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KIRREL (NEPH1) is a member of the nephrin-like protein family, which includes NEPH2 and NEPH3. The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. NEPH1 is a member of the nephrin-like protein family, which includes NEPH2. The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003).
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Protein Aliases: FLJ10845; Kin of IRRE-like protein 1; Kin of irregular chiasm-like protein 1; MGC129542; MGC129543; nephrin related; Nephrin-like protein 1
Gene Aliases: KIRREL; KIRREL1; NEPH1
UniProt ID: (Human) Q96J84
Entrez Gene ID: (Human) 55243
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