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The Thermo Scientific Orbitrap Astral mass spectrometer can help you rapidly and comprehensively capture the dynamic, temporal, and spatial complexity of biology but don’t just take our word for it. Discover what scientists in universities, hospitals and other research centers are saying about Orbitrap Astral MS.
In this on-demand webinar, Dr. Jesper V. Olsen of the University of Copenhagen will describe new methodologies and their application to biomedical research, including using narrow quadrupole isolation window data-independent acquisition (DIA) mode with short LC gradients.
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To accommodate larger sample groups, high throughput is essential. The Orbitrap Astral Mass Spectrometer achieves this by analyzing samples in just 8 minutes injection-to-injection, allowing acquisition of 180 samples per day. Each injection can identify 8,000+ proteins in a standard cell lysate sample, breaking through the bottleneck of sample analysis. This faster throughput enables the analysis of over 1.4 million cumulative protein group measurements across 180 samples in a single day, meaning a single Orbitrap Astral Mass Spectrometer can measure tens of thousands of samples in a year. This resets the scope of study scale, enhancing statistical power and revealing novel insights.
Hear from Jennifer Van Eyk, Ph.D., Professor at Cedars-Sinai Medical Center and Joshua Coon, Ph.D., Professor of Biomolecular Chemistry at the University of Wisconsin-Madison, as they share insights on the exceptional data generated at high throughput by the Orbitrap Astral mass spectrometer.
Due to the proteome's wide variability, both highly abundant and scarce proteins need measurement. The Orbitrap Astral Mass Spectrometer broadens this range, measuring proteins down to a level of just 200 copies per cell in bulk samples. For low-input samples, like single-cell proteomics, this instrument offers twice the throughput without sacrificing sensitivity, resulting in increased coverage and the analysis of more single-cells per day. These capabilities help decipher the heterogeneity of single cells to provide meaningful biological information.
Traditionally, achieving a comprehensive understanding of the entire proteome has been challenging. Cutting-edge methods can analyze roughly 12,000 proteins, but this demands extensive sample processing, multiple enzymes, and more than a day of LC-MS analysis time. Enter the Orbitrap Astral Mass Spectrometer, which swiftly achieves a proteome depth of over 12,000 proteins in just an hour from a single human cell lysate sample. Through multi-shot techniques, it reaches nearly whole proteome coverage of 15,000 proteins in 4.5 hours. The era of whole proteome sequencing has arrived.
Hear from Dr. Jesper V. Olsen of the University of Copenhagen and Sophia Steigerwald, Ph.D. Student at the Max Planck Institute of Biochemistry as they share insights on the deep whole proteome coverage of the Orbitrap Astral Mass Spectrometer.
Actionable insights require precise quantitative measurements, especially for complex biological processes. While some changes are clear cut, most involve subtle alterations in biomarkers like their levels, localization, or structure due to factors like modifications or interactions. The Orbitrap Astral Mass Spectrometer offers faster and more thorough analysis with heightened sensitivity. It generates high-quality data for accurate quantitation, boosting confidence in results. This is achieved through label-free quantitation (LFQ) or advanced methods like isobaric labeling with Tandem Mass Tags (TMT), ensuring meaningful outcomes in experiments.
Hear from Mike MacCoss, Ph.D., Professor of Genome Sciences at the University of Washington, and Qing Yu, Research Associate at Harvard Medical School, as they discuss how the uniquely precise quantitation of the Orbitrap Astral Mass Spectrometer has benefitted their research.
Rethink what is possible. Novel technology to advance your research capabilities. Learn what makes the Orbitrap Astral Mass Spectrometer different.
The Orbitrap Astral Mass Spectrometer empowers new possibilities across an extensive set of applications. Learn more about some of these new capabilities.
The Orbitrap Astral Mass Spectrometer is ideally suited for accurate and precise quantitation at an unprecedented depth of coverage and throughput for samples from single cells to body fluids to bulk tissues.