Nalgene Rapid-Flow Filters | Thermo Fisher Scientific

Filtration is an integral piece of nearly every workflow of every lab. whether its cell culture, protein research, water testing, bioprocess design, or QC/QC testing of beverages – filtration will play a role in your lab’s daily routine. And Thermo Fisher Scientific has the tools you need.

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Rapid-Flow System Features

1. Printed with lot numbers for traceability

2. Easy to read graduations

3. Membranes up to 90mm for maximum flowrate and throughput

4. Color-coded by membrane

5. Featuring Nalgene's famous leak-proof seal

6. Ergonomic handgrips

Rapid-Flow Filter with PES Membrane

Available in the widest range of membranes:

Polyethersulfone (PES) is the most broadly applicable and best-performing membrane for most cell and tissue culture media. Features fast flow rates, low rates of clogging, and low protein binding. 0.2 μm is stem cell tested.
Surfactant free cellulose acetate (SFCA) contains no wetting agents found in regular cellulose acetate known to be toxic to certain cell lines. SFCA has low protein binding.
Nylon is tough and alcohol-resistant, and has a lower levels of extractables.
Cellulose nitrate (CN) is ideal for filtering and clarifying buffers and other aqueous solutions when protein binding is not a concern.

Available in the widest range of pore sizes:

0.1 µm protects against mycoplasma contamination
0.2 µm is considered sterilizing grade and removes all bacteria and larger microbes
0.45 µm and 0.8 µm for specialty applications, particle removal, and general clarification

Filtration Performance

Does laboratory filtration of culture media affect cell growth?

Laboratory filtration of culture media does not affect cell growth when the correct filter device and membrane are used.

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Does your choice in filtration device matter for overall performance?

Yes, you can increase efficiency in the time it takes to filter, enhance your speed with faster flow rates, and improve the stability of your media to save time in the lab by choosing the right filtration device.

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When evaluating extractables, less is more

The lower the extractables, the less chance of those compounds leaching into your filtered sample. Thermo Scientific Nalgene Rapid-Flow Receiver Bottles have lower extractables present compared to all other equivalent filtration devices. We source only virgin resins from high-quality suppliers to ensure consistency and quality. We also optimize our products and processes to avoid the use of various additives and slip agents whenever possible.

Image depicting the results from the Rapid-Flow filter unit receiver bottle compared to other equivalent receiver bottles. Results include the total organic carbon (TOC), absorbance, and metals analysis.

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High flow, low clogging membranes boost lab efficiency

The secret is in the support plate

In a study designed to look at the flow rates of the Thermo Scientific Nalgene Rapid-Flow Filter units, the column-based membrane support design had up to 38% faster flow rates than competitors using a radial spoke membrane support design.

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Performance on many levels

Testing shows that Rapid-Flow filters deliver superior performance

Nalgene Rapid-Flow Sterile Single Use Filter Units have a column-based membrane support plate.

The radial spoke design used by other suppliers can result in suboptimal flow rates.

Consistently consistent
All Nalgene filters now have the Rapid-Flow multi-column membrane-support system. This proprietary system provides a uniform, consistent separation between touchpoints with the membrane, minimizing gap stress to maintain optimal flow.

← Membrane

Mind the gaps
Other filters use a radial spoke support system. The gaps between spokes lack uniformity and consistency in membrane support, leading to increased stress and distortion. The result? Suboptimal flow rate and throughput.

← Membrane