory T cells.

Fri Jun 17 00:00:00 EDT 2022

REDD1 promotes obesity-induced metabolic dysfunction via atypical NF-κB activation.

Nature communications

Lee DK,Kim T,Byeon J,Park M,Kim S,Kim J,Choi S,Lee G,Park C,Lee KW,Kwon YJ,Lee JH,Kwon YG,Kim YM

15-4801-82 was used in Magnetic cell separation to demonstrate that the REDD1-NF-κB axis is crucial for metabolic inflammation and dysregulation.

Sat Oct 22 00:00:00 EDT 2022

Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis.

Cell host & microbe

Pandey SP,Bender MJ,McPherson AC,Phelps CM,Sanchez LM,Rana M,Hedden L,Sangani KA,Chen L,Shapira JH,Siller M,Goel C,Verdú EF,Jabri B,Chang A,Chandran UR,Mullett SJ,Wendell SG,Singhi AD,Tilstra JS,Pierre JF,Arteel GE,Hinterleitner R,Meisel M

15-4801-82 was used in Flow cytometry/Cell sorting to demonstrate that I3A is required for L. reuteri-induced Tc1 cell differentiation in vitro and AIH-like pathology in vivo, both of which are restrained by Tet2 within CD8 T cells.

Wed Jul 13 00:00:00 EDT 2022

Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade.

Cancer discovery

Lander VE,Belle JI,Kingston NL,Herndon JM,Hogg GD,Liu X,Kang LI,Knolhoff BL,Bogner SJ,Baer JM,Zuo C,Borcherding NC,Lander DP,Mpoy C,Scott J,Zahner M,Rogers BE,Schwarz JK,Kim H,DeNardo DG

15-4801-82 was used in Flow Cytometry to show that FAK inhibition allows RT to prime tumor immunity and unlock responsiveness to checkpoint immunotherapy.

Fri Dec 02 00:00:00 EST 2022

Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication.

Cell reports

Vu R,Jin S,Sun P,Haensel D,Nguyen QH,Dragan M,Kessenbrock K,Nie Q,Dai X

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Aug 02 00:00:00 EDT 2022

Candida albicans oscillating UME6 expression during intestinal colonization primes systemic Th17 protective immunity.

Cell reports

Shao TY,Kakade P,Witchley JN,Frazer C,Murray KL,Ene IV,Haslam DB,Hagan T,Noble SM,Bennett RJ,Way SS

15-4801-82 was used in Flow cytometry/Cell sorting to show that dynamic gene expression fluctuations by C. albicans during symbiotic colonization are essential for priming host immunity against disseminated infection.

Tue May 17 00:00:00 EDT 2022

PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice.

The Journal of experimental medicine

Cheng YW,Zhang ZB,Lan BD,Lin JR,Chen XH,Kong LR,Xu L,Ruan CC,Gao PJ

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Sep 06 00:00:00 EDT 2021

A bilirubin-derived nanomedicine attenuates the pathological cascade of pulmonary fibrosis.

Biomaterials

Keum H,Kim D,Kim J,Kim TW,Whang CH,Jung W,Jon S

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Sun Aug 01 00:00:00 EDT 2021

Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling.

The EMBO journal

Wieghofer P,Hagemeyer N,Sankowski R,Schlecht A,Staszewski O,Amann L,Gruber M,Koch J,Hausmann A,Zhang P,Boneva S,Masuda T,Hilgendorf I,Goldmann T,Böttcher C,Priller J,Rossi FM,Lange C,Prinz M

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Mar 15 00:00:00 EDT 2021

Tumor- and osteoclast-derived NRP2 in prostate cancer bone metastases.

Bone research

Polavaram NS,Dutta S,Islam R,Bag AK,Roy S,Poitz D,Karnes J,Hofbauer LC,Kohli M,Costello BA,Jimenez R,Batra SK,Teply BA,Muders MH,Datta K

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri May 14 00:00:00 EDT 2021

Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects.

Basic research in cardiology

Frenis K,Helmstädter J,Ruan Y,Schramm E,Kalinovic S,Kröller-Schön S,Bayo Jimenez MT,Hahad O,Oelze M,Jiang S,Wenzel P,Sommer CJ,Frauenknecht KBM,Waisman A,Gericke A,Daiber A,Münzel T,Steven S

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Apr 30 00:00:00 EDT 2021

Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation.

Diabetes

Jin Y,Ji Y,Song Y,Choe SS,Jeon YG,Na H,Nam TW,Kim HJ,Nahmgoong H,Kim SM,Kim JW,Nam KT,Seong JK,Hwang D,Park CB,Lee IH,Kim JB,Lee HW

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2021

Interleukin 6 regulates the expression of programmed cell death ligand 1 in thyroid cancer.

Cancer science

Zhang GQ,Jiao Q,Shen CT,Song HJ,Zhang HZ,Qiu ZL,Luo QY

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Mar 01 00:00:00 EST 2021

Optimizing Flow Cytometric Analysis of Immune Cells in Samples Requiring Cryopreservation from Tumor-Bearing Mice.

Journal of immunology (Baltimore, Md. : 1950)

Carlson PM,Mohan M,Patel RB,Birstler J,Nettenstrom L,Sheerar D,Fox K,Rodriguez M,Hoefges A,Hernandez R,Zahm C,Kim K,McNeel DG,Weichert J,Morris ZS,Sondel PM

15-4801-82 was used in Flow Cytometry to confirm the utility of our cryopreservation protocol by comparing tumors treated with in situ tumor vaccines, analyzing both fresh and cryopreserved tumor samples with similar results.

Thu Jul 15 00:00:00 EDT 2021

Optimizing Flow Cytometric Analysis of Immune Cells in Samples Requiring Cryopreservation from Tumor-Bearing Mice.

Journal of immunology (Baltimore, Md. : 1950)

Carlson PM,Mohan M,Patel RB,Birstler J,Nettenstrom L,Sheerar D,Fox K,Rodriguez M,Hoefges A,Hernandez R,Zahm C,Kim K,McNeel DG,Weichert J,Morris ZS,Sondel PM

Thu Jul 15 00:00:00 EDT 2021

Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma.

Scientific reports

Mittal A,Wang M,Vidyarthi A,Yanez D,Pizzurro G,Thakral D,Tracy E,Colegio OR

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon May 24 00:00:00 EDT 2021

Comprehensive analysis of liver macrophage composition by flow cytometry and immunofluorescence in murine NASH.

STAR protocols

Daemen S,Chan MM,Schilling JD

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Jun 18 00:00:00 EDT 2021

Generation and utilization of a HEK-293T murine GM-CSF expressing cell line.

PloS one

Robinson EK,Covarrubias S,Zhou S,Carpenter S

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Sep 15 00:00:00 EDT 2021

Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy.

Journal of neuroinflammation

Oladiran O,Shi XQ,Yang M,Fournier S,Zhang J

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Mar 22 00:00:00 EDT 2021

STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer.

Cellular and molecular gastroenterology and hepatology

Vonderhaar EP,Barnekow NS,McAllister D,McOlash L,Eid MA,Riese MJ,Tarakanova VL,Johnson BD,Dwinell MB

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Jan 24 00:00:00 EST 2022

CX3CR1 But Not CCR2 Expression Is Required for the Development of Autoimmune Peripheral Neuropathy in Mice.

Frontiers in immunology

Oladiran O,Shi XQ,Fournier S,Zhang J

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Dec 21 00:00:00 EST 2021

Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period.

Frontiers in immunology

Ji WH,Li DD,Wei DP,Gu AQ,Yang Y,Peng JP

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Feb 10 00:00:00 EST 2022

Characterisation of Macrophage Polarisation in Mice Infected with Ninoa Strain of Trypanosoma cruzi.

Pathogens (Basel, Switzerland)

Medina-Buelvas DM,Rodríguez-Sosa M,Vega L

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Sat Nov 06 00:00:00 EDT 2021

Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Sang W,Xie L,Wang G,Li J,Zhang Z,Li B,Guo S,Deng CX,Dai Y

15-4801 was used in Flow cytometry/Cell sorting to presents a multifunctional metal-phenolic nanoplatform for efficient X-ray mediated RT-RDT in combination with immunotherapy and may provide a new therapeutic option for cancer treatment.

Mon Feb 01 00:00:00 EST 2021

Peptide-TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens.

Nature biotechnology

Lynn GM,Sedlik C,Baharom F,Zhu Y,Ramirez-Valdez RA,Coble VL,Tobin K,Nichols SR,Itzkowitz Y,Zaidi N,Gammon JM,Blobel NJ,Denizeau J,de la Rochere P,Francica BJ,Decker B,Maciejewski M,Cheung J,Yamane H,Smelkinson MG,Francica JR,Laga R,Bernstock JD,Seymour LW,Drake CG,Jewell CM,Lantz O,Piaggio E,Ishizuka AS,Seder RA

15-4801 was used in Flow cytometry/Cell sorting to develope a vaccine platform (SNP-7/8a) based on charge-modified peptide-TLR-7/8a conjugates that are chemically programmed to self-assemble into nanoparticles of uniform size (~20 nm) irrespective of the peptide antigen composition.

Sun Mar 01 00:00:00 EST 2020

A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice.

Immunity

Laczkó D,Hogan MJ,Toulmin SA,Hicks P,Lederer K,Gaudette BT,Castaño D,Amanat F,Muramatsu H,Oguin TH,Ojha A,Zhang L,Mu Z,Parks R,Manzoni TB,Roper B,Strohmeier S,Tombácz I,Arwood L,Nachbagauer R,Karikó K,Greenhouse J,Pessaint L,Porto M,Putman-Taylor T,Strasbaugh A,Campbell TA,Lin PJC,Tam YK,Sempowski GD,Farzan M,Choe H,Saunders KO,Haynes BF,Andersen H,Eisenlohr LC,Weissman D,Krammer F,Bates P,Allman D,Locci M,Pardi N

15-4801 was used in Flow cytometry/Cell sorting to study the immunogenicity of lipid nanoparticle-encapsulated, nucleoside-modified mRNA vaccines against SARS-CoV-2 in mice.

Tue Oct 13 00:00:00 EDT 2020

Dual-Wavelength Photosensitive Nano-in-Micro Scaffold Regulates Innate and Adaptive Immune Responses for Osteogenesis.

Nano-micro letters

Zhao Q,Shi M,Yin C,Zhao Z,Zhang J,Wang J,Shen K,Zhang L,Tang H,Xiao Y,Zhang Y

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Sat Nov 21 00:00:00 EST 2020

Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells.

Oncogene

Cheng R,Billet S,Liu C,Haldar S,Choudhury D,Tripathi M,Hav M,Merchant A,Hu T,Huang H,Zhou H,Bhowmick NA

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Sat Feb 01 00:00:00 EST 2020

Regulating colonic dendritic cells by commensal glycosylated large surface layer protein A to sustain gut homeostasis against pathogenic inflammation.

Mucosal immunology

Ge Y,Gong M,Zadeh M,Li J,Abbott JR,Li W,Morel L,Sonon R,Supekar NT,Azadi P,Wang Y,Jones DP,Li S,Mohamadzadeh M

15-4801 was used in Flow cytometry/Cell sorting to study the molecular mechanisms responsible for regulating gut homeostasis.

Wed Jan 01 00:00:00 EST 2020

NLRX1 is a key regulator of immune signaling during invasive pulmonary aspergillosis.

PLoS pathogens

Kastelberg B,Tubau-Juni N,Ayubi T,Leung A,Leber A,Hontecillas R,Bassaganya-Riera J,Kale SD

15-4801 was used in Flow cytometry/Cell sorting to point strongly towards the cell-specific and contextual function of Nlrx1 during invasive pulmonary aspergillosis and may lead to novel therapeutics to reduce Th2 responses by CD103+ DCs or heightened recruitment of neutrophils.

Tue Sep 01 00:00:00 EDT 2020

Macrophage GIT1 Contributes to Bone Regeneration by Regulating Inflammatory Responses in an ERK/NRF2-Dependent Way.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Zhao SJ,Liu H,Chen J,Qian DF,Kong FQ,Jie J,Yin GY,Li QQ,Fan J

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Neonatal Heart Responds to Pressure Overload With Differential Alterations in Various Cardiomyocyte Maturation Programs That Accommodate Simultaneous Hypertrophy and Hyperplasia.

Frontiers in cell and developmental biology

Ding X,Wang S,Wang Y,Yang J,Bao N,Liu J,Zhang Z

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Dec 18 00:00:00 EST 2020

Differential Activation of Macrophages Based on Their Environment in Advanced Age.

Chonnam medical journal

Lee DY,Lim JS,Cho KA

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

Spider venom administration impairs glioblastoma growth and modulates immune response in a non-clinical model.

Scientific reports

Bonfanti AP,Barreto N,Munhoz J,Caballero M,Cordeiro G,Rocha-E-Silva T,Sutti R,Moura F,Brunetto S,Ramos CD,Thomé R,Verinaud L,Rapôso C

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Apr 03 00:00:00 EDT 2020

Lipin-1 Contributes to IL-4 Mediated Macrophage Polarization.

Frontiers in immunology

Chandran S,Schilke RM,Blackburn CMR,Yurochko A,Mirza R,Scott RS,Finck BN,Woolard MD

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Mar 29 00:00:00 EDT 2021

Lipin-1 Contributes to IL-4 Mediated Macrophage Polarization.

Frontiers in immunology

Chandran S,Schilke RM,Blackburn CMR,Yurochko A,Mirza R,Scott RS,Finck BN,Woolard MD

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Mar 29 00:00:00 EDT 2021

High-salt diet decreases mechanical thresholds in mice that is mediated by a CCR2-dependent mechanism.

Journal of neuroinflammation

Fan A,Oladiran O,Shi XQ,Zhang J

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Jun 09 00:00:00 EDT 2020

Macrophage-Associated Lipin-1 Promotes β-Oxidation in Response to Proresolving Stimuli.

ImmunoHorizons

Schilke RM,Blackburn CMR,Rao S,Krzywanski DM,Finck BN,Woolard MD

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Oct 19 00:00:00 EDT 2020

Macrophage-Associated Lipin-1 Promotes β-Oxidation in Response to Proresolving Stimuli.

ImmunoHorizons

Schilke RM,Blackburn CMR,Rao S,Krzywanski DM,Finck BN,Woolard MD

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Oct 19 00:00:00 EDT 2020

Host deficiency in ephrin-A1 inhibits breast cancer metastasis.

F1000Research

Shiuan E,Inala A,Wang S,Song W,Youngblood V,Chen J,Brantley-Sieders DM

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

MFG-E8 accelerates wound healing in diabetes by regulating "NLRP3 inflammasome-neutrophil extracellular traps" axis.

Cell death discovery

Huang W,Jiao J,Liu J,Huang M,Hu Y,Ran W,Yan L,Xiong Y,Li M,Quan Z,Rao Y,Chen J,Huang Y,Zhang D

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Sep 26 00:00:00 EDT 2023

MFG-E8 accelerates wound healing in diabetes by regulating "NLRP3 inflammasome-neutrophil extracellular traps" axis.

Cell death discovery

Huang W,Jiao J,Liu J,Huang M,Hu Y,Ran W,Yan L,Xiong Y,Li M,Quan Z,Rao Y,Chen J,Huang Y,Zhang D

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Sep 26 00:00:00 EDT 2023

Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer.

Journal of hematology & oncology

Lu CS,Shiau AL,Su BH,Hsu TS,Wang CT,Su YC,Tsai MS,Feng YH,Tseng YL,Yen YT,Wu CL,Shieh GS

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2020

Hyaluronan control of the primary vascular barrier during early mouse pregnancy is mediated by uterine NK cells.

JCI insight

Hadas R,Gershon E,Cohen A,Atrakchi O,Lazar S,Golani O,Dassa B,Elbaz M,Cohen G,Eilam R,Dekel N,Neeman M

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Nov 19 00:00:00 EST 2020

Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway.

eLife

Kim EH,Woodruff MC,Grigoryan L,Maier B,Lee SH,Mandal P,Cortese M,Natrajan MS,Ravindran R,Ma H,Merad M,Gitlin AD,Mocarski ES,Jacob J,Pulendran B

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Jun 09 00:00:00 EDT 2020

Inhibition of Fatty Acid-Binding Protein 4 Attenuated Kidney Fibrosis by Mediating Macrophage-to-Myofibroblast Transition.

Frontiers in immunology

Feng Y,Guo F,Xia Z,Liu J,Mai H,Liang Y,Zhu G,Li Y,Bai L,Li L,Huang R,Shi M,Ma L,Fu P

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Jun 03 00:00:00 EDT 2021

Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms.

Cells

Nuti E,Rossello A,Cuffaro D,Camodeca C,Van Bael J,van der Maat D,Martens E,Fiten P,Pereira RVS,Ugarte-Berzal E,Gouwy M,Opdenakker G,Vandooren J

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Jul 07 00:00:00 EDT 2020

Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression.

Nature communications

Yu L,Zhang B,Deochand D,Sacta MA,Coppo M,Shang Y,Guo Z,Zeng X,Rollins DA,Tharmalingam B,Li R,Chinenov Y,Rogatsky I,Hu X

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri May 08 00:00:00 EDT 2020

Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals.

Cell & bioscience

Jiang M,Ye J,Wang X,Li N,Wang Y,Shi Y

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Apr 14 00:00:00 EDT 2022

Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia.

Cell reports

Xu G,van Bruggen R,Gualtieri CO,Moradin N,Fois A,Vallerand D,De Sa Tavares Russo M,Bassenden A,Lu W,Tam M,Lesage S,Girouard H,Avizonis DZ,Deblois G,Prchal JT,Stevenson M,Berghuis A,Muir T,Rabinowitz J,Vidal SM,Fodil N,Gros P

15-4801 was used in Flow cytometry/Cell sorting to highlight the importance of BPGM as a regulator of hemoglobin/oxyhemoglobin in malaria pathogenesis and suggest a new potential malaria therapeutic target.

Tue Sep 22 00:00:00 EDT 2020

CD8⁺ T Cell Functional Exhaustion Overrides Pregnancy-Induced Fetal Antigen Alloimmunization.

Cell reports

Kinder JM,Turner LH,Stelzer IA,Miller-Handley H,Burg A,Shao TY,Pham G,Way SS

15-4801-82 was used in Flow Cytometry to demonstrate distinct mechanisms whereby fetal tolerance is maintained during primary compared with subsequent pregnancies.

Tue Jun 23 00:00:00 EDT 2020

Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.

STAR protocols

Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Jun 19 00:00:00 EDT 2020

Plasma Cell Fate Is Orchestrated by Elaborate Changes in Genome Compartmentalization and Inter-chromosomal Hubs.

Cell reports

Bortnick A,He Z,Aubrey M,Chandra V,Denholtz M,Chen K,Lin YC,Murre C

15-4801 was used in Flow cytometry/Cell sorting to examine whether plasma cell development is also associated with changes in nuclear architecture.

Tue Apr 07 00:00:00 EDT 2020

Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.

Nature

Escolano A,Gristick HB,Abernathy ME,Merkenschlager J,Gautam R,Oliveira TY,Pai J,West AP,Barnes CO,Cohen AA,Wang H,Golijanin J,Yost D,Keeffe JR,Wang Z,Zhao P,Yao KH,Bauer J,Nogueira L,Gao H,Voll AV,Montefiori DC,Seaman MS,Gazumyan A,Silva M,McGuire AT,Stamatatos L,Irvine DJ,Wells L,Martin MA,Bjorkman PJ,Nussenzweig MC

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Sat Jun 01 00:00:00 EDT 2019

Pro-inflammatory Aorta-Associated Macrophages Are Involved in Embryonic Development of Hematopoietic Stem Cells.

Immunity

Mariani SA,Li Z,Rice S,Krieg C,Fragkogianni S,Robinson M,Vink CS,Pollard JW,Dzierzak E

15-4801-82 was used in Immunohistochemistry (Frozen) to show here that macrophage appearance in the AGM was dependent on the chemokine receptor Cx3cr1.

Tue Jun 18 00:00:00 EDT 2019

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.

Cell metabolism

Halbrook CJ,Pontious C,Kovalenko I,Lapienyte L,Dreyer S,Lee HJ,Thurston G,Zhang Y,Lazarus J,Sajjakulnukit P,Hong HS,Kremer DM,Nelson BS,Kemp S,Zhang L,Chang D,Biankin A,Shi J,Frankel TL,Crawford HC,Morton JP,Pasca di Magliano M,Lyssiotis CA

15-4801 was used in Flow cytometry/Cell sorting to characterise the role of macrophages in pancreatic ductal adenocarcinoma and possibilities for pancreatic cancer therapy.

Tue Jun 04 00:00:00 EDT 2019

A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis.

The Journal of clinical investigation

Han YH,Shin KO,Kim JY,Khadka DB,Kim HJ,Lee YM,Cho WJ,Cha JY,Lee BJ,Lee MO

15-4801 was used in Flow cytometry/Cell sorting to study the hepatic microenvironments that support the function of RORa as a polarity regulator.

Mon Mar 11 00:00:00 EDT 2019

Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection.

PLoS pathogens

Santecchia I,Vernel-Pauillac F,Rasid O,Quintin J,Gomes-Solecki M,Boneca IG,Werts C

15-4801 was used in Flow cytometry/Cell sorting to conclude that host-directed treatment using a TLR2/NOD2 agonist could be envisioned as a novel prophylactic strategy against acute leptospirosis.

Wed May 01 00:00:00 EDT 2019

Aggregated and Hyperstable Damage-Associated Molecular Patterns Are Released During ER Stress to Modulate Immune Function.

Frontiers in cell and developmental biology

Andersohn A,Garcia MI,Fan Y,Thompson MC,Akimzhanov AM,Abdullahi A,Jeschke MG,Boehning D

15-4801-82 was used in Flow Cytometry to show that induction of chronic ER stress leads to the release of known and novel damage-associated molecular patterns.

Mon Sep 28 00:00:00 EDT 2020

Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis.

Purinergic signalling

Rothweiler S,Feldbrügge L,Jiang ZG,Csizmadia E,Longhi MS,Vaid K,Enjyoji K,Popov YV,Robson SC

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Sun Sep 01 00:00:00 EDT 2019

Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.

Anti-cancer drugs

Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice.

PLoS genetics

Madaro L,Torcinaro A,De Bardi M,Contino FF,Pelizzola M,Diaferia GR,Imeneo G,Bouchè M,Puri PL,De Santa F

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila.

Cell reports

Zhang R,Earnest JT,Kim AS,Winkler ES,Desai P,Adams LJ,Hu G,Bullock C,Gold B,Cherry S,Diamond MS

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Sep 03 00:00:00 EDT 2019

MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.

Journal for immunotherapy of cancer

Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Nov 28 00:00:00 EST 2019

Peritoneal Cells Mediate Immune Responses and Cross-Protection Against Influenza A Virus.

Frontiers in immunology

Gautam A,Park BK,Kim TH,Akauliya M,Kim D,Maharjan S,Park J,Kim J,Lee H,Park MS,Lee Y,Kwon HJ

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Aug 17 00:00:00 EDT 2020

Therapeutic ultrasound attenuates DSS-induced colitis through the cholinergic anti-inflammatory pathway.

EBioMedicine

Nunes NS,Chandran P,Sundby M,Visioli F,da Costa Gonçalves F,Burks SR,Paz AH,Frank JA

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Jul 01 00:00:00 EDT 2019

Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity.

Nature metabolism

Seo JB,Riopel M,Cabrales P,Huh JY,Bandyopadhyay GK,Andreyev AY,Murphy AN,Beeman SC,Smith GI,Klein S,Lee YS,Olefsky JM

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2019

A Shift in Myeloid Cell Phenotype via Down Regulation of Siglec-1 in Island Macrophages of Bone Marrow Is Associated With Decreased Late Erythroblasts Seen in Anemia of Critical Illness.

Frontiers in medicine

Hasan S,Johnson MC,Kini AR,Baldea AJ,Muthumalaiappan K

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Nov 03 00:00:00 EST 2020

Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth.

Nature communications

Kusano T,Ehirchiou D,Matsumura T,Chobaz V,Nasi S,Castelblanco M,So A,Lavanchy C,Acha-Orbea H,Nishino T,Okamoto K,Busso N

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Oct 28 00:00:00 EDT 2019

TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding.

Journal of translational medicine

Liu C,Li P,Li H,Wang S,Ding L,Wang H,Ye H,Jin Y,Hou J,Fang X,Shu Q

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Sep 02 00:00:00 EDT 2019

Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses.

Nature communications

Kurelac I,Iommarini L,Vatrinet R,Amato LB,De Luise M,Leone G,Girolimetti G,Umesh Ganesh N,Bridgeman VL,Ombrato L,Columbaro M,Ragazzi M,Gibellini L,Sollazzo M,Feichtinger RG,Vidali S,Baldassarre M,Foriel S,Vidone M,Cossarizza A,Grifoni D,Kofler B,Malanchi I,Porcelli AM,Gasparre G

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Feb 22 00:00:00 EST 2019

The nuclear variant of bone morphogenetic protein 2 (nBMP2) is expressed in macrophages and alters calcium response.

Scientific reports

Tellez Freitas CM,Burrell HR,Valdoz JC,Hamblin GJ,Raymond CM,Cox TD,Johnson DK,Andersen JL,Weber KS,Bridgewater LC

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Jan 30 00:00:00 EST 2019

Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection.

Cell death discovery

Wang N,Yang X,Sun J,Sun Z,Ma Q,Wang Z,Chen Z,Wang Z,Hu F,Wang H,Zhou L,Zhang M,Xu J

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis.

Cellular and molecular gastroenterology and hepatology

Wen HJ,Gao S,Wang Y,Ray M,Magnuson MA,Wright CVE,Di Magliano MP,Frankel TL,Crawford HC

15-4801 was used in Flow cytometry/Cell sorting to demonstrate pancreas healing is supported by myeloid cell HB-EGF-induced epithelial cell proliferation and EGFR-dependent DNA repair.

Thu Jul 02 00:00:00 EDT 2020

Control of expression and activity of peroxisome proliferated-activated receptor γ by Annexin A1 on microglia during efferocytosis.

Cell biochemistry and function

da Rocha GHO,Loiola RA,Pantaleão LDN,Reutelingsperger C,Solito E,Farsky SHP

15-4801-82 was used in Flow cytometry/Cell sorting to provide evidence that the glucocorticoid-mediated protein annexin A1 modulates PPARγ expression and that PPARγ is important for annexin A1-mediated efferocytosis.

Tue Oct 01 00:00:00 EDT 2019

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release.

Nature

Morioka S,Perry JSA,Raymond MH,Medina CB,Zhu Y,Zhao L,Serbulea V,Onengut-Gumuscu S,Leitinger N,Kucenas S,Rathmell JC,Makowski L,Ravichandran KS

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Nov 01 00:00:00 EDT 2018

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Cell

Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Jun 28 00:00:00 EDT 2018

Chanzyme TRPM7 Mediates the Ca²⁺ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation.

Immunity

Schappe MS,Szteyn K,Stremska ME,Mendu SK,Downs TK,Seegren PV,Mahoney MA,Dixit S,Krupa JK,Stipes EJ,Rogers JS,Adamson SE,Leitinger N,Desai BN

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Jan 16 00:00:00 EST 2018

Insulin resistance causes inflammation in adipose tissue.

The Journal of clinical investigation

Shimobayashi M,Albert V,Woelnerhanssen B,Frei IC,Weissenberger D,Meyer-Gerspach AC,Clement N,Moes S,Colombi M,Meier JA,Swierczynska MM,Jenö P,Beglinger C,Peterli R,Hall MN

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Apr 02 00:00:00 EDT 2018

Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue.

Diabetes

Zhao H,Shang Q,Pan Z,Bai Y,Li Z,Zhang H,Zhang Q,Guo C,Zhang L,Wang Q

15-4801 was used in Flow cytometry/Cell sorting to examine the roles of adipose-derived stem cells in obesity and related pathological conditions.

Thu Feb 01 00:00:00 EST 2018

Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis.

Frontiers in immunology

Villares R,Criado G,Juarranz Y,Lopez-Santalla M,García-Cuesta EM,Rodríguez-Frade JM,Leceta J,Lucas P,Pablos JL,Martínez-A C,Garin MI,Gomariz RP,Mellado M

Fri Aug 16 00:00:00 EDT 2019

Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock.

Journal of leukocyte biology

Jiao Y,Li Z,Loughran PA,Fan EK,Scott MJ,Li Y,Billiar TR,Wilson MA,Shi X,Fan J

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice.

International journal of obesity (2005)

Chang CJ,Lu CC,Lin CS,Martel J,Ko YF,Ojcius DM,Wu TR,Tsai YH,Yeh TS,Lu JJ,Lai HC,Young JD

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Mesenchymal Stem Cells Recruit CCR2⁺ Monocytes To Suppress Allergic Airway Inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Takeda K,Webb TL,Ning F,Shiraishi Y,Regan DP,Chow L,Smith MJ,Ashino S,Guth AM,Hopkins S,Gelfand EW,Dow S

15-4801 was used in Flow cytometry/Cell sorting to show that mesenchymal stem cell activation by IFN-γ, followed by increased expression of CCL2 and recruitment of monocytes to the lungs, is essential for suppression by mesenchymal stem cells in allergen-induced airway hyperresponsiveness and airway inflammation.

Thu Feb 15 00:00:00 EST 2018

Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor 1 Shed by ADAM17 Drives Mouse Macrophage Proliferation in Acute and Chronic Inflammation.

Molecular and cellular biology

Tang J,Frey JM,Wilson CL,Moncada-Pazos A,Levet C,Freeman M,Rosenfeld ME,Stanley ER,Raines EW,Bornfeldt KE

15-4801 was used in Flow cytometry/Cell sorting to identify a significant defect in macrophage proliferation in mice lacking leukocyte transmembrane protease, ADAM17.

Sat Sep 01 00:00:00 EDT 2018

Primary cilia disruption differentially affects the infiltrating and resident macrophage compartment in the liver.

American journal of physiology. Gastrointestinal and liver physiology

Zimmerman KA,Song CJ,Gonzalez-Mize N,Li Z,Yoder BK

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Jun 01 00:00:00 EDT 2018

Characterization of Stress and Innate Immunity Resistance of Wild-Type and Δp66 Borrelia burgdorferi.

Infection and immunity

Curtis MW,Hahn BL,Zhang K,Li C,Robinson RT,Coburn J

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Antiasthmatic Effects of Sanglong Pingchuan Decoction through Inducing a Balanced Th1/Th2 Immune Response.

Evidence-based complementary and alternative medicine : eCAM

Zhu B,Dong J,Gao X,He Y,Sun H

15-4801 was used in Flow cytometry/Cell sorting to investigate the antiasthmatic effects of Sanglong pingchuan decoction and to explore its mechanisms of action.

Fri Mar 18 00:00:00 EDT 2022

iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction.

JCI insight

Barnette DN,Cahill TJ,Gunadasa-Rohling M,Carr CA,Freeman M,Riley PR

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Feb 08 00:00:00 EST 2018

Toll-like receptor 2 deficiency hyperactivates the FoxO1 transcription factor and induces aging-associated cardiac dysfunction in mice.

The Journal of biological chemistry

Spurthi KM,Sarikhani M,Mishra S,Desingu PA,Yadav S,Rao S,Maity S,Tamta AK,Kumar S,Majumdar S,Jain A,Raghuraman A,Khan D,Singh I,Samuel RJ,Ramachandra SG,Nandi D,Sundaresan NR

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Aug 24 00:00:00 EDT 2018

Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1.

The Journal of biological chemistry

Rijal D,Ariana A,Wight A,Kim K,Alturki NA,Aamir Z,Ametepe ES,Korneluk RG,Tiedje C,Menon MB,Gaestel M,McComb S,Sad S

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Jul 27 00:00:00 EDT 2018

BNIP3 modulates the interface between B16-F10 melanoma cells and immune cells.

Oncotarget

Romano E,Rufo N,Korf H,Mathieu C,Garg AD,Agostinis P

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Apr 03 00:00:00 EDT 2018

An immune cell spray (ICS) formulation allows for the delivery of functional monocyte/macrophages.

Scientific reports

Beneke V,Küster F,Neehus AL,Hesse C,Lopez-Rodriguez E,Haake K,Rafiei Hashtchin A,Schott JW,Walter D,Braun A,Wolkers WF,Ackermann M,Lachmann N

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Nov 02 00:00:00 EDT 2018

Low-density lipoprotein receptor-related protein-1 dysfunction synergizes with dietary cholesterol to accelerate steatohepatitis progression.

The Journal of biological chemistry

Hamlin AN,Chinnarasu S,Ding Y,Xian X,Herz J,Jaeschke A,Hui DY

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Jun 22 00:00:00 EDT 2018

Characterization of Multiple Cytokine Combinations and TGF-β on Differentiation and Functions of Myeloid-Derived Suppressor Cells.

International journal of molecular sciences

Lee CR,Lee W,Cho SK,Park SG

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Mar 15 00:00:00 EDT 2018

Commensal Fungi Recapitulate the Protective Benefits of Intestinal Bacteria.

Cell host & microbe

Jiang TT,Shao TY,Ang WXG,Kinder JM,Turner LH,Pham G,Whitt J,Alenghat T,Way SS

15-4801-82 was used in Flow Cytometry to show that commensal fungi can functionally replace intestinal bacteria by conferring protection against injury to mucosal tissues and positively calibrating the responsiveness of circulating immune cells.

Wed Dec 13 00:00:00 EST 2017

Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy.

Cell stem cell

Lechner AJ,Driver IH,Lee J,Conroy CM,Nagle A,Locksley RM,Rock JR

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Jul 06 00:00:00 EDT 2017

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.

The Journal of clinical investigation

Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis.

The Journal of clinical investigation

Géraud C,Koch PS,Zierow J,Klapproth K,Busch K,Olsavszky V,Leibing T,Demory A,Ulbrich F,Diett M,Singh S,Sticht C,Breitkopf-Heinlein K,Richter K,Karppinen SM,Pihlajaniemi T,Arnold B,Rodewald HR,Augustin HG,Schledzewski K,Goerdt S

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.

The Journal of experimental medicine

Thomas DC,Clare S,Sowerby JM,Pardo M,Juss JK,Goulding DA,van der Weyden L,Storisteanu D,Prakash A,Espéli M,Flint S,Lee JC,Hoenderdos K,Kane L,Harcourt K,Mukhopadhyay S,Umrania Y,Antrobus R,Nathan JA,Adams DJ,Bateman A,Choudhary JS,Lyons PA,Condliffe AM,Chilvers ER,Dougan G,Smith KG

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Apr 03 00:00:00 EDT 2017

RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease.

EMBO molecular medicine

Zhu H,Lou F,Yin Q,Gao Y,Sun Y,Bai J,Xu Z,Liu Z,Cai W,Ke F,Zhang L,Zhou H,Wang H,Wang G,Chen X,Zhang H,Wang Z,Ginhoux F,Lu C,Su B,Wang H

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

Prolonged Deleterious Influences of Chemotherapeutic Agent CPT-11 on Resident Peritoneal Macrophages and B1 Cells.

Frontiers in immunology

Bai WJ,Li CG,Zhang CC,Xu LH,Zeng QZ,Hu B,Hong Z,He XH,Ouyang DY

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

p40 -Deficient Mice Exhibit Impaired Bacterial Clearance and Enhanced Pro-inflammatory Responses during Salmonella enterica serovar Typhimurium Infection.

Frontiers in immunology

Li Y,Lv M,Su C,Long S,Zhang W,Conway KL,Li W,Xavier RJ,Shi HN

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

CCR2^- and CCR2⁺ corneal macrophages exhibit distinct characteristics and balance inflammatory responses after epithelial abrasion.

Mucosal immunology

Liu J,Xue Y,Dong D,Xiao C,Lin C,Wang H,Song F,Fu T,Wang Z,Chen J,Pan H,Li Y,Cai D,Li Z

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Sep 01 00:00:00 EDT 2017

Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing.

PLoS pathogens

Shenoy AT,Brissac T,Gilley RP,Kumar N,Wang Y,Gonzalez-Juarbe N,Hinkle WS,Daugherty SC,Shetty AC,Ott S,Tallon LJ,Deshane J,Tettelin H,Orihuela CJ

Tue Aug 01 00:00:00 EDT 2017

Evaluation of trained immunity by β-1, 3 (d)-glucan on murine monocytes in vitro and duration of response in vivo.

Immunology and cell biology

Garcia-Valtanen P,Guzman-Genuino RM,Williams DL,Hayball JD,Diener KR

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

Aging-Impaired Filamentous Actin Polymerization Signaling Reduces Alveolar Macrophage Phagocytosis of Bacteria.

Journal of immunology (Baltimore, Md. : 1950)

Li Z,Jiao Y,Fan EK,Scott MJ,Li Y,Li S,Billiar TR,Wilson MA,Shi X,Fan J

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Nov 01 00:00:00 EDT 2017

Cooperation of Gastric Mononuclear Phagocytes with Helicobacter pylori during Colonization.

Journal of immunology (Baltimore, Md. : 1950)

Viladomiu M,Bassaganya-Riera J,Tubau-Juni N,Kronsteiner B,Leber A,Philipson CW,Zoccoli-Rodriguez V,Hontecillas R

15-4801 was used in Flow cytometry/Cell sorting to report the induction of IL-10-driven regulatory responses mediated by CD11b+F4/80hiCD64+CX3CR1+ MNPs that contribute to maintaining high levels of Helicobacter pylori loads in the stomach by modulating effector T cell responses at the gastric mucosa.

Sat Apr 15 00:00:00 EDT 2017

Microarray analysis of circular RNA expression patterns in polarized macrophages.

International journal of molecular medicine

Zhang Y,Zhang Y,Li X,Zhang M,Lv K

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.

RNA biology

Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu May 04 00:00:00 EDT 2017

The Second-Generation PGI2 Analogue Treprostinil Fails to Chemoprevent Tumors in a Murine Lung Adenocarcinoma Model.

Cancer prevention research (Philadelphia, Pa.)

Dwyer-Nield L,Hickey GA,Friedman M,Choo K,McArthur DG,Tennis MA,New ML,Geraci M,Keith RL

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Nov 01 00:00:00 EDT 2017

Zoledronic acid inhibits infiltration of tumor-associated macrophages and angiogenesis following transcatheter arterial chemoembolization in rat hepatocellular carcinoma models.

Oncology letters

Zhou DY,Qin J,Huang J,Wang F,Xu GP,Lv YT,Zhang JB,Shen LM

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2017

Phenotypic switch in lung interstitial macrophage polarization in an ovalbumin-induced mouse model of asthma.

Experimental and therapeutic medicine

Nie H,Wang A,He Q,Yang Q,Liu L,Zhang G,Huang Y,Ding X,Yu H,Hu S

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice.

Scientific reports

Shintani Y,Ito T,Fields L,Shiraishi M,Ichihara Y,Sato N,Podaru M,Kainuma S,Tanaka H,Suzuki K

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Jul 31 00:00:00 EDT 2017

Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury.

Stem cell research & therapy

Zhu D,Tan J,Maleken AS,Muljadi R,Chan ST,Lau SN,Elgass K,Leaw B,Mockler J,Chambers D,Leeman KT,Kim CF,Wallace EM,Lim R

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Nov 10 00:00:00 EST 2017

TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2.

eLife

Ku AT,Shaver TM,Rao AS,Howard JM,Rodriguez CN,Miao Q,Garcia G,Le D,Yang D,Borowiak M,Cohen DN,Chitsazzadeh V,Diwan AH,Tsai KY,Nguyen H

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed May 03 00:00:00 EDT 2017

BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination.

Scientific reports

Shim DW,Shin WY,Yu SH,Kim BH,Ye SK,Koppula S,Won HS,Kang TB,Lee KH

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Nov 08 00:00:00 EST 2017

Loss of epidermal AP1 transcription factor function reduces filaggrin level, alters chemokine expression and produces an ichthyosis-related phenotype.

Cell death & disease

Young CA,Rorke EA,Adhikary G,Xu W,Eckert RL

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Jun 01 00:00:00 EDT 2017

In vivo quantification of quantum dot systemic transport in C57BL/6 hairless mice following skin application post-ultraviolet radiation.

Particle and fibre toxicology

Jatana S,Palmer BC,Phelan SJ,Gelein R,DeLouise LA

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Apr 14 00:00:00 EDT 2017

Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB.

PloS one

Gao SY,Zheng GS,Wang L,Liang YJ,Zhang SE,Lao XM,Li K,Liao GQ

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Sep 18 00:00:00 EDT 2017

Exercise training enhances in vivo clearance of endotoxin and attenuates inflammatory responses by potentiating Kupffer cell phagocytosis.

Scientific reports

Komine S,Akiyama K,Warabi E,Oh S,Kuga K,Ishige K,Togashi S,Yanagawa T,Shoda J

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Sep 20 00:00:00 EDT 2017

Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer.

JCI insight

Sato-Kaneko F,Yao S,Ahmadi A,Zhang SS,Hosoya T,Kaneda MM,Varner JA,Pu M,Messer KS,Guiducci C,Coffman RL,Kitaura K,Matsutani T,Suzuki R,Carson DA,Hayashi T,Cohen EE

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Sep 21 00:00:00 EDT 2017

Characterization of Schistosoma japonicum CP1412 protein as a novel member of the ribonuclease T2 molecule family with immune regulatory function.

Parasites & vectors

Ke XD,Shen S,Song LJ,Yu CX,Kikuchi M,Hirayama K,Gao H,Wang J,Yin X,Yao Y,Liu Q,Zhou W

15-4801 was used in Flow cytometry/Cell sorting to investigate the role of CP1412 in immune regulation during Schistosoma japonicum infection.

Fri Feb 17 00:00:00 EST 2017

IGF1 Shapes Macrophage Activation in Response to Immunometabolic Challenge.

Cell reports

Spadaro O,Camell CD,Bosurgi L,Nguyen KY,Youm YH,Rothlin CV,Dixit VD

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Apr 11 00:00:00 EDT 2017

Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission.

Immunity

Tian Y,Kuo CF,Akbari O,Ou JH

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue May 17 00:00:00 EDT 2016

Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia.

Cancer discovery

Lee KE,Spata M,Bayne LJ,Buza EL,Durham AC,Allman D,Vonderheide RH,Simon MC

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Mar 01 00:00:00 EST 2016

Increasing Regulatory T Cells With Interleukin-2 and Interleukin-2 Antibody Complexes Attenuates Lung Inflammation and Heart Failure Progression.

Hypertension (Dallas, Tex. : 1979)

Wang H,Hou L,Kwak D,Fassett J,Xu X,Chen A,Chen W,Blazar BR,Xu Y,Hall JL,Ge JB,Bache RJ,Chen Y

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Jul 01 00:00:00 EDT 2016

Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer.

Oncogene

Das S,Rachagani S,Sheinin Y,Smith LM,Gurumurthy CB,Roy HK,Batra SK

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu May 19 00:00:00 EDT 2016

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.

Immunology

Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2016

Tg6F ameliorates the increase in oxidized phospholipids in the jejunum of mice fed unsaturated LysoPC or WD.

Journal of lipid research

Chattopadhyay A,Navab M,Hough G,Grijalva V,Mukherjee P,Fogelman HR,Hwang LH,Faull KF,Lusis AJ,Reddy ST,Fogelman AM

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

Recruited monocytes modulate malaria-induced lung injury through CD36-mediated clearance of sequestered infected erythrocytes.

Journal of leukocyte biology

Lagassé HA,Anidi IU,Craig JM,Limjunyawong N,Poupore AK,Mitzner W,Scott AL

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

Multimodal analysis of ocular inflammation using the endotoxin-induced uveitis mouse model.

Disease models & mechanisms

Chu CJ,Gardner PJ,Copland DA,Liyanage SE,Gonzalez-Cordero A,Kleine Holthaus SM,Luhmann UF,Smith AJ,Ali RR,Dick AD

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Apr 01 00:00:00 EDT 2016

Effects of ketanserin on experimental colitis in mice and macrophage function.

International journal of molecular medicine

Xiao J,Shao L,Shen J,Jiang W,Feng Y,Zheng P,Liu F

15-4801 was used in Flow cytometry/Cell sorting to study the effects of ketanserin on experimental colitis in mice and macrophage function.

Tue Mar 01 00:00:00 EST 2016

Low intensity vibration mitigates tumor progression and protects bone quantity and quality in a murine model of myeloma.

Bone

Pagnotti GM,Chan ME,Adler BJ,Shroyer KR,Rubin J,Bain SD,Rubin CT

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2016

PER1 prevents excessive innate immune response during endotoxin-induced liver injury through regulation of macrophage recruitment in mice.

Cell death & disease

Wang T,Wang Z,Yang P,Xia L,Zhou M,Wang S,Du J,Zhang J

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Apr 07 00:00:00 EDT 2016

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.

Stem cell reports

Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Aug 09 00:00:00 EDT 2016

Macrophages form functional vascular mimicry channels in vivo.

Scientific reports

Barnett FH,Rosenfeld M,Wood M,Kiosses WB,Usui Y,Marchetti V,Aguilar E,Friedlander M

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Nov 11 00:00:00 EST 2016

Evidence for a dynamic role for mononuclear phagocytes during endometrial repair and remodelling.

Scientific reports

Cousins FL,Kirkwood PM,Saunders PT,Gibson DA

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Nov 09 00:00:00 EST 2016

Targeting STAT3 signaling reduces immunosuppressive myeloid cells in head and neck squamous cell carcinoma.

Oncoimmunology

Bu LL,Yu GT,Deng WW,Mao L,Liu JF,Ma SR,Fan TF,Hall B,Kulkarni AB,Zhang WF,Sun ZJ

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

Increased apoptosis and browning of TAK1-deficient adipocytes protects against obesity.

JCI insight

Sassmann-Schweda A,Singh P,Tang C,Wietelmann A,Wettschureck N,Offermanns S

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu May 19 00:00:00 EDT 2016

EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.

Scientific reports

Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Jun 02 00:00:00 EDT 2016

Myeloid-Specific Blockade of Notch Signaling Attenuates Choroidal Neovascularization through Compromised Macrophage Infiltration and Polarization in Mice.

Scientific reports

Dou GR,Li N,Chang TF,Zhang P,Gao X,Yan XC,Liang L,Han H,Wang YS

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Jun 24 00:00:00 EDT 2016

Macrophagic control of the response to uropathogenic E. coli infection by regulation of iron retention in an IL-6-dependent manner.

Immunity, inflammation and disease

Owusu-Boaitey N,Bauckman KA,Zhang T,Mysorekar IU

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2016

Anti-α-enolase antibody limits the invasion of myeloid-derived suppressor cells and attenuates their restraining effector T cell response.

Oncoimmunology

Cappello P,Tonoli E,Curto R,Giordano D,Giovarelli M,Novelli F

15-4801 was used in Flow cytometry/Cell sorting to evaluate the effects of anti-ENO1 binding on myeloid-derived suppressor cells functions and the T cell response.

Sun May 01 00:00:00 EDT 2016

Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.

Scientific reports

Ochi T,Feng Y,Kitamoto S,Nagao-Kitamoto H,Kuffa P,Atarashi K,Honda K,Teitelbaum DH,Kamada N

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Jun 15 00:00:00 EDT 2016

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.

Nature medicine

Shankman LS,Gomez D,Cherepanova OA,Salmon M,Alencar GF,Haskins RM,Swiatlowska P,Newman AA,Greene ES,Straub AC,Isakson B,Randolph GJ,Owens GK

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2015

Host microbiota constantly control maturation and function of microglia in the CNS.

Nature neuroscience

Erny D,Hrabě de Angelis AL,Jaitin D,Wieghofer P,Staszewski O,David E,Keren-Shaul H,Mahlakoiv T,Jakobshagen K,Buch T,Schwierzeck V,Utermöhlen O,Chun E,Garrett WS,McCoy KD,Diefenbach A,Staeheli P,Stecher B,Amit I,Prinz M

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2015

MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation.

The Journal of clinical investigation

Ying W,Tseng A,Chang RC,Morin A,Brehm T,Triff K,Nair V,Zhuang G,Song H,Kanameni S,Wang H,Golding MC,Bazer FW,Chapkin RS,Safe S,Zhou B

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Nov 02 00:00:00 EST 2015

SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL.

Autophagy

Choi SH,Gonen A,Diehl CJ,Kim J,Almazan F,Witztum JL,Miller YI

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Feb 23 00:00:00 EST 2016

Ibrutinib exerts potent antifibrotic and antitumor activities in mouse models of pancreatic adenocarcinoma.

Cancer research

Massó-Vallés D,Jauset T,Serrano E,Sodir NM,Pedersen K,Affara NI,Whitfield JR,Beaulieu ME,Evan GI,Elias L,Arribas J,Soucek L

15-4801 was used in Flow cytometry/Cell sorting to show that ibrutinib is highly effective at limiting the growth of Pancreatic ductal adenocarcinoma in both transgenic mouse and patient-derived xenograft models of the disease.

Wed Apr 15 00:00:00 EDT 2015

MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.

Proceedings of the National Academy of Sciences of the United States of America

Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Dec 29 00:00:00 EST 2015

Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.

Frontiers in immunology

Vogel AJ,Brown DM

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Jul 10 00:00:00 EDT 2015

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.

eLife

Freedman TS,Tan YX,Skrzypczynska KM,Manz BN,Sjaastad FV,Goodridge HS,Lowell CA,Weiss A

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Oct 30 00:00:00 EDT 2015

Systemically delivered adipose stromal vascular fraction cells disseminate to peripheral artery walls and reduce vasomotor tone through a CD11b+ cell-dependent mechanism.

Stem cells translational medicine

Morris ME,Beare JE,Reed RM,Dale JR,LeBlanc AJ,Kaufman CL,Zheng H,Ng CK,Williams SK,Hoying JB

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2015

Glycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease.

Disease models & mechanisms

Williams BB,Tebbutt NC,Buchert M,Putoczki TL,Doggett K,Bao S,Johnstone CN,Masson F,Hollande F,Burgess AW,Scott AM,Ernst M,Heath JK

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Sat Aug 01 00:00:00 EDT 2015

Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance.

International journal of obesity (2005)

Khan IM,Perrard XY,Brunner G,Lui H,Sparks LM,Smith SR,Wang X,Shi ZZ,Lewis DE,Wu H,Ballantyne CM

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Sun Nov 01 00:00:00 EDT 2015

Urokinase receptor-deficient mice mount an innate immune response to and clarify respiratory viruses as efficiently as wild-type mice.

Virulence

Ramos M,Lao Y,Eguiluz C,Del Val M,Martínez I

15-4801 was used in Flow cytometry/Cell sorting to indicate that uPAR does not play a major role in limiting virus replication or in orchestrating the innate immune response against HRSV or influenza infections.

Tue Aug 16 00:00:00 EDT 2016

IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosis.

Journal of immunology (Baltimore, Md. : 1950)

Watkins AA,Yasuda K,Wilson GE,Aprahamian T,Xie Y,Maganto-Garcia E,Shukla P,Oberlander L,Laskow B,Menn-Josephy H,Wu Y,Duffau P,Fried SK,Lichtman AH,Bonegio RG,Rifkin IR

15-4801 was used in Flow cytometry/Cell sorting to reveal a protective role for IRF5 in lupus-associated atherosclerosis that is mediated through the effects of IRF5 in both immune and nonimmune cells.

Sun Feb 15 00:00:00 EST 2015

Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice.

Endocrinology

Schoiswohl G,Stefanovic-Racic M,Menke MN,Wills RC,Surlow BA,Basantani MK,Sitnick MT,Cai L,Yazbeck CF,Stolz DB,Pulinilkunnil T,O'Doherty RM,Kershaw EE

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2015

A far-red fluorescent probe for flow cytometry and image-based functional studies of xenobiotic sequestering macrophages.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Keswani RK,Yoon GS,Sud S,Stringer KA,Rosania GR

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nanoantioxidant for treatment of two acute hepatitis models.

The Journal of pharmacology and experimental therapeutics

Maeda H,Hirata K,Watanabe H,Ishima Y,Chuang VT,Taguchi K,Inatsu A,Kinoshita M,Tanaka M,Sasaki Y,Otagiri M,Maruyama T

15-4801 was used in Flow cytometry/Cell sorting to study the use of polythiolated- and mannosylated human serum albumin as a rescue therapy for hepatopathy.

Sun Feb 01 00:00:00 EST 2015

Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectors.

American journal of physiology. Renal physiology

Yuan A,Lee Y,Choi U,Moeckel G,Karihaloo A

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2015

Local delivery of VEGF and SDF enhances endothelial progenitor cell recruitment and resultant recovery from ischemia.

Tissue engineering. Part A

Anderson EM,Kwee BJ,Lewin SA,Raimondo T,Mehta M,Mooney DJ

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2015

Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-κB Pathway.

BioMed research international

Jin X,Yao T,Zhou Z,Zhu J,Zhang S,Hu W,Shen C

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Mar 18 00:00:00 EDT 2016

Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.

PloS one

Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Apr 28 00:00:00 EDT 2016

Vesicles from different Trypanosoma cruzi strains trigger differential innate and chronic immune responses.

Journal of extracellular vesicles

Nogueira PM,Ribeiro K,Silveira AC,Campos JH,Martins-Filho OA,Bela SR,Campos MA,Pessoa NL,Colli W,Alves MJ,Soares RP,Torrecilhas AC

15-4801 was used in Flow cytometry/Cell sorting to reveal polymorphisms in the vesicles surface may be determinant in the immunopathologic events throughout infection.

Sat Nov 28 00:00:00 EST 2015

Severity of DSS-induced colitis is reduced in Ido1-deficient mice with down-regulation of TLR-MyD88-NF-kB transcriptional networks.

Scientific reports

Shon WJ,Lee YK,Shin JH,Choi EY,Shin DM

15-4801 was used in Flow cytometry/Cell sorting to explore the role of IDO1 in producing inflammatory responses and modulating transcriptional networks during the development of colitis.

Fri Nov 27 00:00:00 EST 2015

Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice.

Nature communications

Singh NK,Kotla S,Dyukova E,Traylor JG,Orr AW,Chernoff J,Marion TN,Rao GN

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Jun 24 00:00:00 EDT 2015

Structure-based programming of lymph-node targeting in molecular vaccines.

Nature

Liu H,Moynihan KD,Zheng Y,Szeto GL,Li AV,Huang B,Van Egeren DS,Park C,Irvine DJ

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Mar 27 00:00:00 EDT 2014

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.

Nature

Colegio OR,Chu NQ,Szabo AL,Chu T,Rhebergen AM,Jairam V,Cyrus N,Brokowski CE,Eisenbarth SC,Phillips GM,Cline GW,Phillips AJ,Medzhitov R

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Sep 25 00:00:00 EDT 2014

A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity.

Cell metabolism

Hernandez ED,Lee SJ,Kim JY,Duran A,Linares JF,Yajima T,Müller TD,Tschöp MH,Smith SR,Diaz-Meco MT,Moscat J

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Miscellaneous

Tue Sep 02 00:00:00 EDT 2014

A role for the ITAM signaling module in specifying cytokine-receptor functions.

Nature immunology

Bezbradica JS,Rosenstein RK,DeMarco RA,Brodsky I,Medzhitov R

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Apr 01 00:00:00 EDT 2014

Macrophages contribute to the cyclic activation of adult hair follicle stem cells.

PLoS biology

Castellana D,Paus R,Perez-Moreno M

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Dec 01 00:00:00 EST 2014

A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.

Development (Cambridge, England)

Gilmour J,Assi SA,Jaegle U,Kulu D,van de Werken H,Clarke D,Westhead DR,Philipsen S,Bonifer C

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Sun Jun 01 00:00:00 EDT 2014

The plexin C1 receptor promotes acute inflammation.

European journal of immunology

König K,Marth L,Roissant J,Granja T,Jennewein C,Devanathan V,Schneider M,Köhler D,Zarbock A,Rosenberger P

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Sep 01 00:00:00 EDT 2014

Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing.

Stem cells (Dayton, Ohio)

Suga H,Rennert RC,Rodrigues M,Sorkin M,Glotzbach JP,Januszyk M,Fujiwara T,Longaker MT,Gurtner GC

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Tani Y,Isobe Y,Imoto Y,Segi-Nishida E,Sugimoto Y,Arai H,Arita M

15-4801 was used in Flow cytometry/Cell sorting to demonstrate that eosinophils control the resolution of inflammation and draining lymph node hypertrophy through proresolving lipid mediators and the CXCL13 pathway.

Mon Sep 01 00:00:00 EDT 2014

Krüppel like factor 4 promoter undergoes active demethylation during monocyte/macrophage differentiation.

PloS one

Karpurapu M,Ranjan R,Deng J,Chung S,Lee YG,Xiao L,Nirujogi TS,Jacobson JR,Park GY,Christman JW

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Jan 20 00:00:00 EST 2015

Niacin reverses migratory macrophage foam cell arrest mediated by oxLDL in vitro.

PloS one

Huang H,Koelle P,Fendler M,Schroettle A,Czihal M,Hoffmann U,Kuhlencordt PJ

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Dec 17 00:00:00 EST 2015

Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice.

PloS one

König S,Nitzki F,Uhmann A,Dittmann K,Theiss-Suennemann J,Herrmann M,Reichardt HM,Schwendener R,Pukrop T,Schulz-Schaeffer W,Hahn H

15-4801 was used in Flow cytometry/Cell sorting to suggest that cutaneous macrophages and DC in the tumor microenvironment exert an antitumor effect on basal cell carcinomas.

Tue Jun 09 00:00:00 EDT 2015

Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development.

PLoS genetics

Li Q,Wang HY,Chepelev I,Zhu Q,Wei G,Zhao K,Wang RF

15-4801 was used in Western Blotting to provide molecular insights into the mechanisms by which Jmjd3 regulates gene expression in the embryonic stages of lung development.

Tue Jul 01 00:00:00 EDT 2014

Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development.

PLoS genetics

Li Q,Wang HY,Chepelev I,Zhu Q,Wei G,Zhao K,Wang RF

15-4801 was used in Western Blotting to provide molecular insights into the mechanisms by which Jmjd3 regulates gene expression in the embryonic stages of lung development.

Tue Jul 01 00:00:00 EDT 2014

Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface.

PloS one

Habbeddine M,Verbeke P,Karaz S,Bobé P,Kanellopoulos-Langevin C

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Jun 10 00:00:00 EDT 2015

Modular 'click-in-emulsion' bone-targeted nanogels.

Advanced materials (Deerfield Beach, Fla.)

Heller DA,Levi Y,Pelet JM,Doloff JC,Wallas J,Pratt GW,Jiang S,Sahay G,Schroeder A,Schroeder JE,Chyan Y,Zurenko C,Querbes W,Manzano M,Kohane DS,Langer R,Anderson DG

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Wed Mar 13 00:00:00 EDT 2013

Dose-dense chemotherapy improves mechanisms of antitumor immune response.

Cancer research

Chang CL,Hsu YT,Wu CC,Lai YZ,Wang C,Yang YC,Wu TC,Hung CF

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2013

Resistin-like molecule β is abundantly expressed in foam cells and is involved in atherosclerosis development.

Arteriosclerosis, thrombosis, and vascular biology

Kushiyama A,Sakoda H,Oue N,Okubo M,Nakatsu Y,Ono H,Fukushima T,Kamata H,Nishimura F,Kikuchi T,Fujishiro M,Nishiyama K,Aburatani H,Kushiyama S,Iizuka M,Taki N,Encinas J,Sentani K,Ogonuki N,Ogura A,Kawazu S,Yasui W,Higashi Y,Kurihara H,Katagiri H,Asano T

15-4801 was used in Flow cytometry/Cell sorting to demonstrate that RELMβ is abundantly expressed in foam cells within plaques and contributes to atherosclerosis development.

Thu Aug 01 00:00:00 EDT 2013

Traumatic brain injury induces macrophage subsets in the brain.

European journal of immunology

Hsieh CL,Kim CC,Ryba BE,Niemi EC,Bando JK,Locksley RM,Liu J,Nakamura MC,Seaman WE

15-4801 was used in Flow cytometry/Cell sorting to better understand the mechanisms involved in the innate inflammatory responses to brain injury.

Thu Aug 01 00:00:00 EDT 2013

Distinct development and functions of resident and recruited liver Kupffer cells/macrophages.

Journal of leukocyte biology

Ikarashi M,Nakashima H,Kinoshita M,Sato A,Nakashima M,Miyazaki H,Nishiyama K,Yamamoto J,Seki S

15-4801 was used in Flow cytometry/Cell sorting to study how liver CD68+ Kupffer cells and CD11b+ Kupffer cells/macrophages are developmentally and functionally distinct subsets.

Sun Dec 01 00:00:00 EST 2013

Dietary oleic acid increases m2 macrophages in the mesenteric adipose tissue.

PloS one

Camell C,Smith CW

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon May 12 00:00:00 EDT 2014

Intermittent hypoxia inhibits clearance of triglyceride-rich lipoproteins and inactivates adipose lipoprotein lipase in a mouse model of sleep apnoea.

European heart journal

Drager LF,Li J,Shin MK,Reinke C,Aggarwal NR,Jun JC,Bevans-Fonti S,Sztalryd C,O'Byrne SM,Kroupa O,Olivecrona G,Blaner WS,Polotsky VY

15-4801 was used in Flow cytometry/Cell sorting to show how chronic intermittent hypoxia may contribute to the atherogenesis observed in obstructive sleep apnoea.

Thu Mar 01 00:00:00 EST 2012

Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages.

Blood

He H,Xu J,Warren CM,Duan D,Li X,Wu L,Iruela-Arispe ML

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Oct 11 00:00:00 EDT 2012

Induction of autophagy is essential for monocyte-macrophage differentiation.

Blood

Zhang Y,Morgan MJ,Chen K,Choksi S,Liu ZG

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Mar 22 00:00:00 EDT 2012

Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac-1-, and p38 MAPK-dependent mechanisms.

The American journal of pathology

Ninković J,Roy S

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Mar 01 00:00:00 EST 2012

The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury.

PloS one

König K,Köhler D,Granja T,Jennewein C,Tran N,Mirakaj V,Kröhnert F,Rosenberger P

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Apr 02 00:00:00 EDT 2013

Inflammatory monocytes damage the hippocampus during acute picornavirus infection of the brain.

Journal of neuroinflammation

Howe CL,Lafrance-Corey RG,Sundsbak RS,Lafrance SJ

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Mar 09 00:00:00 EST 2012

PI3Kγ drives priming and survival of autoreactive CD4(+) T cells during experimental autoimmune encephalomyelitis.

PloS one

Comerford I,Litchfield W,Kara E,McColl SR

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Feb 26 00:00:00 EST 2013

Interferon-γ production by neutrophils during bacterial pneumonia in mice.

American journal of respiratory and critical care medicine

Yamada M,Gomez JC,Chugh PE,Lowell CA,Dinauer MC,Dittmer DP,Doerschuk CM

15-4801 was used in Flow cytometry/Cell sorting to reveal that neutrophils produce IFN-γ early in the inflammatory response during pneumonia induced by some bacteria, but not others.

Sun May 15 00:00:00 EDT 2011

p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages.

Blood

Cudejko C,Wouters K,Fuentes L,Hannou SA,Paquet C,Bantubungi K,Bouchaert E,Vanhoutte J,Fleury S,Remy P,Tailleux A,Chinetti-Gbaguidi G,Dombrowicz D,Staels B,Paumelle R

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2011

Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice.

The Journal of allergy and clinical immunology

Arias K,Chu DK,Flader K,Botelho F,Walker T,Arias N,Humbles AA,Coyle AJ,Oettgen HC,Chang HD,Van Rooijen N,Waserman S,Jordana M

15-4801 was used in Flow cytometry/Cell sorting to investigate the relative contribution of immunoglobulin-dependent effector pathways to anaphylactic responses to food.

Wed Jun 01 00:00:00 EDT 2011

The tumor suppressor ARF regulates innate immune responses in mice.

Journal of immunology (Baltimore, Md. : 1950)

Través PG,López-Fontal R,Luque A,Hortelano S

15-4801 was used in Flow cytometry/Cell sorting to investigate the role of the tumour suppressor alternative reading frame (ARF) in the regulation of innate immunity in mice.

Thu Dec 15 00:00:00 EST 2011

DNA alkylating therapy induces tumor regression through an HMGB1-mediated activation of innate immunity.

Journal of immunology (Baltimore, Md. : 1950)

Guerriero JL,Ditsworth D,Catanzaro JM,Sabino G,Furie MB,Kew RR,Crawford HC,Zong WX

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Mar 15 00:00:00 EDT 2011

Myeloid cells migrate in response to IL-24.

Cytokine

Buzas K,Oppenheim JJ,Zack Howard OM

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2011

Abscisic acid regulates inflammation via ligand-binding domain-independent activation of peroxisome proliferator-activated receptor gamma.

The Journal of biological chemistry

Bassaganya-Riera J,Guri AJ,Lu P,Climent M,Carbo A,Sobral BW,Horne WT,Lewis SN,Bevan DR,Hontecillas R

15-4801 was used in Flow cytometry/Cell sorting to conclude ABA decreases LPS-mediated inflammation and regulates innate immune responses through a bifurcating pathway involving LANCL2.

Fri Jan 28 00:00:00 EST 2011

Suppression and regression of choroidal neovascularization in mice by a novel CCR2 antagonist, INCB3344.

PloS one

Xie P,Kamei M,Suzuki M,Matsumura N,Nishida K,Sakimoto S,Sakaguchi H,Nishida K

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Mon Apr 23 00:00:00 EDT 2012

T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice.

Obesity (Silver Spring, Md.)

Strissel KJ,DeFuria J,Shaul ME,Bennett G,Greenberg AS,Obin MS

15-4801 was used in Flow cytometry/Cell sorting to conclude that T-cell enrichment and IFN-γ gene induction occur subsequent to AT macrophage (ATMΦ) recruitment, onset of IR and resolution of eAT remodeling.

Fri Oct 01 00:00:00 EDT 2010

Decitabine maintains hematopoietic precursor self-renewal by preventing repression of stem cell genes by a differentiation-inducing stimulus.

Molecular cancer therapeutics

Hu Z,Negrotto S,Gu X,Mahfouz R,Ng KP,Ebrahem Q,Copelan E,Singh H,Maciejewski JP,Saunthararajah Y

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2010

Loss of negative feedback control of nuclear factor-kappaB2 activity in lymphocytes leads to fatal lung inflammation.

The American journal of pathology

Yang L,Cui H,Wang Z,Zhang B,Ding J,Liu L,Ding HF

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2010

Interleukin-10 production by tumor infiltrating macrophages plays a role in Human Papillomavirus 16 tumor growth.

BMC immunology

Bolpetti A,Silva JS,Villa LL,Lepique AP

15-4801 was used in Flow cytometry/Cell sorting to establish if IL-10 is associated with HPV tumour-associated-macrophages inducing a Treg phenotype, inhibiting anti-tumour activity and facilitating tumour growth.

Mon Jun 07 00:00:00 EDT 2010

Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses.

Journal of immunology (Baltimore, Md. : 1950)

Walsh KP,Brady MT,Finlay CM,Boon L,Mills KH

15-4801 was used in Flow cytometry/Cell sorting to provide evidence that parasites can exert bystander immunosuppression of pathogenic T cells that mediate autoimmune diseases.

Sat Aug 01 00:00:00 EDT 2009

Enhanced susceptibility to Leishmania infection in resistant mice in the absence of immediate early response gene X-1.

Journal of immunology (Baltimore, Md. : 1950)

Akilov OE,Ustyugova IV,Zhi L,Hasan T,Wu MX

15-4801 was used in Immunohistochemistry on paraffin embedded tissues to explore a potential role for immediate early response gene X-1 in control of the susceptibility to Leishmania major infection.

Tue Dec 15 00:00:00 EST 2009

Treatment with LL-37 peptide enhances antitumor effects induced by CpG oligodeoxynucleotides against ovarian cancer.

Human gene therapy

Chuang CM,Monie A,Wu A,Mao CP,Hung CF

15-4801 was used in Flow cytometry/Cell sorting to demonstrate the potential of combined CpG-ODN-LL-37 peptide treatment for the control of ovarian tumours.

Wed Apr 01 00:00:00 EDT 2009

Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells.

Nature immunology

Lee SW,Park Y,So T,Kwon BS,Cheroutre H,Mittler RS,Croft M

Published figure using F4/80 monoclonal antibody (Product # 15-4801-82) in Flow Cytometry

Fri Aug 01 00:00:00 EDT 2008

Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice.

Cell

Ueki Y,Lin CY,Senoo M,Ebihara T,Agata N,Onji M,Saheki Y,Kawai T,Mukherjee PM,Reichenberger E,Olsen BR

15-4801 was used in Flow cytometry/Cell sorting to demonstrate that Sh3bp2 "cherubism'' mice exhibit trabecular bone loss, TNF-α-dependent systemic inflammation, and cortical bone erosion.

Fri Jan 12 00:00:00 EST 2007

Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro.

Journal of leukocyte biology

Geutskens SB,Otonkoski T,Pulkkinen MA,Drexhage HA,Leenen PJ

Sat Oct 01 00:00:00 EDT 2005

Bioinformatics

Protein Aliases: Adhesion G protein-coupled receptor E1; Cell surface glycoprotein F4/80; EGF-like module containing, mucin-like, hormone receptor-like sequence 1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor; lymphocyte antigen 71

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Gene Aliases: Adgre1; DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480; Ly71; TM7LN3

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UniProt ID: (Mouse) Q61549

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Entrez Gene ID: (Mouse) 13733

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Function(s)

signal transducer activity transmembrane signaling receptor activity G-protein coupled receptor activity calcium ion binding G-protein coupled receptor

Process(es)

signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway

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F4/80 Monoclonal Antibody (BM8), PE-Cyanine5, eBioscience™

F4/80 Antibody (15-4801-82) in Flow

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15-4801-82

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