Product References
Rapamycin improves Graves' orbitopathy by suppressing CD4+ cytotoxic T lymphocytes.
JCI insight
Zhang M,Chong KK,Chen ZY,Guo H,Liu YF,Kang YY,Li YJ,Shi TT,Lai KK,He MQ,Ye K,Kahaly GJ,Shi BY,Wang Y
Published figure using Granzyme B monoclonal antibody (Product # GRB05) in Flow Cytometry
Wed Feb 08 00:00:00 EST 2023
Rapamycin improves Graves' orbitopathy by suppressing CD4+ cytotoxic T lymphocytes.
JCI insight
Zhang M,Chong KK,Chen ZY,Guo H,Liu YF,Kang YY,Li YJ,Shi TT,Lai KK,He MQ,Ye K,Kahaly GJ,Shi BY,Wang Y
Published figure using Granzyme B monoclonal antibody (Product # GRB05) in Flow Cytometry
Wed Feb 08 00:00:00 EST 2023
HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease.
JCI insight
Little AJ,Chen PM,Vesely MD,Khan RN,Fiedler J,Garritano J,Maisha FI,McNiff JM,Craft J
GRB05 was used in Flow Cytometry to demonstrate in human CLE tissue that the T cell-rich inflammatory infiltrate exhibited increased amounts of HIF-1 and a cytotoxic signature.
Tue Aug 22 00:00:00 EDT 2023
Assessing in vivo presentation of exogenous antigen in the tumor microenvironment in mice.
STAR protocols
Nixon BG,Ji L,Li MO
GRB05 was used in Flow Cytometry to demonstrate presentation of exogenous antigen that is acquired and processed in the tumor microenvironment.
Wed Mar 22 00:00:00 EDT 2023
Divergent metabolic programmes control two populations of MAIT cells that protect the lung.
Nature cell biology
Riffelmacher T,Paynich Murray M,Wientjens C,Chandra S,Cedillo-Castelán V,Chou TF,McArdle S,Dillingham C,Devereaux J,Nilsen A,Brunel S,Lewinsohn DM,Hasty J,Seumois G,Benedict CA,Vijayanand P,Kronenberg M
GRB05 was used in Flow Cytometry to investigate the metabolic dependencies that enable tuning of memory-like MAIT cell responses following pulmonary immunization with a Salmonella vaccine strain, revealing distinct CD127+ and Klrg1+ MAIT cell populations with divergent metabolic profiles and functions.
Thu Jun 01 00:00:00 EDT 2023
Systematic characterization of the tumor microenvironment in Chinese patients with hepatocellular carcinoma highlights intratumoral B cells as a potential immunotherapy target.
Oncology reports
Feng Y,Liu L,Li J,Huang J,Xie JH,Menard L,Shi Y,Zhao X,Xie S,Zang W,Tan H,Yang Z,Ni L
GRB05 was used in Flow cytometry/Cell sorting to assess the expression of membrane spanning 4‚domains A1 (MS4A1; encoding CD20) in tumors and normal liver tissues.
Tue Feb 01 00:00:00 EST 2022
Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation.
Nature communications
Lainé A,Labiad O,Hernandez-Vargas H,This S,Sanlaville A,Léon S,Dalle S,Sheppard D,Travis MA,Paidassi H,Marie JC
GRB05 was used in Flow Cytometry to investigate whether TGFβ activation within the tumor depends on different cell types and mechanisms than its production.
Thu Oct 28 00:00:00 EDT 2021
Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation.
Nature communications
Lainé A,Labiad O,Hernandez-Vargas H,This S,Sanlaville A,Léon S,Dalle S,Sheppard D,Travis MA,Paidassi H,Marie JC
GRB05 was used in Flow Cytometry to investigate whether TGFβ activation within the tumor depends on different cell types and mechanisms than its production.
Thu Oct 28 00:00:00 EDT 2021
Natural killer cells and dendritic epidermal γδ T cells orchestrate type 1 conventional DC spatiotemporal repositioning toward CD8+ T cells.
iScience
Ghilas S,Ambrosini M,Cancel JC,Brousse C,Massé M,Lelouard H,Dalod M,Crozat K
Published figure using Granzyme B monoclonal antibody (Product # GRB05) in Flow Cytometry
Fri Sep 24 00:00:00 EDT 2021
Restoration of type I interferon signaling in intrahepatically primed CD8+ T cells promotes functional differentiation.
JCI insight
Kawashima K,Isogawa M,Onishi M,Baudi I,Saito S,Nakajima A,Fujita T,Tanaka Y
GRB05 was used in Flow Cytometry to demonstrate that intrahepatic priming suppresses IFN-I signaling in CD8+ T cells, which may contribute to the dysfunctionality, and a therapeutic value of the robust induction of intrahepatic IFN-Is for the treatment of chronic HBV infection.
Mon Feb 08 00:00:00 EST 2021
Restoration of type I interferon signaling in intrahepatically primed CD8+ T cells promotes functional differentiation.
JCI insight
Kawashima K,Isogawa M,Onishi M,Baudi I,Saito S,Nakajima A,Fujita T,Tanaka Y
GRB05 was used in Flow Cytometry to demonstrate that intrahepatic priming suppresses IFN-I signaling in CD8+ T cells, which may contribute to the dysfunctionality, and a therapeutic value of the robust induction of intrahepatic IFN-Is for the treatment of chronic HBV infection.
Mon Feb 08 00:00:00 EST 2021
Bispecific T-Cell Engaging Antibodies Against MUC16 Demonstrate Efficacy Against Ovarian Cancer in Monotherapy and in Combination With PD-1 and VEGF Inhibition.
Frontiers in immunology
Yeku OO,Rao TD,Laster I,Kononenko A,Purdon TJ,Wang P,Cui Z,Liu H,Brentjens RJ,Spriggs D
GRB05 was used in Flow Cytometry to show the feasibility and efficacy of human MUC16 ectodomain- specific BiTEDs and provide a basis for the combination with anti-VEGF therapy for ovarian cancer.
Thu Oct 21 00:00:00 EDT 2021
Bispecific T-Cell Engaging Antibodies Against MUC16 Demonstrate Efficacy Against Ovarian Cancer in Monotherapy and in Combination With PD-1 and VEGF Inhibition.
Frontiers in immunology
Yeku OO,Rao TD,Laster I,Kononenko A,Purdon TJ,Wang P,Cui Z,Liu H,Brentjens RJ,Spriggs D
GRB05 was used in Flow Cytometry to show the feasibility and efficacy of human MUC16 ectodomain- specific BiTEDs and provide a basis for the combination with anti-VEGF therapy for ovarian cancer.
Thu Oct 21 00:00:00 EDT 2021
Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway.
eLife
Kim EH,Woodruff MC,Grigoryan L,Maier B,Lee SH,Mandal P,Cortese M,Natrajan MS,Ravindran R,Ma H,Merad M,Gitlin AD,Mocarski ES,Jacob J,Pulendran B
GRB05 was used in Flow cytometry/Cell sorting to demonstrate that squalene emulsion-based vaccine adjuvants induce antigen-specific CD8 T cell and antibody responses, through RIPK3-dependent and-independent pathways, respectively.
Tue Jun 09 00:00:00 EDT 2020
Restored immune cell functions upon clearance of senescence in the irradiated splenic environment.
Aging cell
Palacio L,Goyer ML,Maggiorani D,Espinosa A,Villeneuve N,Bourbonnais S,Moquin-Beaudry G,Le O,Demaria M,Davalos AR,Decaluwe H,Beauséjour C
GRB05 was used in Flow cytometry/Cell sorting to provide molecular insight on how senescence-inducing IR promotes loss of immune cell fitness, which suggest senolytic drugs may improve immune cell function in aged and patients undergoing cancer treatment.
Thu Aug 01 00:00:00 EDT 2019
A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression.
Nature communications
Myers LM,Tal MC,Torrez Dulgeroff LB,Carmody AB,Messer RJ,Gulati G,Yiu YY,Staron MM,Angel CL,Sinha R,Markovic M,Pham EA,Fram B,Ahmed A,Newman AM,Glenn JS,Davis MM,Kaech SM,Weissman IL,Hasenkrug KJ
GRB05 was used in Flow cytometry/Cell sorting to demonstrate that even during exhaustion there is a subset of functional CD8+ T cells defined by surface expression of SIRPα.
Fri Feb 15 00:00:00 EST 2019
PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy.
The Journal of clinical investigation
Zamarin D,Ricca JM,Sadekova S,Oseledchyk A,Yu Y,Blumenschein WM,Wong J,Gigoux M,Merghoub T,Wolchok JD
GRB05 was used in Flow cytometry/Cell sorting to use human tumour histocultures and syngeneic tumour models treated with Newcastle disease virus to identify immune targets upregulated by OV treatment.
Mon Apr 02 00:00:00 EDT 2018
PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity.
Clinical cancer research : an official journal of the American Association for Cancer Research
Buchan SL,Fallatah M,Thirdborough SM,Taraban VY,Rogel A,Thomas LJ,Penfold CA,He LZ,Curran MA,Keler T,Al-Shamkhani A
GRB05 was used in Flow cytometry/Cell sorting to show that suboptimal T-cell invigoration in cancer patients undergoing treatment with PD-1 checkpoint blockers will be improved by dual PD-1 blockade and CD27 agonism.
Tue May 15 00:00:00 EDT 2018
Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria.
Science immunology
Balin SJ,Pellegrini M,Klechevsky E,Won ST,Weiss DI,Choi AW,Hakimian J,Lu J,Ochoa MT,Bloom BR,Lanier LL,Stenger S,Modlin RL
GRB05 was used in Flow cytometry/Cell sorting to determine that CD8+ CTLs expressing granzyme B, perforin, and granulysin, as well as the activating NK receptor NKG2C, represent a population of "antimicrobial CTLs" (amCTLs) capable of T cell receptor (TCR)-dependent and TCR-independent release of cytotoxic granule proteins that mediate antimicrobial activity.
Fri Aug 31 00:00:00 EDT 2018
Adaptive Immune Responses to Zika Virus Are Important for Controlling Virus Infection and Preventing Infection in Brain and Testes.
Journal of immunology (Baltimore, Md. : 1950)
Winkler CW,Myers LM,Woods TA,Messer RJ,Carmody AB,McNally KL,Scott DP,Hasenkrug KJ,Best SM,Peterson KE
GRB05 was used in Flow cytometry/Cell sorting to study the response of the adaptive immune system to ZIKV infection and determine its role in regulating viral infection and preventing disease.
Mon May 01 00:00:00 EDT 2017
Lymphocytes have a role in protection, but not in pathogenesis, during La Crosse Virus infection in mice.
Journal of neuroinflammation
Winkler CW,Myers LM,Woods TA,Carmody AB,Taylor KG,Peterson KE
Published figure using Granzyme B monoclonal antibody (Product # GRB05) in Flow Cytometry
Fri Mar 24 00:00:00 EDT 2017
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Nature communications
Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP
GRB05 was used in Flow cytometry/Cell sorting to highlight that intratumoral immunomodulation with an oncolytic virus expressing a rationally selected ligand can be an effective strategy to drive systemic efficacy of immune checkpoint blockade.
Mon Feb 13 00:00:00 EST 2017
Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.
Nature immunology
Laidlaw BJ,Cui W,Amezquita RA,Gray SM,Guan T,Lu Y,Kobayashi Y,Flavell RA,Kleinstein SH,Craft J,Kaech SM
Published figure using Granzyme B monoclonal antibody (Product # GRB05) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2015
OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.
Journal of immunology (Baltimore, Md. : 1950)
Buchan S,Manzo T,Flutter B,Rogel A,Edwards N,Zhang L,Sivakumaran S,Ghorashian S,Carpenter B,Bennett C,Freeman GJ,Sykes M,Croft M,Al-Shamkhani A,Chakraverty R
GRB05 was used in Flow cytometry/Cell sorting to study how CD27-mediated co-stimulation can synergise with co-inhibitory checkpoint blockade to switch off molecular programs for quiescence in exhausted T cell populations.
Thu Jan 01 00:00:00 EST 2015
Characterization of the early inflammatory infiltrate at the feeding site of infected sand flies in mice protected from vector-transmitted Leishmania major by exposure to uninfected bites.
PLoS neglected tropical diseases
Teixeira C,Gomes R,Oliveira F,Meneses C,Gilmore DC,Elnaiem DE,Valenzuela JG,Kamhawi S
GRB05 was used in flow cytometry to characterize early inflammation at the feeding site of infected sand flies in mice protected from vector-transmitted Leishmania major by exposure to uninfected bites
Tue Apr 01 00:00:00 EDT 2014
Anti-melanoma vaccines engineered to simultaneously modulate cytokine priming and silence PD-L1 characterized using ex vivo myeloid-derived suppressor cells as a readout of therapeutic efficacy.
Oncoimmunology
Liechtenstein T,Perez-Janices N,Blanco-Luquin I,Goyvaerts C,Schwarze J,Dufait I,Lanna A,Ridder M,Guerrero-Setas D,Breckpot K,Escors D
GRB05 was used in flow cytometry to study engineered anti-melanoma vaccines that modulate cytokine priming and silence PD-L1 simultaneously by use of ex vivo myeloid-derived suppressor cells as a readout of therapeutic efficacy
Thu Feb 18 00:00:00 EST 2021
Broadening the repertoire of functional herpes simplex virus type 1-specific CD8+ T cells reduces viral reactivation from latency in sensory ganglia.
Journal of immunology (Baltimore, Md. : 1950)
St Leger AJ,Jeon S,Hendricks RL
GRB05 was used in Flow cytometry/Cell sorting to show that CD8+ T cell dominance hierachy in the trigeminal ganglia established during acute infection is maintained during latency.
Sun Sep 01 00:00:00 EDT 2013
Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division.
Journal of immunology (Baltimore, Md. : 1950)
Lemaître F,Moreau HD,Vedele L,Bousso P
GRB05 was used in Flow cytometry/Cell sorting to study the development of heterogeneous populations from single CD8(+) T cell progenies.
Thu Aug 15 00:00:00 EDT 2013
Cutting edge: tumor-targeting antibodies enhance NKG2D-mediated NK cell cytotoxicity by stabilizing NK cell-tumor cell interactions.
Journal of immunology (Baltimore, Md. : 1950)
Deguine J,Breart B,Lemaître F,Bousso P
GRB05 was used in Flow cytometry/Cell sorting to investigate how natural killer cells integrate signals from antibody-coated targets and stress ligands on tumour cells.
Sat Dec 15 00:00:00 EST 2012
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.
The Journal of experimental medicine
Randall KL,Chan SS,Ma CS,Fung I,Mei Y,Yabas M,Tan A,Arkwright PD,Al Suwairi W,Lugo Reyes SO,Yamazaki-Nakashimada MA,Garcia-Cruz Mde L,Smart JM,Picard C,Okada S,Jouanguy E,Casanova JL,Lambe T,Cornall RJ,Russell S,Oliaro J,Tangye SG,Bertram EM,Goodnow CC
GRB05 was used in flow cytometry to determine the role for DOCK8 in peripheral CD8 T cell survival and function
Mon Oct 24 00:00:00 EDT 2011
CTLA-4 ablation and interleukin-12 driven differentiation synergistically augment cardiac pathogenicity of cytotoxic T lymphocytes.
Circulation research
Love VA,Grabie N,Duramad P,Stavrakis G,Sharpe A,Lichtman A
GRB05 was used in flow cytometry to elucidate CTLA-4 regulation of cytotoxic T lymphocytes in a transgenic model of CD8+ T-cell-mediated myocarditis
Fri Aug 03 00:00:00 EDT 2007
IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production.
Journal of immunology (Baltimore, Md. : 1950)
Coquet JM,Kyparissoudis K,Pellicci DG,Besra G,Berzins SP,Smyth MJ,Godfrey DI
GRB05 was used in flow cytometry to report that NKT cells produce IL-21 and that IL-21 regulates NKT function
Thu Mar 01 00:00:00 EST 2007
T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells.
Blood
Matsuda JL,Zhang Q,Ndonye R,Richardson SK,Howell AR,Gapin L
GRB05 was used in flow cytometry to examine the role of T-bet in Valpha14i natural killer T cell function
Sat Apr 01 00:00:00 EST 2006
