Analyze using the Prima PRO Process Mass Spectrometer
A key stage in many pharmaceutical processes is the complete or partial removal of a solvent, or solvents, from a product or intermediate. The drying process required can occur in a variety of process vessels, including vacuum dryers, tray dryers and rotary dryers.
In the past, the success of the drying process was measured upon conclusion by simply taking a sample for laboratory analysis. Organic solvent concentrations in the active pharmaceutical ingredient (API), or intermediate, were measured by gas chromatography; residual water levels were typically checked by performing a Karl Fischer titration. The amount of residual solvent was defined by the loss on drying (LOD).
Download our free application note, Monitoring pharmaceutical solvent drying processes using the Prima PRO Process Mass Spectrometer, to learn more.