Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: QGTQTRFSQE PADQTVVAGQ RAVLPCVLLN YSGIVQWTKD GLALGMGQGL KAWPRYRVVG SADAGQYNLE ITDAELSDDA SYECQATEAA LRSRRAKLTV LIPPEDTRID GGPVILLQAG TPHNLTCRAF NAKPAATIIW FRDGTQQEGA VASTELLKDG KRETTVSQLL INPTDLDIGR VFTC; Positive Samples: Mouse kidney, Mouse lung; Cellular Location: Cell membrane, Single-pass type I membrane protein
KIRREL (NEPH1) is a member of the nephrin-like protein family, which includes NEPH2 and NEPH3. The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. NEPH1 is a member of the nephrin-like protein family, which includes NEPH2. The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003).
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Protein Aliases: FLJ10845; kin of IRRE like 1; Kin of IRRE-like protein 1; Kin of irregular chiasm-like protein 1; MGC129542; MGC129543; nephrin 1; Nephrin-like protein 1
Gene Aliases: 6720469N11Rik; Kirrel; Kirrel1; Neph1
UniProt ID: (Rat) Q6X936, (Mouse) Q80W68
Entrez Gene ID: (Rat) 310695, (Mouse) 170643
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