A pyramidal neuron from rat hippocampus was first exposed to Alzheimer’s ß-amyloid peptide and then to the excitatory amino acid glutamate.

A pyramidal neuron from rat hippocampus was first exposed to Alzheimer’s ß-amyloid peptide and then to the excitatory amino acid glutamate. Confocal laser-scanning microscopy imaging using the intracellular Ca2+ indicator fluo-3 (Cat. no. F1241, F1242, F14218, F14242, F23915) shows that ß-amyloid peptide destabilizes the neuron’s calcium homeostasis and increases its vulnerability to excitotoxicity. The image was contributed by Mark P. Mattson, Sanders-Brown Center on Aging, University of Kentucky.

A pyramidal neuron from rat hippocampus was first exposed to Alzheimer’s ß-amyloid peptide and then to the excitatory amino acid glutamate. Confocal laser-scanning microscopy imaging using the intracellular Ca2+ indicator fluo-3 (Cat. no. F1241, F1242, F14218, F14242, F23915) shows that ß-amyloid peptide destabilizes the neuron’s calcium homeostasis and increases its vulnerability to excitotoxicity. The image was contributed by Mark P. Mattson, Sanders-Brown Center on Aging, University of Kentucky.

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