RNA therapeutics include an expanding category of drugs that will transform the standard of care for various diseases and actualize personalized medicine. These drugs are cost effective, relatively simple to manufacture, and can target previously undruggable pathways.

The development of oligonucleotides requires comprehensive characterization and quantification of impurities in accordance with strict regulatory guidance, with main challenge posed by the complexity of the oligonucleotide molecules themselves and the modifications that are being applied to them. Chemical modifications are utilized extensively to improve drug efficacy and safety and these continue to evolve.

In this eBook, you’ll learn about how Thermo Fisher Scientific’s chromatography and mass spectrometry solutions allow you to rapidly characterize and quantify components of your oligonucleotide therapeutics with greater clarity and accelerate the progression to market.

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