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Virtual IC Column Separation Simulator
Discover the fastest, easiest and most economical way to optimize IC separations using the IC Virtual Column Separation Simulator in the Thermo Scientific Chromeleon Chromatography Data System.
Why optimize IC the hard way?
Seeking the best column and separation conditions for an IC analysis used to be a gamble. You had to guess where to start and which parameters to vary, never sure if you were headed in the right direction. You had to spend hours generating chromatograms, consuming samples and eluents while tying up your instrument and putting wear and tear on your pump, autosampler, and column.
Fast, risk-free optimization
The Virtual Column Separation Simulator eliminates the risks and hassles in optimizing IC separations by modeling their behavior in software, using known retention data and IC-specific retention algorithms. Specify the analytes you want to separate, choose the Thermo Scientific Dionex column and eluent system you want to model, and the Virtual Column Separation Simulator can find and display the optimal separation, together with a resolution map indicating the eluent concentration(s) required.
Based on the columns and conditions selected, you can view the predicted analyte separation (Chromeleon 7 CDS shown).
Easy answers to challenging questions
Want to shorten the run time, balance the separation of the peaks, or resolve a pair of difficult peaks? Simply click a command to find the conditions that will yield the fastest chromatogram with acceptable resolution, or the best spread of the peaks, or the best resolution of two specific peaks.
On the resolution response plot you can instantly gauge the effect of conditions on resolution (Chromeleon 7 shown).
Solutions to cover your application needs
The Virtual Column Separation Simulator models all of the most popular Dionex anion-exchange and cation-exchange columns, using retention data for hundreds of analytes—you don't spend any time "training" the software. Use the Virtual Column Separation Simulator in the Thermo Scientific Chromeleon Chromatography Data System (CDS) software’s powerful Application Wizard and generate the exact Control Program and Quantification method for your newly developed separation.
Develop gradient separations as easily as isocratic separations
Gradient separations can greatly increase the capability and performance of ion chromatography, but until recently, only experts were willing to try them. Now with a Virtual Column Complete license and Reagent-Free IC (RFIC) systems, everyone can take advantage of the power of gradient ion chromatography. A few minutes invested into modeling your application under gradient conditions could save you hundreds of hours per year.
Optimize separation of your specific analytes
When sulfite is added to the standard anions, it co-elutes with phosphate under standard separation conditions.
In just a few seconds, the Virtual Column simulator finds conditions that separate all analytes with baseline resolution.
Speed up your separations
Standard separation conditions for the Thermo Scientific Dionex IonPac AS15 column yield excellent resolution of standard anions and thiosulfate, but result in an analysis time of over 36 min.
On the resolution response plot you can instantly gauge the effect of conditions on resolution (Chromeleon 7 shown).
Isolate a specific peak of interest
Requirements
Workstation or client station with Chromeleon CDS, version 6.6 or higher. Gradient simulations requires Chromeleon CDS, version 6.7 or higher.
Columns
Anions: IonPac™ AS4A-SC, AS9-HC, AS10, AS11,AS11-HC, AS12A, AS14, AS14A, AS15, AS16, AS17, AS18, AS19, AS20, AS22, AS24 Cations: CS12A, CS16, CS17, CS18 Carbohydrates: CarboPac™ PA20
Methodologies (traditional and Reagent-Free™)
Anions: gradient hydroxide, isocratic hydroxide, isocratic carbonate/bicarbonate Cations: gradient methanesulfonic acid (MSA), isocratic MSA Carbohydrates: isocratic hydroxide
Optimization Criteria
Minimum resolution, normalized resolution product, optimize for specific analyte
Commands
Find fastest chromatogram, find global optimum, apply product test conditions.
User-Editable Peak Values
Area, asymmetry, theoretical plates
Additional Variables
Operating temperature, flow rate, void volume
Storage
An unlimited number of optimization projects can be saved, loaded, modified, and resaved.
Discover the fastest, easiest and most economical way to optimize IC separations using the IC Virtual Column Separation Simulator in the Thermo Scientific Chromeleon Chromatography Data System.
Why optimize IC the hard way?
Seeking the best column and separation conditions for an IC analysis used to be a gamble. You had to guess where to start and which parameters to vary, never sure if you were headed in the right direction. You had to spend hours generating chromatograms, consuming samples and eluents while tying up your instrument and putting wear and tear on your pump, autosampler, and column.
Fast, risk-free optimization
The Virtual Column Separation Simulator eliminates the risks and hassles in optimizing IC separations by modeling their behavior in software, using known retention data and IC-specific retention algorithms. Specify the analytes you want to separate, choose the Thermo Scientific Dionex column and eluent system you want to model, and the Virtual Column Separation Simulator can find and display the optimal separation, together with a resolution map indicating the eluent concentration(s) required.
Based on the columns and conditions selected, you can view the predicted analyte separation (Chromeleon 7 CDS shown).
Easy answers to challenging questions
Want to shorten the run time, balance the separation of the peaks, or resolve a pair of difficult peaks? Simply click a command to find the conditions that will yield the fastest chromatogram with acceptable resolution, or the best spread of the peaks, or the best resolution of two specific peaks.
On the resolution response plot you can instantly gauge the effect of conditions on resolution (Chromeleon 7 shown).
Solutions to cover your application needs
The Virtual Column Separation Simulator models all of the most popular Dionex anion-exchange and cation-exchange columns, using retention data for hundreds of analytes—you don't spend any time "training" the software. Use the Virtual Column Separation Simulator in the Thermo Scientific Chromeleon Chromatography Data System (CDS) software’s powerful Application Wizard and generate the exact Control Program and Quantification method for your newly developed separation.
Develop gradient separations as easily as isocratic separations
Gradient separations can greatly increase the capability and performance of ion chromatography, but until recently, only experts were willing to try them. Now with a Virtual Column Complete license and Reagent-Free IC (RFIC) systems, everyone can take advantage of the power of gradient ion chromatography. A few minutes invested into modeling your application under gradient conditions could save you hundreds of hours per year.
Optimize separation of your specific analytes
When sulfite is added to the standard anions, it co-elutes with phosphate under standard separation conditions.
In just a few seconds, the Virtual Column simulator finds conditions that separate all analytes with baseline resolution.
Speed up your separations
Standard separation conditions for the Thermo Scientific Dionex IonPac AS15 column yield excellent resolution of standard anions and thiosulfate, but result in an analysis time of over 36 min.
On the resolution response plot you can instantly gauge the effect of conditions on resolution (Chromeleon 7 shown).
Isolate a specific peak of interest
Requirements
Workstation or client station with Chromeleon CDS, version 6.6 or higher. Gradient simulations requires Chromeleon CDS, version 6.7 or higher.
Columns
Anions: IonPac™ AS4A-SC, AS9-HC, AS10, AS11,AS11-HC, AS12A, AS14, AS14A, AS15, AS16, AS17, AS18, AS19, AS20, AS22, AS24 Cations: CS12A, CS16, CS17, CS18 Carbohydrates: CarboPac™ PA20
Methodologies (traditional and Reagent-Free™)
Anions: gradient hydroxide, isocratic hydroxide, isocratic carbonate/bicarbonate Cations: gradient methanesulfonic acid (MSA), isocratic MSA Carbohydrates: isocratic hydroxide
Optimization Criteria
Minimum resolution, normalized resolution product, optimize for specific analyte
Commands
Find fastest chromatogram, find global optimum, apply product test conditions.
User-Editable Peak Values
Area, asymmetry, theoretical plates
Additional Variables
Operating temperature, flow rate, void volume
Storage
An unlimited number of optimization projects can be saved, loaded, modified, and resaved.
Resources
Webinars
- Getting It “Right First Time” Webinar Series (Part 1 of 5): Right First Time, Every Time
- Getting It "Right First Time" Webinar Series (Part 2 of 5): eWorkflows
- Getting It "Right First Time" Webinar Series (Part 3 of 5): Run-Time Ready Check and Smart Startup
- Getting It "Right First Time" Webinar Series (Part 4 of 5): Intelligent Run Control
- Getting It "Right First Time" Webinar Series (Part 5 of 5): Report Designer Pro
- Simply Intelligent: Chromatography Data System Software Goes Mass Spec
- Maximize Laboratory Productivity Using Streamlined Gas Chromatography Workflows that Automate Sample Preparation, Injection, and Data Acquisition
CMD SchemaApp code