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Product Details
602-570
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to C-terminus of human LRRK2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with proprietary stabilizer
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
Product Specific Information
Positive control: Mouse brain tissue
Cellular location: Membrane, Cytoplasm.
Target Information
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in LRRK2 have been associated with Parkinson's disease. LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: augmented in rheumatoid arthritis 17; BC 300-268; Dardarin; DKFZp434H2111; FLJ45829; leucine-rich repeat kinase 2; Leucine-rich repeat serine/threonine-protein kinase 2; LRR kinase 2; LRRK 2; LRRK-2
Gene Aliases: AURA17; DARDARIN; LRRK2; PARK8; RIPK7; ROCO2
UniProt ID: (Human) Q5S007
Entrez Gene ID: (Human) 120892
SNARE binding
glycoprotein binding
actin binding
GTPase activity
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase activity
GTPase activator activity
protein binding
ATP binding
GTP binding
microtubule binding
tubulin binding
kinase activity
Rho GTPase binding
syntaxin-1 binding
receptor signaling complex scaffold activity
clathrin binding
GTP-dependent protein kinase activity
peroxidase inhibitor activity
co-receptor binding
identical protein binding
protein homodimerization activity
ion channel binding
protein kinase A binding
beta-catenin destruction complex binding
scaffold/adaptor protein
MAPK cascade
activation of MAPKK activity
activation of MAPK activity
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
protein phosphorylation
endocytosis
autophagy
response to oxidative stress
mitochondrion organization
Golgi organization
lysosome organization
small GTPase mediated signal transduction
neuromuscular junction development
determination of adult lifespan
cellular response to starvation
regulation of autophagy
positive regulation of autophagy
regulation of protein kinase A signaling
negative regulation of protein processing
regulation of neuron maturation
negative regulation of macroautophagy
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
calcium-mediated signaling
olfactory bulb development
tangential migration from the subventricular zone to the olfactory bulb
positive regulation of protein ubiquitination
negative regulation of protein binding
positive regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of GTPase activity
cellular response to oxidative stress
cellular protein localization
intracellular signal transduction
regulation of kidney size
exploration behavior
locomotory exploration behavior
regulation of lysosomal lumen pH
regulation of locomotion
regulation of membrane potential
positive regulation of programmed cell death
positive regulation of MAP kinase activity
positive regulation of GTPase activity
GTP metabolic process
protein autophosphorylation
intracellular distribution of mitochondria
neuron projection morphogenesis
regulation of calcium-mediated signaling
mitochondrion localization
regulation of mitochondrial depolarization
regulation of synaptic transmission, glutamatergic
canonical Wnt signaling pathway
excitatory postsynaptic potential
regulation of dopamine receptor signaling pathway
positive regulation of dopamine receptor signaling pathway
regulation of canonical Wnt signaling pathway
regulation of dendritic spine morphogenesis
protein localization to mitochondrion
neuron death
cellular response to manganese ion
reactive oxygen species metabolic process
regulation of mitochondrial fission
positive regulation of canonical Wnt signaling pathway
negative regulation of excitatory postsynaptic potential
regulation of neuron death
negative regulation of neuron death
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of protein autoubiquitination
regulation of neuroblast proliferation
regulation of synaptic vesicle transport
negative regulation of late endosome to lysosome transport
negative regulation of autophagosome assembly
negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
negative regulation of hydrogen peroxide-induced cell death
negative regulation of protein targeting to mitochondrion
negative regulation of protein processing involved in protein targeting to mitochondrion
cellular response to dopamine
Wnt signalosome assembly
regulation of retrograde transport, endosome to Golgi
regulation of branching morphogenesis of a nerve
regulation of synaptic vesicle exocytosis
negative regulation of peroxidase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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