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Overview
Comprehensive solutions for characterization, confirmation, and monitoring of your vaccine
Thermo Fisher Scientific is your trusted partner to help ensure your vaccine quality with speed at every stage of the development process – from discovery to commercial production – so that you can go to market quickly and confidently.
Use our proven portfolio of comprehensive analytical solutions for characterization, confirmation, and monitoring—whether you are working on a whole inactivated, live attenuated, protein based, virus-like particle (VLP), mRNA, viral vector, or non-viral vector DNA vaccines. The analytical approaches for different types of vaccines are provided in these pages.
Vaccine characterization
Key Thermo Scientific products for vaccine characterization
Biomolecule separations | HPLC Systems | Charge Aerosol Detection | IC Systems | Mass Spectrometry | Chromatography Data Systems |
|---|---|---|---|---|---|
 BioLC Columns |
|  Ion Chromatography (IC) Systems |  Orbitrap Exploris Mass Spectrometer |  Chromeleon 7.3 CDS |
Analytical support for your vaccine characterization
Characterize the full diversity of your vaccine biomolecules
Get high resolution, high efficiency separation of your vaccine associated biological samples. Our unique column chemistries for biological samples have been specifically designed for the separation of proteins, peptides, monoclonal antibodies, carbohydrates, nucleic acids, and more.
Accelerate your vaccine development with confidence
Thermo Scientific Vanquish HPLC and UHPLC systems are the most advanced liquid chromatography instruments available. The Vanquish LC platform improves performance, repeatability, and dependability with no trade-offs in quality or ease-of-use. Vanquish LC systems provide the versatility to solve the toughest vaccine analytics challenges.
Ensuring the safety of your final vaccine products
A highly flexible Thermo Scientific Dionex ion chromatography (IC) system provides customers with the freedom to develop, explore, and run different methods simultaneously. Utilizing unique IC technologies with unparalleled robustness and capabilities, one can accurately identify and monitor formulation and process residual components and ensure appropriate adjuvant concentrations, with ease.
Universal detection and quantification for non-chromophore containing adjuvants and formulations
Utilize the increased separation speed and resolution of the Thermo Scientific Vanquish UHPLC system with charged aerosol detection (CAD). CAD can detect and quantify virtually any substance with enhanced linear dynamic range and accurate, consistent response. Measure low-level impurities and active pharmaceutical ingredients (APIs) simultaneously, as well as other compounds, regardless of chemical structure using CAD.
Comprehensive vaccine characterization
Thermo Scientific Orbitrap Exploris mass spectrometry system is quantitative high-resolution, accurate-mass (HRAM) liquid chromatography mass spectrometry (LC-MS) with record-setting performance for your next-generation of vaccine products. Extraordinary power is now available in an expanded portfolio to meet your exact analytical requirements, deliver comprehensive characterization of your most advanced vaccine drug products, and accelerate their development.
The Expanding Role of Mass Spectrometry in the Field of Vaccine Development
Track everything, simplify compliance, and boost productivity
Achieve productivity and compliance with one software platform. As an integral part of your laboratory's IT structure, the latest Thermo Scientific Chromeleon 7.3 Chromatography Data System (CDS) is vital for compliant, efficient, and reliable handling of today’s chromatography and mass spectrometry data. It ensures data quality and manages all the analytical processes from instrument control, to raw data storage and processing, to generating the final results.
Characterize the full diversity of your vaccine biomolecules
Get high resolution, high efficiency separation of your vaccine associated biological samples. Our unique column chemistries for biological samples have been specifically designed for the separation of proteins, peptides, monoclonal antibodies, carbohydrates, nucleic acids, and more.
Accelerate your vaccine development with confidence
Thermo Scientific Vanquish HPLC and UHPLC systems are the most advanced liquid chromatography instruments available. The Vanquish LC platform improves performance, repeatability, and dependability with no trade-offs in quality or ease-of-use. Vanquish LC systems provide the versatility to solve the toughest vaccine analytics challenges.
Ensuring the safety of your final vaccine products
A highly flexible Thermo Scientific Dionex ion chromatography (IC) system provides customers with the freedom to develop, explore, and run different methods simultaneously. Utilizing unique IC technologies with unparalleled robustness and capabilities, one can accurately identify and monitor formulation and process residual components and ensure appropriate adjuvant concentrations, with ease.
Universal detection and quantification for non-chromophore containing adjuvants and formulations
Utilize the increased separation speed and resolution of the Thermo Scientific Vanquish UHPLC system with charged aerosol detection (CAD). CAD can detect and quantify virtually any substance with enhanced linear dynamic range and accurate, consistent response. Measure low-level impurities and active pharmaceutical ingredients (APIs) simultaneously, as well as other compounds, regardless of chemical structure using CAD.
Comprehensive vaccine characterization
Thermo Scientific Orbitrap Exploris mass spectrometry system is quantitative high-resolution, accurate-mass (HRAM) liquid chromatography mass spectrometry (LC-MS) with record-setting performance for your next-generation of vaccine products. Extraordinary power is now available in an expanded portfolio to meet your exact analytical requirements, deliver comprehensive characterization of your most advanced vaccine drug products, and accelerate their development.
The Expanding Role of Mass Spectrometry in the Field of Vaccine Development
Track everything, simplify compliance, and boost productivity
Achieve productivity and compliance with one software platform. As an integral part of your laboratory's IT structure, the latest Thermo Scientific Chromeleon 7.3 Chromatography Data System (CDS) is vital for compliant, efficient, and reliable handling of today’s chromatography and mass spectrometry data. It ensures data quality and manages all the analytical processes from instrument control, to raw data storage and processing, to generating the final results.
Analytical workflows for your vaccine
Select the type of vaccine below to review the recommended analytical workflows for your vaccine.
Protein Vaccines
- Robust Charge Variant Profiling
- Glycan Profiling
- Intact Glycoform Analysis
- Glycopeptide Workflow
- Peptide Mapping
- Residual Host Cell Protein Analysis (HCPs)
- Peptide Mapping for QC/Lot release
- Release Glycan Monitoring
mRNA Vaccines
Template, dsRNA
- Host Cell Material
- mRNA Vaccine Identity Analysis
- Nucleic acid mapping
Vector Vaccines
- Impurity Analysis
Non-viral Vector DNA Vaccines:
- Impurity Analysis
Formulations & Residuals
Process Residuals Analysis
Adjuvant
Excipients
- Buffer
- Salts
- Surfactants
- Stabilizers
Resources
The expanding role of mass spectrometry in the field of vaccine development
Profiling the HLA-II immunopeptidome of SARS-CoV-2 spike glycoprotein by mass spectrometry
Characterization of lipid nanoparticle (LNP) composition using UHPLC-CAD
Characterization and quantification of lipid nanoparticle components and their impurities/degradants using an LC-HRAM MS platform
Sign up to attend workshops of interest
- BioPharma Finder software for characterization of protein and oligonucleotide biotherapeutics
- BioPharma Finder software for in-depth protein characterization, intact mass analysis, peptide mapping, and new host cell protein workflow
- BioPharma Finder software for in-depth oligonucleotide characterization with intact mass analysis, oligonucleotide analysis, and mRNA mapping
- GlycanExplorer software for high throughput biotherapeutic glycan characterization
- Proteome Discoverer software for increasing proteoform level insight with quantitative top-down proteomics
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Style Sheet for Global Design System
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