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Product Details
PA1-16990
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues 900-1000 of mouse LRRK2.
Conjugate
Form
Liquid
Concentration
1.09 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.1% sodium azide
Storage conditions
4° C, do not freeze
Shipping conditions
Wet ice
RRID
AB_2137907
Product Specific Information
Suggested positive control: mouse brain lysate, mouse brain protein.
Target Information
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in LRRK2 have been associated with Parkinson's disease. LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BC 300-268; DKFZp434H2111; FLJ45829; Leucine-rich repeat serine/threonine-protein kinase 2; LRR kinase 2; LRRK 2; LRRK-2
Gene Aliases: 4921513O20Rik; 9330188B09Rik; AW561911; cI-46; D630001M17Rik; Gm927; Lrrk2
UniProt ID: (Mouse) Q5S006
Entrez Gene ID: (Mouse) 66725
SNARE binding
nucleotide binding
glycoprotein binding
actin binding
GTPase activity
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase activity
GTPase activator activity
protein binding
ATP binding
GTP binding
tubulin binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Rho GTPase binding
syntaxin-1 binding
clathrin binding
GTP-dependent protein kinase activity
peroxidase inhibitor activity
identical protein binding
protein homodimerization activity
ion channel binding
protein kinase A binding
scaffold/adaptor protein
MAPK cascade
activation of MAPKK activity
activation of MAPK activity
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
protein phosphorylation
endocytosis
autophagy
response to oxidative stress
mitochondrion organization
Golgi organization
small GTPase mediated signal transduction
neuromuscular junction development
determination of adult lifespan
positive regulation of autophagy
regulation of protein kinase A signaling
negative regulation of protein processing
regulation of neuron maturation
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
olfactory bulb development
tangential migration from the subventricular zone to the olfactory bulb
cell differentiation
positive regulation of protein ubiquitination
negative regulation of protein binding
positive regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of GTPase activity
cellular response to oxidative stress
cellular protein localization
intracellular signal transduction
regulation of kidney size
exploration behavior
locomotory exploration behavior
synaptic vesicle recycling
regulation of locomotion
regulation of membrane potential
positive regulation of programmed cell death
positive regulation of GTPase activity
GTP metabolic process
protein autophosphorylation
intracellular distribution of mitochondria
neuron projection morphogenesis
mitochondrion localization
regulation of mitochondrial depolarization
regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
regulation of dopamine receptor signaling pathway
positive regulation of dopamine receptor signaling pathway
regulation of dendritic spine morphogenesis
neuron death
cellular response to manganese ion
reactive oxygen species metabolic process
regulation of neuron death
negative regulation of neuron death
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of protein autoubiquitination
regulation of neuroblast proliferation
regulation of synaptic vesicle transport
negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
negative regulation of hydrogen peroxide-induced cell death
negative regulation of protein targeting to mitochondrion
cellular response to dopamine
regulation of branching morphogenesis of a nerve
regulation of synaptic vesicle exocytosis
negative regulation of peroxidase activity
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