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In this webinar, the speakers showcase where allele-specific DSA could easily be missed without running the LABScreen Single Antigen ExPlex panel. They also discuss cases where some “pan-reactive” antibodies expressing less common HLA alleles could be questioned or even dismissed as potentially false positives if high-resolution typing and expanded antibody testing are not performed.
Topics:
Robert Liwski, MD, PhD, FRCPC, A(ACHI)
Dalhousie University
Nova Scotia, Canada
Sandra Tafulo, PhD
Instituto Portugues de Sangue e da Transplantacao
Porto, Portugal
Dr. Rob Liwski is the Medical Director of the HLA Laboratory at the Queen Elizabeth II Health Sciences Centre and a Professor of Pathology at Dalhousie University in Halifax, Canada. He is also the Medical and Scientific Director of the HLA Laboratory at the Canadian Blood Services Head Office in Ottawa. Dr. Liwski serves on the American Society for Histocompatibility and Immunogenetics (ASHI) Board of Directors and is the Chair of the Canadian HLA Laboratory Proficiency Testing Committee, Co-chair of the ASHI Proficiency Testing Committee, and a consultant to the Brazilian Histocompatibility Association (ABH) Proficiency Testing Committee. His research interests include transplantation immunology and optimization of diagnostic testing in transplantation. Dr. Liwski has been an active member of the histocompatibility community, contributing articles to Human Immunology, ASHI Quarterly, and teaching topics in histocompatibility at several venues including ASHI Annual Meetings and Regional Workshops, APHIA Annual Meeting and Workshops, the Georgetown University Lecture Series, the American Foundation for Donation and Transplantation (AFDT) Histocompatibility Specialist Course, and the Brazilian Histocompatibility Association (ABH) Workshops.
Dr. Sandra Tafulo is currently a supervisor at the HLA allosensitization laboratory in Porto Blood and Transplantation Center, Oporto, Portugal and has recently been appointed as Coordinator of the newly formed Histocompatibility and Immunogenetic Group within the Portuguese Transplantation Society. Sandra completed an MSc degree in Molecular Genetics in 2006, an MSc degree in Clinical Analysis in 2012, and her Ph.D. degree in Biomedical Science from Oporto University in 2021. She also obtained the European Specialization in Histocompatibility and Immunogenetics (ESHI) in 2022, being a member of the European Board of Transplant Immunology (EBTI) since then. Sandra has been an active member of EFI, serving as an EFI Inspector since 2016, and is on the EFI External Proficiency Testing committee.
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