Product References
Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis.
Neural regeneration research
Liu C,Guo S,Liu R,Guo M,Wang Q,Chai Z,Xiao B,Ma C
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2024
Trojan-horse silk fibroin nanocarriers loaded with a re-call antigen to redirect immunity against cancer.
Journal for immunotherapy of cancer
Bari E,Ferrera F,Altosole T,Perteghella S,Mauri P,Rossi R,Passignani G,Mastracci L,Galati M,Astone GI,Mastrogiacomo M,Castagnola P,Fenoglio D,Di Silvestre D,Torre ML,Filaci G
17-7101-82 was used in Flow cytometry/Cell sorting to conclude that both SFNs-OVA and SFNs-CpG induce effective anticancer response through complementary mechanisms and show the efficacy of an innovative active immunotherapy approach based on the redirection of pre-existing immunity against cancer cells.
Sun Jan 01 00:00:00 EST 2023
Myeloid cell-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation.
EMBO reports
Zhu K,Wang Y,Sarlus H,Geng K,Nutma E,Sun J,Kung SY,Bay C,Han J,Min JH,Benito-Cuesta I,Lund H,Amor S,Wang J,Zhang XM,Kutter C,Guerreiro-Cacais AO,Högberg B,Harris RA
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Tue Jul 05 00:00:00 EDT 2022
RORγt phosphorylation protects against T cell-mediated inflammation.
Cell reports
Ma S,Patel SA,Abe Y,Chen N,Patel PR,Cho BS,Abbasi N,Zeng S,Schnabl B,Chang JT,Huang WJM
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Tue Mar 15 00:00:00 EDT 2022
Lysosomal acid lipase, CSF1R, and PD-L1 determine functions of CD11c+ myeloid-derived suppressor cells.
JCI insight
Zhao T,Liu S,Ding X,Johnson EM,Hanna NH,Singh K,Sen CK,Wan J,Du H,Yan C
17-7101-82 was used in Flow cytometry/Cell sorting to investigate if CD11c+ cells switched their functions to immune suppression and tumor growth stimulation through CSF1R/PD-L1 upregulation and metabolic reprogramming.
Thu Sep 08 00:00:00 EDT 2022
Methotrexate-loaded nanoparticles ameliorate experimental model of autoimmune arthritis by regulating the balance of interleukin-17-producing T cells and regulatory T cells.
Journal of translational medicine
Park JS,Lee D,Yang S,Jeong HY,Na HS,Cho KH,Choi J,Koo H,Cho ML,Park SH
17-7101-82 was used in Flow Cytometry to study the efficacy of methotrexate-loaded nanoparticles against experimental model of rheumatoid arthritis.
Fri Feb 11 00:00:00 EST 2022
Gut epithelial IL-27 confers intestinal immunity through the induction of intraepithelial lymphocytes.
The Journal of experimental medicine
Lin CH,Chen MC,Lin LL,Christian DA,Min B,Hunter CA,Lu LF
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Mon Nov 01 00:00:00 EDT 2021
Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.
Oncology letters
Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.
Theranostics
Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Fri Jan 28 00:00:00 EST 2022
Characterisation of Macrophage Polarisation in Mice Infected with Ninoa Strain of Trypanosoma cruzi.
Pathogens (Basel, Switzerland)
Medina-Buelvas DM,Rodríguez-Sosa M,Vega L
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Sat Nov 06 00:00:00 EDT 2021
Local Sustained GM-CSF Delivery by Genetically Engineered Encapsulated Cells Enhanced Both Cellular and Humoral SARS-CoV-2 Spike-Specific Immune Response in an Experimental Murine Spike DNA Vaccination Model.
Vaccines
Vernet R,Charrier E,Cosset E,Fièvre S,Tomasello U,Grogg J,Mach N
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Mon May 10 00:00:00 EDT 2021
Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases.
iScience
Xu Y,Liu E,Xie X,Wang J,Zheng H,Ju Y,Chen L,Li C,Zhou X,Li Z,Li X,Meng S
17-7101-82 was used in Flow cytometry/Cell sorting to show that gp96 immunization restricted antibody-induced and Th-induced autoimmune diseases by integrating Treg expansion and activation, indicating its potential clinical usefulness against autoimmune diseases.
Fri Dec 17 00:00:00 EST 2021
Memory CD73+IgM+ B cells protect against Plasmodium yoelii infection and express Granzyme B.
PloS one
Parra M,Weitner M,Yang A,Akue A,Liu X,Schmidt T,Allman WR,Akkoyunlu M,Derrick SC
17-7101 was used in Flow cytometry/Cell sorting to show that immune B cells generated during a primary PyNL infection were largely responsible for protection from a second PyNL infection.
Tue Oct 27 00:00:00 EDT 2020
Mesenchymal stromal cells induce distinct myeloid-derived suppressor cells in inflammation.
JCI insight
Lee HJ,Ko JH,Kim HJ,Jeong HJ,Oh JY
17-7101 was used in Flow cytometry/Cell sorting to reveal that suppression of prostaglandin E2 (PGE2) and HGF secretion in MSCs by siRNA transfection partially reversed the effects of MSCs on MDSC differentiation.
Thu Jun 18 00:00:00 EDT 2020
Protein Kinase A Catalytic Subunit Is a Molecular Switch that Promotes the Pro-tumoral Function of Macrophages.
Cell reports
Na YR,Kwon JW,Kim DY,Chung H,Song J,Jung D,Quan H,Kim D,Kim JS,Ju YW,Han W,Ryu HS,Lee YS,Hong JJ,Seok SH
17-7101 was used in Flow cytometry/Cell sorting to demonstrate critical roles of TAM PKA-C in tumor progression and suggest that targeting PKA-C efficiently augments cancer treatment responses.
Tue May 12 00:00:00 EDT 2020
Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.
Scientific reports
Kedzierska AE,Lorek D,Slawek A,Chelmonska-Soyta A
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Mon Jun 29 00:00:00 EDT 2020
Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.
Scientific reports
Kedzierska AE,Lorek D,Slawek A,Chelmonska-Soyta A
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Mon Jun 29 00:00:00 EDT 2020
High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation.
Immunity
Zhang D,Jin W,Wu R,Li J,Park SA,Tu E,Zanvit P,Xu J,Liu O,Cain A,Chen W
17-7101-82 was used in Flow Cytometry to reveal a previously unrecognized mechanism underlying the adverse effects of high glucose intake in the pathogenesis of autoimmunity and inflammation.
Tue Oct 15 00:00:00 EDT 2019
Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States.
Immunity
Wei SC,Sharma R,Anang NAS,Levine JH,Zhao Y,Mancuso JJ,Setty M,Sharma P,Wang J,Pe'er D,Allison JP
17-7101 was used in Flow cytometry/Cell sorting to implicate negative co-stimulation as a key regulator and determinant of T cell differentiation and suggest that checkpoint blockade might work in part by altering the limits of T cell phenotypes.
Tue Apr 16 00:00:00 EDT 2019
Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells.
Cell reports
Zhu X,Zhang W,Guo J,Zhang X,Li L,Wang T,Yan J,Zhang F,Hou B,Gao N,Gao GF,Zhou X
17-7101 was used in Flow cytometry/Cell sorting to identify the control of Treg activation and immune tolerance maintenance is due to Noc4L mediated ribosome biogenesis.
Tue Apr 23 00:00:00 EDT 2019
Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.
Nature communications
Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM
17-7101 was used in Flow cytometry/Cell sorting to study polysaccharide A as an immunomodulatory symbiosis factor whcih coordinates anti-inflammatory responses during viral infections.
Tue May 14 00:00:00 EDT 2019
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.
Nature communications
Sasaki K,Himeno A,Nakagawa T,Sasaki Y,Kiyonari H,Iwai K
17-7101-82 was used in Flow Cytometry to show that T cell-mediated killing and sequential autoinflammation are common and crucial for pathogenic diversity during T cell-mediated autoimmune responses.
Wed Aug 28 00:00:00 EDT 2019
c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells.
Nature immunology
Gabryšová L,Alvarez-Martinez M,Luisier R,Cox LS,Sodenkamp J,Hosking C,Pérez-Mazliah D,Whicher C,Kannan Y,Potempa K,Wu X,Bhaw L,Wende H,Sieweke MH,Elgar G,Wilson M,Briscoe J,Metzis V,Langhorne J,Luscombe NM,O'Garra A
17-7101 was used in Flow cytometry/Cell sorting to study the role of c-Maf as a regulator of the expression of cytokine-encoding genes.
Tue May 01 00:00:00 EDT 2018
Mesenchymal Stem Cells Recruit CCR2+ Monocytes To Suppress Allergic Airway Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Takeda K,Webb TL,Ning F,Shiraishi Y,Regan DP,Chow L,Smith MJ,Ashino S,Guth AM,Hopkins S,Gelfand EW,Dow S
17-7101 was used in Flow cytometry/Cell sorting to show that mesenchymal stem cell activation by IFN-γ, followed by increased expression of CCL2 and recruitment of monocytes to the lungs, is essential for suppression by mesenchymal stem cells in allergen-induced airway hyperresponsiveness and airway inflammation.
Thu Feb 15 00:00:00 EST 2018
Analysis of the Trichuris suis excretory/secretory proteins as a function of life cycle stage and their immunomodulatory properties.
Scientific reports
Leroux LP,Nasr M,Valanparambil R,Tam M,Rosa BA,Siciliani E,Hill DE,Zarlenga DS,Jaramillo M,Weinstock JV,Geary TG,Stevenson MM,Urban JF,Mitreva M,Jardim A
17-7101 was used in Flow cytometry/Cell sorting to analyse the Trichuris suis excretory/secretory proteins as a function of life cycle stage and their immunomodulatory properties.
Mon Oct 29 00:00:00 EDT 2018
IL-7 treatment augments and prolongs sepsis-induced expansion of IL-10-producing B lymphocytes and myeloid-derived suppressor cells.
PloS one
Kulkarni U,Herrmenau C,Win SJ,Bauer M,Kamradt T
17-7101 was used in Flow cytometry/Cell sorting to investigate the expansion of immunoregulatory cells as long-term sequelae of sepsis with or without IL-7 treatment.
Mon Apr 09 00:00:00 EDT 2018
Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet.
PloS one
Metghalchi S,Vandestienne M,Haddad Y,Esposito B,Dairou J,Tedgui A,Mallat Z,Potteaux S,Taleb S
17-7101 was used in Flow cytometry/Cell sorting to show that the knockout of IDO prevented VSMC apoptosis in AngII -treated Ldlr-/- mice fed with HFD, suggesting a detrimental role of IDO in AAA formation and thus would be an important target for the treatment of aneurysm.
Fri Jun 22 00:00:00 EDT 2018
Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity.
Frontiers in immunology
Araujo Furlan CL,Tosello Boari J,Rodriguez C,Canale FP,Fiocca Vernengo F,Boccardo S,Beccaria CG,Adoue V,Joffre O,Gruppi A,Montes CL,Acosta Rodriguez EV
17-7101 was used in Flow cytometry/Cell sorting to study the role of regulatory T cells during Trypanosoma cruzi infection.
Thu Sep 26 00:00:00 EDT 2019
Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.
The Journal of clinical investigation
Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
Inducible and naturally occurring regulatory T cells enhance lung allergic responses through divergent transcriptional pathways.
The Journal of allergy and clinical immunology
Joetham A,Schedel M,O'Connor BP,Kim S,Takeda K,Abbott J,Gelfand EW
17-7101 was used in Flow cytometry/Cell sorting to study the differences between the pathways leading to enhancement of lung allergic responses by both transferred naturally occurring regulatory T and inducible regulatory T cells.
Sat Apr 01 00:00:00 EDT 2017
Cooperation of Gastric Mononuclear Phagocytes with Helicobacter pylori during Colonization.
Journal of immunology (Baltimore, Md. : 1950)
Viladomiu M,Bassaganya-Riera J,Tubau-Juni N,Kronsteiner B,Leber A,Philipson CW,Zoccoli-Rodriguez V,Hontecillas R
17-7101 was used in Flow cytometry/Cell sorting to report the induction of IL-10-driven regulatory responses mediated by CD11b+F4/80hiCD64+CX3CR1+ MNPs that contribute to maintaining high levels of Helicobacter pylori loads in the stomach by modulating effector T cell responses at the gastric mucosa.
Sat Apr 15 00:00:00 EDT 2017
Blocking IL-10 signalling at the time of immunization does not increase unwanted side effects in mice.
BMC immunology
Ni G,Liao Z,Chen S,Wang T,Yuan J,Pan X,Mounsey K,Cavezza S,Liu X,Wei MQ
17-7101 was used in Flow cytometry/Cell sorting to determine the effect of blocking IL-10 during immunisation on intestinal inflammation responses.
Tue Aug 15 00:00:00 EDT 2017
Identification of 14-dehydroergosterol as a novel anti-inflammatory compound inducing tolerogenic dendritic cells.
Scientific reports
Ano Y,Ikado K,Shindo K,Koizumi H,Fujiwara D
17-7101 was used in Flow cytometry/Cell sorting to investigate if 14-dehydroergosterol induces tolerogenic dendritic cells (DCs) to convert to a tolerogenic type.
Tue Oct 24 00:00:00 EDT 2017
Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission.
Immunity
Tian Y,Kuo CF,Akbari O,Ou JH
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Tue May 17 00:00:00 EDT 2016
CNS accumulation of regulatory B cells is VLA-4-dependent.
Neurology(R) neuroimmunology & neuroinflammation
Lehmann-Horn K,Sagan SA,Winger RC,Spencer CM,Bernard CC,Sobel RA,Zamvil SS
17-7101 was used in Immunocytochemistry to demonstrate that accumulation of Breg in the CNS is dependent on VLA-4.
Fri Apr 01 00:00:00 EDT 2016
Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence.
PLoS pathogens
Clement M,Marsden M,Stacey MA,Abdul-Karim J,Gimeno Brias S,Costa Bento D,Scurr MJ,Ghazal P,Weaver CT,Carlesso G,Clare S,Jones SA,Godkin A,Jones GW,Humphreys IR
17-7101 was used in Flow cytometry/Cell sorting to reveal that cytokine signalling events during initial infection profoundly influence virus chronicity.
Thu Dec 01 00:00:00 EST 2016
Blockade of MK2 is protective in inflammation-associated colorectal cancer development.
International journal of cancer
Ray AL,Castillo EF,Morris KT,Nofchissey RA,Weston LL,Samedi VG,Hanson JA,Gaestel M,Pinchuk IV,Beswick EJ
17-7101 was used in Flow cytometry/Cell sorting to investigate the role of MAPK-activated protein kinase 2 in development of colitis-associated colon cancer.
Mon Feb 01 00:00:00 EST 2016
IL-12 and IL-4 activate a CD39-dependent intrinsic peripheral tolerance mechanism in CD8(+) T cells.
European journal of immunology
Noble A,Mehta H,Lovell A,Papaioannou E,Fairbanks L
17-7101 was used in Flow cytometry/Cell sorting to study the upregulation of CD39 on CD8(+) T cells and identify a novel pathway of peripheral tolerance.
Wed Jun 01 00:00:00 EDT 2016
G-CSF-Induced Suppressor IL-10+ Neutrophils Promote Regulatory T Cells That Inhibit Graft-Versus-Host Disease in a Long-Lasting and Specific Way.
Journal of immunology (Baltimore, Md. : 1950)
Perobelli SM,Mercadante AC,Galvani RG,Gonçalves-Silva T,Alves AP,Pereira-Neves A,Benchimol M,Nóbrega A,Bonomo A
17-7101 was used in Flow cytometry/Cell sorting to study the role of incoming IL-10+ neutrophils from G-CSF-treated donor spleen in inhibiting acute graft-versus-host disease.
Tue Nov 01 00:00:00 EDT 2016
TLR Tolerance as a Treatment for Central Nervous System Autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Anstadt EJ,Fujiwara M,Wasko N,Nichols F,Clark RB
17-7101 was used in Flow cytometry/Cell sorting to assess the role of Toll-like receptor 2 signalling in central nervous system autoimmune diseases, and the potential of inducing TLR tolerance to ameliorate disease.
Thu Sep 15 00:00:00 EDT 2016
Heterologous Immunity between Adenoviruses and Hepatitis C Virus: A New Paradigm in HCV Immunity and Vaccines.
PloS one
Singh S,Vedi S,Samrat SK,Li W,Kumar R,Agrawal B
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Tue Jul 19 00:00:00 EDT 2016
NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.
Nature communications
Alrefai H,Muhammad K,Rudolf R,Pham DA,Klein-Hessling S,Patra AK,Avots A,Bukur V,Sahin U,Tenzer S,Goebeler M,Kerstan A,Serfling E
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Wed May 25 00:00:00 EDT 2016
Lymphocytic Microparticles Modulate Angiogenic Properties of Macrophages in Laser-induced Choroidal Neovascularization.
Scientific reports
Tahiri H,Omri S,Yang C,Duhamel F,Samarani S,Ahmad A,Vezina M,Bussières M,Vaucher E,Sapieha P,Hickson G,Hammamji K,Lapointe R,Rodier F,Tremblay S,Royal I,Cailhier JF,Chemtob S,Hardy P
17710182 was used in flow cytometry to study the ability of lymphocyte-derived microparticles to modulate the gene expression pattern of angiogenesis-related factors in macrophages
Tue Nov 22 00:00:00 EST 2016
MHC-I and PirB Upregulation in the Central and Peripheral Nervous System following Sciatic Nerve Injury.
PloS one
Bombeiro AL,Thomé R,Oliveira Nunes SL,Monteiro Moreira B,Verinaud L,Oliveira AL
17710182 was used in flow cytometry to measure expression of major histocompatibility complex class one and paired immunoglobulin-like receptor B in the central and peripheral nervous system after sciatic nerve injury in mice
Wed Jul 26 00:00:00 EDT 2017
Towards programming immune tolerance through geometric manipulation of phosphatidylserine.
Biomaterials
Roberts RA,Eitas TK,Byrne JD,Johnson BM,Short PJ,McKinnon KP,Reisdorf S,Luft JC,DeSimone JM,Ting JP
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2015
Tristetraprolin Limits Inflammatory Cytokine Production in Tumor-Associated Macrophages in an mRNA Decay-Independent Manner.
Cancer research
Kratochvill F,Gratz N,Qualls JE,Van De Velde LA,Chi H,Kovarik P,Murray PJ
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2015
Mouse bone marrow-derived mesenchymal stem cells inhibit leukemia/lymphoma cell proliferation in vitro and in a mouse model of allogeneic bone marrow transplant.
International journal of molecular medicine
Song N,Gao L,Qiu H,Huang C,Cheng H,Zhou H,Lv S,Chen L,Wang J
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Wed Jul 01 00:00:00 EDT 2015
Regulatory CD8(+)CD122 (+) T-cells predominate in CNS after treatment of experimental stroke in male mice with IL-10-secreting B-cells.
Metabolic brain disease
Bodhankar S,Chen Y,Lapato A,Vandenbark AA,Murphy SJ,Saugstad JA,Offner H
17-7101 was used in Immunofluorescence to demonstrate a major neuroprotective role for IL-10(+) B-cells in treating MCAO in male WT mice.
Sat Aug 01 00:00:00 EDT 2015
Schistosoma mansoni Larvae Do Not Expand or Activate Foxp3+ Regulatory T Cells during Their Migratory Phase.
Infection and immunity
Redpath SA,van der Werf N,MacDonald AS,Maizels RM,Taylor MD
17-7101 was used in Flow cytometry/Cell sorting to explore the induction and role of Foxp3(+) Treg cells during the early, prepatent, larval stage of S. mansoni infection.
Thu Oct 01 00:00:00 EDT 2015
Cd1d regulates B cell development but not B cell accumulation and IL10 production in mice with pathologic CD5(+) B cell expansion.
BMC immunology
Palmer VL,Nganga VK,Rothermund ME,Perry GA,Swanson PC
17-7101 was used in Flow cytometry/Cell sorting to investigate the effect of CD1d expression on CD5+ B cell accumulation, IL10 competence and antibody production in mice with pathologic CD5+ B cell expansion.
Wed Nov 04 00:00:00 EST 2015
JNK2 regulates the functional plasticity of naturally occurring T regulatory cells and the enhancement of lung allergic responses.
Journal of immunology (Baltimore, Md. : 1950)
Joetham A,Schedel M,Takeda K,Jia Y,Ashino S,Dakhama A,Lluis A,Okamoto M,Gelfand EW
17-7101 was used in Flow cytometry/Cell sorting to study the mechanism by which GITR stimulation of naturally occurring regulatory T cells triggers the loss of regulatory function while concomitantly gaining pathogenic CD4(+) effector function.
Mon Sep 01 00:00:00 EDT 2014
IL-27 limits central nervous system viral clearance by promoting IL-10 and enhances demyelination.
Journal of immunology (Baltimore, Md. : 1950)
de Aquino MT,Kapil P,Hinton DR,Phares TW,Puntambekar SS,Savarin C,Bergmann CC,Stohlman SA
17-7101 was used in Flow cytometry/Cell sorting to define a detrimental role of IL-27 in promoting demyelination by delaying viral control.
Tue Jul 01 00:00:00 EDT 2014
Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.
Human vaccines & immunotherapeutics
Wang S,Wu B,Xue J,Wang M,Chen R,Wang B
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Mon Jan 05 00:00:00 EST 2015
BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9.
Cellular immunology
Bakhru P,Sirisaengtaksin N,Soudani E,Mukherjee S,Khan A,Jagannath C
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2014
Treatment of experimental stroke with IL-10-producing B-cells reduces infarct size and peripheral and CNS inflammation in wild-type B-cell-sufficient mice.
Metabolic brain disease
Bodhankar S,Chen Y,Vandenbark AA,Murphy SJ,Offner H
17-7101 was used in Immunofluorescence to investigate the beneficial immunoregulatory effects of IL-10-producing B-cell stroke treatment in mice.
Sat Mar 01 00:00:00 EST 2014
Hematopoietic not systemic impairment of Roquin expression accounts for intestinal inflammation in Roquin-deficient mice.
Scientific reports
Montufar-Solis D,Vigneswaran N,Nakra N,Schaefer JS,Klein JR
17-7101 was used in Flow cytometry/Cell sorting to investigate the intestinal immunopathology caused by insufficient Roquin, showing that hematopoietic, not systematic, impairment of Roquin expression accounts for pathology.
Mon May 12 00:00:00 EDT 2014
Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy.
Nature communications
Burton BR,Britton GJ,Fang H,Verhagen J,Smithers B,Sabatos-Peyton CA,Carney LJ,Gough J,Strobel S,Wraith DC
17-7101 was used in Flow cytometry/Cell sorting to study the markers significant for antigen-specific immunotherapy such as regulatory CD4(+) T-cell transcription factors.
Wed Sep 03 00:00:00 EDT 2014
Anti-melanoma vaccines engineered to simultaneously modulate cytokine priming and silence PD-L1 characterized using ex vivo myeloid-derived suppressor cells as a readout of therapeutic efficacy.
Oncoimmunology
Liechtenstein T,Perez-Janices N,Blanco-Luquin I,Goyvaerts C,Schwarze J,Dufait I,Lanna A,Ridder M,Guerrero-Setas D,Breckpot K,Escors D
17-7101 was used in Flow cytometry/Cell sorting to show that the simultaneous delivery of IL12 and a PD-L1-silencing shRNA exhibits therapeutically relevant anti-tumour activities.
Thu Feb 18 00:00:00 EST 2021
Worm proteins of Schistosoma mansoni reduce the severity of experimental chronic colitis in mice by suppressing colonic proinflammatory immune responses.
PloS one
Heylen M,Ruyssers NE,De Man JG,Timmermans JP,Pelckmans PA,Moreels TG,De Winter BY
17-7101 was used in Flow cytometry/Cell sorting to investigate the therapeutic potential and immunological mechanisms of Schistosoma mansoni soluble worm protein in an adoptive T cell transfer mouse model of chronic colitis.
Tue Jun 23 00:00:00 EDT 2015
Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
Cardiovascular research
Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium.
Mucosal immunology
Manta C,Heupel E,Radulovic K,Rossini V,Garbi N,Riedel CU,Niess JH
Published figure using IL-10 monoclonal antibody (Product # 17-7101-82) in Flow Cytometry
Tue Jan 01 00:00:00 EST 2013
IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
PLoS pathogens
Schmitz I,Schneider C,Fröhlich A,Frebel H,Christ D,Leonard WJ,Sparwasser T,Oxenius A,Freigang S,Kopf M
17-7101 was used in Flow cytometry/Cell sorting to investigate the role of Foxp3+ regulatory T (Treg) cells during viral infections, showing that IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
Mon Dec 09 00:00:00 EST 2013
Regulatory CD8+ T cells associated with erosion of immune surveillance in persistent virus infection suppress in vitro and have a reversible proliferative defect.
Journal of immunology (Baltimore, Md. : 1950)
Hu Z,Zhang W,Usherwood EJ
17-7101 was used in Flow cytometry/Cell sorting to investigate the generation, phenotype and function of IL-10 producing CD8+ T cells during persistent virus infection.
Mon Jul 01 00:00:00 EDT 2013
IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke.
Metabolic brain disease
Bodhankar S,Chen Y,Vandenbark AA,Murphy SJ,Offner H
17-7101 was used in Flow cytometry/Cell sorting to determine whether the IL-10-producing regulatory B-cell subset can limit CNS inflammation and reduce infarct volume following ischemic stroke in B-cell deficient mice.
Sun Sep 01 00:00:00 EDT 2013
Hookworm excretory/secretory products induce interleukin-4 (IL-4)+ IL-10+ CD4+ T cell responses and suppress pathology in a mouse model of colitis.
Infection and immunity
Ferreira I,Smyth D,Gaze S,Aziz A,Giacomin P,Ruyssers N,Artis D,Laha T,Navarro S,Loukas A,McSorley HJ
17-7101 was used in Flow cytometry/Cell sorting to investigate the effect of hookwork excretory/secretory products on chemically induced colitis.
Sat Jun 01 00:00:00 EDT 2013
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
Immunity
Hall AO,Beiting DP,Tato C,John B,Oldenhove G,Lombana CG,Pritchard GH,Silver JS,Bouladoux N,Stumhofer JS,Harris TH,Grainger J,Wojno ED,Wagage S,Roos DS,Scott P,Turka LA,Cherry S,Reiner SL,Cua D,Belkaid Y,Elloso MM,Hunter CA
17-7101 was used in Flow cytometry/Cell sorting to study the promotion of distinct Treg cell populations by the cytokines IL-27 and IFN-y, and the role they play in limiting infection induced pathology.
Fri Sep 21 00:00:00 EDT 2012
A specific role for TLR1 in protective T(H)17 immunity during mucosal infection.
The Journal of experimental medicine
DePaolo RW,Kamdar K,Khakpour S,Sugiura Y,Wang W,Jabri B
17-7101 was used in Flow cytometry/Cell sorting to study the role of TLR1 in TH17 cell responses during Yersinia enterocolitica infection.
Mon Jul 30 00:00:00 EDT 2012
Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice.
Journal of autoimmunity
Tian L,De Hertogh G,Fedeli M,Staats KA,Schonefeldt S,Humblet-Baron S,Van Den Bosch L,Dellabona P,Dooley J,Liston A
17-7101 was used in Flow cytometry/Cell sorting to elucidate the dominant effects of the T cell microRNA expression network and explore it as a potential therapeutic target for autoimmune diseases.
Wed Feb 01 00:00:00 EST 2012
Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.
Mucosal immunology
Loebbermann J,Thornton H,Durant L,Sparwasser T,Webster KE,Sprent J,Culley FJ,Johansson C,Openshaw PJ
17-7101 was used in Flow cytometry/Cell sorting to study the various effects of the selective depletion of Tregs during acute RSV infection.
Thu Mar 01 00:00:00 EST 2012
IL-10-producing Th1 cells and disease progression are regulated by distinct CD11c⁺ cell populations during visceral leishmaniasis.
PLoS pathogens
Owens BM,Beattie L,Moore JW,Brown N,Mann JL,Dalton JE,Maroof A,Kaye PM
17-7101 was used in Flow cytometry/Cell sorting to demonstrate that only CD11c(hi) dendritic cells that produce both IL-10 and IL-27 are capable of inducing IL-10-producing Th1 cells in vivo.
Tue Jan 29 00:00:00 EST 2013
Intrastriatal B-cell administration limits infarct size after stroke in B-cell deficient mice.
Metabolic brain disease
Chen Y,Bodhankar S,Murphy SJ,Vandenbark AA,Alkayed NJ,Offner H
17-7101 was used in Flow cytometry to determine if the effect of B-cells to limit the inflammatory response to cerebral ischaemia is mediated by their action centrally or peripherally, and observe regulatory B-cell infiltration.
Sat Dec 01 00:00:00 EST 2012
Hematopoietic miR155 deficiency enhances atherosclerosis and decreases plaque stability in hyperlipidemic mice.
PloS one
Donners MM,Wolfs IM,Stöger LJ,van der Vorst EP,Pöttgens CC,Heymans S,Schroen B,Gijbels MJ,de Winther MP
17-7101 was used in Flow cytometry/Cell sorting to investigate the role of miR155 in atherosclerosis in vivo, showing that miR155 deficiency enhances atherosclerosis and decreases plaque stability.
Thu Sep 13 00:00:00 EDT 2012
IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice.
PloS one
Loebbermann J,Schnoeller C,Thornton H,Durant L,Sweeney NP,Schuijs M,O'Garra A,Johansson C,Openshaw PJ
17-7101 was used in Flow cytometry/Cell sorting to study experimental respiratory syncytial virus infection in IL-10 deficient mice and mice treated with anti-IL-10 receptor antibody.
Mon Jul 23 00:00:00 EDT 2012
Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation.
The Journal of biological chemistry
Joetham A,Ohnishi H,Okamoto M,Takeda K,Schedel M,Domenico J,Dakhama A,Gelfand EW
17-7101 was used in Flow cytometry/Cell sorting to demonstrate that regulation of JNK phosphorylation plays a central role in Treg cell function.
Fri May 18 00:00:00 EDT 2012
Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis.
Blood
Tian L,Altin JA,Makaroff LE,Franckaert D,Cook MC,Goodnow CC,Dooley J,Liston A
17-7101 was used in Immunocytochemistry to demonstrate that Th2-driven diseases may be more responsive to regulatory T-cell manipulation.
Thu Aug 18 00:00:00 EDT 2011
Regulatory B cells limit CNS inflammation and neurologic deficits in murine experimental stroke.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ren X,Akiyoshi K,Dziennis S,Vandenbark AA,Herson PS,Hurn PD,Offner H
17-7101 was used in Flow cytometry/Cell sorting to evaluate the contribution of B cells to the development of middle cerebral artery occlusion in mice.
Wed Jun 08 00:00:00 EDT 2011
CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease.
Journal of immunology (Baltimore, Md. : 1950)
Joetham A,Okamoto M,Takeda K,Schedel M,Ohnishi H,Dakhama A,Gelfand EW
17-7101 was used in Flow cytometry/Cell sorting to identify the critical role of CD8-T regulatory cell interactions in regulating the suppressive phenotype of nTregs through control of IL-6 production.
Sat Jan 01 00:00:00 EST 2011
CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype.
Journal of immunology (Baltimore, Md. : 1950)
Kitamura K,Farber JM,Kelsall BL
17-7101 was used in Flow cytometry/Cell sorting to conclude that CCR6 expression on Treg cells was required for the full function of Treg cell-mediated suppression in a model of colitis.
Wed Sep 15 00:00:00 EDT 2010
Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis.
Cell host & microbe
Depaolo RW,Tang F,Kim I,Han M,Levin N,Ciletti N,Lin A,Anderson D,Schneewind O,Jabri B
17-7101 was used in Flow cytometry/Cell sorting to reveal how TLR2 mediates both pro- and anti-inflammatory responses, identifying TLR6 as a distinct receptor driving regulatory IL-10 responses.
Thu Oct 16 00:00:00 EDT 2008
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells.
The Journal of experimental medicine
Lochner M,Peduto L,Cherrier M,Sawa S,Langa F,Varona R,Riethmacher D,Si-Tahar M,Di Santo JP,Eberl G
17-7101 was used in Flow cytometry/Cell sorting to study how potentially antagonistic pro-inflammatory IL-17-producing and regulatory Foxp3(+) RORgamma t(+) T cells coexist and are tightly controlled.
Mon Jun 09 00:00:00 EDT 2008
Activation of naturally occurring lung CD4(+)CD25(+) regulatory T cells requires CD8 and MHC I interaction.
Proceedings of the National Academy of Sciences of the United States of America
Joetham A,Takeda K,Miyahara N,Matsubara S,Ohnishi H,Koya T,Dakhama A,Gelfand EW
17-7101 was used in Flow cytometry/Cell sorting to demonstrate that functional activation of nTregs requires the interaction between MHC I on CD4(+)CD25(+) T cells and CD8.
Tue Sep 18 00:00:00 EDT 2007
TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets.
Journal of leukocyte biology
Pyzik M,Piccirillo CA
17-7101 was used in Flow cytometry/Cell sorting to investigate the effects of TGF-beta on the induction or maintenance of regulatory functions in different T cell subsets.
Wed Aug 01 00:00:00 EDT 2007
Cross-presentation of disialoganglioside GD3 to natural killer T cells.
The Journal of experimental medicine
Wu DY,Segal NH,Sidobre S,Kronenberg M,Chapman PB
17-7101 was used in Flow cytometry/Cell sorting to demonstrate that immunising mice with the SK-MEL-28 cell line or with syngeneic APCs loaded with GD3 can induce a GD3-reactive natural killer T cell response.
Mon Jul 07 00:00:00 EDT 2003
