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Product Details
H00008398-D01P
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PLA2G6 (NP_001004426.1, 1 a.a. approximately 752 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MQFFGRLVNT FSGVTNLFSN PFRVKEVAVA DYTSSDRVRE EGQLILFQNT PNRTWDCVLV NPRNSQSGFR LFQLELEADA LVNFHQYSSQ LLPFYESSPQ VLHTEVLQHL TDLIRNHPSW SVAHLAVELG IRECFHHSRI ISCANCAENE EGCTPLHLAC RKGDGEILVE LVQYCHTQMD VTDYKGETVF HYAVQGDNSQ VLQLLGRNAV AGLNQVNNQG LTPLHLACQL GKQEMVRVLL LCNARCNIMG PNGYPIHSAM KFSQKGCAEM IISMDSSQIH SKDPRYGASP LHWAKNAEMA RMLLKRGCNV NSTSSAGNTA LHVAVMRNRF DCAIVLLTHG ANADARGEHG NTPLHLAMSK DNVEMIKALI VFGAEVDTPN DFGETPTFLA SKIGRQLQDL MHISRARKPA FILGSMRDEK RTHDHLLCLD GGGVKGLIII QLLIAIEKAS GVATKDLFDW VAGTSTGGIL ALAILHSKSM AYMRGMYFRM KDEVFRGSRP YESGPLEEFL KREFGEHTKM TDVRKPKVML TGTLSDRQPA ELHLFRNYDA PETVREPRFN QNVNLRPPAQ PSDQLVWRAA RSSGAAPTYF RPNGRFLDGG LLANNPTLDA MTEIHEYNQD LIRKGQANKV KKLSIVVSLG TGRSPQVPVT CVDVFRPSNP WELAKTVFGA KELGKMVVDC CTDPDGRAVD RARAWCEMVG IQYFRLNPQL GTDIMLDEVS DTVLVNALWE TEVYIYEHRE EFQKLIQLLL SP
Target Information
The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only two of them have been determined to date.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2-lysophosphatidylcholine acylhydrolase; 85 kDa calcium-independent phospholipase A2; 85/88 kDa calcium-independent phospholipase A2; CaI-PLA2; Group VI phospholipase A2; GVI PLA2; Intracellular membrane-associated calcium-independent phospholipase A2 beta; iPLA2-beta; neurodegeneration with brain iron accumulation 2; Palmitoyl-CoA hydrolase; Patatin-like phospholipase domain-containing protein 9; phospholipase A2, group VI (cytosolic, calcium-independent); PNPLA9
Gene Aliases: BB112799; CaI-PLA2; GVI; INAD1; iPLA(2)beta; iPLA2; IPLA2-VIA; iPLA2beta; NBIA2; NBIA2A; NBIA2B; PARK14; PLA2; PLA2G6; PLPLA9; PNPLA9
UniProt ID: (Human) O60733, (Mouse) P97819
Entrez Gene ID: (Human) 8398, (Mouse) 53357
positive regulation of protein phosphorylation
chemotaxis
positive regulation of cytosolic calcium ion concentration
memory
urinary bladder smooth muscle contraction
lipid catabolic process
antibacterial humoral response
cardiolipin biosynthetic process
response to endoplasmic reticulum stress
positive regulation of insulin secretion involved in cellular response to glucose stimulus
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of vasodilation
positive regulation of exocytosis
negative regulation of synaptic transmission, glutamatergic
maternal process involved in female pregnancy
positive regulation of protein kinase C signaling
positive regulation of release of cytochrome c from mitochondria
positive regulation of arachidonic acid secretion
regulation of store-operated calcium channel activity
positive regulation of ceramide biosynthetic process
lipid metabolic process
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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