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Product Details
PA5-50637
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human phospholipase A2, group VI (cytosolic, calcium-independent)
Conjugate
Form
Liquid
Concentration
1.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2636090
Product Specific Information
The antibody detects endogenous levels of total PLA2G6 protein.
Target Information
The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only two of them have been determined to date.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2-lysophosphatidylcholine acylhydrolase; 85 kDa calcium-independent phospholipase A2; 85/88 kDa calcium-independent phospholipase A2; CaI-PLA2; Group VI phospholipase A2; GVI PLA2; Intracellular membrane-associated calcium-independent phospholipase A2 beta; iPLA2-beta; neurodegeneration with brain iron accumulation 2; Palmitoyl-CoA hydrolase; Patatin-like phospholipase domain-containing protein 9; phospholipase A2, group VI (cytosolic, calcium-independent); PNPLA9
Gene Aliases: BB112799; CaI-PLA2; GVI; INAD1; iPLA(2)beta; iPLA2; IPLA2-VIA; iPLA2beta; NBIA2; NBIA2A; NBIA2B; PARK14; PLA2; PLA2G6; PLPLA9; PNPLA9
UniProt ID: (Human) O60733, (Rat) Q66HD1, (Mouse) P97819
Entrez Gene ID: (Human) 8398, (Rat) 360426, (Mouse) 53357
positive regulation of protein phosphorylation
chemotaxis
positive regulation of cytosolic calcium ion concentration
memory
urinary bladder smooth muscle contraction
lipid catabolic process
antibacterial humoral response
cardiolipin biosynthetic process
response to endoplasmic reticulum stress
positive regulation of insulin secretion involved in cellular response to glucose stimulus
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of vasodilation
positive regulation of exocytosis
negative regulation of synaptic transmission, glutamatergic
maternal process involved in female pregnancy
positive regulation of protein kinase C signaling
positive regulation of release of cytochrome c from mitochondria
positive regulation of arachidonic acid secretion
regulation of store-operated calcium channel activity
positive regulation of ceramide biosynthetic process
lipid metabolic process
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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