Proteintech

GATA2 Polyclonal Antibody

GATA2 Antibody in Immunocytochemistry (ICC/IF)

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GATA2 Antibody (11103-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using GATA2 antibody 11103-1-AP at 1:100 dilution and FITC-labeled donkey anti-rabbit IGG (green). Blue pseudocolor = DAPI (fluorescent DNA dye).

GATA2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

11103-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 2 publications 2 publications

ChIP assay (ChIP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GATA2 Fusion Protein Ag1557 (168-467 aa encoded by BC018988)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.36 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SHLFGFPPT PPKEVSPDPS TTGAASPASS SAGGSAARGE DKDGVKYQVS LTESMKMESG SPLRPGLATM GTQPATHHPI PTYPSYVPAA AHDYSSGLFH PGGFLGGPAS SFTPKQRSKA RSCSEGRECV NCGATATPLW RRDGTGHYLC NACGLYHKMN GQNRPLIKPK RRLTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SNKSKKSKKG AECFEELSKC MQEKSSPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG (168-467 aa encoded by BC018988)

Target Information

GATA2 (GATA binding protein 2) belongs to the GATA family of transcription factors. GATA proteins play a very important role in signaling pathways controlling proliferation and differentiation of erythroid progenitor cells. There are 6 transcription factors in the GATA family: GATA1 to GATA6. GATA2 is a transcriptional activator regulating endothelin-1 gene expression in endothelial cells. It also appears to be involved in differentiation of other tissue types (uro-genital and nervous) during embryogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Downregulation of AC092894.1 promotes oxaliplatin resistance in colorectal cancer via the USP3/AR/RASGRP3 axis.

BMC medicine

Zheng Z,Wu M,Li H,Xu W,Yang M,Pan K,Ni Y,Jiang T,Zheng H,Jin X,Zhang Y,Ding L,Fu J

Mon Apr 03 00:00:00 EDT 2023

Divergent transcriptional regulation of astrocyte reactivity across disorders.

Nature

Burda JE,O'Shea TM,Ao Y,Suresh KB,Wang S,Bernstein AM,Chandra A,Deverasetty S,Kawaguchi R,Kim JH,McCallum S,Rogers A,Wahane S,Sofroniew MV

Wed Jun 01 00:00:00 EDT 2022

Functional Lactotrophs in Induced Adenohypophysis Differentiated From Human iPS Cells.

Endocrinology

Miyake N,Nagai T,Suga H,Osuka S,Kasai T,Sakakibara M,Soen M,Ozaki H,Miwata T,Asano T,Kano M,Muraoka A,Nakanishi N,Nakamura T,Goto M,Yasuda Y,Kawaguchi Y,Miyata T,Kobayashi T,Sugiyama M,Onoue T,Hagiwara D,Iwama S,Iwase A,Inoshita N,Arima H,Kajiyama H

Tue Mar 01 00:00:00 EST 2022

GATA2 regulates the CAD susceptibility gene ADTRP rs6903956 through preferential interaction with the G allele.

Molecular genetics and genomics : MGG

Luo C,Tang B,Qin S,Yuan C,Du Y,Yang J

Thu Jul 01 00:00:00 EDT 2021

LncRNA H19-Derived miR-675-5p Accelerates the Invasion of Extravillous Trophoblast Cells by Inhibiting GATA2 and Subsequently Activating Matrix Metalloproteinases.

International journal of molecular sciences

Ogoyama M,Ohkuchi A,Takahashi H,Zhao D,Matsubara S,Takizawa T

Wed Jan 27 00:00:00 EST 2021

PGE2 and Thrombin Induce Myofibroblast Transdifferentiation via Activin A and CTGF in Endometrial Stromal Cells.

Endocrinology

Kusama K,Fukushima Y,Yoshida K,Azumi M,Yoshie M,Mizuno Y,Kajihara T,Tamura K

Wed Dec 01 00:00:00 EST 2021

PGE2 and Thrombin Induce Myofibroblast Transdifferentiation via Activin A and CTGF in Endometrial Stromal Cells.

Endocrinology

Kusama K,Fukushima Y,Yoshida K,Azumi M,Yoshie M,Mizuno Y,Kajihara T,Tamura K

Wed Dec 01 00:00:00 EST 2021

The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia.

PLoS genetics

Shen C,Chen MT,Zhang XH,Yin XL,Ning HM,Su R,Lin HS,Song L,Wang F,Ma YN,Zhao HL,Yu J,Zhang JW

Thu Sep 01 00:00:00 EDT 2016

The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia.

PLoS genetics

Shen C,Chen MT,Zhang XH,Yin XL,Ning HM,Su R,Lin HS,Song L,Wang F,Ma YN,Zhao HL,Yu J,Zhang JW

Thu Sep 01 00:00:00 EDT 2016

Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells.

The EMBO journal

Ma Y,Yao N,Liu G,Dong L,Liu Y,Zhang M,Wang F,Wang B,Wei X,Dong H,Wang L,Ji S,Zhang J,Wang Y,Huang Y,Yu J

Tue Feb 03 00:00:00 EST 2015

Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells.

The EMBO journal

Ma Y,Yao N,Liu G,Dong L,Liu Y,Zhang M,Wang F,Wang B,Wei X,Dong H,Wang L,Ji S,Zhang J,Wang Y,Huang Y,Yu J

Tue Feb 03 00:00:00 EST 2015

Bioinformatics

Protein Aliases: Endothelial transcription factor GATA-2; FLJ45948; GATA-binding protein 2; GATA-bindning protein 2; gata2 {ECO:0000312|EMBL:AAK51128.1}; MGC2306

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Gene Aliases: DCML; Gata-2; GATA2; IMD21; MONOMAC; NFE1B

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UniProt ID: (Human) P23769, (Mouse) O09100, (Rat) Q924Y4

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Entrez Gene ID: (Human) 2624, (Mouse) 14461, (Rat) 25159

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Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding zinc ion binding C2H2 zinc finger domain binding DNA binding sequence-specific DNA binding metal ion binding DNA-binding transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter urogenital system development cell fate determination neuron migration embryonic placenta development transcription, DNA-templated transcription from RNA polymerase II promoter phagocytosis positive regulation of cytosolic calcium ion concentration heart development blood coagulation organ morphogenesis tissue development regulation of primitive erythrocyte differentiation ventral spinal cord interneuron differentiation cell differentiation in hindbrain commitment of neuronal cell to specific neuron type in forebrain central nervous system neuron development pituitary gland development response to lipid somatic stem cell population maintenance regulation of histone acetylation eosinophil fate commitment inner ear morphogenesis mast cell degranulation negative regulation of fat cell differentiation positive regulation of erythrocyte differentiation negative regulation of macrophage differentiation positive regulation of megakaryocyte differentiation positive regulation of neuron differentiation negative regulation of Notch signaling pathway positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter cell maturation digestive tract development homeostasis of number of cells within a tissue positive regulation of phagocytosis positive regulation of phagocytosis, engulfment definitive hemopoiesis semicircular canal development negative regulation of fat cell proliferation GABAergic neuron differentiation negative regulation of neural precursor cell proliferation regulation of forebrain neuron differentiation regulation of transcription, DNA-templated hemopoiesis cell differentiation neuron differentiation negative regulation of myeloid cell differentiation neuron fate commitment

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GATA2 Polyclonal Antibody

GATA2 Antibody (11103-1-AP) in ICC/IF

Product Details

11103-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

ChIP assay (ChIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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