Product References
Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening.
Proceedings of the National Academy of Sciences of the United States of America
Griffin KH,Thorpe SW,Sebastian A,Hum NR,Coonan TP,Sagheb IS,Loots GG,Randall RL,Leach JK
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Tue Sep 26 00:00:00 EDT 2023
STS1 and STS2 Phosphatase Inhibitor Baicalein Enhances the Expansion of Hematopoietic and Progenitor Stem Cells and Alleviates 5-Fluorouracil-Induced Myelosuppression.
International journal of molecular sciences
Li N,Wang Y,Wang A,Zhang J,Jia C,Yu C,Song Z,Wang S,Liu L,Yi J,Bao Y,Huang Y,Sun L
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Fri Feb 03 00:00:00 EST 2023
The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut.
Biology open
Ramadan R,Wouters VM,van Neerven SM,de Groot NE,Garcia TM,Muncan V,Franklin OD,Battle M,Carlson KS,Leach J,Sansom OJ,Boulard O,Chamaillard M,Vermeulen L,Medema JP,Huels DJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Dec 15 00:00:00 EST 2022
The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut.
Biology open
Ramadan R,Wouters VM,van Neerven SM,de Groot NE,Garcia TM,Muncan V,Franklin OD,Battle M,Carlson KS,Leach J,Sansom OJ,Boulard O,Chamaillard M,Vermeulen L,Medema JP,Huels DJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Dec 15 00:00:00 EST 2022
Cardiac Mesenchymal Stem Cells Promote Fibrosis and Remodeling in Heart Failure: Role of PDGF Signaling.
JACC. Basic to translational science
Hamid T,Xu Y,Ismahil MA,Rokosh G,Jinno M,Zhou G,Wang Q,Prabhu SD
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Sun May 01 00:00:00 EDT 2022
Hematopoietic-Mesenchymal Signals Regulate the Properties of Mesenchymal Stem Cells.
International journal of molecular sciences
Kanazawa S,Okada H,Riu D,Mabuchi Y,Akazawa C,Iwata J,Hoshi K,Hikita A
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Tue Jul 26 00:00:00 EDT 2022
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia.
Cell stem cell
Vasquez EG,Nasreddin N,Valbuena GN,Mulholland EJ,Belnoue-Davis HL,Eggington HR,Schenck RO,Wouters VM,Wirapati P,Gilroy K,Lannagan TRM,Flanagan DJ,Najumudeen AK,Omwenga S,McCorry AMB,Easton A,Koelzer VH,East JE,Morton D,Trusolino L,Maughan T,Campbell AD,Loughrey MB,Dunne PD,Tsantoulis P,Huels DJ,Tejpar S,Sansom OJ,Leedham SJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Aug 04 00:00:00 EDT 2022
Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration.
NPJ Regenerative medicine
Krawetz RJ,Abubacker S,Leonard C,Masson AO,Shah S,Narendran N,Tailor P,Regmi SC,Labit E,Ninkovic N,Corpuz JM,Ito K,Underhill TM,Salo PT,Schmidt TA,Biernaskie JA
14-5981-82 was used in Flow cytometry/Cell sorting to propose that rhPRG4 may represent a potential therapy to mitigate scar and improve wound healing.
Fri Jun 24 00:00:00 EDT 2022
Nociceptive nerves regulate haematopoietic stem cell mobilization.
Nature
Gao X,Zhang D,Xu C,Li H,Caron KM,Frenette PS
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration.
Cell death and differentiation
Deng CL,Hu CB,Ling ST,Zhao N,Bao LH,Zhou F,Xiong YC,Chen T,Sui BD,Yu XR,Hu CH
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Mon Mar 01 00:00:00 EST 2021
Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin.
Cell death and differentiation
Velletri T,Huang Y,Wang Y,Li Q,Hu M,Xie N,Yang Q,Chen X,Chen Q,Shou P,Gan Y,Candi E,Annicchiarico-Petruzzelli M,Agostini M,Yang H,Melino G,Shi Y,Wang Y
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss.
EMBO reports
Hu Y,Li X,Zhi X,Cong W,Huang B,Chen H,Wang Y,Li Y,Wang L,Fang C,Guo J,Liu Y,Cui J,Cao L,Weng W,Zhou Q,Wang S,Chen X,Su J
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
Effects of signaling pathway inhibitors on hematopoietic stem cells.
Molecular medicine reports
Jiang Y,Xu Z,Ma N,Yin L,Hao C,Li J
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Age-related trabecular bone loss is associated with a decline in serum Galectin-1 level.
BMC musculoskeletal disorders
Xu W,Ni C,Wang Y,Zheng G,Zhang J,Xu Y
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Tue Apr 27 00:00:00 EDT 2021
Differential activation of Ca2+ influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration.
NPJ Regenerative medicine
Ahamad N,Sun Y,Nascimento Da Conceicao V,Xavier Paul Ezhilan CRD,Natarajan M,Singh BB
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Immunohistochemistry
Wed Oct 20 00:00:00 EDT 2021
The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism.
eLife
Roy A,Tomaz da Silva M,Bhat R,Bohnert KR,Iwawaki T,Kumar A
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Tue Nov 23 00:00:00 EST 2021
Conditionally pathogenic genetic variants of a hematopoietic disease-suppressing enhancer.
Science advances
Soukup AA,Matson DR,Liu P,Johnson KD,Bresnick EH
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Fri Dec 10 00:00:00 EST 2021
Therapeutic Potential of Mesenchymal Stem Cells in a Pre-Clinical Model of Diabetic Kidney Disease and Obesity.
International journal of molecular sciences
Sávio-Silva C,Soinski-Sousa PE,Simplício-Filho A,Bastos RMC,Beyerstedt S,Rangel ÉB
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Feb 04 00:00:00 EST 2021
Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification.
Stem cell reports
Kretzschmar K,Boonekamp KE,Bleijs M,Asra P,Koomen M,Chuva de Sousa Lopes SM,Giovannone B,Clevers H
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Tue Sep 14 00:00:00 EDT 2021
Activation of skeletal muscle-resident glial cells upon nerve injury.
JCI insight
Proietti D,Giordani L,De Bardi M,D'Ercole C,Lozanoska-Ochser B,Amadio S,Volonté C,Marinelli S,Muchir A,Bouché M,Borsellino G,Sacco A,Puri PL,Madaro L
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Apr 08 00:00:00 EDT 2021
MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells.
Nature communications
Wei Q,Pinho S,Dong S,Pierce H,Li H,Nakahara F,Xu J,Xu C,Boulais PE,Zhang D,Maryanovich M,Cuervo AM,Frenette PS
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Tue May 04 00:00:00 EDT 2021
Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.
EMBO reports
Szade K,Zukowska M,Szade A,Nowak W,Skulimowska I,Ciesla M,Bukowska-Strakova K,Gulati GS,Kachamakova-Trojanowska N,Kusienicka A,Einwallner E,Kijowski J,Czauderna S,Esterbauer H,Benes V,L Weissman I,Dulak J,Jozkowicz A
14-5981 was used in Flow cytometry/Cell sorting to demonstrate how heme oxygenase 1 (HO-1) extrinsic activity prevents hematopoietic stem cells (HSCs) from premature exhaustion and may restore their function when aged.
Wed Feb 05 00:00:00 EST 2020
Multipotency of mouse trophoblast stem cells.
Stem cell research & therapy
Hou M,Han J,Li G,Kwon MY,Jiang J,Emani S,Taglauer ES,Park JA,Choi EB,Vodnala M,Fong YW,Emani SM,Rosas IO,Perrella MA,Liu X
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Feb 13 00:00:00 EST 2020
Multipotency of mouse trophoblast stem cells.
Stem cell research & therapy
Hou M,Han J,Li G,Kwon MY,Jiang J,Emani S,Taglauer ES,Park JA,Choi EB,Vodnala M,Fong YW,Emani SM,Rosas IO,Perrella MA,Liu X
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Feb 13 00:00:00 EST 2020
Multipotency of mouse trophoblast stem cells.
Stem cell research & therapy
Hou M,Han J,Li G,Kwon MY,Jiang J,Emani S,Taglauer ES,Park JA,Choi EB,Vodnala M,Fong YW,Emani SM,Rosas IO,Perrella MA,Liu X
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Feb 13 00:00:00 EST 2020
Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.
Nature communications
Wilkes MC,Siva K,Chen J,Varetti G,Youn MY,Chae H,Ek F,Olsson R,Lundbäck T,Dever DP,Nishimura T,Narla A,Glader B,Nakauchi H,Porteus MH,Repellin CE,Gazda HT,Lin S,Serrano M,Flygare J,Sakamoto KM
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Fri Jul 03 00:00:00 EDT 2020
XIAOPI formula inhibits the pre-metastatic niche formation in breast cancer via suppressing TAMs/CXCL1 signaling.
Cell communication and signaling : CCS
Zheng Y,Wang N,Wang S,Yang B,Situ H,Zhong L,Lin Y,Wang Z
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Mar 26 00:00:00 EDT 2020
Use of Busulfan to Condition Mice for Bone Marrow Transplantation.
STAR protocols
Montecino-Rodriguez E,Dorshkind K
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Fri Dec 18 00:00:00 EST 2020
Interaction of Deubiquitinase 2A-DUB/MYSM1 with DNA Repair and Replication Factors.
International journal of molecular sciences
Kroeger C,Roesler R,Wiese S,Hainzl A,Gatzka MV
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Tue May 26 00:00:00 EDT 2020
A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling.
eLife
Geng A,Wu T,Cai C,Song W,Wang J,Yu QC,Zeng YA
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Tue Aug 04 00:00:00 EDT 2020
Apoptotic bodies derived from mesenchymal stem cells promote cutaneous wound healing via regulating the functions of macrophages.
Stem cell research & therapy
Liu J,Qiu X,Lv Y,Zheng C,Dong Y,Dou G,Zhu B,Liu A,Wang W,Zhou J,Liu S,Liu S,Gao B,Jin Y
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Fri Nov 27 00:00:00 EST 2020
Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals.
Cell & bioscience
Jiang M,Ye J,Wang X,Li N,Wang Y,Shi Y
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Apr 14 00:00:00 EDT 2022
Novel CD11b+Gr-1+Sca-1+ myeloid cells drive mortality in bacterial infection.
Science advances
Park MY,Kim HS,Lee HY,Zabel BA,Bae YS
14-5981-82 was used in Flow Cytometry to find a previously unidentified pathogenic CD11b+Gr-1+ myeloid cell population that expresses stem cell antigen-1 (Sca-1) induced upon experimental infection with Staphylococcus aureus.
Wed Jan 01 00:00:00 EST 2020
miR-142 induces accumulation of reactive oxygen species (ROS) by inhibiting pexophagy in aged bone marrow mesenchymal stem cells.
Scientific reports
Houri K,Mori T,Onodera Y,Tsujimoto T,Takehara T,Nakao S,Teramura T,Fukuda K
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Fri Feb 28 00:00:00 EST 2020
Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking.
The Journal of clinical investigation
Zhang J,Supakorndej T,Krambs JR,Rao M,Abou-Ezzi G,Ye RY,Li S,Trinkaus K,Link DC
14-5981 was used in Flow cytometry/Cell sorting to show that HSPC mobilization after cDC ablation is attenuated in mice lacking CXCR2 expression.
Tue Apr 30 00:00:00 EDT 2019
EDA fibronectin-TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis.
The Journal of experimental medicine
Malara A,Gruppi C,Abbonante V,Cattaneo D,De Marco L,Massa M,Iurlo A,Gianelli U,Balduini CL,Tira ME,Muro AF,Chauhan AK,Rosti V,Barosi G,Balduini A
14-5981 was used in Flow cytometry/Cell sorting to find that the EDA FN is increased in plasma and BM biopsies of PMF patients as compared with healthy controls, correlating with fibrotic phase.
Mon Mar 04 00:00:00 EST 2019
Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures.
Proceedings of the National Academy of Sciences of the United States of America
Boonekamp KE,Kretzschmar K,Wiener DJ,Asra P,Derakhshan S,Puschhof J,López-Iglesias C,Peters PJ,Basak O,Clevers H
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Tue Jul 16 00:00:00 EDT 2019
PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment.
PLoS pathogens
Naipauer J,Rosario S,Gupta S,Premer C,Méndez-Solís O,Schlesinger M,Ponzinibbio V,Jain V,Gay L,Renne R,Chan HL,Morey L,Salyakina D,Abba M,Williams S,Hare JM,Goldschmidt-Clermont PJ,Mesri EA
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Sun Dec 01 00:00:00 EST 2019
Mechanical Loading Promotes the Expansion of Primitive Osteoprogenitors and Organizes Matrix and Vascular Morphology in Long Bone Defects.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Liu C,Cabahug-Zuckerman P,Stubbs C,Pendola M,Cai C,Mann KA,Castillo AB
14-5981-82 was used in Immunohistochemistry to illustrate the adaptation of both collagen matrix and vascular morphology to better withstand mechanical load during bone repair.
Wed May 01 00:00:00 EDT 2019
Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice.
PLoS genetics
Madaro L,Torcinaro A,De Bardi M,Contino FF,Pelizzola M,Diaferia GR,Imeneo G,Bouchè M,Puri PL,De Santa F
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2019
TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis.
Nature communications
Li J,Ayoub A,Xiu Y,Yin X,Sanders JO,Mesfin A,Xing L,Yao Z,Boyce BF
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Wed Jun 26 00:00:00 EDT 2019
Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis.
Science advances
van de Vlekkert D,Demmers J,Nguyen XX,Campos Y,Machado E,Annunziata I,Hu H,Gomero E,Qiu X,Bongiovanni A,Feghali-Bostwick CA,d'Azzo A
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Mon Jul 01 00:00:00 EDT 2019
The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression.
Nature communications
Huang J,Zhao L,Fan Y,Liao L,Ma PX,Xiao G,Chen D
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Fri Jun 28 00:00:00 EDT 2019
Procr-expressing progenitor cells are responsible for murine ovulatory rupture repair of ovarian surface epithelium.
Nature communications
Wang J,Wang D,Chu K,Li W,Zeng YA
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Oct 31 00:00:00 EDT 2019
Breast Tumor Cells Highly Resistant to Drugs Are Controlled Only by the Immune Response Induced in an Immunocompetent Mouse Model.
Integrative cancer therapies
Lasso P,Llano Murcia M,Sandoval TA,Urueña C,Barreto A,Fiorentino S
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Wed Dec 11 00:00:00 EST 2019
Site-Specific Load-Induced Expansion of Sca-1+Prrx1+ and Sca-1-Prrx1+ Cells in Adult Mouse Long Bone Is Attenuated With Age.
JBMR plus
Cabahug-Zuckerman P,Liu C,Cai C,Mahaffey I,Norman SC,Cole W,Castillo AB
14-5981 was used in Immunohistochemistry to show that the acute response of adult bone to loading involves expansion of Sca-1+Prrx1+ and Sca-1-Prrx1+ cells in the periosteum.
Sun Sep 01 00:00:00 EDT 2019
PDGF is a potent initiator of bone formation in a tissue engineered model of pathological ossification.
Journal of tissue engineering and regenerative medicine
Davies OG,Grover LM,Lewis MP,Liu Y
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Mon Jan 01 00:00:00 EST 2018
Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.
Experimental hematology
Serrano-Lopez J,Nattamai K,Pease NA,Shephard MS,Wellendorf AM,Sertorio M,Smith EA,Geiger H,Wells SI,Cancelas JA,Privette Vinnedge LM
14-5981 was used in Flow cytometry/Cell sorting to investigate the role of DEK in normal hematopoiesis and response to DNA damaging agents in vivo.
Thu Mar 01 00:00:00 EST 2018
The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.
eLife
Schmidt K,Zhang Q,Tasdogan A,Petzold A,Dahl A,Arneth BM,Slany R,Fehling HJ,Kranz A,Stewart AF,Anastassiadis K
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Tue Jun 19 00:00:00 EDT 2018
Tracking of Adipose-Derived Mesenchymal Stromal/Stem Cells in a Model of Cisplatin-Induced Acute Kidney Injury: Comparison of Bioluminescence Imaging versus qRT-PCR.
International journal of molecular sciences
Schubert R,Sann J,Frueh JT,Ullrich E,Geiger H,Baer PC
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Wed Aug 29 00:00:00 EDT 2018
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Sep 06 00:00:00 EDT 2018
HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles.
Scientific reports
Lee D,Taniguchi N,Sato K,Choijookhuu N,Hishikawa Y,Kataoka H,Morinaga H,Lotz M,Chosa E
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Mon Jun 25 00:00:00 EDT 2018
Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow.
Nature communications
Xu C,Gao X,Wei Q,Nakahara F,Zimmerman SE,Mar J,Frenette PS
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Fri Jun 22 00:00:00 EDT 2018
Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow.
Nature communications
Xu C,Gao X,Wei Q,Nakahara F,Zimmerman SE,Mar J,Frenette PS
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Fri Jun 22 00:00:00 EDT 2018
RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.
The Journal of biological chemistry
Ge J,Burnier L,Adamopoulou M,Kwa MQ,Schaks M,Rottner K,Brakebusch C
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Fri Jun 15 00:00:00 EDT 2018
LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells.
Genome biology
Grigoryan A,Guidi N,Senger K,Liehr T,Soller K,Marka G,Vollmer A,Markaki Y,Leonhardt H,Buske C,Lipka DB,Plass C,Zheng Y,Mulaw MA,Geiger H,Florian MC
14-5981 was used in Flow cytometry/Cell sorting to show that not all histone modifications display a polar localization and that a reduction in H4K16ac amount and loss of epipolarity are specific to aged HSCs.
Wed Nov 07 00:00:00 EST 2018
Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease.
Nature medicine
Hahm E,Wei C,Fernandez I,Li J,Tardi NJ,Tracy M,Wadhwani S,Cao Y,Peev V,Zloza A,Lusciks J,Hayek SS,O'Connor C,Bitzer M,Gupta V,Sever S,Sykes DB,Scadden DT,Reiser J
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2017
FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging.
The Journal of clinical investigation
Li H,Liu P,Xu S,Li Y,Dekker JD,Li B,Fan Y,Zhang Z,Hong Y,Yang G,Tang T,Ren Y,Tucker HO,Yao Z,Guo X
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Mon Apr 03 00:00:00 EDT 2017
GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis.
The Journal of clinical investigation
Géraud C,Koch PS,Zierow J,Klapproth K,Busch K,Olsavszky V,Leibing T,Demory A,Ulbrich F,Diett M,Singh S,Sticht C,Breitkopf-Heinlein K,Richter K,Karppinen SM,Pihlajaniemi T,Arnold B,Rodewald HR,Augustin HG,Schledzewski K,Goerdt S
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
Poor Mobilization in T-Cell-Deficient Nude Mice Is Explained by Defective Activation of Granulocytes and Monocytes.
Cell transplantation
Wysoczynski M,Adamiak M,Suszynska M,Abdel-Latif A,Ratajczak J,Ratajczak MZ
14-5981 was used in Flow cytometry/Cell sorting to give evidence that proper function of Gr1+ cells is crucial for optimal mobilization of heamatopoietic stem/progenitor cells.
Tue Jan 24 00:00:00 EST 2017
Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours.
Nature communications
Tao L,Xiang D,Xie Y,Bronson RT,Li Z
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Mon Feb 13 00:00:00 EST 2017
Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.
Nature communications
Shirai CL,White BS,Tripathi M,Tapia R,Ley JN,Ndonwi M,Kim S,Shao J,Carver A,Saez B,Fulton RS,Fronick C,O'Laughlin M,Lagisetti C,Webb TR,Graubert TA,Walter MJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Mon Jan 09 00:00:00 EST 2017
Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature.
Nature communications
Reismann D,Stefanowski J,Günther R,Rakhymzhan A,Matthys R,Nützi R,Zehentmeier S,Schmidt-Bleek K,Petkau G,Chang HD,Naundorf S,Winter Y,Melchers F,Duda G,Hauser AE,Niesner RA
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Immunofluorescence
Mon Dec 18 00:00:00 EST 2017
Microgrooved-surface topography enhances cellular division and proliferation of mouse bone marrow-derived mesenchymal stem cells.
PloS one
Chaudhary JK,Rath PC
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Oct 19 00:00:00 EDT 2017
Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB.
PloS one
Gao SY,Zheng GS,Wang L,Liang YJ,Zhang SE,Lao XM,Li K,Liao GQ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Mon Sep 18 00:00:00 EDT 2017
WASH maintains NKp46+ ILC3 cells by promoting AHR expression.
Nature communications
Xia P,Liu J,Wang S,Ye B,Du Y,Xiong Z,Han ZG,Tong L,Fan Z
14-5981 was used in Flow cytometry/Cell sorting to study how WASH-mediated AHR expression has a critical function in the maintenance of NKp46(+) ILC3s.
Wed Jun 07 00:00:00 EDT 2017
Fibroblastic reticular cells of the lymphoid tissues modulate T cell activation threshold during homeostasis via hyperactive cyclooxygenase-2/prostaglandin E2 axis.
Scientific reports
Yu M,Guo G,Zhang X,Li L,Yang W,Bollag R,Cui Y
14-5981 was used in Flow cytometry/Cell sorting to identify an intrinsic mechanism of fibroblastic reticular cells shared between mice and humans for suppressing T cell sensitivity to activation via PGE2.
Tue Jun 13 00:00:00 EDT 2017
Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis.
PloS one
Tornack J,Reece ST,Bauer WM,Vogelzang A,Bandermann S,Zedler U,Stingl G,Kaufmann SH,Melchers F
14-5981-82 was used in Flow Cytometry to conclude that LT-pHSCs, together with MSCs of Mtb-infected humans and mice serve as a hitherto unappreciated quiescent cellular depot for Mtb during latent TB infection.
Tue Sep 05 00:00:00 EDT 2017
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Cell
Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Aug 25 00:00:00 EDT 2016
Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.
Circulation research
Sager HB,Hulsmans M,Lavine KJ,Moreira MB,Heidt T,Courties G,Sun Y,Iwamoto Y,Tricot B,Khan OF,Dahlman JE,Borodovsky A,Fitzgerald K,Anderson DG,Weissleder R,Libby P,Swirski FK,Nahrendorf M
14-5981 was used in Flow cytometry/Cell sorting to elucidate the origin and roles of macrophages in the post-myocardial infarction remodelling of nonischaemic remote myocardium.
Fri Sep 16 00:00:00 EDT 2016
Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo.
Nucleic acids research
Yang Y,Poe JC,Yang L,Fedoriw A,Desai S,Magnuson T,Li Z,Fedoriw Y,Araki K,Gao Y,Tateishi S,Sarantopoulos S,Vaziri C
14-5981-82 was used in Flow Cytometry to investigate the physiological roles of Rad18 in DNA damage tolerance and carcinogenesis.
Thu May 19 00:00:00 EDT 2016
Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo.
Nucleic acids research
Yang Y,Poe JC,Yang L,Fedoriw A,Desai S,Magnuson T,Li Z,Fedoriw Y,Araki K,Gao Y,Tateishi S,Sarantopoulos S,Vaziri C
14-5981-82 was used in Flow Cytometry to investigate the physiological roles of Rad18 in DNA damage tolerance and carcinogenesis.
Thu May 19 00:00:00 EDT 2016
Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa.
Proceedings of the National Academy of Sciences of the United States of America
Oh JE,Kim BC,Chang DH,Kwon M,Lee SY,Kang D,Kim JY,Hwang I,Yu JW,Nakae S,Lee HK
14-5981 was used in Flow cytometry/Cell sorting to provide insight into the mechanisms of homeostasis maintained by commensal bacteria, and reveal a deleterious consequence of dysbiosis in antiviral immune defense.
Tue Feb 09 00:00:00 EST 2016
Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization.
Mucosal immunology
Gold MJ,Hiebert PR,Park HY,Stefanowicz D,Le A,Starkey MR,Deane A,Brown AC,Liu G,Horvat JC,Ibrahim ZA,Sukkar MB,Hansbro PM,Carlsten C,VanEeden S,Sin DD,McNagny KM,Knight DA,Hirota JA
14-5981 was used in Flow cytometry/Cell sorting to investigate the mechanisms governing induction of innate immune responses and allergic sensitisation by particulate matter.
Sun May 01 00:00:00 EDT 2016
Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.
Journal of immunology (Baltimore, Md. : 1950)
Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA
14-5981 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.
Tue Nov 15 00:00:00 EST 2016
Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity.
Experimental cell research
Hettmer S,Lin MM,Tchessalova D,Tortorici SJ,Castiglioni A,Desai T,Mao J,McMahon AP,Wagers AJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities.
Pain reports
Cabañero D,Irie T,Celorrio M,Trousdale C,Owens DM,Virley D,Albrecht PJ,Caterina MJ,Rice FL,Morón JA
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Sep 01 00:00:00 EDT 2016
Identification of a CD133-CD55- population functions as a fetal common skeletal progenitor.
Scientific reports
Weng L,Hu X,Kumar B,Garcia M,Todorov I,Jung X,Marcucci G,Forman SJ,Chen CC
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Immunofluorescence
Thu Dec 08 00:00:00 EST 2016
The lysine methyltransferase Ehmt2/G9a is dispensable for skeletal muscle development and regeneration.
Skeletal muscle
Zhang RH,Judson RN,Liu DY,Kast J,Rossi FM
14-5981 was used in Flow cytometry/Cell sorting to demonstrate that Ehmt2 and H3K9me2 do not play significant roles in skeletal muscle development and regeneration in vivo.
Thu Oct 06 00:00:00 EDT 2016
T cells conditioned with MDSC show an increased anti-tumor activity after adoptive T cell based immunotherapy.
Oncotarget
Raber PL,Sierra RA,Thevenot PT,Shuzhong Z,Wyczechowska DD,Kumai T,Celis E,Rodriguez PC
14-5981 was used in Flow cytometry/Cell sorting to test the impact of conditioning CD8+ T cells with myeloid-derived suppressor cells on their differentiation potential and adoptive T cell-based immunotherapy efficacy.
Tue Apr 05 00:00:00 EDT 2016
Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction.
PloS one
Kanda M,Nagai T,Takahashi T,Liu ML,Kondou N,Naito AT,Akazawa H,Sashida G,Iwama A,Komuro I,Kobayashi Y
14-5981 was used in Immunofluorescence on frozen tissues to show that LIF stimulates stem cell-derived cardiomyocyte regeneration, in part by activating cardiac stem or precursor cells.
Thu Jul 06 00:00:00 EDT 2017
KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.
Nature medicine
Shankman LS,Gomez D,Cherepanova OA,Salmon M,Alencar GF,Haskins RM,Swiatlowska P,Newman AA,Greene ES,Straub AC,Isakson B,Randolph GJ,Owens GK
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Immunofluorescence
Mon Jun 01 00:00:00 EDT 2015
KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.
Nature medicine
Shankman LS,Gomez D,Cherepanova OA,Salmon M,Alencar GF,Haskins RM,Swiatlowska P,Newman AA,Greene ES,Straub AC,Isakson B,Randolph GJ,Owens GK
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Immunofluorescence
Mon Jun 01 00:00:00 EDT 2015
Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.
Nature
Wong TN,Ramsingh G,Young AL,Miller CA,Touma W,Welch JS,Lamprecht TL,Shen D,Hundal J,Fulton RS,Heath S,Baty JD,Klco JM,Ding L,Mardis ER,Westervelt P,DiPersio JF,Walter MJ,Graubert TA,Ley TJ,Druley T,Link DC,Wilson RK
14-5981 was used in Flow cytometry/Cell sorting to investigate how prior exposure to cytotoxic therapy influences leukemogenesis and TP53 mutations in t-AML/t-MDS patients.
Thu Feb 26 00:00:00 EST 2015
Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.
Cancer cell
Cole A,Wang Z,Coyaud E,Voisin V,Gronda M,Jitkova Y,Mattson R,Hurren R,Babovic S,Maclean N,Restall I,Wang X,Jeyaraju DV,Sukhai MA,Prabha S,Bashir S,Ramakrishnan A,Leung E,Qia YH,Zhang N,Combes KR,Ketela T,Lin F,Houry WA,Aman A,Al-Awar R,Zheng W,Wienholds E,Xu CJ,Dick J,Wang JC,Moffat J,Minden MD,Eaves CJ,Bader GD,Hao Z,Kornblau SM,Raught B,Schimmer AD
14-5981-82 was used in Flow Cytometry to study the inhibition of ClpP as a therapeutic strategy for human Acute Myeloid Leukaemia.
Mon Jun 08 00:00:00 EDT 2015
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity.
Nature cell biology
Jeffery E,Church CD,Holtrup B,Colman L,Rodeheffer MS
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Western Blot
Wed Apr 01 00:00:00 EDT 2015
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity.
Nature cell biology
Jeffery E,Church CD,Holtrup B,Colman L,Rodeheffer MS
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Western Blot
Wed Apr 01 00:00:00 EDT 2015
Cis-regulatory mechanisms governing stem and progenitor cell transitions.
Science advances
Johnson KD,Kong G,Gao X,Chang YI,Hewitt KJ,Sanalkumar R,Prathibha R,Ranheim EA,Dewey CN,Zhang J,Bresnick EH
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis.
Mucosal immunology
Visekruna A,Linnerz T,Martinic V,Vachharajani N,Hartmann S,Harb H,Joeris T,Pfefferle PI,Hofer MJ,Steinhoff U
14-5981 was used in Flow cytometry/Cell sorting to investigate the role c-Rel plays in regulating innate lymphoid cells which induce anti-CD40-mediated innate colitis in mice.
Sun Mar 01 00:00:00 EST 2015
Cellular and molecular characterization of human cardiac stem cells reveals key features essential for their function and safety.
Stem cells and development
Vahdat S,Mousavi SA,Omrani G,Gholampour M,Sotoodehnejadnematalahi F,Ghazizadeh Z,Gharechahi J,Baharvand H,Salekdeh GH,Aghdami N
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Mon Jun 15 00:00:00 EDT 2015
Multi-Drug Resistance ABC Transporter Inhibition Enhances Murine Ventral Prostate Stem/Progenitor Cell Differentiation.
Stem cells and development
Samant MD,Jackson CM,Felix CL,Jones AJ,Goodrich DW,Foster BA,Huss WJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Fri May 15 00:00:00 EDT 2015
Limited miR-17-92 overexpression drives hematologic malignancies.
Leukemia research
Danielson LS,Reavie L,Coussens M,Davalos V,Castillo-Martin M,Guijarro MV,Coffre M,Cordon-Cardo C,Aifantis I,Ibrahim S,Liu C,Koralov SB,Hernando E
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Sun Mar 01 00:00:00 EST 2015
Cardiac-Specific Activation of IKK2 Leads to Defects in Heart Development and Embryonic Lethality.
PloS one
Kraut B,Maier HJ,Kókai E,Fiedler K,Boettger T,Illing A,Kostin S,Walther P,Braun T,Wirth T
14-5981 was used in Immunohistochemistry to investigate what effect activation of NF-κB has during murine heart development.
Mon Jun 13 00:00:00 EDT 2016
Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells.
Nature communications
Gao Y,Yang P,Shen H,Yu H,Song X,Zhang L,Zhang P,Cheng H,Xie Z,Hao S,Dong F,Ma S,Ji Q,Bartlow P,Ding Y,Wang L,Liu H,Li Y,Cheng H,Miao W,Yuan W,Yuan Y,Cheng T,Xie XQ
14-5981 was used in Flow cytometry/Cell sorting to investigate how putative small-molecule inhibitors for p18 protein are valuable for further dissecting the signalling pathways of stem cell self-renewal.
Wed Feb 18 00:00:00 EST 2015
CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.
Nature communications
Mackley EC,Houston S,Marriott CL,Halford EE,Lucas B,Cerovic V,Filbey KJ,Maizels RM,Hepworth MR,Sonnenberg GF,Milling S,Withers DR
14-5981 was used in Flow cytometry/Cell sorting to investigate whether group 3 innate lymphoid cells migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues.
Fri Jan 09 00:00:00 EST 2015
Human Cardiac Progenitor Spheroids Exhibit Enhanced Engraftment Potential.
PloS one
Oltolina F,Zamperone A,Colangelo D,Gregoletto L,Reano S,Pietronave S,Merlin S,Talmon M,Novelli E,Diena M,Nicoletti C,Musarò A,Filigheddu N,Follenzi A,Prat M
14-5981 was used in Immunofluorescence to investigate how spherical in vivo ready-to-implant scaffold-less aggregates of hCPCs able to engraft also in the hostile environment of an injured myocardium can be produced with an economic, easy and fast protocol.
Fri May 27 00:00:00 EDT 2016
Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair.
Circulation research
Furtado MB,Costa MW,Pranoto EA,Salimova E,Pinto AR,Lam NT,Park A,Snider P,Chandran A,Harvey RP,Boyd R,Conway SJ,Pearson J,Kaye DM,Rosenthal NA
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Fri Apr 25 00:00:00 EDT 2014
Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.
The Journal of clinical investigation
Kong G,Wunderlich M,Yang D,Ranheim EA,Young KH,Wang J,Chang YI,Du J,Liu Y,Tey SR,Zhang X,Juckett M,Mattison R,Damnernsawad A,Zhang J,Mulloy JC,Zhang J
14-5981 was used in Flow cytometry/Cell sorting to investigate the effect of combined targeting of MEK/ERK and JAK/STAT signalling on the murine myeloproliferative neoplasm.
Sun Jun 01 00:00:00 EDT 2014
The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.
The Journal of experimental medicine
Male V,Nisoli I,Kostrzewski T,Allan DS,Carlyle JR,Lord GM,Wack A,Brady HJ
14-5981 was used in Flow cytometry/Cell sorting to propose that E4bp4 is required for commitment to the NK lineage and can promote NK development by directly regulating the expression of the downstream transcription factors Eomes and Id2.
Mon Apr 07 00:00:00 EDT 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Mon Sep 22 00:00:00 EDT 2014
Overexpressing sonic hedgehog peptide restores periosteal bone formation in a murine bone allograft transplantation model.
Molecular therapy : the journal of the American Society of Gene Therapy
Huang C,Tang M,Yehling E,Zhang X
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Sat Feb 01 00:00:00 EST 2014
Cell-autonomous heparanase modulates self-renewal and migration in bone marrow-derived mesenchymal stem cells.
Journal of biomedical science
Cheng CC,Lee YH,Lin SP,Huangfu WC,Liu IH
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Mar 13 00:00:00 EDT 2014
Recruitment of bone marrow-derived cells to periodontal tissue defects.
Frontiers in cell and developmental biology
Kimura Y,Komaki M,Iwasaki K,Sata M,Izumi Y,Morita I
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Mon Nov 03 00:00:00 EST 2014
Evidence for Transfer of Membranes from Mesenchymal Stem Cells to HL-1 Cardiac Cells.
Stem cells international
Boomsma RA,Geenen DL
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Wed Oct 08 00:00:00 EDT 2014
Immunohistological localization of endogenous unlabeled stem cells in wounded skin.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Hong S,Alapure BV,Lu Y,Tian H,Wang Q
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Immunofluorescence
Tue Apr 01 00:00:00 EDT 2014
Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.
PloS one
Xiao GY,Liu IH,Cheng CC,Chang CC,Lee YH,Cheng WT,Wu SC
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu May 28 00:00:00 EDT 2015
Validation of the effects of TGF-β1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical properties.
Cancer cell international
Wu TH,Chou YW,Chiu PH,Tang MJ,Hu CW,Yeh ML
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Mon Mar 03 00:00:00 EST 2014
Interferon-γ induces expression of MHC class II on intestinal epithelial cells and protects mice from colitis.
PloS one
Thelemann C,Eren RO,Coutaz M,Brasseit J,Bouzourene H,Rosa M,Duval A,Lavanchy C,Mack V,Mueller C,Reith W,Acha-Orbea H
14-5981 was used in Flow cytometry/Cell sorting to investigate how epithelial MHCII expression is induced and how a deficiency in inducible epithelial MHCII expression alters susceptibility to colitis and the outcome of colon-specific immune responses.
Mon Dec 22 00:00:00 EST 2014
Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection.
Cell host & microbe
Jordan S,Ruzsics Z,Mitrović M,Baranek T,Arapović J,Krmpotić A,Vivier E,Dalod M,Jonjić S,Dölken L,Koszinowski UH
14-5981 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms of extramedullary hematopoiesis.
Wed May 15 00:00:00 EDT 2013
Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells.
Nature immunology
Roediger B,Kyle R,Yip KH,Sumaria N,Guy TV,Kim BS,Mitchell AJ,Tay SS,Jain R,Forbes-Blom E,Chen X,Tong PL,Bolton HA,Artis D,Paul WE,Fazekas de St Groth B,Grimbaldeston MA,Le Gros G,Weninger W
14-5981 was used in Flow cytometry/Cell sorting to report the identification in normal mouse dermis of an abundant, phenotypically unique group 2 innate lymphoid cell subset that depended on interleukin 7 and constitutively produced IL-13.
Sat Jun 01 00:00:00 EDT 2013
Nrf2 regulates haematopoietic stem cell function.
Nature cell biology
Tsai JJ,Dudakov JA,Takahashi K,Shieh JH,Velardi E,Holland AM,Singer NV,West ML,Smith OM,Young LF,Shono Y,Ghosh A,Hanash AM,Tran HT,Moore MA,van den Brink MR
14-5981 was used in Flow cytometry/Cell sorting to investigate the link between Nrf2 and CXCR4, thought to partially contribute to the maintenance of haematopoietic stem cell function.
Fri Mar 01 00:00:00 EST 2013
COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1.
Blood
Yoshida A,Kato JY,Nakamae I,Yoneda-Kato N
14-5981 was used in Flow cytometry/Cell sorting to investigate the role of COP1 in tumourigenesis.
Thu Sep 05 00:00:00 EDT 2013
MIP-1α/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia.
The Journal of experimental medicine
Baba T,Naka K,Morishita S,Komatsu N,Hirao A,Mukaida N
14-5981 was used in Flow cytometry/Cell sorting to investigate the interaction between leukaemia-initiating cells and normal hematopoietic cells at the early phase of chronic myeloid leukaemia, showing MIP-1α/CCL3-mediated maintenance of initiating cells.
Mon Nov 18 00:00:00 EST 2013
HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.
The Journal of experimental medicine
Gautier EL,Westerterp M,Bhagwat N,Cremers S,Shih A,Abdel-Wahab O,Lütjohann D,Randolph GJ,Levine RL,Tall AR,Yvan-Charvet L
14-5981 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms leading to high metabolic rate in myeloproliferative disorders, showing that HDL and Glut1 inhibition reverse hypermetabolic state.
Mon Feb 11 00:00:00 EST 2013
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation.
eLife
Kerenyi MA,Shao Z,Hsu YJ,Guo G,Luc S,O'Brien K,Fujiwara Y,Peng C,Nguyen M,Orkin SH
14-5981 was used in Flow cytometry/Cell sorting to study how Lsd1-mediated concurrent repression of enhancer and promoter activity of stem and progenitor cell genes is a pivotal epigenetic mechanism required for proper hematopoietic maturation.
Tue Jun 18 00:00:00 EDT 2013
New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells.
Journal of molecular cell biology
Lee SO,Ma Z,Yeh CR,Luo J,Lin TH,Lai KP,Yamashita S,Liang L,Tian J,Li L,Jiang Q,Huang CK,Niu Y,Yeh S,Chang C
14-5981 was used in Immunofluorescence to explore a new therapy to battle prostate cancer as an alternative to androgen deprivation therapy.
Fri Feb 01 00:00:00 EST 2013
A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).
Disease models & mechanisms
Carofino BL,Ayanga B,Justice MJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Fri Nov 01 00:00:00 EDT 2013
In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation.
PloS one
Vink PM,Smout WM,Driessen-Engels LJ,de Bruin AM,Delsing D,Krajnc-Franken MA,Jansen AJ,Rovers EF,van Puijenbroek AA,Kaptein A,Nolte MA,Garritsen A,van Eenennaam H
14-5981 was used in Flow cytometry/Cell sorting to study the function of TAK1 protein in the adult immune system.
Fri Sep 06 00:00:00 EDT 2013
Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer.
Cancer cell
Xu K,Usary J,Kousis PC,Prat A,Wang DY,Adams JR,Wang W,Loch AJ,Deng T,Zhao W,Cardiff RD,Yoon K,Gaiano N,Ling V,Beyene J,Zacksenhaus E,Gridley T,Leong WL,Guidos CJ,Perou CM,Egan SE
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Tue May 15 00:00:00 EDT 2012
Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.
Blood
Hu T,Ghazaryan S,Sy C,Wiedmeyer C,Chang V,Wu L
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu May 10 00:00:00 EDT 2012
Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.
The Journal of clinical investigation
Johnson KD,Hsu AP,Ryu MJ,Wang J,Gao X,Boyer ME,Liu Y,Lee Y,Calvo KR,Keles S,Zhang J,Holland SM,Bresnick EH
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Mon Oct 01 00:00:00 EDT 2012
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
The Journal of experimental medicine
Billiard F,Lobry C,Darrasse-Jèze G,Waite J,Liu X,Mouquet H,DaNave A,Tait M,Idoyaga J,Leboeuf M,Kyratsous CA,Burton J,Kalter J,Klinakis A,Zhang W,Thurston G,Merad M,Steinman RM,Murphy AJ,Yancopoulos GD,Aifantis I,Skokos D
14-5981 was used in Flow cytometry/Cell sorting to investigate how Dll4-Notch signaling affects pro-T cell fate and thymic DC development, showing that it is a novel Flt3-independent pathway for DC development and autoimmunity.
Mon May 07 00:00:00 EDT 2012
Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation.
The Journal of experimental medicine
Boulard O,Kirchberger S,Royston DJ,Maloy KJ,Powrie FM
14-5981 was used in Flow cytometry/Cell sorting to investigate the genetic factors influencing the progression from Helicobacter hepaticus-driven colitis to tumorigenesis in a mouse model.
Mon Jul 02 00:00:00 EDT 2012
CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion.
The EMBO journal
Gu P,Min JN,Wang Y,Huang C,Peng T,Chai W,Chang S
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Wed May 16 00:00:00 EDT 2012
Induction of cardiac myogenic lineage development differs between mesenchymal and satellite cells and is accelerated by bone morphogenetic protein-4.
Journal of molecular and cellular cardiology
Grajales L,García J,Geenen DL
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2012
Necdin controls proliferation of white adipocyte progenitor cells.
PloS one
Fujiwara K,Hasegawa K,Ohkumo T,Miyoshi H,Tseng YH,Yoshikawa K
14-5981 was used in Immunohistochemistry on frozen tissues to investigate the molecular mechanisms that regulate preadipocyte proliferation during adipose tissue development, showing that proliferation is controlled by Necdin.
Mon Jun 04 00:00:00 EDT 2012
Necdin controls proliferation of white adipocyte progenitor cells.
PloS one
Fujiwara K,Hasegawa K,Ohkumo T,Miyoshi H,Tseng YH,Yoshikawa K
14-5981 was used in Immunohistochemistry on frozen tissues to investigate the molecular mechanisms that regulate preadipocyte proliferation during adipose tissue development, showing that proliferation is controlled by Necdin.
Mon Jun 04 00:00:00 EDT 2012
Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity.
Nature immunology
Chang YJ,Kim HY,Albacker LA,Baumgarth N,McKenzie AN,Smith DE,Dekruyff RH,Umetsu DT
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Sun May 29 00:00:00 EDT 2011
Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation.
Blood
Zlotoff DA,Zhang SL,De Obaldia ME,Hess PR,Todd SP,Logan TD,Bhandoola A
14-5981 was used in Flow cytometry/Cell sorting to explain why T cells are among the last of the hematopoietic lineages to recover after bone marrow transplantation (BMT).
Thu Aug 18 00:00:00 EDT 2011
Essential roles for Pot1b in HSC self-renewal and survival.
Blood
Wang Y,Shen MF,Chang S
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2011
Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.
Blood
Kharazi S,Mead AJ,Mansour A,Hultquist A,Böiers C,Luc S,Buza-Vidas N,Ma Z,Ferry H,Atkinson D,Reckzeh K,Masson K,Cammenga J,Rönnstrand L,Arai F,Suda T,Nerlov C,Sitnicka E,Jacobsen SE
14-5981 was used in Flow cytometry/Cell sorting to study the relationship between gene dosage and FLT3 production.
Thu Sep 29 00:00:00 EDT 2011
Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice.
The Journal of experimental medicine
Christopher MJ,Rao M,Liu F,Woloszynek JR,Link DC
14-5981 was used in Flow cytometry/Cell sorting to suggest a model in which G-CSFR signals in bone marrow monocytic cells inhibit the production of trophic factors required for osteoblast lineage cell maintenance.
Mon Feb 14 00:00:00 EST 2011
CD24-positive cells from normal adult mouse liver are hepatocyte progenitor cells.
Stem cells and development
Qiu Q,Hernandez JC,Dean AM,Rao PH,Darlington GJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2011
Adipose-derived stem cells promote lymphangiogenesis in response to VEGF-C stimulation or TGF-β1 inhibition.
Future oncology (London, England)
Yan A,Avraham T,Zampell JC,Haviv YS,Weitman E,Mehrara BJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2011
A high omega-3 fatty acid diet has different effects on early and late stage myeloid progenitors.
Lipids
Varney ME,Buchanan JT,Dementieva Y,Hardman WE,Sollars VE
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Sat Jan 01 00:00:00 EST 2011
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis.
Nature cell biology
Joe AW,Yi L,Natarajan A,Le Grand F,So L,Wang J,Rudnicki MA,Rossi FM
14-5981 was used in Flow cytometry/Cell sorting to study how FAPs expand upon damage to provide a transient source of pro-differentiation signals for proliferating myogenic progenitors.
Mon Feb 01 00:00:00 EST 2010
Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad.
Blood
Frenzel A,Labi V,Chmelewskij W,Ploner C,Geley S,Fiegl H,Tzankov A,Villunger A
14-5981 was used in Flow cytometry/Cell sorting to demonstrate the potential of BH3-only proapoptotic Bcl-2 family members to regulate excessive lymphocyte proliferation.
Thu Feb 04 00:00:00 EST 2010
Delayed enrichment of mesenchymal cells promotes cardiac lineage and calcium transient development.
Journal of molecular and cellular cardiology
Grajales L,García J,Banach K,Geenen DL
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2010
Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma.
Cancer cell
Read TA,Fogarty MP,Markant SL,McLendon RE,Wei Z,Ellison DW,Febbo PG,Wechsler-Reya RJ
14-5981 was used in Flow cytometry/Cell sorting to identify CD15 as a marker for tumour-propagating cells in a mouse model of medulloblastoma.
Tue Feb 03 00:00:00 EST 2009
Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisions.
Blood
Cochrane SW,Zhao Y,Welner RS,Sun XH
14-5981 was used in Flow cytometry/Cell sorting to suggest a crucial function for E proteins in the myeloid-versus-lymphoid lineage decision.
Thu Jan 29 00:00:00 EST 2009
Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.
Blood
Guibal FC,Alberich-Jorda M,Hirai H,Ebralidze A,Levantini E,Di Ruscio A,Zhang P,Santana-Lemos BA,Neuberg D,Wagers AJ,Rego EM,Tenen DG
14-5981 was used in Flow cytometry/Cell sorting to provide further understanding of the biology of APL by demonstrating that a committed transformed progenitor can propagate the disease.
Thu Dec 24 00:00:00 EST 2009
MLL5 contributes to hematopoietic stem cell fitness and homeostasis.
Blood
Zhang Y,Wong J,Klinger M,Tran MT,Shannon KM,Killeen N
14-5981 was used in Flow cytometry/Cell sorting to show that inactivation of the Mll5 gene in mice results in the reduction in frequency and function of haematopoietic stem cells.
Thu Feb 12 00:00:00 EST 2009
Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells.
Cell stem cell
Le Grand F,Jones AE,Seale V,Scimè A,Rudnicki MA
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Fri Jun 05 00:00:00 EDT 2009
Reporter gene-expressing bone marrow-derived stromal cells are immune-tolerated following implantation in the central nervous system of syngeneic immunocompetent mice.
BMC biotechnology
Bergwerf I,De Vocht N,Tambuyzer B,Verschueren J,Reekmans K,Daans J,Ibrahimi A,Van Tendeloo V,Chatterjee S,Goossens H,Jorens PG,Baekelandt V,Ysebaert D,Van Marck E,Berneman ZN,Linden AV,Ponsaerts P
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Wed Jan 07 00:00:00 EST 2009
Reporter gene-expressing bone marrow-derived stromal cells are immune-tolerated following implantation in the central nervous system of syngeneic immunocompetent mice.
BMC biotechnology
Bergwerf I,De Vocht N,Tambuyzer B,Verschueren J,Reekmans K,Daans J,Ibrahimi A,Van Tendeloo V,Chatterjee S,Goossens H,Jorens PG,Baekelandt V,Ysebaert D,Van Marck E,Berneman ZN,Linden AV,Ponsaerts P
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 14-5981-82) in Flow Cytometry
Wed Jan 07 00:00:00 EST 2009
Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis.
PloS one
Chan AS,Jensen KK,Skokos D,Doty S,Lederman HK,Kaplan RN,Rafii S,Rivella S,Lyden D
14-5981 was used in Flow cytometry/Cell sorting to identify Id1 as crucial for the dynamic cross-talk between bone and bone marrow haematopoietic cells.
Tue Nov 24 00:00:00 EST 2009
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-5981-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 EDT 2008
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-5981-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 EDT 2008
Isolation of murine hair-inducing cells using the cell surface marker prominin-1/CD133.
The Journal of investigative dermatology
Ito Y,Hamazaki TS,Ohnuma K,Tamaki K,Asashima M,Okochi H
14-5981 was used in Flow cytometry/Cell sorting to propose that the CD133 is a novel surface marker useful for collecting DP cells in the anagen stage.
Tue May 01 00:00:00 EDT 2007
A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision.
The Journal of experimental medicine
Benz C,Bleul CC
14-5981 was used in Flow cytometry/Cell sorting to identify a multipotent thymic precursor that maps to the branching point of the T versus B lineage decision.
Mon Jul 04 00:00:00 EDT 2005
Stem cell antigen-1 expression in the pulmonary vascular endothelium.
American journal of physiology. Lung cellular and molecular physiology
Kotton DN,Summer RS,Sun X,Ma BY,Fine A
14-5981 was used in Western Blotting to indicate that Sca-1 expression helps define the surface phenotype of endothelial cells throughout the pulmonary vasculature in mice.
Sun Jun 01 00:00:00 EDT 2003
