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In vitro assays and screening technologies
At Life Technologies we have developed two pre-configured fluorescent assay solutions to address HTS, hit confirmation and lead optimization programs for nuclear receptor targets.
The core assay formats we have developed are:
View the table below for a complete list of the biochemical assays offered for your nuclear receptor research.
If you do not see the target or assay format of your choice please contact us.
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Target | Alias(es) | Accession number | PolarScreen™ Nuclear Receptor Competitor Assay (Fluorescent Polarization) | LanthaScreen® Competitive Binding Assay (TR-FRET)* | LanthaScreen® Coactivator Assay (TR-FRET)* |
---|---|---|---|---|---|
Androgen receptor | AR, NR3C4 | NP_036634 | A15878 | ||
Constitutive androstane receptor | CAR, NR1I3 | NP_005113.1 | PV4836 | ||
Estrogen receptor alpha | ER Alpha, ERA, ESR1, NR3A1 | NP_000116.2 | A15887 | A15885 | |
Estrogen receptor beta | ER Beta, ERB, ESR2, NR3A2 | NP_001428.1 | A15895 | A15893 | |
Estrogen-related receptor alpha | ERR Alpha, ERR1, ESRRA, ESRL1, NR3B1 | NP_004442.2 | PV4663 | ||
Estrogen-related receptor beta | ERR Beta, ERR2,ESRRB, NR3B2 | NP_004443.2 | PV4800 | ||
Estrogen-related receptor gamma | ERR Gamma, ERR3, ESRRG, NR3B3 | NP_001429 | PV4408 | ||
Farnesoid X receptor | FXR,NR1H4 | NP_005114.1 | PV4833 | ||
Glucocorticoid receptor | GR, GCCR, GCR, NR3C1 | NP_000167 | A15901 | A15899 | |
Liver X receptor alpha | LXR Alpha, LXRA, NR1H3 | NP_005684 | PV4655 | ||
Liver X receptor beta | LXR Beta, LXRB, NR1H2 | NP_009052 | PV4658 | ||
Peroxisome proliferator-activated receptor alpha | PPAR Alpha, PPARA, NR1C1 | NP_005027 | PV4892 | PV4684 | |
Peroxisome proliferator-activated receptor delta | PPAR Delta, PPARD, NR1C2 | NP_006229 | PV4893 | PV4685 | |
Peroxisome proliferator-activated receptor gamma | PPAR Gamma, PPARG, NR1C3 | NP_005028 | PV6136 -Green | PV4894 | PV4548 |
Pregnane X receptor | PXR(SXR), NR1I2 | NP_003880.3 | PV4839 | ||
Progesterone receptor | PR, PGR, NR3C3 | NP_000917.2 | A15903 | ||
Retinoic acid receptor alpha | RAR Alpha, RARA, NR1B1 | NP_000955 | PV4409 | ||
Retinoic acid receptor beta | RAR Beta, RARB, NR1B2 | NP_000956 | PV4688 | ||
Retinoic acid receptor gamma | RAR Gamma, RARG,NR1B3 | NP_000957 | PV4411 | ||
Retinoid-related Orphan Receptor alpha | ROR Alpha, RORA, NR1F1 | NP_599023.1 | PV5889 | ||
Retinoid X receptor alpha | RXR Alpha, RXRA, NR2B1 | NP_002948.1 | PV4797 | ||
Retinoid X receptor beta | RXR Beta, RXRB, NR2B2 | NP_068811 | PV4385 | ||
Thyroid receptor alpha | TR Alpha, THRA, NR1A1 | NP_955366.1 | PV4687 | ||
Thyroid receptor beta | TR Beta, THRB, T3RB, NR1A2 | NP_000452.2 | PV4686 | ||
Vitamin D3 receptor | VDR, NR1I1 | NP_000367 | PV4554 |
* Other LanthaScreen® Fluorescent Coregulator Peptides are available for your development of additional coactivator or corepressor assays.
For Research Use Only. Not for use in diagnostic procedures.