Product References
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity.
Nature communications
Read KA,Jones DM,Pokhrel S,Hales EDS,Varkey A,Tuazon JA,Eisele CD,Abdouni O,Saadey A,Leonard MR,Warren RT,Powell MD,Boss JM,Hemann EA,Yount JS,Xin G,Ghoneim HE,Lio CJ,Freud AG,Collins PL,Oestreich KJ
GRB04 was used in Flow Cytometry to identify Aiolos as a pivotal regulator of CD4-CTL and TFH programming and highlight its potential as a target for manipulating CD4+ T cell responses.
Fri Mar 24 00:00:00 EDT 2023
Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy.
Science advances
Poh AR,Love CG,Chisanga D,Steer JH,Baloyan D,Chopin M,Nutt S,Rautela J,Huntington ND,Etemadi N,O'Brien M,O'Keefe R,Ellies LG,Macri C,Mintern JD,Whitehead L,Gangadhara G,Boon L,Chand AL,Lowell CA,Shi W,Pixley FJ,Ernst M
GRB04 was used in Flow cytometry/Cell sorting to suggest that therapeutic targeting of HCK activity enhances response to immunotherapy by simultaneously stimulating immune cell activation and inhibiting the immunosuppressive tumor microenvironment.
Fri Jun 24 00:00:00 EDT 2022
Functional virus-specific memory T cells survey glioblastoma.
Cancer immunology, immunotherapy : CII
Ning J,Gavil NV,Wu S,Wijeyesinghe S,Weyu E,Ma J,Li M,Grigore FN,Dhawan S,Skorput AGJ,Musial SC,Chen CC,Masopust D,Rosato PC
GRB04 was used in Flow cytometry/Cell sorting to indicate that virus-specific memory T cells are a significant part of the glioblastoma immune microenvironment and may be leveraged to promote anti-tumoral immunity.
Mon Aug 01 00:00:00 EDT 2022
BATF regulates progenitor to cytolytic effector CD8+ T cell transition during chronic viral infection.
Nature immunology
Chen Y,Zander RA,Wu X,Schauder DM,Kasmani MY,Shen J,Zheng S,Burns R,Taparowsky EJ,Cui W
GRB04 was used in Flow cytometry/Cell sorting to show that these mechanistic insights can potentially be harnessed to overcome T cell exhaustion during chronic infection and cancer.
Sun Aug 01 00:00:00 EDT 2021
CD8+ T cell self-tolerance permits responsiveness but limits tissue damage.
eLife
Truckenbrod EN,Burrack KS,Knutson TP,Borges da Silva H,Block KE,O'Flanagan SD,Stagliano KR,Hurwitz AA,Fulton RB,Renkema KR,Jameson SC
GRB04 was used in Flow cytometry/Cell sorting to conclude that CD8+ T cell self-specificity is poorly predicted by precursor frequency, phenotype, or even initial responsiveness, while deficient activation-induced CD25 expression and other gene expression characteristics may help to identify functionally tolerant cells.
Fri Apr 30 00:00:00 EDT 2021
A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2.
Cell
Hassan AO,Kafai NM,Dmitriev IP,Fox JM,Smith BK,Harvey IB,Chen RE,Winkler ES,Wessel AW,Case JB,Kashentseva E,McCune BT,Bailey AL,Zhao H,VanBlargan LA,Dai YN,Ma M,Adams LJ,Shrihari S,Danis JE,Gralinski LE,Hou YJ,Schäfer A,Kim AS,Keeler SP,Weiskopf D,Baric RS,Holtzman MJ,Fremont DH,Curiel DT,Diamond MS
GRB04 was used in Flow cytometry/Cell sorting to establish that immunization with ChAd-SARS-CoV-2-S induces both neutralizing antibody and antigen-specific CD8+ T cell responses.
Thu Oct 01 00:00:00 EDT 2020
CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset that Protects against Chronic Infection and Cancer.
Immunity
Zander R,Schauder D,Xin G,Nguyen C,Wu X,Zajac A,Cui W
GRB04 was used in Flow cytometry/Cell sorting to use single-cell RNA sequencing, we show that CD8+ T cells responding to chronic infection were more heterogeneous than previously appreciated.
Tue Dec 17 00:00:00 EST 2019
Interleukin-24 Regulates T Cell Activity in Patients With Colorectal Adenocarcinoma.
Frontiers in oncology
Zhang Y,Liu Y,Xu Y
GRB04 was used in Flow Cytometry to indicate that IL-24 might regulate T cell function in a dose-dependent manner.
Wed Sep 30 00:00:00 EDT 2020
Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy.
Nature communications
Rosato PC,Wijeyesinghe S,Stolley JM,Nelson CE,Davis RL,Manlove LS,Pennell CA,Blazar BR,Chen CC,Geller MA,Vezys V,Masopust D
Published figure using Granzyme B monoclonal antibody (Product # GRB04) in Flow Cytometry
Mon Feb 04 00:00:00 EST 2019
Synergy of therapeutic heterologous prime-boost hepatitis B vaccination with CpG-application to improve immune control of persistent HBV infection.
Scientific reports
Kosinska AD,Moeed A,Kallin N,Festag J,Su J,Steiger K,Michel ML,Protzer U,Knolle PA
GRB04 was used in Flow cytometry/Cell sorting to demonstrate the synergy of prime-boost hepatitis B vaccination and CpG-injection in inducing enhanced CD8 T cell immunity in the liver.
Thu Jul 25 00:00:00 EDT 2019
Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice.
Cell reports
Salazar V,Jagger BW,Mongkolsapaya J,Burgomaster KE,Dejnirattisai W,Winkler ES,Fernandez E,Nelson CA,Fremont DH,Pierson TC,Crowe JE,Screaton GR,Diamond MS
GRB04 was used in Flow cytometry/Cell sorting to investigate the pathogenic spectrum of Spondweni virus.
Tue Feb 05 00:00:00 EST 2019
Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine.
The Journal of experimental medicine
Li N,van Unen V,Höllt T,Thompson A,van Bergen J,Pezzotti N,Eisemann E,Vilanova A,Chuva de Sousa Lopes SM,Lelieveldt BPF,Koning F
GRB04 was used in Flow cytometry/Cell sorting to identify a previously unknown intermediate innate subset that can differentiate into ILC3 and NK cells.
Mon May 07 00:00:00 EDT 2018
Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells.
International immunology
Lettau M,Armbrust F,Dohmen K,Drews L,Poch T,Dietz M,Kabelitz D,Janssen O
GRB04 was used in Flow cytometry/Cell sorting to show that distinct cytotoxic effector granules are differentially regulates with respect to signalling requirements and transport mechanisms.
Wed Apr 25 00:00:00 EDT 2018
Differentiation and Protective Capacity of Virus-Specific CD8+ T Cells Suggest Murine Norovirus Persistence in an Immune-Privileged Enteric Niche.
Immunity
Tomov VT,Palko O,Lau CW,Pattekar A,Sun Y,Tacheva R,Bengsch B,Manne S,Cosma GL,Eisenlohr LC,Nice TJ,Virgin HW,Wherry EJ
GRB04 was used in Flow Cytometry to elucidate a strategy of immune evasion by mouse norovirus via the induction of a CD8+ T cell program normally reserved for latent pathogens and persistence in an immune-privileged enteric niche.
Tue Oct 17 00:00:00 EDT 2017
Low-dose interleukin-2 promotes STAT-5 phosphorylation, Treg survival and CTLA-4-dependent function in autoimmune liver diseases.
Clinical and experimental immunology
Jeffery HC,Jeffery LE,Lutz P,Corrigan M,Webb GJ,Hirschfield GM,Adams DH,Oo YH
GRB04 was used in flow cytometry to examine the potential of IL-2 to enhance T regulatory cell therapy
Thu Jun 01 00:00:00 EDT 2017
The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis.
Journal of virology
Gorman MJ,Poddar S,Farzan M,Diamond MS
GRB04 was used in flow cytometry to assess the contribution of interferon-induced transmembrane protein 3 to West Nile virus infection
Thu Sep 15 00:00:00 EDT 2016
Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8(+) T Lymphocyte Fates.
Scientific reports
Metz PJ,Lopez J,Kim SH,Akimoto K,Ohno S,Chang JT
GRB04 was used in Flow cytometry/Cell sorting to show that deletion of both PKCζ and PKCλ/ι isoforms impairs cytokinesis and thus leads to disproportionate inheritance of effector fate-associated molecules in daughter cells.
Thu Jan 14 00:00:00 EST 2016
Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells.
The Journal of experimental medicine
Herz J,Johnson KR,McGavern DB
GRB04 was used in flow cytometry to determine if therapeutic antiviral T cells eliminate viral load in the brain of mice persistently infected from birth with lymphocytic choriomeningitis virus without causing blood-brain barrier breakdown or tissue damage
Mon Jul 27 00:00:00 EDT 2015
Cutaneous Infection with Leishmania major Mediates Heterologous Protection against Visceral Infection with Leishmania infantum.
Journal of immunology (Baltimore, Md. : 1950)
Romano A,Doria NA,Mendez J,Sacks DL,Peters NC
Published figure using Granzyme B monoclonal antibody (Product # GRB04) in Flow Cytometry
Thu Oct 15 00:00:00 EDT 2015
Regulation of asymmetric division and CD8+ T lymphocyte fate specification by protein kinase Cζ and protein kinase Cλ/ι.
Journal of immunology (Baltimore, Md. : 1950)
Metz PJ,Arsenio J,Kakaradov B,Kim SH,Remedios KA,Oakley K,Akimoto K,Ohno S,Yeo GW,Chang JT
GRB04 was used in Flow cytometry/Cell sorting to show that PKCζ and PKCλ/i regulate asymmetric localization of effector fate-associated factors during the first CD8+ T cell division in vivo.
Sun Mar 01 00:00:00 EST 2015
Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.
Gene therapy
Rodriguez-Peña AB,Gomez-Rodriguez J,Kortum RL,Palmer DC,Yu Z,Guittard GC,Wohlfert EA,Silver PB,Misplon JA,Sommers CL,Feigenbaum L,Epstein SL,Caspi RR,Belkaid Y,Restifo NP,Samelson LE,Balagopalan L
Published figure using Granzyme B monoclonal antibody (Product # GRB04) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2015
Genetic Adjuvantation of Recombinant MVA with CD40L Potentiates CD8 T Cell Mediated Immunity.
Frontiers in immunology
Lauterbach H,Pätzold J,Kassub R,Bathke B,Brinkmann K,Chaplin P,Suter M,Hochrein H
GRB04 was used in flow cytometry to optimize the CD8 T cell-inducing capacity of modified vaccinia Ankara
Thu Aug 29 00:00:00 EDT 2013
Persistent enteric murine norovirus infection is associated with functionally suboptimal virus-specific CD8 T cell responses.
Journal of virology
Tomov VT,Osborne LC,Dolfi DV,Sonnenberg GF,Monticelli LA,Mansfield K,Virgin HW,Artis D,Wherry EJ
GRB04 was used in Flow cytometry/Cell sorting to investigate the magnitude, location, and dynamics of the murine norovirus-specific immune response.
Sat Jun 01 00:00:00 EDT 2013
Regulatory CD8+ T cells associated with erosion of immune surveillance in persistent virus infection suppress in vitro and have a reversible proliferative defect.
Journal of immunology (Baltimore, Md. : 1950)
Hu Z,Zhang W,Usherwood EJ
GRB04 was used in flow cytometry to determine the generation, phenotype, and function of IL-10-producing CD8(+) T cells in mice infected with murine γ-herpesvirus-68.
Mon Jul 01 00:00:00 EDT 2013
Breakdown in repression of IFN-γ mRNA leads to accumulation of self-reactive effector CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Chang PP,Lee SK,Hu X,Davey G,Duan G,Cho JH,Karupiah G,Sprent J,Heath WR,Bertram EM,Vinuesa CG
GRB04 was used in flow cytometry to study CD8(+) T cell homeostasis and CD8-mediated autoimmunity.
Sun Jul 15 00:00:00 EDT 2012
Autocrine IL-2 is required for secondary population expansion of CD8(+) memory T cells.
Nature immunology
Feau S,Arens R,Togher S,Schoenberger SP
Published figure using Granzyme B monoclonal antibody (Product # GRB04) in Flow Cytometry
Sun Jul 31 00:00:00 EDT 2011
Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.
Journal of immunology (Baltimore, Md. : 1950)
Hamada H,Garcia-Hernandez Mde L,Reome JB,Misra SK,Strutt TM,McKinstry KK,Cooper AM,Swain SL,Dutton RW
GRB04 was used in flow cytometry to elucidate the role of IL-17 in influenza A infection
Sun Mar 15 00:00:00 EDT 2009
A significantly impaired natural killer cell activity due to a low activity on a per-cell basis in rheumatoid arthritis.
Modern rheumatology
Aramaki T,Ida H,Izumi Y,Fujikawa K,Huang M,Arima K,Tamai M,Kamachi M,Nakamura H,Kawakami A,Origuchi T,Matsuoka N,Eguchi K
GRB04 was used in flow cytometry to characterize peripheral natural killer cells in patients with rheumatoid arthritis
Tue Oct 27 00:00:00 EDT 2009
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells.
The Journal of clinical investigation
Gattinoni L,Klebanoff CA,Palmer DC,Wrzesinski C,Kerstann K,Yu Z,Finkelstein SE,Theoret MR,Rosenberg SA,Restifo NP
GRB04 was used in Flow Cytometry to suggest that the current methodology for selecting T cells for transfer is inadequate and provide new criteria for the generation and the screening of optimal lymphocyte populations for adoptive immunotherapy.
Wed Jun 01 00:00:00 EDT 2005
Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Klebanoff CA,Gattinoni L,Torabi-Parizi P,Kerstann K,Cardones AR,Finkelstein SE,Palmer DC,Antony PA,Hwang ST,Rosenberg SA,Waldmann TA,Restifo NP
GRB04 was used in flow cytometry to evaluate the therapeutic potential of different tumor-reactive CD8+ T cell memory subsets in vivo
Tue Jul 05 00:00:00 EDT 2005
