Product References
Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening.
Proceedings of the National Academy of Sciences of the United States of America
Griffin KH,Thorpe SW,Sebastian A,Hum NR,Coonan TP,Sagheb IS,Loots GG,Randall RL,Leach JK
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Tue Sep 26 00:00:00 EDT 2023
Traumatic brain injury stimulates sympathetic tone-mediated bone marrow myelopoiesis to favor fracture healing.
Signal transduction and targeted therapy
Liu W,Chen W,Xie M,Chen C,Shao Z,Zhang Y,Zhao H,Song Q,Hu H,Xing X,Cai X,Deng X,Li X,Wang P,Liu G,Xiong L,Lv X,Zhang Y
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Wed Jul 05 00:00:00 EDT 2023
STS1 and STS2 Phosphatase Inhibitor Baicalein Enhances the Expansion of Hematopoietic and Progenitor Stem Cells and Alleviates 5-Fluorouracil-Induced Myelosuppression.
International journal of molecular sciences
Li N,Wang Y,Wang A,Zhang J,Jia C,Yu C,Song Z,Wang S,Liu L,Yi J,Bao Y,Huang Y,Sun L
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Fri Feb 03 00:00:00 EST 2023
The ZIP8/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis.
The Journal of clinical investigation
Liang J,Huang G,Liu X,Taghavifar F,Liu N,Wang Y,Deng N,Yao C,Xie T,Kulur V,Dai K,Burman A,Rowan SC,Weigt SS,Belperio J,Stripp B,Parks WC,Jiang D,Noble PW
17-5981-82 was used in Flow Cytometry to identify deficiency of a specific zinc transporter, SLC39A8 (ZIP8), in AEC2s from both IPF lungs and lungs of old mice.
Wed Jun 01 00:00:00 EDT 2022
The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut.
Biology open
Ramadan R,Wouters VM,van Neerven SM,de Groot NE,Garcia TM,Muncan V,Franklin OD,Battle M,Carlson KS,Leach J,Sansom OJ,Boulard O,Chamaillard M,Vermeulen L,Medema JP,Huels DJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu Dec 15 00:00:00 EST 2022
Cardiac Mesenchymal Stem Cells Promote Fibrosis and Remodeling in Heart Failure: Role of PDGF Signaling.
JACC. Basic to translational science
Hamid T,Xu Y,Ismahil MA,Rokosh G,Jinno M,Zhou G,Wang Q,Prabhu SD
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Sun May 01 00:00:00 EDT 2022
Hematopoietic-Mesenchymal Signals Regulate the Properties of Mesenchymal Stem Cells.
International journal of molecular sciences
Kanazawa S,Okada H,Riu D,Mabuchi Y,Akazawa C,Iwata J,Hoshi K,Hikita A
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Tue Jul 26 00:00:00 EDT 2022
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia.
Cell stem cell
Vasquez EG,Nasreddin N,Valbuena GN,Mulholland EJ,Belnoue-Davis HL,Eggington HR,Schenck RO,Wouters VM,Wirapati P,Gilroy K,Lannagan TRM,Flanagan DJ,Najumudeen AK,Omwenga S,McCorry AMB,Easton A,Koelzer VH,East JE,Morton D,Trusolino L,Maughan T,Campbell AD,Loughrey MB,Dunne PD,Tsantoulis P,Huels DJ,Tejpar S,Sansom OJ,Leedham SJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu Aug 04 00:00:00 EDT 2022
Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration.
Nature communications
Lin C,Yang Q,Guo D,Xie J,Yang YS,Chaugule S,DeSouza N,Oh WT,Li R,Chen Z,John AA,Qiu Q,Zhu LJ,Greenblatt MB,Ghosh S,Li S,Gao G,Haynes C,Emerson CP,Shim JH
17-5981-82 was used in Flow cytometry/Cell sorting to identify mitochondrial oxidative phosphorylation as the prominent energy-driving force for osteogenesis of skeletal progenitors, governing musculoskeletal integrity.
Fri Nov 11 00:00:00 EST 2022
Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression.
Science advances
Abu El Maaty MA,Terzic J,Keime C,Rovito D,Lutzing R,Yanushko D,Parisotto M,Grelet E,Namer IJ,Lindner V,Laverny G,Metzger D
17-5981-82 was used in Flow cytometry/Cell sorting to characterize prostatic intraepithelial neoplasia (PIN) progression and demonstrate that HIF1A is a target for PCa prevention and that TGM2 is a promising prognostic biomarker of early relapse after prostatectomy.
Fri Jul 22 00:00:00 EDT 2022
Nociceptive nerves regulate haematopoietic stem cell mobilization.
Nature
Gao X,Zhang D,Xu C,Li H,Caron KM,Frenette PS
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration.
Cell death and differentiation
Deng CL,Hu CB,Ling ST,Zhao N,Bao LH,Zhou F,Xiong YC,Chen T,Sui BD,Yu XR,Hu CH
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Mon Mar 01 00:00:00 EST 2021
Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin.
Cell death and differentiation
Velletri T,Huang Y,Wang Y,Li Q,Hu M,Xie N,Yang Q,Chen X,Chen Q,Shou P,Gan Y,Candi E,Annicchiarico-Petruzzelli M,Agostini M,Yang H,Melino G,Shi Y,Wang Y
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss.
EMBO reports
Hu Y,Li X,Zhi X,Cong W,Huang B,Chen H,Wang Y,Li Y,Wang L,Fang C,Guo J,Liu Y,Cui J,Cao L,Weng W,Zhou Q,Wang S,Chen X,Su J
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
Reproductive history determines Erbb2 locus amplification, WNT signalling and tumour phenotype in a murine breast cancer model.
Disease models & mechanisms
Ordonez LD,Melchor L,Greenow KR,Kendrick H,Tornillo G,Bradford J,Giles P,Smalley MJ
17-5981-82 was used in Flow Cytometry to find that basal epithelial cells are less sensitive to transformation by the activated NeuKI allele, with mammary epithelial tumour formation largely confined to luminal ER- cells.
Sat May 01 00:00:00 EDT 2021
Effects of signaling pathway inhibitors on hematopoietic stem cells.
Molecular medicine reports
Jiang Y,Xu Z,Ma N,Yin L,Hao C,Li J
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Inhibition of Gabrp reduces the differentiation of airway epithelial progenitor cells into goblet cells.
Experimental and therapeutic medicine
Wang A,Zhang Q,Wang Y,Li X,Li K,Li Y,Wang J,Li L,Chen H
17-5981 was used in Flow cytometry/Cell sorting to investigate whether the GABAA receptor pi (Gabrp) is essential for Club cell proliferation and differentiation in mice.
Thu Jul 01 00:00:00 EDT 2021
Age-related trabecular bone loss is associated with a decline in serum Galectin-1 level.
BMC musculoskeletal disorders
Xu W,Ni C,Wang Y,Zheng G,Zhang J,Xu Y
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Tue Apr 27 00:00:00 EDT 2021
The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism.
eLife
Roy A,Tomaz da Silva M,Bhat R,Bohnert KR,Iwawaki T,Kumar A
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Tue Nov 23 00:00:00 EST 2021
Conditionally pathogenic genetic variants of a hematopoietic disease-suppressing enhancer.
Science advances
Soukup AA,Matson DR,Liu P,Johnson KD,Bresnick EH
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Fri Dec 10 00:00:00 EST 2021
Therapeutic Potential of Mesenchymal Stem Cells in a Pre-Clinical Model of Diabetic Kidney Disease and Obesity.
International journal of molecular sciences
Sávio-Silva C,Soinski-Sousa PE,Simplício-Filho A,Bastos RMC,Beyerstedt S,Rangel ÉB
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu Feb 04 00:00:00 EST 2021
Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification.
Stem cell reports
Kretzschmar K,Boonekamp KE,Bleijs M,Asra P,Koomen M,Chuva de Sousa Lopes SM,Giovannone B,Clevers H
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Tue Sep 14 00:00:00 EDT 2021
Activation of skeletal muscle-resident glial cells upon nerve injury.
JCI insight
Proietti D,Giordani L,De Bardi M,D'Ercole C,Lozanoska-Ochser B,Amadio S,Volonté C,Marinelli S,Muchir A,Bouché M,Borsellino G,Sacco A,Puri PL,Madaro L
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu Apr 08 00:00:00 EDT 2021
MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells.
Nature communications
Wei Q,Pinho S,Dong S,Pierce H,Li H,Nakahara F,Xu J,Xu C,Boulais PE,Zhang D,Maryanovich M,Cuervo AM,Frenette PS
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Tue May 04 00:00:00 EDT 2021
Gut Microbial Metabolite Pravastatin Attenuates Intestinal Ischemia/Reperfusion Injury Through Promoting IL-13 Release From Type II Innate Lymphoid Cells via IL-33/ST2 Signaling.
Frontiers in immunology
Deng F,Hu JJ,Yang X,Sun QS,Lin ZB,Zhao BC,Yao ZW,Luo SD,Chen ZL,Liu Y,Yan ZZ,Li C,Liu WF,Liu KX
17-5981-82 was used in Flow Cytometry to indicate that the gut microbial metabolite PA can attenuate intestinal I/R injury by promoting the release of IL-13 from ILC2s via IL-33/ST2 signaling.
Tue Dec 21 00:00:00 EST 2021
Distinct skeletal stem cell types orchestrate long bone skeletogenesis.
eLife
Ambrosi TH,Sinha R,Steininger HM,Hoover MY,Murphy MP,Koepke LS,Wang Y,Lu WJ,Morri M,Neff NF,Weissman IL,Longaker MT,Chan CK
17-5981-82 was used in Flow Cytometry to address previously unappreciated shortcomings of SSC research.
Mon Jul 19 00:00:00 EDT 2021
Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification.
The Journal of clinical investigation
Feng H,Xing W,Han Y,Sun J,Kong M,Gao B,Yang Y,Yin Z,Chen X,Zhao Y,Bi Q,Zou W
17-5981 was used in Flow cytometry/Cell sorting to show that Ctsk-Cre labels a subpopulation of TDPCs contributing to HO and that their cell-fate changes are driven by activation of Hh signaling.
Tue Dec 01 00:00:00 EST 2020
Linc-MYH configures INO80 to regulate muscle stem cell numbers and skeletal muscle hypertrophy.
The EMBO journal
Schutt C,Hallmann A,Hachim S,Klockner I,Valussi M,Atzberger A,Graumann J,Braun T,Boettger T
17-5981 was used in Flow cytometry/Cell sorting to demonstrate that the evolutionary conserved long noncoding RNA linc-MYH plays a major role in the control of MuSC proliferation by specifically regulating composition and activity of the INO80 complex.
Mon Nov 16 00:00:00 EST 2020
Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression.
Developmental cell
Wei Q,Nakahara F,Asada N,Zhang D,Gao X,Xu C,Alfieri A,Brodin NP,Zimmerman SE,Mar JC,Guha C,Guo W,Frenette PS
17-5981-82 was used in Flow Cytometry to conclude that SNAI2 is a critical regulator of the transcriptional network maintaining MSPCs by the suppression of osteopontin expression.
Mon Jun 08 00:00:00 EDT 2020
Upregulation of Extracellular Vesicles-Encapsulated miR-132 Released From Mesenchymal Stem Cells Attenuates Ischemic Neuronal Injury by Inhibiting Smad2/c-jun Pathway via Acvr2b Suppression.
Frontiers in cell and developmental biology
Feng B,Meng L,Luan L,Fang Z,Zhao P,Zhao G
17-5981-82 was used in Flow Cytometry to demonstrate that activin receptor type IIB expression is inhibited by miR-132 from mesenchymal stem cells which attenuates ischemic neuronal injury.
Fri Mar 26 00:00:00 EDT 2021
Multipotency of mouse trophoblast stem cells.
Stem cell research & therapy
Hou M,Han J,Li G,Kwon MY,Jiang J,Emani S,Taglauer ES,Park JA,Choi EB,Vodnala M,Fong YW,Emani SM,Rosas IO,Perrella MA,Liu X
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu Feb 13 00:00:00 EST 2020
Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.
Nature communications
Wilkes MC,Siva K,Chen J,Varetti G,Youn MY,Chae H,Ek F,Olsson R,Lundbäck T,Dever DP,Nishimura T,Narla A,Glader B,Nakauchi H,Porteus MH,Repellin CE,Gazda HT,Lin S,Serrano M,Flygare J,Sakamoto KM
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Fri Jul 03 00:00:00 EDT 2020
XIAOPI formula inhibits the pre-metastatic niche formation in breast cancer via suppressing TAMs/CXCL1 signaling.
Cell communication and signaling : CCS
Zheng Y,Wang N,Wang S,Yang B,Situ H,Zhong L,Lin Y,Wang Z
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu Mar 26 00:00:00 EDT 2020
Use of Busulfan to Condition Mice for Bone Marrow Transplantation.
STAR protocols
Montecino-Rodriguez E,Dorshkind K
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Fri Dec 18 00:00:00 EST 2020
Interaction of Deubiquitinase 2A-DUB/MYSM1 with DNA Repair and Replication Factors.
International journal of molecular sciences
Kroeger C,Roesler R,Wiese S,Hainzl A,Gatzka MV
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Tue May 26 00:00:00 EDT 2020
A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling.
eLife
Geng A,Wu T,Cai C,Song W,Wang J,Yu QC,Zeng YA
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Tue Aug 04 00:00:00 EDT 2020
Apoptotic bodies derived from mesenchymal stem cells promote cutaneous wound healing via regulating the functions of macrophages.
Stem cell research & therapy
Liu J,Qiu X,Lv Y,Zheng C,Dong Y,Dou G,Zhu B,Liu A,Wang W,Zhou J,Liu S,Liu S,Gao B,Jin Y
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Fri Nov 27 00:00:00 EST 2020
Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals.
Cell & bioscience
Jiang M,Ye J,Wang X,Li N,Wang Y,Shi Y
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu Apr 14 00:00:00 EDT 2022
Smooth muscle-derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis.
JCI insight
Lu S,Jolly AJ,Strand KA,Dubner AM,Mutryn MF,Moulton KS,Nemenoff RA,Majesky MW,Weiser-Evans MC
17-5981 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms regulating the heterogeneity and behavior of resident vascular adventitial SCA1+ progenitor (AdvSca1) cells in homeostasis and injury responses.
Thu Dec 03 00:00:00 EST 2020
Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.
Cell reports
Hidalgo San Jose L,Sunshine MJ,Dillingham CH,Chua BA,Kruta M,Hong Y,Hatters DM,Signer RAJ
17-5981 was used in Flow cytometry/Cell sorting to show that hematopoietic stem cells (HSCs) are dependent on low protein synthesis to maintain proteostasis, which promotes their self-renewal.
Tue Jan 07 00:00:00 EST 2020
miR-142 induces accumulation of reactive oxygen species (ROS) by inhibiting pexophagy in aged bone marrow mesenchymal stem cells.
Scientific reports
Houri K,Mori T,Onodera Y,Tsujimoto T,Takehara T,Nakao S,Teramura T,Fukuda K
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Fri Feb 28 00:00:00 EST 2020
Distinct Waves from the Hemogenic Endothelium Give Rise to Layered Lymphoid Tissue Inducer Cell Ontogeny.
Cell reports
Simic M,Manosalva I,Spinelli L,Gentek R,Shayan RR,Siret C,Girard-Madoux M,Wang S,de Fabritus L,Verschoor J,Kerdiles YM,Bajenoff M,Stumm R,Golub R,van de Pavert SA
17-5981-82 was used in Flow Cytometry to identify a major contribution from embryonic hemogenic endothelium, but not the yolk sac, toward LTi progenitors.
Tue Aug 11 00:00:00 EDT 2020
Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1.
iScience
Iwanami N,Takeshita K,Lawir DF,Suetake I,Tajima S,Sikora K,Trancoso I,ÓMeara C,Siamishi I,Takahama Y,Furutani-Seiki M,Kondoh H,Yonezawa Y,Schorpp M,Boehm T
17-5981 was used in Flow cytometry/Cell sorting to identify new recessive dnmt1 alleles in medaka and zebrafish and, guided by the structures of mutant proteins, generated a recessive variant of mouse Dnmt1.
Fri Jul 24 00:00:00 EDT 2020
GATA3-Controlled Nucleosome Eviction Drives MYC Enhancer Activity in T-cell Development and Leukemia.
Cancer discovery
Belver L,Yang AY,Albero R,Herranz D,Brundu FG,Quinn SA,Pérez-Durán P,Álvarez S,Gianni F,Rashkovan M,Gurung D,Rocha PP,Raviram R,Reglero C,Cortés JR,Cooke AJ,Wendorff AA,Cordó V,Meijerink JP,Rabadan R,Ferrando AA
17-5981 was used in Flow cytometry/Cell sorting to demonstrate a role for aberrant chromatin accessibility in the regulation of MYC expression in T-cell lymphoblastic leukemia (T-ALL).
Sun Dec 01 00:00:00 EST 2019
Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation.
The Journal of clinical investigation
Han Y,Feng H,Sun J,Liang X,Wang Z,Xing W,Dai Q,Yang Y,Han A,Wei Z,Bi Q,Ji H,Kang T,Zou W
17-5981-82 was used in Flow Cytometry to identify periosteum-derived Ctsk-Cre expressing cells as a cell of origin for osteogenic tumor and suggested the LKB1-mTORC1 pathway as a promising target for treatment of osteogenic tumor.
Wed May 01 00:00:00 EDT 2019
Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures.
Proceedings of the National Academy of Sciences of the United States of America
Boonekamp KE,Kretzschmar K,Wiener DJ,Asra P,Derakhshan S,Puschhof J,López-Iglesias C,Peters PJ,Basak O,Clevers H
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Tue Jul 16 00:00:00 EDT 2019
PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment.
PLoS pathogens
Naipauer J,Rosario S,Gupta S,Premer C,Méndez-Solís O,Schlesinger M,Ponzinibbio V,Jain V,Gay L,Renne R,Chan HL,Morey L,Salyakina D,Abba M,Williams S,Hare JM,Goldschmidt-Clermont PJ,Mesri EA
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Sun Dec 01 00:00:00 EST 2019
Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice.
PLoS genetics
Madaro L,Torcinaro A,De Bardi M,Contino FF,Pelizzola M,Diaferia GR,Imeneo G,Bouchè M,Puri PL,De Santa F
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2019
TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis.
Nature communications
Li J,Ayoub A,Xiu Y,Yin X,Sanders JO,Mesfin A,Xing L,Yao Z,Boyce BF
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Wed Jun 26 00:00:00 EDT 2019
Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis.
Science advances
van de Vlekkert D,Demmers J,Nguyen XX,Campos Y,Machado E,Annunziata I,Hu H,Gomero E,Qiu X,Bongiovanni A,Feghali-Bostwick CA,d'Azzo A
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Mon Jul 01 00:00:00 EDT 2019
The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression.
Nature communications
Huang J,Zhao L,Fan Y,Liao L,Ma PX,Xiao G,Chen D
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Fri Jun 28 00:00:00 EDT 2019
Procr-expressing progenitor cells are responsible for murine ovulatory rupture repair of ovarian surface epithelium.
Nature communications
Wang J,Wang D,Chu K,Li W,Zeng YA
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu Oct 31 00:00:00 EDT 2019
Breast Tumor Cells Highly Resistant to Drugs Are Controlled Only by the Immune Response Induced in an Immunocompetent Mouse Model.
Integrative cancer therapies
Lasso P,Llano Murcia M,Sandoval TA,Urueña C,Barreto A,Fiorentino S
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Wed Dec 11 00:00:00 EST 2019
In Situ Modification of Tissue Stem and Progenitor Cell Genomes.
Cell reports
Goldstein JM,Tabebordbar M,Zhu K,Wang LD,Messemer KA,Peacker B,Ashrafi Kakhki S,Gonzalez-Celeiro M,Shwartz Y,Cheng JKW,Xiao R,Barungi T,Albright C,Hsu YC,Vandenberghe LH,Wagers AJ
17-5981 was used in Flow cytometry/Cell sorting to demonstrate in vivo transduction of endogenous tissue stem cells in the muscle, blood, and skin by systemic or local administration of adeno-associated viruses (AAVs) encoding genome-modifying enzymes.
Tue Apr 23 00:00:00 EDT 2019
Characterization and Purification of Mouse Mucosal-Associated Invariant T (MAIT) Cells.
Current protocols in immunology
Chen Z,Wang H,D'Souza C,Koay HF,Meehan B,Zhao Z,Pediongco T,Shi M,Zhu T,Wang B,Kjer-Nielsen L,Eckle SBG,Rossjohn J,Fairlie DP,Godfrey DI,Strugnell RA,McCluskey J,Corbett AJ
17-5981-82 was used in Flow cytometry/Cell sorting to provide a step-by-step protocol for mucosal-associated invariant T (MAIT) cell sorting and adoptive transfer.
Sun Dec 01 00:00:00 EST 2019
Identification of functional lipid metabolism biomarkers of brown adipose tissue aging.
Molecular metabolism
Gohlke S,Zagoriy V,Cuadros Inostroza A,Méret M,Mancini C,Japtok L,Schumacher F,Kuhlow D,Graja A,Stephanowitz H,Jähnert M,Krause E,Wernitz A,Petzke KJ,Schürmann A,Kleuser B,Schulz TJ
17-5981 was used in Flow cytometry/Cell sorting to execute analysis which identifies biomarkers of brown adipose tissue aging and the molecular mechanisms that could contribute to brown adipocyte degradation.
Sat Jun 01 00:00:00 EDT 2019
A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth.
Cell stem cell
Wang ECE,Dai Z,Ferrante AW,Drake CG,Christiano AM
17-5981-82 was used in Flow Cytometry to show that Oncostatin M, an IL-6 family cytokine, negatively regulates hair growth by signaling through JAK-STAT5 to maintain hair follicle stem cells quiescence.
Thu Apr 04 00:00:00 EDT 2019
Growth Factor Screening in Dystrophic Muscles Reveals PDGFB/PDGFRB-Mediated Migration of Interstitial Stem Cells.
International journal of molecular sciences
Camps J,Grosemans H,Gijsbers R,Maes C,Sampaolesi M
17-5981 was used in Flow cytometry/Cell sorting to determine which chemokines are expressed in dystrophic muscles undergoing tissue remodelling.
Tue Mar 05 00:00:00 EST 2019
Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy.
Nature communications
Khattar E,Maung KZY,Chew CL,Ghosh A,Mok MMH,Lee P,Zhang J,Chor WHJ,Cildir G,Wang CQ,Mohd-Ismail NK,Chin DWL,Lee SC,Yang H,Shin YJ,Nam DH,Chen L,Kumar AP,Deng LW,Ikawa M,Gunaratne J,Osato M,Tergaonkar V
17-5981-82 was used in Flow Cytometry to provide the genetic evidence that mammalian Rap1 plays a major role in hematopoietic stem cell survival, oncogenesis and response to chemotherapy.
Fri Dec 13 00:00:00 EST 2019
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.
Immunity
Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC
17-5981 was used in Immunohistochemistry to indicate that the VHL-HIF-glycolysis axis is essential for the late-stage maturation and function of ILC2s via targeting IL-33-ST2 pathway.
Tue Feb 20 00:00:00 EST 2018
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
17-5981 was used in Flow cytometry/Cell sorting to study circular RNA-mediated maintenance of hematopoeitic stem cell homeostasis.
Tue Apr 17 00:00:00 EDT 2018
Endothelial cells in the innate response to allergens and initiation of atopic asthma.
The Journal of clinical investigation
Asosingh K,Weiss K,Queisser K,Wanner N,Yin M,Aronica M,Erzurum S
17-5981 was used in Flow cytometry/Cell sorting to identify that lung endothelium and proangiogenic haematopoietic progenitor cells in the airway sense allergen and elicit an angiogenic response that is central to the innate non-immune origins of Th2 inflammation.
Mon Jul 02 00:00:00 EDT 2018
Bone marrow-derived fibroblasts are a functionally distinct stromal cell population in breast cancer.
The Journal of experimental medicine
Raz Y,Cohen N,Shani O,Bell RE,Novitskiy SV,Abramovitz L,Levy C,Milyavsky M,Leider-Trejo L,Moses HL,Grisaru D,Erez N
17-5981-82 was used in Flow cytometry/Cell sorting to conclude that PDGFRα expression distinguishes two functionally unique CAF populations in breast tumors and metastases and may have important implications for patient stratification and precision therapeutics.
Mon Dec 03 00:00:00 EST 2018
PDGF is a potent initiator of bone formation in a tissue engineered model of pathological ossification.
Journal of tissue engineering and regenerative medicine
Davies OG,Grover LM,Lewis MP,Liu Y
17-5981 was used in Flow cytometry/Cell sorting to study the role of inflammation in heterotopic ossification.
Mon Jan 01 00:00:00 EST 2018
PDGF is a potent initiator of bone formation in a tissue engineered model of pathological ossification.
Journal of tissue engineering and regenerative medicine
Davies OG,Grover LM,Lewis MP,Liu Y
17-5981 was used in Flow cytometry/Cell sorting to study the role of inflammation in heterotopic ossification.
Mon Jan 01 00:00:00 EST 2018
Clonal expansion and myeloid leukemia progression modeled by multiplex gene editing of murine hematopoietic progenitor cells.
Experimental hematology
Shi X,Kitano A,Jiang Y,Luu V,Hoegenauer KA,Nakada D
17-5981 was used in Flow cytometry/Cell sorting to establish that the CRISPR/Cas9-mediated multiplex mutagenesis can be used to engineer a variety of murine models of hematological malignancies with complex genetic architectures seen in human disease.
Wed Aug 01 00:00:00 EDT 2018
The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.
eLife
Schmidt K,Zhang Q,Tasdogan A,Petzold A,Dahl A,Arneth BM,Slany R,Fehling HJ,Kranz A,Stewart AF,Anastassiadis K
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Tue Jun 19 00:00:00 EDT 2018
Tracking of Adipose-Derived Mesenchymal Stromal/Stem Cells in a Model of Cisplatin-Induced Acute Kidney Injury: Comparison of Bioluminescence Imaging versus qRT-PCR.
International journal of molecular sciences
Schubert R,Sann J,Frueh JT,Ullrich E,Geiger H,Baer PC
17-5981 was used in Flow cytometry/Cell sorting to investigate the cell fate of mesenchymal stromal/stem cells following transplantation in an acute kidney injury mouse mode.
Wed Aug 29 00:00:00 EDT 2018
Tracking of Adipose-Derived Mesenchymal Stromal/Stem Cells in a Model of Cisplatin-Induced Acute Kidney Injury: Comparison of Bioluminescence Imaging versus qRT-PCR.
International journal of molecular sciences
Schubert R,Sann J,Frueh JT,Ullrich E,Geiger H,Baer PC
17-5981 was used in Flow cytometry/Cell sorting to investigate the cell fate of mesenchymal stromal/stem cells following transplantation in an acute kidney injury mouse mode.
Wed Aug 29 00:00:00 EDT 2018
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu Sep 06 00:00:00 EDT 2018
HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles.
Scientific reports
Lee D,Taniguchi N,Sato K,Choijookhuu N,Hishikawa Y,Kataoka H,Morinaga H,Lotz M,Chosa E
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Mon Jun 25 00:00:00 EDT 2018
Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow.
Nature communications
Xu C,Gao X,Wei Q,Nakahara F,Zimmerman SE,Mar J,Frenette PS
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Fri Jun 22 00:00:00 EDT 2018
RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.
The Journal of biological chemistry
Ge J,Burnier L,Adamopoulou M,Kwa MQ,Schaks M,Rottner K,Brakebusch C
17-5981 was used in Flow cytometry/Cell sorting to provide molecular insights into the role of Rho GTPases in TGFβ signalling and understanding of mesenchymal stem cells in fibriosis.
Fri Jun 15 00:00:00 EDT 2018
RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.
The Journal of biological chemistry
Ge J,Burnier L,Adamopoulou M,Kwa MQ,Schaks M,Rottner K,Brakebusch C
17-5981 was used in Flow cytometry/Cell sorting to provide molecular insights into the role of Rho GTPases in TGFβ signalling and understanding of mesenchymal stem cells in fibriosis.
Fri Jun 15 00:00:00 EDT 2018
Mesenchymal stromal cells-derived matrix Gla protein contribute to the alleviation of experimental colitis.
Cell death & disease
Feng Y,Liao Y,Huang W,Lai X,Luo J,Du C,Lin J,Zhang Z,Qiu D,Liu Q,Shen H,Xiang AP,Zhang Q
17-5981 was used in Flow cytometry/Cell sorting to study the role of matrix Gla protein as a novel mediator of mesenchymal stromal cell-mediated immunomodulation in treating Crohn's disease.
Thu Jun 07 00:00:00 EDT 2018
Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation.
Cell death & disease
Ding Y,Liang X,Zhang Y,Yi L,Shum HC,Chen Q,Chan BP,Fan H,Liu Z,Tergaonkar V,Qi Z,Tse HF,Lian Q
17-5981 was used in Flow cytometry/Cell sorting to indicate that Rap1 is essential to maintain the immunomodulatory function of MSCs.
Wed Mar 07 00:00:00 EST 2018
Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease.
Nature medicine
Hahm E,Wei C,Fernandez I,Li J,Tardi NJ,Tracy M,Wadhwani S,Cao Y,Peev V,Zloza A,Lusciks J,Hayek SS,O'Connor C,Bitzer M,Gupta V,Sever S,Sykes DB,Scadden DT,Reiser J
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2017
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.
Cell
Cabezas-Wallscheid N,Buettner F,Sommerkamp P,Klimmeck D,Ladel L,Thalheimer FB,Pastor-Flores D,Roma LP,Renders S,Zeisberger P,Przybylla A,Schönberger K,Scognamiglio R,Altamura S,Florian CM,Fawaz M,Vonficht D,Tesio M,Collier P,Pavlinic D,Geiger H,Schroeder T,Benes V,Dick TP,Rieger MA,Stegle O,Trumpp A
17-5981-82 was used in Flow Cytometry to highlight the impact of dietary vitamin A on the regulation of cell-cycle-mediated stem cell plasticity.
Thu May 18 00:00:00 EDT 2017
Increased Vascular Permeability in the Bone Marrow Microenvironment Contributes to Disease Progression and Drug Response in Acute Myeloid Leukemia.
Cancer cell
Passaro D,Di Tullio A,Abarrategi A,Rouault-Pierre K,Foster K,Ariza-McNaughton L,Montaner B,Chakravarty P,Bhaw L,Diana G,Lassailly F,Gribben J,Bonnet D
17-5981-82 was used in Flow Cytometry to find several abnormalities in the vascular architecture and function in patient-derived xenografts (PDX), such as vascular leakiness and increased hypoxia.
Mon Sep 11 00:00:00 EDT 2017
Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification.
Cell stem cell
Pillai ICL,Li S,Romay M,Lam L,Lu Y,Huang J,Dillard N,Zemanova M,Rubbi L,Wang Y,Lee J,Xia M,Liang O,Xie YH,Pellegrini M,Lusis AJ,Deb A
17-5981 was used in Flow cytometry/Cell sorting to study the cell identify and mechanisms contributing to pathological heart muscle calcification.
Thu Feb 02 00:00:00 EST 2017
Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration.
Cell stem cell
Ambrosi TH,Scialdone A,Graja A,Gohlke S,Jank AM,Bocian C,Woelk L,Fan H,Logan DW,Schürmann A,Saraiva LR,Schulz TJ
17-5981 was used in Flow cytometry/Cell sorting to specify the cellular identities of the adipogenic and osteogenic lineages of the bone.
Thu Jun 01 00:00:00 EDT 2017
FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging.
The Journal of clinical investigation
Li H,Liu P,Xu S,Li Y,Dekker JD,Li B,Fan Y,Zhang Z,Hong Y,Yang G,Tang T,Ren Y,Tucker HO,Yao Z,Guo X
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Mon Apr 03 00:00:00 EDT 2017
GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis.
The Journal of clinical investigation
Géraud C,Koch PS,Zierow J,Klapproth K,Busch K,Olsavszky V,Leibing T,Demory A,Ulbrich F,Diett M,Singh S,Sticht C,Breitkopf-Heinlein K,Richter K,Karppinen SM,Pihlajaniemi T,Arnold B,Rodewald HR,Augustin HG,Schledzewski K,Goerdt S
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
The receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis.
Development (Cambridge, England)
Soady KJ,Tornillo G,Kendrick H,Meniel V,Olijnyk-Dallis D,Morris JS,Stein T,Gusterson BA,Isacke CM,Smalley MJ
17-5981 was used in Flow cytometry/Cell sorting to demonstrate that PTPRB regulates branching morphogenesis by modulating the response of the FGFR signalling pathway to FGF stimulation.
Sun Oct 15 00:00:00 EDT 2017
The role of TGFβ‑HGF‑Smad4 axis in regulating the proliferation of mouse airway progenitor cells.
Molecular medicine reports
Li X,Yang L,Sun X,Wu J,Li Y,Zhang Q,Zhang Y,Li K,Wu Q,Chen H
17-5981-82 was used in Flow cytometry/Cell sorting to suggest a role for the TGF‚β‚TGF‚βR1/2‚HGF‚Smad4 axis in airway epithelial homeostasis.
Fri Dec 01 00:00:00 EST 2017
Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours.
Nature communications
Tao L,Xiang D,Xie Y,Bronson RT,Li Z
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Mon Feb 13 00:00:00 EST 2017
Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.
Nature communications
Shirai CL,White BS,Tripathi M,Tapia R,Ley JN,Ndonwi M,Kim S,Shao J,Carver A,Saez B,Fulton RS,Fronick C,O'Laughlin M,Lagisetti C,Webb TR,Graubert TA,Walter MJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Mon Jan 09 00:00:00 EST 2017
Microgrooved-surface topography enhances cellular division and proliferation of mouse bone marrow-derived mesenchymal stem cells.
PloS one
Chaudhary JK,Rath PC
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu Oct 19 00:00:00 EDT 2017
Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB.
PloS one
Gao SY,Zheng GS,Wang L,Liang YJ,Zhang SE,Lao XM,Li K,Liao GQ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Mon Sep 18 00:00:00 EDT 2017
Administration of multipotent mesenchymal stromal cells restores liver regeneration and improves liver function in obese mice with hepatic steatosis after partial hepatectomy.
Stem cell research & therapy
Ezquer F,Bahamonde J,Huang YL,Ezquer M
17-5981 was used in Flow cytometry/Cell sorting to evaluate the role of mesenchymal stromal cells in liver regeneration in an animal model of severe hepatic steatosis with impaired liver regeneration.
Sat Jan 28 00:00:00 EST 2017
Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation.
PloS one
Zhao Y,Wu K,Nguyen C,Smbatyan G,Melendez E,Higuchi Y,Chen Y,Kahn M
17-5981 was used in Flow cytometry/Cell sorting to report that the small molecule YH250 stimulates hematopoiesis in lethally or sublethally irradiated mice.
Tue Sep 26 00:00:00 EDT 2017
Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature.
Nature communications
Reismann D,Stefanowski J,Günther R,Rakhymzhan A,Matthys R,Nützi R,Zehentmeier S,Schmidt-Bleek K,Petkau G,Chang HD,Naundorf S,Winter Y,Melchers F,Duda G,Hauser AE,Niesner RA
17-5981 was used in Immunohistochemistry-immunofluorescence to develop longitudinal intravital imaging of the bone marrow to analyse cellular dynamics within the deep marrow.
Mon Dec 18 00:00:00 EST 2017
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Cell
Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu Aug 25 00:00:00 EDT 2016
CD8+ T cells drive autoimmune hematopoietic stem cell dysfunction and bone marrow failure.
Journal of autoimmunity
Gravano DM,Al-Kuhlani M,Davini D,Sanders PD,Manilay JO,Hoyer KK
17-5981 was used in Flow cytometry/Cell sorting to investigate whether CD8+ T cells play a non-redundant role in driving bone marrow failure.
Thu Dec 01 00:00:00 EST 2016
Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance.
Cell death and differentiation
Belle JI,Petrov JC,Langlais D,Robert F,Cencic R,Shen S,Pelletier J,Gros P,Nijnik A
17-5981 was used in Flow cytometry/Cell sorting to elucidate the mechanisms underlying the transcriptional activation of p53 stress responses in Mysm1-deficient haematopoietic stem and progenitor cells.
Sun May 01 00:00:00 EDT 2016
Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity.
Experimental cell research
Hettmer S,Lin MM,Tchessalova D,Tortorici SJ,Castiglioni A,Desai T,Mao J,McMahon AP,Wagers AJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.
Biology open
Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ
17-5981 was used in Flow cytometry/Cell sorting to investigate how PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.
Sun May 15 00:00:00 EDT 2016
Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities.
Pain reports
Cabañero D,Irie T,Celorrio M,Trousdale C,Owens DM,Virley D,Albrecht PJ,Caterina MJ,Rice FL,Morón JA
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu Sep 01 00:00:00 EDT 2016
Immobilized WNT Proteins Act as a Stem Cell Niche for Tissue Engineering.
Stem cell reports
Lowndes M,Rotherham M,Price JC,El Haj AJ,Habib SJ
17-5981 was used in Flow cytometry/Cell sorting to describe a one-step immobilization technique to covalently bind WNT3A proteins as a basal surface with easy storage and long-lasting activity.
Tue Jul 12 00:00:00 EDT 2016
KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.
Nature medicine
Shankman LS,Gomez D,Cherepanova OA,Salmon M,Alencar GF,Haskins RM,Swiatlowska P,Newman AA,Greene ES,Straub AC,Isakson B,Randolph GJ,Owens GK
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2015
Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails.
Cell research
Fu Y,Huang C,Xu X,Gu H,Ye Y,Jiang C,Qiu Z,Xie X
17-5981 was used in Immunofluorescence to showcase a method for the generation of chemical-induced cardiomyocyte-like cells.
Tue Sep 01 00:00:00 EDT 2015
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity.
Nature cell biology
Jeffery E,Church CD,Holtrup B,Colman L,Rodeheffer MS
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2015
Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.
The Journal of clinical investigation
Henry CJ,Casás-Selves M,Kim J,Zaberezhnyy V,Aghili L,Daniel AE,Jimenez L,Azam T,McNamee EN,Clambey ET,Klawitter J,Serkova NJ,Tan AC,Dinarello CA,DeGregori J
17-5981 was used in Flow cytometry/Cell sorting to conclude that chronic inflammatory microenvironments in old age lead to reductions in the fitness of B cell progenitor populations.
Tue Dec 01 00:00:00 EST 2015
Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway.
The Journal of experimental medicine
Tesio M,Tang Y,Müdder K,Saini M,von Paleske L,Macintyre E,Pasparakis M,Waisman A,Trumpp A
17-5981 was used in Flow cytometry/Cell sorting to elucidate the molecular mechanisms regulating haematopoietic stem cell dormancy.
Mon Apr 06 00:00:00 EDT 2015
Cis-regulatory mechanisms governing stem and progenitor cell transitions.
Science advances
Johnson KD,Kong G,Gao X,Chang YI,Hewitt KJ,Sanalkumar R,Prathibha R,Ranheim EA,Dewey CN,Zhang J,Bresnick EH
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Myogenic-specific ablation of Fgfr1 impairs FGF2-mediated proliferation of satellite cells at the myofiber niche but does not abolish the capacity for muscle regeneration.
Frontiers in aging neuroscience
Yablonka-Reuveni Z,Danoviz ME,Phelps M,Stuelsatz P
17-5981 was used in Flow cytometry/Cell sorting to investigate FGFR gene expression in quiescent SCs and their proliferating progeny, and its role in myogenesis.
Mon Jun 15 00:00:00 EDT 2015
Inhibition of the CXCL12/CXCR4 chemokine axis with AMD3100, a CXCR4 small molecule inhibitor, worsens murine hepatic injury.
Hepatology research : the official journal of the Japan Society of Hepatology
Saiman Y,Jiao J,Fiel MI,Friedman SL,Aloman C,Bansal MB
17-5981 was used in Flow cytometry/Cell sorting to suggest that inhibition of the CXCR4/CXCL12 chemokine axis is injurious through modulation of the hepatic inflammatory response.
Wed Jul 01 00:00:00 EDT 2015
Cellular and molecular characterization of human cardiac stem cells reveals key features essential for their function and safety.
Stem cells and development
Vahdat S,Mousavi SA,Omrani G,Gholampour M,Sotoodehnejadnematalahi F,Ghazizadeh Z,Gharechahi J,Baharvand H,Salekdeh GH,Aghdami N
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Mon Jun 15 00:00:00 EDT 2015
Multi-Drug Resistance ABC Transporter Inhibition Enhances Murine Ventral Prostate Stem/Progenitor Cell Differentiation.
Stem cells and development
Samant MD,Jackson CM,Felix CL,Jones AJ,Goodrich DW,Foster BA,Huss WJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Fri May 15 00:00:00 EDT 2015
Diminished satellite cells and elevated adipogenic gene expression in muscle as caused by ovariectomy are averted by low-magnitude mechanical signals.
Journal of applied physiology (Bethesda, Md. : 1985)
Frechette DM,Krishnamoorthy D,Adler BJ,Chan ME,Rubin CT
17-5981 was used in Flow cytometry/Cell sorting to identify the impact of ovariectomy on adiposity and satellite cell populations and whether mechanical signals could influence outcomes.
Wed Jul 01 00:00:00 EDT 2015
Limited miR-17-92 overexpression drives hematologic malignancies.
Leukemia research
Danielson LS,Reavie L,Coussens M,Davalos V,Castillo-Martin M,Guijarro MV,Coffre M,Cordon-Cardo C,Aifantis I,Ibrahim S,Liu C,Koralov SB,Hernando E
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Sun Mar 01 00:00:00 EST 2015
Extraocular muscle satellite cells are high performance myo-engines retaining efficient regenerative capacity in dystrophin deficiency.
Developmental biology
Stuelsatz P,Shearer A,Li Y,Muir LA,Ieronimakis N,Shen QW,Kirillova I,Yablonka-Reuveni Z
17-5981 was used in Flow cytometry/Cell sorting to characterise extraocular muscle cells and assess their potential as a cell-based therapy to combat skeletal muscle wasting.
Thu Jan 01 00:00:00 EST 2015
Alleviation of skin inflammation after Lin(-) cell transplantation correlates with their differentiation into myeloid-derived suppressor cells.
Scientific reports
Jeong Ryu S,Ju JM,Kim W,Bum Kim M,Hee Oh K,Sup Lee D,Lee H,Eun Oh J,Soo Park K,Young Choi E
17-5981 was used in Magnetic cell separation to study the migration, expansion and differentiation of hematopoietic stem cells in response to inflammation following HSC transplantation.
Tue Oct 06 00:00:00 EDT 2015
Sleep disruption impairs haematopoietic stem cell transplantation in mice.
Nature communications
Rolls A,Pang WW,Ibarra I,Colas D,Bonnavion P,Korin B,Heller HC,Weissman IL,de Lecea L
17-5981 was used in Flow cytometry/Cell sorting to provide insights into cellular and molecular mechanisms underlying the effects of sleep deprivation on HSCs.
Wed Oct 14 00:00:00 EDT 2015
Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.
PloS one
Iglesias JM,Cairney CJ,Ferrier RK,McDonald L,Soady K,Kendrick H,Pringle MA,Morgan RO,Martin F,Smalley MJ,Blyth K,Stein T
17-5981 was used in Flow cytometry/Cell sorting to identify ANXA8 as a potential mediator of quiescence in the normal mouse mammary ductal epithelium.
Tue Feb 23 00:00:00 EST 2016
Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate.
Nature cell biology
Lim A,Shin K,Zhao C,Kawano S,Beachy PA
17-5981 was used in Flow cytometry/Cell sorting to study how spatially restricting Hedgehog signalling can regulate HGF-induced branching of the adult prostate.
Mon Dec 01 00:00:00 EST 2014
Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair.
Circulation research
Furtado MB,Costa MW,Pranoto EA,Salimova E,Pinto AR,Lam NT,Park A,Snider P,Chandran A,Harvey RP,Boyd R,Conway SJ,Pearson J,Kaye DM,Rosenthal NA
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Fri Apr 25 00:00:00 EDT 2014
Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation.
The Journal of clinical investigation
Li J,Razumilava N,Gores GJ,Walters S,Mizuochi T,Mourya R,Bessho K,Wang YH,Glaser SS,Shivakumar P,Bezerra JA
17-5981 was used in Flow cytometry/Cell sorting to demonstrate the role of the Th2-promoting cytokine, IL-33, in cholangiocyte proliferation.
Tue Jul 01 00:00:00 EDT 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Mon Sep 22 00:00:00 EDT 2014
Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.
Autophagy
Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y
17-5981 was used in Flow cytometry/Cell sorting to study how inflammatory microenvironment-induced autophagy can downregulate the immunosuppressive function of mesenchymal stem cells.
Tue Jul 01 00:00:00 EDT 2014
Overexpressing sonic hedgehog peptide restores periosteal bone formation in a murine bone allograft transplantation model.
Molecular therapy : the journal of the American Society of Gene Therapy
Huang C,Tang M,Yehling E,Zhang X
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Sat Feb 01 00:00:00 EST 2014
Cell-autonomous heparanase modulates self-renewal and migration in bone marrow-derived mesenchymal stem cells.
Journal of biomedical science
Cheng CC,Lee YH,Lin SP,Huangfu WC,Liu IH
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu Mar 13 00:00:00 EDT 2014
Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup.
PLoS biology
Cowley M,Garfield AS,Madon-Simon M,Charalambous M,Clarkson RW,Smalley MJ,Kendrick H,Isles AR,Parry AJ,Carney S,Oakey RJ,Heisler LK,Moorwood K,Wolf JB,Ward A
17-5981 was used in Flow cytometry/Cell sorting to identify Grb10 as a key genetic component of developmental programming in mice.
Sat Feb 01 00:00:00 EST 2014
Recruitment of bone marrow-derived cells to periodontal tissue defects.
Frontiers in cell and developmental biology
Kimura Y,Komaki M,Iwasaki K,Sata M,Izumi Y,Morita I
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Mon Nov 03 00:00:00 EST 2014
Prolactin-induced prostate tumorigenesis links sustained Stat5 signaling with the amplification of basal/stem cells and emergence of putative luminal progenitors.
The American journal of pathology
Sackmann-Sala L,Chiche A,Mosquera-Garrote N,Boutillon F,Cordier C,Pourmir I,Pascual-Mathey L,Kessal K,Pigat N,Camparo P,Goffin V
17-5981 was used in Flow cytometry/Cell sorting to provide a deeper understanding of the initial stages of prostate tumorigenesis induced by prolactin.
Sat Nov 01 00:00:00 EDT 2014
Evidence for Transfer of Membranes from Mesenchymal Stem Cells to HL-1 Cardiac Cells.
Stem cells international
Boomsma RA,Geenen DL
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Wed Oct 08 00:00:00 EDT 2014
Oxidative stress leads to increased mutation frequency in a murine model of myelodysplastic syndrome.
Leukemia research
Chung YJ,Robert C,Gough SM,Rassool FV,Aplan PD
17-5981 was used in Flow cytometry/Cell sorting to assess the contribution of oxidative stress to oncologic disease progression.
Wed Jan 01 00:00:00 EST 2014
Ancestral Myf5 gene activity in periocular connective tissue identifies a subset of fibro/adipogenic progenitors but does not connote a myogenic origin.
Developmental biology
Stuelsatz P,Shearer A,Yablonka-Reuveni Z
17-5981 was used in Flow cytometry/Cell sorting to identify and characterise the differences between myogenic progenitors (satellite cells) in extraocular muscles to those of the limb and diaphragm of adult mice.
Wed Jan 15 00:00:00 EST 2014
Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.
PloS one
Xiao GY,Liu IH,Cheng CC,Chang CC,Lee YH,Cheng WT,Wu SC
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu May 28 00:00:00 EDT 2015
Validation of the effects of TGF-β1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical properties.
Cancer cell international
Wu TH,Chou YW,Chiu PH,Tang MJ,Hu CW,Yeh ML
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Mon Mar 03 00:00:00 EST 2014
Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis.
Immunity
McHedlidze T,Waldner M,Zopf S,Walker J,Rankin AL,Schuchmann M,Voehringer D,McKenzie AN,Neurath MF,Pflanz S,Wirtz S
17-5981 was used in Flow cytometry/Cell sorting to investigate the role of inflammatory networks in liver fibrosis, showing that it is mediated by interleukin-33-dependent innate lymphoid cells.
Thu Aug 22 00:00:00 EDT 2013
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
Nature cell biology
Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF
17-5981 was used in Flow cytometry/Cell sorting to investigate the role of miR-126 and miR-126* in tumour progression.
Fri Mar 01 00:00:00 EST 2013
The function of hematopoietic stem cells is altered by both genetic and inflammatory factors in lupus mice.
Blood
Niu H,Fang G,Tang Y,Xie L,Yang H,Morel L,Diamond B,Zou YR
17-5981 was used in Flow cytometry/Cell sorting to demonstrate that inflammatory cytokines and HMGB1 in lupus mice modify hematopoietic stem cells function.
Thu Mar 14 00:00:00 EDT 2013
Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization.
The Journal of experimental medicine
Tesio M,Oser GM,Baccelli I,Blanco-Bose W,Wu H,Göthert JR,Kogan SC,Trumpp A
17-5981 was used in Flow cytometry/Cell sorting to investigate the effect of PTEN deletion in bone marrow, showing that it leads to G-CSF-mediated hematopoietic stem cell mobilisation.
Mon Oct 21 00:00:00 EDT 2013
ΔNp63 regulates select routes of reprogramming via multiple mechanisms.
Cell death and differentiation
Alexandrova EM,Petrenko O,Nemajerova A,Romano RA,Sinha S,Moll UM
17-5981 was used in Flow cytometry/Cell sorting to report that in stark contrast to p53, p73 has no role in the molecular mechanisms of reprogramming the conversion of somatic cells into induced pluripotent stem cells.
Sun Dec 01 00:00:00 EST 2013
Sca1-derived cells are a source of myocardial renewal in the murine adult heart.
Stem cell reports
Uchida S,De Gaspari P,Kostin S,Jenniches K,Kilic A,Izumiya Y,Shiojima I,Grosse Kreymborg K,Renz H,Walsh K,Braun T
17-5981 was used in Flow cytometry/Cell sorting to reveal a source of cells for cardiomyocyte renewal, providing explanation for the limited contribution of Sca1-derived cells to myocardial repair.
Mon Oct 26 00:00:00 EDT 2015
Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics.
Stem cells (Dayton, Ohio)
Grosselin J,Sii-Felice K,Payen E,Chretien S,Tronik-Le Roux D,Leboulch P
17-5981-82 was used in Flow Cytometry to demonstrate arrayed lentiviral barcoding as a versatile and powerful approach to deconvolute cell dynamics in vivo with applications in hematology, embryology, and cancer biology.
Tue Oct 01 00:00:00 EDT 2013
A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).
Disease models & mechanisms
Carofino BL,Ayanga B,Justice MJ
17-5981 was used in Flow cytometry/Cell sorting to demonstrate that increased expression of Prdm14 drives development of T-Cell acute lymphoblastic leukemia in mice.
Fri Nov 01 00:00:00 EDT 2013
Flow cytometry analysis of murine hematopoietic stem cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Mayle A,Luo M,Jeong M,Goodell MA
17-5981 was used in Flow cytometry/Cell sorting to discuss methods for rapid flow cytometric analysis of peripheral blood cell types and novel strategies for working with rare cell populations such as hematopoietic stem cells in the analysis of cell cycle status by BrdU, Ki-67, and Pyronin Y staining.
Tue Jan 01 00:00:00 EST 2013
Isolation, characterization, and transplantation of cardiac endothelial cells.
BioMed research international
Pratumvinit B,Reesukumal K,Janebodin K,Ieronimakis N,Reyes M
17-5981 was used in Flow cytometry/Cell sorting to develop a method to expand the study of endothelial cell biology for multiple clinical applications..
Tue Jun 17 00:00:00 EDT 2014
Characterization of cardiac-resident progenitor cells expressing high aldehyde dehydrogenase activity.
BioMed research international
Roehrich ME,Spicher A,Milano G,Vassalli G
17-5981 was used in Flow cytometry/Cell sorting to investigate the presence of cardiac-resident progenitor cells with high aldehyde dehydrogenase activity isolated from mouse hearts.
Tue Sep 03 00:00:00 EDT 2013
A survey of ex vivo/in vitro transduction efficiency of mammalian primary cells and cell lines with Nine natural adeno-associated virus (AAV1-9) and one engineered adeno-associated virus serotype.
Virology journal
Ellis BL,Hirsch ML,Barker JC,Connelly JP,Steininger RJ,Porteus MH
17-5981 was used in Flow cytometry/Cell sorting to produce a comprehensive study of the transduction efficiency of viral vectors.
Wed Mar 06 00:00:00 EST 2013
Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer.
Cancer cell
Xu K,Usary J,Kousis PC,Prat A,Wang DY,Adams JR,Wang W,Loch AJ,Deng T,Zhao W,Cardiff RD,Yoon K,Gaiano N,Ling V,Beyene J,Zacksenhaus E,Gridley T,Leong WL,Guidos CJ,Perou CM,Egan SE
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Tue May 15 00:00:00 EDT 2012
Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.
Blood
Hu T,Ghazaryan S,Sy C,Wiedmeyer C,Chang V,Wu L
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu May 10 00:00:00 EDT 2012
Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.
The Journal of clinical investigation
Johnson KD,Hsu AP,Ryu MJ,Wang J,Gao X,Boyer ME,Liu Y,Lee Y,Calvo KR,Keles S,Zhang J,Holland SM,Bresnick EH
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Mon Oct 01 00:00:00 EDT 2012
CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion.
The EMBO journal
Gu P,Min JN,Wang Y,Huang C,Peng T,Chai W,Chang S
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Wed May 16 00:00:00 EDT 2012
Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype.
Molecular cancer research : MCR
Joseph J,Shiozawa Y,Jung Y,Kim JK,Pedersen E,Mishra A,Zalucha JL,Wang J,Keller ET,Pienta KJ,Taichman RS
17-5981 was used in Flow cytometry/Cell sorting to identify haematopoietic stem and progenitor cells as novel targets for therapies targeting the bone abnormalities of prostate cancer.
Thu Mar 01 00:00:00 EST 2012
Induction of cardiac myogenic lineage development differs between mesenchymal and satellite cells and is accelerated by bone morphogenetic protein-4.
Journal of molecular and cellular cardiology
Grajales L,García J,Geenen DL
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2012
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.
Nature
Zuber J,Shi J,Wang E,Rappaport AR,Herrmann H,Sison EA,Magoon D,Qi J,Blatt K,Wunderlich M,Taylor MJ,Johns C,Chicas A,Mulloy JC,Kogan SC,Brown P,Valent P,Bradner JE,Lowe SW,Vakoc CR
17-5981 was used in Flow cytometry/Cell sorting to establish small-molecule inhibition of Brd4 as a promising therapeutic strategy in acute myeloid leukaemia.
Wed Aug 03 00:00:00 EDT 2011
Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.
Blood
Welch JS,Klco JM,Varghese N,Nagarajan R,Ley TJ
17-5981 was used in Flow cytometry/Cell sorting to test the prediction that RARA (retinoic acid receptor alpha) haploinsufficiency would contribute to acute promyelocytic leukemia (APL) pathogenesis.
Thu Feb 24 00:00:00 EST 2011
Essential roles for Pot1b in HSC self-renewal and survival.
Blood
Wang Y,Shen MF,Chang S
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2011
Angiopoietin-1 promotes endothelial differentiation from embryonic stem cells and induced pluripotent stem cells.
Blood
Joo HJ,Kim H,Park SW,Cho HJ,Kim HS,Lim DS,Chung HM,Kim I,Han YM,Koh GY
17-5981 was used in Flow cytometry/Cell sorting to study the role of Ang1/Tie2 signalling in ESC differentiation.
Thu Aug 25 00:00:00 EDT 2011
PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice.
The Journal of clinical investigation
Welch JS,Yuan W,Ley TJ
17-5981 was used in Flow cytometry/Cell sorting to study a platform for more accurately dissecting the early events in acute promyelocytic leukemia pathogenesis.
Fri Apr 01 00:00:00 EDT 2011
Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow.
The Journal of clinical investigation
Shiozawa Y,Pedersen EA,Havens AM,Jung Y,Mishra A,Joseph J,Kim JK,Patel LR,Ying C,Ziegler AM,Pienta MJ,Song J,Wang J,Loberg RD,Krebsbach PH,Pienta KJ,Taichman RS
17-5981 was used in Flow cytometry/Cell sorting to show that the haematopoietic stem cell niche plays a central role in bone metastases.
Fri Apr 01 00:00:00 EDT 2011
Prevention of bone marrow cell apoptosis and regulation of hematopoiesis by type I IFNs during systemic responses to pneumocystis lung infection.
Journal of immunology (Baltimore, Md. : 1950)
Taylor D,Wilkison M,Voyich J,Meissner N
17-5981 was used in Flow cytometry/Cell sorting to define the mechanisms involved in the induction of bone marrow failure, in response to loss of type 1 interferon signalling.
Sun May 15 00:00:00 EDT 2011
CD24-positive cells from normal adult mouse liver are hepatocyte progenitor cells.
Stem cells and development
Qiu Q,Hernandez JC,Dean AM,Rao PH,Darlington GJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2011
Adipose-derived stem cells promote lymphangiogenesis in response to VEGF-C stimulation or TGF-β1 inhibition.
Future oncology (London, England)
Yan A,Avraham T,Zampell JC,Haviv YS,Weitman E,Mehrara BJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2011
Adipose-derived stem cells promote lymphangiogenesis in response to VEGF-C stimulation or TGF-β1 inhibition.
Future oncology (London, England)
Yan A,Avraham T,Zampell JC,Haviv YS,Weitman E,Mehrara BJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2011
Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche.
Experimental hematology
Jung Y,Shiozawa Y,Wang J,Patel LR,Havens AM,Song J,Krebsbach PH,Roodman GD,Taichman RS
17-5981 was used in Flow cytometry/Cell sorting to investigate the role that annexin-2 plays in presenting stromal cell-derived factor-1 to hematopoietic stem cells.
Tue Feb 01 00:00:00 EST 2011
Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche.
Experimental hematology
Jung Y,Shiozawa Y,Wang J,Patel LR,Havens AM,Song J,Krebsbach PH,Roodman GD,Taichman RS
17-5981 was used in Flow cytometry/Cell sorting to investigate the role that annexin-2 plays in presenting stromal cell-derived factor-1 to hematopoietic stem cells.
Tue Feb 01 00:00:00 EST 2011
A high omega-3 fatty acid diet has different effects on early and late stage myeloid progenitors.
Lipids
Varney ME,Buchanan JT,Dementieva Y,Hardman WE,Sollars VE
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Sat Jan 01 00:00:00 EST 2011
The antidiabetic effect of MSCs is not impaired by insulin prophylaxis and is not improved by a second dose of cells.
PloS one
Ezquer F,Ezquer M,Simon V,Conget P
17-5981 was used in Flow cytometry/Cell sorting to evaluate whether insulin prophylaxis and administration of a second dose of cells affect the antidiabetic therapeutic effect of MSC transplantation.
Thu Jan 27 00:00:00 EST 2011
Protein kinase D2 is an essential regulator of murine myoblast differentiation.
PloS one
Kleger A,Loebnitz C,Pusapati GV,Armacki M,Müller M,Tümpel S,Illing A,Hartmann D,Brunner C,Liebau S,Rudolph KL,Adler G,Seufferlein T
17-5981 was used in Flow cytometry/Cell sorting to identify protein kinase D2 as a major mediator of muscle cell differentiation in vitro and a potential novel target for the modulation of muscle regeneration.
Thu Jan 27 00:00:00 EST 2011
Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.
The Journal of clinical investigation
Xiang Z,Luo H,Payton JE,Cain J,Ley TJ,Opferman JT,Tomasson MH
17-5981 was used in Flow cytometry/Cell sorting to demonstrate a critical and dose-dependent role for Mcl1 in acute myelogenous leukaemia pathogenesis.
Tue Jun 01 00:00:00 EDT 2010
Isolation, cultivation and characterization of adult murine prostate stem cells.
Nature protocols
Lukacs RU,Goldstein AS,Lawson DA,Cheng D,Witte ON
17-5981 was used in Flow cytometry/Cell sorting to develop a protocol to isolate, cultivate and characterise adult murine prostate stem cells, allowing further studies in organ replenishment and their role in cancer initiation.
Thu Apr 01 00:00:00 EDT 2010
Delayed enrichment of mesenchymal cells promotes cardiac lineage and calcium transient development.
Journal of molecular and cellular cardiology
Grajales L,García J,Banach K,Geenen DL
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2010
A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice.
Cell cycle (Georgetown, Tex.)
Leonova KI,Shneyder J,Antoch MP,Toshkov IA,Novototskaya LR,Komarov PG,Komarova EA,Gudkov AV
17-5981 was used in Flow cytometry/Cell sorting to demonstrate that although PFTb administration led to increased numbers of HSCs and HPCs, it was not carcinogenic in mice.
Thu Apr 01 00:00:00 EDT 2010
Erythropoietin couples hematopoiesis with bone formation.
PloS one
Shiozawa Y,Jung Y,Ziegler AM,Pedersen EA,Wang J,Wang Z,Song J,Wang J,Lee CH,Sud S,Pienta KJ,Krebsbach PH,Taichman RS
17-5981 was used in Flow cytometry/Cell sorting to demonstrate that erythropoietin regulates the formation of bone by both direct and indirect pathways.
Thu May 27 00:00:00 EDT 2010
Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential.
Cell stem cell
Benveniste P,Frelin C,Janmohamed S,Barbara M,Herrington R,Hyam D,Iscove NN
17-5981 was used in Flow cytometry/Cell sorting to investigate the presence of "intermediate-term" multipotent hematopoietic stem cells, revealing that these cells are able to sustain clones of differentiating cells for only 4-6 weeks.
Fri Jan 08 00:00:00 EST 2010
CBFbeta is critical for AML1-ETO and TEL-AML1 activity.
Blood
Roudaia L,Cheney MD,Manuylova E,Chen W,Morrow M,Park S,Lee CT,Kaur P,Williams O,Bushweller JH,Speck NA
17-5981 was used in Flow cytometry/Cell sorting to validate the AML1-ETO and TEL-AML1 chimeric protein Runt domain/CBFbeta interaction as a therapeutic target in core binding factor leukemias.
Thu Mar 26 00:00:00 EDT 2009
Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells.
Cell stem cell
Le Grand F,Jones AE,Seale V,Scimè A,Rudnicki MA
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Fri Jun 05 00:00:00 EDT 2009
Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
Astrakhan A,Ochs HD,Rawlings DJ
17-5981 was used in Flow cytometry/Cell sorting to investigate the role for WASp within the iNKT lineage.
Mon Jun 15 00:00:00 EDT 2009
Reporter gene-expressing bone marrow-derived stromal cells are immune-tolerated following implantation in the central nervous system of syngeneic immunocompetent mice.
BMC biotechnology
Bergwerf I,De Vocht N,Tambuyzer B,Verschueren J,Reekmans K,Daans J,Ibrahimi A,Van Tendeloo V,Chatterjee S,Goossens H,Jorens PG,Baekelandt V,Ysebaert D,Van Marck E,Berneman ZN,Linden AV,Ponsaerts P
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 17-5981-82) in Flow Cytometry
Wed Jan 07 00:00:00 EST 2009
The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche.
Circulation research
Aicher A,Kollet O,Heeschen C,Liebner S,Urbich C,Ihling C,Orlandi A,Lapidot T,Zeiher AM,Dimmeler S
17-5981 was used in Flow cytometry/Cell sorting to examine whether the Wnt signalling antagonist, Dickkopf-1, is involved in the mobilisation of vasculogenic progenitor cells.
Fri Oct 10 00:00:00 EDT 2008
Vaccinia virus infection modulates the hematopoietic cell compartments in the bone marrow.
Stem cells (Dayton, Ohio)
Singh P,Yao Y,Weliver A,Broxmeyer HE,Hong SC,Chang CH
17-5981 was used in Flow cytometry/Cell sorting to show that in vivo VV infection results in the expansion of c-Kit(hi)Sca-1+Lin- (KSL) haematopoietic stem cells.
Tue Apr 01 00:00:00 EDT 2008
E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Yang Q,Kardava L,St Leger A,Martincic K,Varnum-Finney B,Bernstein ID,Milcarek C,Borghesi L
17-5981 was used in Flow cytometry/Cell sorting to show E47 controls the developmental integrity and cell cycle quiescence of hematopoietic progenitors.
Sat Nov 01 00:00:00 EDT 2008
Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate.
BMC genomics
Kendrick H,Regan JL,Magnay FA,Grigoriadis A,Mitsopoulos C,Zvelebil M,Smalley MJ
17-5981 was used in Flow cytometry/Cell sorting to characterise cell fate determination in the mammary epithelium and the contribution of different cell types to the pathology of breast disease.
Mon Dec 08 00:00:00 EST 2008
Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation.
The Journal of experimental medicine
Besseyrias V,Fiorini E,Strobl LJ,Zimber-Strobl U,Dumortier A,Koch U,Arcangeli ML,Ezine S,Macdonald HR,Radtke F
17-5981 was used in Flow cytometry/Cell sorting to study the Notch-Delta interactions that promote T cell development.
Mon Feb 19 00:00:00 EST 2007
Hematopoiesis and stem cell renewal in long-term bone marrow cultures containing catalase.
Blood
Gupta R,Karpatkin S,Basch RS
17-5981 was used in Flow cytometry/Cell sorting to investigate the control of haematopoiesis by peroxide-sensitive regulatory mechanisms.
Wed Mar 01 00:00:00 EST 2006
Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation.
Developmental cell
Berthet C,Klarmann KD,Hilton MB,Suh HC,Keller JR,Kiyokawa H,Kaldis P
17-5981 was used in Flow cytometry/Cell sorting to demonstrate that Cdk2 and Cdk4 cooperate to phosphorylate Rb in vivo and to couple the G1/S phase transition to mitosis via E2F-dependent regulation of gene expression.
Mon May 01 00:00:00 EDT 2006
Hmgb3 regulates the balance between hematopoietic stem cell self-renewal and differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Nemeth MJ,Kirby MR,Bodine DM
17-5981 was used in Flow cytometry/Cell sorting to propose a model in which Hmgb3 is required for the proper balance between hematopoietic stem cell self-renewal and differentiation.
Tue Sep 12 00:00:00 EDT 2006
