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LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in LRRK2 have been associated with Parkinson's disease. LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.
4921513O20Rik; 9330188B09Rik; augmented in rheumatoid arthritis 17; AURA17; AW561911; BC 300-268; cI-46; D630001M17Rik; DARDARIN; DKFZp434H2111; FLJ45829; Gm927; leucine rich repeat kinase 2; leucine-rich repeat kinase 2; leucine-rich repeat serine/threonine-protein kinase 2; LRR kinase 2; LRRK 2; Lrrk2; LRRK-2; PARK8; RIPK7; ROCO2
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