How to Streamline Sample Preparation for Equine Drug Screening Using LC-MS

Everything leaves a trace. Forensic toxicology webinar series.

In this presentation, Joe Di Bussolo from Thermo Fisher Scientific and Carisa Dixon Tate from PETRL discuss how screening blood samples from race horses for prohibited drugs requires validated methods and instrumentation that maximize sensitivity and selectivity while minimizing sample handling.

They will detail the performance of traditional LC-MS systems and methods and how they can be improved by automating on-line sample cleanup by TurboFlow™ technology coupled ultra high-resolution liquid chromatography (UHPLC); as well as their experiences in developing and validating new drug screening methods.

About the presenters

Carisa Dixon Tate, Research Scientist at the Pennsylvania Equine Toxicology and Research Laboratory

Carisa Dixon Tate graduated from West Chester University in 2004 with B.S. degrees in Forensic Chemistry and General Biology. In her senior year, Carisa completed an internship at the Pennsylvania Equine Toxicology and Research Laboratory (PETRL). Since 2008, she has been employed by the University of Pennsylvania’s School of Veterinary Medicine, New Bolton Center, as a research scientist for clinical studies assigned to PETRL where she analyzes race-horse samples as well as develops and validates new screening and conformation methods to detect and measure drugs by LC-MS.

Joe Di Bussolo, Senior Applications Scientist

Joe Di Bussolo earned his B.S. degree in clinical chemistry at West Chester University in 1977. In 1982, he received a Ph.D. degree in biological sciences from Drexel University in Philadelphia. For most of the 20 years that followed, Dr. Di Bussolo helped develop and supported various analytical instruments and software products for the PerkinElmer Corporation. In 2002, Joe joined Cohesive Technologies as an applications scientist. Cohesive was acquired in 2007 by Thermo Fisher Scientific and Joe currently works as a senior scientist training and collaborating with customers and managing the Applications Laboratory at West Chester University of Pennsylvania. He is also an adjunct professor and advisor in the University's Pharmaceutical Product Development program.

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