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The applications of HPLC encompass a broad range of fields and include testing the quality of products you use every day. HPLC helps keep consumers safe through:
- Impurity analysis in medicine
- Characterizing the quality of ingredients in foods and drinks
- Monitoring the levels of pollutants in water and soil
HPLC learning center
Related resources
Pharma & Biopharma
Pharma
The pharmaceutical industry uses HPLC for research and development, manufacturing quality control, and impurity and degradation analysis to ensure our medications are free of unintended or harmful ingredients.
LC-MS/MS method for the quantification of 10 nitrosamine impurities in metformin
Impurity analysis of gabapentin by HPLC-UV-CAD
Forced-degradation evaluation of erythromycin by HPLC and single quadrupole mass spectrometry
Biopharma
Biopharma companies use HPLC to characterize and identify molecular targets, screen drug targets, and produce medicine from peptide mapping and sequencing, analyzing antibodies, and purifying the biological actives.
Identification and quantitation of oligonucleotides, impurities, and degradation products
High-throughput peptide mapping of trastuzumab using tandem LC-MS workflow
High-throughput protein aggregate analysis of monoclonal antibodies using a novel dual-channel UHPLC instrument
Proteomics & metabolomics
Researchers studying complex proteomics and metabolomics biological samples use nano-, capillary-, and micro-flow liquid chromatography hyphenated with high-resolution accurate-mass or triple quadrupole mass spectrometry.
Vanquish Neo UHPLC system sets new performance standards for single-shot nano LC-MS bottom-up proteomics
Fast, sensitive and reproducible nano- and capillary-flow LCMS methods for high-throughput proteome profiling using the Vanquish Neo UHPLC system
Ultra-robust micro-flow LC-MS/MS for targeted high-throughput peptide quantification using the Vanquish Neo UHPLC system
Clinical research
Clinical labs utilize HPLC to analyze complex biological fluids like blood, plasma, and serum, aiding the development of targeted precision medicines.
Quantitative analysis of estradiol and testosterone in plasma for clinical research using the TSQ Altis triple quadrupole mass spectrometer
Quantification of insulin-like growth factor 1 in human serum by Vanquish UHPLC with Q Exactive high-resolution accurate-mass mass spectrometry for clinical research
Tomorrow’s quantitation: increased robustness for quantitation of immunosuppressant drugs in blood with the TSQ Fortis MS for clinical research
Food & beverage
HPLC analysis helps ensure foods and beverages are unadulterated and free of harmful toxins and carcinogens by detecting residual pesticides and verifying the purity and authenticity of ingredients.
A quantitative LC-MS/MS method for 15 mycotoxins in corn-based animal feed
Fast analysis of multi-class pesticides panel in wine using single run LC-triple quadrupole mass spectrometry
Determination of PAH4 in edible oils with automated sample preparation
Environmental
Environmental companies use HPLC to identify, monitor, and quantify metal-free organic-based pollutants in water and soil.
Detection of oxygenated polycyclic aromatic hydrocarbons (oxy-PAHs) in APCI mode with a single quadrupole mass spectrometer
Determination of per- and polyfluorinated alkyl substances (PFAS) in drinking water using automated solid-phase extraction and LC-MS/MS
Extraction and analysis of poly- and perfluoroalkyl substances (PFAS) from soil
Forensics & toxicology
Forensic and toxicology labs depend on HPLC analysis to screen, quantify, and confirm drugs associated with criminal investigations and drug screenings.
Tomorrow’s quantitation with LC-MS/MS: fast screening and quantitation of drugs of abuse in urine for forensic toxicology
Fast and easy separation of 23 drugs of abuse including high, stable resolution of isobaric opioids from human urine by UHPLC-MS/MS
Analysis of Equine Doping Using TurboFlow Technology and Multiplexing with LC-MS/MS
FAQ
HPLC is used across a broad range of industries like drug development in pharma/biopharma. Precision medicine and gene therapy in proteomics research. Monitoring quality control of raw materials and finished goods in product manufacturing. Detecting the presence of pesticides and adulteration of ingredients in food and beverages.
The applications of HPLC encompass a broad range of fields from small-scale research and development to large-scale manufacturing quality control.
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