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Manufacture of cell therapies is varied, complex, and expensive. Transitioning from open systems to closed systems reduces the risk of contamination or human error and can increase manufacturing efficiencies, boosting the likelihood of clinical and commercial manufacturing success while also reducing the need for costly Class A clean room use.
To meet this trend in the field and help you scale and close your process, many of our Gibco CTS reagents are now offered in a BioProcess Container format suitable for a closed system workflow.We know that maintaining flexibility throughout your manufacturing workflow is critical in the development process, so we designed our bioprocess containers to be versatile with the option of aseptic integration into your workflow through sterile welding, Luer-Lock connections, or via a universal MPC quick-connect.
Your workflow is worth it; end the expensive, risky, and time-consuming manual transfer of media and reagents from bottles to bags.
See Gibco Cell Therapy Systems media and reagents that are not in bioprocess containers ›
The Gibco CTS reagents you trust are now available in a flexible BioProcess Container (BPC) format suitable for connection into closed systems.
Line 1 | Line 2 | Line 3 | ||
---|---|---|---|---|
Utility | Not intended for customer use. Fill line used during product manufacture | Larger diameter tubing to accommodate faster flow rate applications (e.g., media transfer) | Smaller diameter tubing composed of two segments that give customers flexibility | |
Connectors | Tubing is sealed | MPC quick connect | Septum port OR Female luer lock | |
Tubing material | EVA Ethyl vinyl acetate | C-Flex | Medical grade PVC, DEHP free OR C-Flex | |
Welding compatible | Not intended for customer use | General sterile welding 18 inches of C-Flex | Sterile welding Rotea compatible 12 inches of PVC | General sterile welding 12 inches of C-Flex |
Tubing dimensions | Not intended for customer use | 1⁄4 inch inner diameter | 3⁄32 inch inner diameter | 1⁄8 inch inner diameter |
3⁄32 inch wall thickness | 1⁄32 inch wall thickness | 1⁄16 inch wall thickness |
Gibco CTS AIM V Medium is a fully defined serum-free formulation for proliferation and/or manipulation of T cells, dendritic cells, and other primary or immortalized cells. It contains L-glutamine and is formulated with or without phenol red and antibiotics, making it ideal for research or manufacturing. Gibco CTS AIM-V Medium, without phenol red, without antibiotics, is now accessible with flexibility to sterile weld or aseptically connect to closed systems in a fill volume relevant for autologous and small-scale allogeneic CGT manufacturing.
*Other aspects of USP <1043> will be the responsibility of the end-user to assess. Thermo Fisher Scientific cannot fulfill USP <1043> in regards to application and therapy-specific aspects (e.g., residual assessment and removal of the AM).
Gibco CTS NK-Xpander Medium is an animal origin-free, GMP-manufactured medium designed to proliferate a high yield of functional human NK cells to address the needs of translational and clinical cell therapy researchers with or without the use of feeder cells. The 5 L BPC can be sterile welded or aseptically connected to closed systems in a fill volume relevant for autologous NK cell therapy manufacturing.
Gibco Cell Therapy Systems CTS DPBS is the classical Dulbecco’s Phosphate Buffered Saline not containing calcium, magnesium, or phenol red. Gibco CTS DPBS, without calcium chloride, without magnesium chloride is now accessible with flexibility to sterile weld or aseptically connect to closed systems in a fill volume relevant for autologous and small-scale allogeneic CGT manufacturing.
Gibco Cell Therapy Systems CTS DPBS, the classical Dulbecco’s Phosphate Buffered Saline containing calcium and magnesium chloride is now available in both a bottle or a flexible BioProcess Container (BPC) suitable for use with closed-system instruments.
Line 1 | Line 2 | ||
---|---|---|---|
Utility | Not intended for customer use Fill line used during product manufacture | Evacuation line for media transfer | |
Connectors | Tubing is sealed | Septum port | Female luer lock |
Tubing material | EVA Ethyl vinyl acetate | C-Flex | |
Welding compatible | Not intended for customer use | ||
General sterile welding 12 inches of C-Flex | |||
Tubing dimensions | Not intended for customer use | 1⁄8 inch inner diameter | |
1⁄16 inch wall thickness |
Gibco CTS OpTmizer Pro SFM, bag format is a novel serum-free medium (SFM) without phenol red developed for the growth and expansion of human T lymphocytes (e.g., CD4+, CD8+, polyclonal cells, or antigen-specific T cells) used in allogeneic cell therapies. The medium maintains central memory T cells further into expansion, which is well suited for longer workflows (>15 days). The result is a larger population of central memory T cells in a shorter period of time.
CTS Immune Cell Serum Replacement (SR) is designed to support expansion of in vitro cultured human immune cells such as T cells. A defined xeno-free formulation proven for clinical use and designed to support expansion of in vitro cultured human T cells when added as a supplement to a basal cell culture medium such as Gibco CTS OpTmizer T Cell Expansion SFM or AIM V Medium.
ICSR also available in 1L format, Large Volume Configuration B
Gibco CTS GlutaMAX supplement is an animal origin–free (AOF) dipeptide alternative to L-glutamine, with increased stability that improves cell health. CTS GlutaMAX supplement can be used as a direct substitute for L-glutamine at equimolar concentrations in mammalian and stem cell culture with minimal or no adaptation.
Gibco CTS TrypLE Select Enzyme, is a recombinant enzyme capable of dissociating a wide range of adherent mammalian cells. CTS TrypLE Select Enzyme is derived from microbial fermentation and provides an animal origin–free (AOF) alternative for porcine trypsin.
Line 1 | Line 2 | Line 3 | |
---|---|---|---|
Utility | Not intended for customer use Fill line used during product manufacture | Larger diameter tubing to accommodate faster flow rate applications (e.g. media transfer) | Smaller diameter tubing for standard use |
Connectors | Tubing is sealed and capped during final product fill/finish | MPC quick connect | Septum port Syringe can be used to sample from or inject into the BPC OR Female luer lock Simple twist-lock connection Used to join tubing, sample from, or supplement the BPC |
Tubing material | EVA Ethyl vinyl acetate | 374 C-Flex | 374 C-Flex |
Welding compatible | Not intended for customer use | Sterile welding supported | |
Sterile welding supported | |||
Tubing dimensions | Not intended for customer use | 1⁄4 inch inner diameter 3⁄32 inch wall thickness | 1⁄8 inch inner diameter |
CTS Immune Cell Serum Replacement (SR) is designed to support expansion of in vitro cultured human immune cells such as T cells. A defined xeno-free formulation proven for clinical use and designed to support expansion of in vitro cultured human T cells when added as a supplement to a basal cell culture medium such as Gibco CTS OpTmizer T Cell Expansion SFM or AIM V Medium.
ICSR also available in 250 mL format, Small Volume Configuration
For Research Use or Manufacturing of Cell, Gene, or Tissue-Based Products. CAUTION: Not intended for direct administration into humans or animals.