Proteintech

INPP5E Polyclonal Antibody

INPP5E Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 23

INPP5E Antibody (17797-1-AP) in ICC/IF

IF result of ciliary INPP5E in human hTERT-RPE1 cell: Upper is from control siRNA transfected cells and bottom is from INPP5E siRNA transfected cells. 17797-1-AP specifically recognizes the ciliary INPP5E (From Dr.Seongjin Seo).

INPP5E Antibody in Immunohistochemistry (Paraffin) (IHC (P))

INPP5E Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17797-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 31 publications 31 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

INPP5E Fusion Protein Ag11959 (1-350 aa encoded by BC028032)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.36 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPSKAENLR PSEPAPQPPE GRTLQGQLPG APPAQRAGSP PDAPGSESPA LACSTPATPS GEDPPARAAP IAPRPPARPR LERALSLDDK GWRRRRFRGS QEDLEARNGT SPSRGSVQSE GPGAPAHSCS PPCLSTSLQE IPKSRGVLSS ERGSPSSGGN PLSGVASSSP NLPHRDAAVA GSSPRLPSLL PPRPPPALSL DIASDSLRTA NKVDSDLADY KLRAQPLLVR AHSSLGPGRP RSPLACDDCS LRSAKSSFSL LAPIRSKDVR SRSYLEGSLL ASGALLGADE LARYFPDRNV ALFVATWNMQ GQKELPPSLD EFLLPAEADY AQDLYVIGVQ EGCSDRREWE T (1-350 aa encoded by BC028032)

Target Information

INPP5E (inositol polyphosphate 5-phosphatase), also known as phosphatidylinositol polyphosphate 5-phosphatase type IV, is a 644 amino acid peripheral membrane protein associated with Golgi stacks. Belonging to the inositol-1, 4, 5-trisphosphate 5-phosphatase type IV family, INPP5E converts phosphatidylinositol-3, 4, 5-triphosphate (PtdIns 3, 4, 5-P3) to PtdIns-P2. While inactive towards water soluble inositol phosphates, the activity of INPP5E is specific for lipid substrates. INPP5E becomes phosphorylated upon DNA damage and is expressed in brain, heart, pancreas, testis and spleen. Defects in INPP5E are the cause of Joubert syndrome type 1 (JBTS1), a disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. In addition, mutations in the INPP5E gene may lead to mental retardation-truncal obesity-retinal dystrophy-micropenis (MORMS), an autosomal recessive disorder characterized by moderate mental retardation, truncal obesity, congenital non-progressive retinal dystrophy, and micropenis in males.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

High-efficient CRISPR/Cas9-mediated gene targeting to establish cell models of ciliopathies.

Methods in cell biology

Hosoba K,Morita T,Zhang Y,Kishi H,Yamamoto T,Miyamoto T

Tue Mar 28 00:00:00 EDT 2023

Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia.

Molecular biology of the cell

Palicharla VR,Hwang SH,Somatilaka BN,Legué E,Shimada IS,Familiari NE,Tran VM,Woodruff JB,Liem KF,Mukhopadhyay S

Wed Mar 01 00:00:00 EST 2023

INPP5E controls ciliary localization of phospholipids and the odor response in olfactory sensory neurons.

Journal of cell science

Ukhanov K,Uytingco C,Green W,Zhang L,Schurmans S,Martens JR

Tue Mar 01 00:00:00 EST 2022

Phylogenetic profiling and cellular analyses of ARL16 reveal roles in traffic of IFT140 and INPP5E.

Molecular biology of the cell

Dewees SI,Vargová R,Hardin KR,Turn RE,Devi S,Linnert J,Wolfrum U,Caspary T,Eliáš M,Kahn RA

Fri Apr 01 00:00:00 EDT 2022

Multiple ciliary localization signals control INPP5E ciliary targeting.

eLife

Cilleros-Rodriguez D,Martin-Morales R,Barbeito P,Deb Roy A,Loukil A,Sierra-Rodero B,Herranz G,Pampliega O,Redrejo-Rodriguez M,Goetz SC,Izquierdo M,Inoue T,Garcia-Gonzalo FR

Mon Sep 05 00:00:00 EDT 2022

The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling.

Cell reports

Schembs L,Willems A,Hasenpusch-Theil K,Cooper JD,Whiting K,Burr K,Bøstrand SMK,Selvaraj BT,Chandran S,Theil T

Tue May 17 00:00:00 EDT 2022

Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via sonic hedgehog signaling.

JCI insight

Shi H,Wang H,Zhang C,Lu Y,Yao J,Chen Z,Xing G,Wei Q,Cao X

Tue Feb 22 00:00:00 EST 2022

The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic.

Molecular biology of the cell

Turn RE,Hu Y,Dewees SI,Devi N,East MP,Hardin KR,Khatib T,Linnert J,Wolfrum U,Lim MJ,Casanova JE,Caspary T,Kahn RA

Tue Feb 01 00:00:00 EST 2022

Differential Roles of Tubby Family Proteins in Ciliary Formation and Trafficking.

Molecules and cells

Hong JJ,Kim KE,Park SY,Bok J,Seo JT,Moon SJ

Tue Aug 31 00:00:00 EDT 2021

Exocyst complex mediates recycling of internal cilia.

Current biology : CB

Rivera-Molina FE,Xi Z,Reales E,Wang B,Toomre D

Mon Dec 20 00:00:00 EST 2021

Disrupted intraflagellar transport due to IFT74 variants causes Joubert syndrome.

Genetics in medicine : official journal of the American College of Medical Genetics

Luo M,Lin Z,Zhu T,Jin M,Meng D,He R,Cao Z,Shen Y,Lu C,Cai R,Zhao Y,Wang X,Li H,Wu S,Zou X,Luo G,Cao L,Huang M,Jiao H,Gao H,Sui R,Zhao C,Ma X,Cao M

Tue Jun 01 00:00:00 EDT 2021

Deletion of the phosphatase INPP5E in the murine retina impairs photoreceptor axoneme formation and prevents disc morphogenesis.

The Journal of biological chemistry

Sharif AS,Gerstner CD,Cady MA,Arshavsky VY,Mitchell C,Ying G,Frederick JM,Baehr W

Mon Aug 23 00:00:00 EDT 2021

Deletion of the phosphatase INPP5E in the murine retina impairs photoreceptor axoneme formation and prevents disc morphogenesis.

The Journal of biological chemistry

Sharif AS,Gerstner CD,Cady MA,Arshavsky VY,Mitchell C,Ying G,Frederick JM,Baehr W

Mon Aug 23 00:00:00 EDT 2021

Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ.

Science advances

Chen C,Xu Q,Zhang Y,Davies BA,Huang Y,Katzmann DJ,Harris PC,Hu J,Ling K

Tue Jun 01 00:00:00 EDT 2021

Down-Regulation of Inpp5e Associated With Abnormal Ciliogenesis During Embryonic Neurodevelopment Under Inositol Deficiency.

Frontiers in neurology

Yue H,Li S,Qin J,Gao T,Lyu J,Liu Y,Wang X,Guan Z,Zhu Z,Niu B,Zhong R,Guo J,Wang J

Sat Nov 11 00:00:00 EST 2023

Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry.

Biology open

Qiu H,Fujisawa S,Nozaki S,Katoh Y,Nakayama K

Mon Jan 25 00:00:00 EST 2021

ARL3 and ARL13B GTPases participate in distinct steps of INPP5E targeting to the ciliary membrane.

Biology open

Fujisawa S,Qiu H,Nozaki S,Chiba S,Katoh Y,Nakayama K

Wed Sep 15 00:00:00 EDT 2021

The autophagy protein ATG16L1 cooperates with IFT20 and INPP5E to regulate the turnover of phosphoinositides at the primary cilium.

Cell reports

Boukhalfa A,Roccio F,Dupont N,Codogno P,Morel E

Tue Apr 27 00:00:00 EDT 2021

The autophagy protein ATG16L1 cooperates with IFT20 and INPP5E to regulate the turnover of phosphoinositides at the primary cilium.

Cell reports

Boukhalfa A,Roccio F,Dupont N,Codogno P,Morel E

Tue Apr 27 00:00:00 EDT 2021

The Major Ciliary Isoforms of RPGR Build Different Interaction Complexes with INPP5E and RPGRIP1L.

International journal of molecular sciences

Vössing C,Atigbire P,Eilers J,Markus F,Stieger K,Song F,Neidhardt J

Tue Mar 30 00:00:00 EDT 2021

Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Wang W,Allard BA,Pottorf TS,Wang HH,Vivian JL,Tran PV

Fri May 01 00:00:00 EDT 2020

ARL13B regulates Sonic hedgehog signaling from outside primary cilia.

eLife

Gigante ED,Taylor MR,Ivanova AA,Kahn RA,Caspary T

Wed Mar 04 00:00:00 EST 2020

Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway.

Life science alliance

Gerakopoulos V,Ngo P,Tsiokas L

Tue Sep 01 00:00:00 EDT 2020

Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP.

Proceedings of the National Academy of Sciences of the United States of America

Zhang Q,Giacalone JC,Searby C,Stone EM,Tucker BA,Sheffield VC

Tue Jan 22 00:00:00 EST 2019

Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP.

Proceedings of the National Academy of Sciences of the United States of America

Zhang Q,Giacalone JC,Searby C,Stone EM,Tucker BA,Sheffield VC

Tue Jan 22 00:00:00 EST 2019

Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP.

Proceedings of the National Academy of Sciences of the United States of America

Zhang Q,Giacalone JC,Searby C,Stone EM,Tucker BA,Sheffield VC

Tue Jan 22 00:00:00 EST 2019

Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP.

Proceedings of the National Academy of Sciences of the United States of America

Zhang Q,Giacalone JC,Searby C,Stone EM,Tucker BA,Sheffield VC

Tue Jan 22 00:00:00 EST 2019

Development of a Molecularly Stable Gene Therapy Vector for the Treatment of RPGR-Associated X-Linked Retinitis Pigmentosa.

Human gene therapy

Giacalone JC,Andorf JL,Zhang Q,Burnight ER,Ochoa D,Reutzel AJ,Collins MM,Sheffield VC,Mullins RF,Han IC,Stone EM,Tucker BA

Thu Aug 01 00:00:00 EDT 2019

TULP3 is required for localization of membrane-associated proteins ARL13B and INPP5E to primary cilia.

Biochemical and biophysical research communications

Han S,Miyoshi K,Shikada S,Amano G,Wang Y,Yoshimura T,Katayama T

Tue Jan 29 00:00:00 EST 2019

TULP3 is required for localization of membrane-associated proteins ARL13B and INPP5E to primary cilia.

Biochemical and biophysical research communications

Han S,Miyoshi K,Shikada S,Amano G,Wang Y,Yoshimura T,Katayama T

Tue Jan 29 00:00:00 EST 2019

Tulp3 Regulates Renal Cystogenesis by Trafficking of Cystoproteins to Cilia.

Current biology : CB

Hwang SH,Somatilaka BN,Badgandi H,Palicharla VR,Walker R,Shelton JM,Qian F,Mukhopadhyay S

Mon Mar 04 00:00:00 EST 2019

A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling.

Cell reports

Frikstad KM,Molinari E,Thoresen M,Ramsbottom SA,Hughes F,Letteboer SJF,Gilani S,Schink KO,Stokke T,Geimer S,Pedersen LB,Giles RH,Akhmanova A,Roepman R,Sayer JA,Patzke S

Tue Aug 13 00:00:00 EDT 2019

The ciliary GTPase Arl3 maintains tissue architecture by directing planar spindle orientation during epidermal morphogenesis.

Development (Cambridge, England)

Bhattarai SR,Begum S,Popow R,Ezratty EJ

Fri May 10 00:00:00 EDT 2019

ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition.

American journal of human genetics

Alkanderi S,Molinari E,Shaheen R,Elmaghloob Y,Stephen LA,Sammut V,Ramsbottom SA,Srivastava S,Cairns G,Edwards N,Rice SJ,Ewida N,Alhashem A,White K,Miles CG,Steel DH,Alkuraya FS,Ismail S,Sayer JA

Thu Oct 04 00:00:00 EDT 2018

ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition.

American journal of human genetics

Alkanderi S,Molinari E,Shaheen R,Elmaghloob Y,Stephen LA,Sammut V,Ramsbottom SA,Srivastava S,Cairns G,Edwards N,Rice SJ,Ewida N,Alhashem A,White K,Miles CG,Steel DH,Alkuraya FS,Ismail S,Sayer JA

Thu Oct 04 00:00:00 EDT 2018

Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Abdelhamed ZA,Ryan TA,Fuller M,Coulson-Gilmer C,Abdelmottaleb DI,Wang TL,Kaun JC,Wang P,Hutson R,Wilkinson N,Bell SM,Johnson CA

Mon Oct 01 00:00:00 EDT 2018

Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Abdelhamed ZA,Ryan TA,Fuller M,Coulson-Gilmer C,Abdelmottaleb DI,Wang TL,Kaun JC,Wang P,Hutson R,Wilkinson N,Bell SM,Johnson CA

Mon Oct 01 00:00:00 EDT 2018

The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane.

Journal of the American Society of Nephrology : JASN

Xu W,Jin M,Hu R,Wang H,Zhang F,Yuan S,Cao Y

Sun Jan 01 00:00:00 EST 2017

The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane.

Journal of the American Society of Nephrology : JASN

Xu W,Jin M,Hu R,Wang H,Zhang F,Yuan S,Cao Y

Sun Jan 01 00:00:00 EST 2017

Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E.

Journal of cell science

Nozaki S,Katoh Y,Terada M,Michisaka S,Funabashi T,Takahashi S,Kontani K,Nakayama K

Wed Feb 01 00:00:00 EST 2017

Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E.

Journal of cell science

Nozaki S,Katoh Y,Terada M,Michisaka S,Funabashi T,Takahashi S,Kontani K,Nakayama K

Wed Feb 01 00:00:00 EST 2017

The guanine nucleotide exchange factor Arf-like protein 13b is essential for assembly of the mouse photoreceptor transition zone and outer segment.

The Journal of biological chemistry

Hanke-Gogokhia C,Wu Z,Sharif A,Yazigi H,Frederick JM,Baehr W

Fri Dec 29 00:00:00 EST 2017

KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.

Nature communications

Schou KB,Mogensen JB,Morthorst SK,Nielsen BS,Aleliunaite A,Serra-Marques A,Fürstenberg N,Saunier S,Bizet AA,Veland IR,Akhmanova A,Christensen ST,Pedersen LB

Mon Jan 30 00:00:00 EST 2017

KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.

Nature communications

Schou KB,Mogensen JB,Morthorst SK,Nielsen BS,Aleliunaite A,Serra-Marques A,Fürstenberg N,Saunier S,Bizet AA,Veland IR,Akhmanova A,Christensen ST,Pedersen LB

Mon Jan 30 00:00:00 EST 2017

The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling.

PloS one

Goetz SC,Bangs F,Barrington CL,Katsanis N,Anderson KV

Fri Sep 08 00:00:00 EDT 2017

The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling.

PloS one

Goetz SC,Bangs F,Barrington CL,Katsanis N,Anderson KV

Fri Sep 08 00:00:00 EDT 2017

MKS1 regulates ciliary INPP5E levels in Joubert syndrome.

Journal of medical genetics

Slaats GG,Isabella CR,Kroes HY,Dempsey JC,Gremmels H,Monroe GR,Phelps IG,Duran KJ,Adkins J,Kumar SA,Knutzen DM,Knoers NV,Mendelsohn NJ,Neubauer D,Mastroyianni SD,Vogt J,Worgan L,Karp N,Bowdin S,Glass IA,Parisi MA,Otto EA,Johnson CA,Hildebrandt F,van Haaften G,Giles RH,Doherty D

Fri Jan 01 00:00:00 EST 2016

MKS1 regulates ciliary INPP5E levels in Joubert syndrome.

Journal of medical genetics

Fri Jan 01 00:00:00 EST 2016

MKS1 regulates ciliary INPP5E levels in Joubert syndrome.

Journal of medical genetics

Fri Jan 01 00:00:00 EST 2016

MKS1 regulates ciliary INPP5E levels in Joubert syndrome.

Journal of medical genetics

Fri Jan 01 00:00:00 EST 2016

Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling.

Human molecular genetics

Hakim S,Dyson JM,Feeney SJ,Davies EM,Sriratana A,Koenig MN,Plotnikova OV,Smyth IM,Ricardo SD,Hobbs RM,Mitchell CA

Wed Jun 01 00:00:00 EDT 2016

Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling.

Human molecular genetics

Hakim S,Dyson JM,Feeney SJ,Davies EM,Sriratana A,Koenig MN,Plotnikova OV,Smyth IM,Ricardo SD,Hobbs RM,Mitchell CA

Wed Jun 01 00:00:00 EDT 2016

Role for the IFT-A Complex in Selective Transport to the Primary Cilium.

Cell reports

Fu W,Wang L,Kim S,Li J,Dynlacht BD

Tue Nov 01 00:00:00 EDT 2016

Role for the IFT-A Complex in Selective Transport to the Primary Cilium.

Cell reports

Fu W,Wang L,Kim S,Li J,Dynlacht BD

Tue Nov 01 00:00:00 EDT 2016

Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis.

Nature communications

Xu Q,Zhang Y,Wei Q,Huang Y,Hu J,Ling K

Fri Feb 26 00:00:00 EST 2016

Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis.

Nature communications

Xu Q,Zhang Y,Wei Q,Huang Y,Hu J,Ling K

Fri Feb 26 00:00:00 EST 2016

INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stability.

Journal of cell science

Plotnikova OV,Seo S,Cottle DL,Conduit S,Hakim S,Dyson JM,Mitchell CA,Smyth IM

Thu Jan 15 00:00:00 EST 2015

INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stability.

Journal of cell science

Plotnikova OV,Seo S,Cottle DL,Conduit S,Hakim S,Dyson JM,Mitchell CA,Smyth IM

Thu Jan 15 00:00:00 EST 2015

Deletion of Inpp5a causes ataxia and cerebellar degeneration in mice.

Neurogenetics

Yang AW,Sachs AJ,Nystuen AM

Thu Oct 01 00:00:00 EDT 2015

Deletion of Inpp5a causes ataxia and cerebellar degeneration in mice.

Neurogenetics

Yang AW,Sachs AJ,Nystuen AM

Thu Oct 01 00:00:00 EDT 2015

Deletion of Inpp5a causes ataxia and cerebellar degeneration in mice.

Neurogenetics

Yang AW,Sachs AJ,Nystuen AM

Thu Oct 01 00:00:00 EDT 2015

Deletion of Inpp5a causes ataxia and cerebellar degeneration in mice.

Neurogenetics

Yang AW,Sachs AJ,Nystuen AM

Thu Oct 01 00:00:00 EDT 2015

A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium.

Human mutation

Thomas S,Wright KJ,Le Corre S,Micalizzi A,Romani M,Abhyankar A,Saada J,Perrault I,Amiel J,Litzler J,Filhol E,Elkhartoufi N,Kwong M,Casanova JL,Boddaert N,Baehr W,Lyonnet S,Munnich A,Burglen L,Chassaing N,Encha-Ravazi F,Vekemans M,Gleeson JG,Valente EM,Jackson PK,Drummond IA,Saunier S,Attié-Bitach T

Wed Jan 01 00:00:00 EST 2014

A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium.

Human mutation

Wed Jan 01 00:00:00 EST 2014

A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium.

Human mutation

Wed Jan 01 00:00:00 EST 2014

A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium.

Human mutation

Wed Jan 01 00:00:00 EST 2014

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.

Proceedings of the National Academy of Sciences of the United States of America

Humbert MC,Weihbrecht K,Searby CC,Li Y,Pope RM,Sheffield VC,Seo S

Tue Nov 27 00:00:00 EST 2012

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.

Proceedings of the National Academy of Sciences of the United States of America

Humbert MC,Weihbrecht K,Searby CC,Li Y,Pope RM,Sheffield VC,Seo S

Tue Nov 27 00:00:00 EST 2012

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.

Proceedings of the National Academy of Sciences of the United States of America

Humbert MC,Weihbrecht K,Searby CC,Li Y,Pope RM,Sheffield VC,Seo S

Tue Nov 27 00:00:00 EST 2012

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.

Proceedings of the National Academy of Sciences of the United States of America

Humbert MC,Weihbrecht K,Searby CC,Li Y,Pope RM,Sheffield VC,Seo S

Tue Nov 27 00:00:00 EST 2012

Bioinformatics

Protein Aliases: 5-phosphatase that induces arborization; 72 kDa inositol polyphosphate 5-phosphatase; inositol polyphosphate 5-phosphatase; Inositol polyphosphate-5-phosphatase E; inositol polyphosphate-5-phosphatase, 72 kDa; Pharbin; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Phosphatidylinositol polyphosphate 5-phosphatase type IV; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; phosphatidylinositol-4,5-bisphosphate 5-phosphatase

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Gene Aliases: 1200002L24Rik; 72kDa; CORS1; CPD4; INPP5E; JBTS1; mKIAA0123; MORMS; PPI5PIV

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UniProt ID: (Human) Q9NRR6, (Rat) Q9WVR1, (Mouse) Q9JII1

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Entrez Gene ID: (Human) 56623, (Rat) 114089, (Mouse) 64436

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Function(s)

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity inositol-polyphosphate 5-phosphatase activity hydrolase activity hydrolase phosphatase metabolite interconversion enzyme

Process(es)

phosphatidylinositol biosynthetic process biological_process positive regulation of neuron projection development inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation phosphatidylinositol metabolic process lipid metabolic process dephosphorylation

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INPP5E Polyclonal Antibody

INPP5E Antibody (17797-1-AP) in ICC/IF

Product Details

17797-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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