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Thermo Fisher Scientific offers a comprehensive CaptureSelect portfolio of biotinylated,HRP and Alexa Fluor conjugated ligands targeting:
The conjugated ligands are available for a variety of analytical assays. The affinity ligand is conjugated to biotin, HRP, or AlexaFluors through a spacer that maintains binding reactivity when immobilized on streptavidin surfaces or used for fluorescent detection.
CaptureSelect conjugated ligands are versatile tools suitable for various applications, including discovery and screening, detection, quantitation, and other product or process analytics. They can be used in:
For examples, protocols, and publications highlighting the conjugated ligands, download the application guide or watch the webinar on the versatility of single domain antibody technology.
Figure 1. Representation of a CaptureSelect biotinylated ligand bound to its target protein. Biotin molecules are chemically linked to the affinity ligand with a spacer, enabling immobilization on streptavidin surfaces.
You can find more detailed information on the selectivity and use of these products in the application guide or by viewing the specific product pages linked below.
CaptureSelect ligand | Biotin | Biotin |
100 µg | 500 µg | |
Anti-IgG-Fc (human) | 7103262100 | 7103262500 |
Anti-IgG-CH1 | 7103202100 | 7103202500 |
Anti-LC-Kappa(human) | 7103272100 | 7103272500 |
Anti-LC-Lambda(human) | 7103082100 | 7103082500 |
Anti-Free LC-Kappa(human) | 7103292100 | 7103292500 |
Anti-IgG3 | 7103042100 | 7103042500 |
Anti-IgG4 | 7102902100 | 7102902500 |
Anti-IgA | 7102882100 | 7102882500 |
Anti-IgM | 7102892100 | 7102892500 |
Anti-IgE | 7103542100 | 7103542500 |
Anti-IgG-FC(multi-species) | 7102852100 | 7102852500 |
Anti-LC-Kappa(murine) | 7103152100 | 7103152500 |
Anti-LC-Lambda(mouse) | 7103232100 | 7103232500 |
Anti-IgG-FC (Rabbit) | 7103642100 | 7103642500 |
CaptureSelect ligand | Biotin | Biotin |
100 µg | 500 µg | |
Anti-Factor VII | 7102992100 | 7102992500 |
Anti-Factor VIII | 7102862100 | 7102862500 |
Anti-Factor IX | 7103002100 | 7103002500 |
Anti-Factor X | 7103702100 | 7103702500 |
Anti-AAT | 7102872100 | 7102872500 |
Anti-Fibrinogen | 7102912100 | 7102912500 |
Anti-HSA | 7102972100 | 7102972100 |
Anti-Transferrin | 7103062100 | 7103062500 |
Anti-HGH | 7103160100 | 7103160500 |
Anti-FSH | 7103180100 | 7103180500 |
Anti-Prothrombin | 7103452100 | 7103452500 |
Anti-EPO | 7103372100 | 7103372500 |
Anti-C1-Inhibitor | 7103402100 | 7103402500 |
Anti-Gonadotropin | 7103412100 | 7103412500 |
Recombinant protein detection and quantitation using C-tag and CaptureSelect conjugated ligands for viral vectors
CaptureSelect Ligand | Anti-C-tag | Anti-AAVX | Anti-AAV8 | Anti-AAV9 | Anti-AdV5 | |
Biotin | 100 µg | 7103252100 | 7103522100 | 7103382100 | 7103332100 | 7103532100 |
Biotin | 500 µg | 7103252500 | 7103522500 | 7103382500 | 7103332500 | 7103532500 |
HRP | 100 µg | 7303072100 | - | - | - | - |
HRP | 100 µL | - | 7303522100 | - | 7303332100 | - |
HRP | 500 µL | - | 7303522500 | - | 7303332500 | - |
Alexa Fluor 488 | - | 7213252100 | - | - | - | - |
Alexa Fluor 647 | 100 µg | - | 7233522100 | - | 7233322100 | - |
CaptureSelect ligand | Biotin | Biotin |
100 µg | 500 µg | |
Anti-IgG-FC PK | 7103322100 | 7103322500 |
Anti-Human Fab-Kappa Kinetics | 7103302100 | 7103302500 |
Anti-Human Fab-Lambda Kinetics | 7103312100 | 7103312500 |
CaptureSelect ligand | Biotin | Biotin | HRP | HRP |
100 µg | 500 µg | 100 µL | 500 µL | |
Anti-CD81 | 7103982100 | 7103982500 | 7303982100 | 7303982500 |
Anti-CD63 | 7103992100 | 7103992500 | 7303992100 | 7303992500 |
Anti-CD9 | 7104002100 | 7104002500 | 7304002100 | 7304002500 |
CaptureSelect ligand | Biotin | Biotin |
100 µg | 500 µg | |
Anti-IgG-Fc (human) | 7103262100 | 7103262500 |
Anti-IgG-CH1 | 7103202100 | 7103202500 |
Anti-LC-Kappa(human) | 7103272100 | 7103272500 |
Anti-LC-Lambda(human) | 7103082100 | 7103082500 |
Anti-Free LC-Kappa(human) | 7103292100 | 7103292500 |
Anti-IgG3 | 7103042100 | 7103042500 |
Anti-IgG4 | 7102902100 | 7102902500 |
Anti-IgA | 7102882100 | 7102882500 |
Anti-IgM | 7102892100 | 7102892500 |
Anti-IgE | 7103542100 | 7103542500 |
Anti-IgG-FC(multi-species) | 7102852100 | 7102852500 |
Anti-LC-Kappa(murine) | 7103152100 | 7103152500 |
Anti-LC-Lambda(mouse) | 7103232100 | 7103232500 |
Anti-IgG-FC (Rabbit) | 7103642100 | 7103642500 |
CaptureSelect ligand | Biotin | Biotin |
100 µg | 500 µg | |
Anti-Factor VII | 7102992100 | 7102992500 |
Anti-Factor VIII | 7102862100 | 7102862500 |
Anti-Factor IX | 7103002100 | 7103002500 |
Anti-Factor X | 7103702100 | 7103702500 |
Anti-AAT | 7102872100 | 7102872500 |
Anti-Fibrinogen | 7102912100 | 7102912500 |
Anti-HSA | 7102972100 | 7102972100 |
Anti-Transferrin | 7103062100 | 7103062500 |
Anti-HGH | 7103160100 | 7103160500 |
Anti-FSH | 7103180100 | 7103180500 |
Anti-Prothrombin | 7103452100 | 7103452500 |
Anti-EPO | 7103372100 | 7103372500 |
Anti-C1-Inhibitor | 7103402100 | 7103402500 |
Anti-Gonadotropin | 7103412100 | 7103412500 |
Recombinant protein detection and quantitation using C-tag and CaptureSelect conjugated ligands for viral vectors
CaptureSelect Ligand | Anti-C-tag | Anti-AAVX | Anti-AAV8 | Anti-AAV9 | Anti-AdV5 | |
Biotin | 100 µg | 7103252100 | 7103522100 | 7103382100 | 7103332100 | 7103532100 |
Biotin | 500 µg | 7103252500 | 7103522500 | 7103382500 | 7103332500 | 7103532500 |
HRP | 100 µg | 7303072100 | - | - | - | - |
HRP | 100 µL | - | 7303522100 | - | 7303332100 | - |
HRP | 500 µL | - | 7303522500 | - | 7303332500 | - |
Alexa Fluor 488 | - | 7213252100 | - | - | - | - |
Alexa Fluor 647 | 100 µg | - | 7233522100 | - | 7233322100 | - |
CaptureSelect ligand | Biotin | Biotin |
100 µg | 500 µg | |
Anti-IgG-FC PK | 7103322100 | 7103322500 |
Anti-Human Fab-Kappa Kinetics | 7103302100 | 7103302500 |
Anti-Human Fab-Lambda Kinetics | 7103312100 | 7103312500 |
CaptureSelect ligand | Biotin | Biotin | HRP | HRP |
100 µg | 500 µg | 100 µL | 500 µL | |
Anti-CD81 | 7103982100 | 7103982500 | 7303982100 | 7303982500 |
Anti-CD63 | 7103992100 | 7103992500 | 7303992100 | 7303992500 |
Anti-CD9 | 7104002100 | 7104002500 | 7304002100 | 7304002500 |
Review our list of biotinylated ligands directed against antibodies and related derivatives. Find more detailed information on selectivity and use of these products in the product information sheets available for download on the specific product pages:
Binds human IgG and all Fab fragments thereof, through recognition of the CH1 domain on all four human IgG subclasses. | |
Binds human IgG, through recognition of the Fc region (CH3 domain) on all four human IgG subclasses. | |
Binds IgG through recognition of the Fc region on IgG of multiple species. View product sheet for species coverage. | |
Biotin Anti-IgG-Fc (Rabbit) | Binds to rabbit IgG (immunoglobulin G) from recombinant and plasma sources. The ligand shows no cross-binding to bovine, horse, sheep, goat, mouse, rat, and human IgG. Moderate cross-binding was observed towards swine IgG. |
Binds human IgA, IgA-dimers and secretory IgA (sIgA), through recognition of the Fc region on both human IgA subclasses. | |
Binds human, mouse and rat IgM. | |
Biotin Anti-IgE | binds to human IgE (immunoglobulin E) from recombinant and plasma sources, through recognition of the Fc region (CH4 domain) |
Binds all human lambda light chains (LC), through recognition of the constant domain (CL-lambda) on any human antibody, Fab fragment or free light chain. | |
Binds all human kappa light chains (LC), through recognition of the constant domain (CL-kappa) on any human antibody, Fab fragment or free light chain. | |
Binds all mouse - and rat kappa light chains (LC), through recognition of the constant domain (CL-kappa) on any mouse and rat antibody, Fab fragment or free light chain. | |
Biotin Anti-LC-lambda (Mouse) | Binds all mouse lambda light chains (LC), through recognition of the constant domain (CL-lambda) on any mouse antibody, Fab fragment or free light chain |
Biotin Anti-LC-lambda (Rat) | Binds all rat lambda light chains (LC), through recognition of the constant domain (CL-lambda) on any rat antibody, Fab fragment or free light chain |
Binds human IgG3 without any cross-binding to other human IgG subclasses or antibody isotypes. | |
Binds human IgG4 without any cross-binding to other human IgG subclasses or antibody isotypes. | |
High affinity capture of human IgG Fab fragments that possess a kappa light chain. Extreme low off-rates are achieved through avidity by targeting the CL-kappa domain of the Fab (light chain) and its IgG CH1 domain (heavy chain) simultaneously, thereby enabling Fab screening on target binding kinetics. | |
High affinity capture of human IgG Fab fragments that possess a lambda light chain. Extreme low off-rates are achieved through avidity by targeting the CL-lambda domain of the Fab (light chain) and its IgG CH1 domain (heavy chain) simultaneously, thereby enabling Fab screening on target binding kinetics. | |
Binds highly selective to free human kappa light chains and dimers thereof, through recognition of an epitope on the human CL-kappa domain that is masked in intact antibodies and Fab fragments, thereby providing a unique tool for specific detection and quantitation of free kappa light chains in (crude) antibody preps. | |
Binds highly selective to human IgG, through recognition of the Fc region on all four human IgG subclasses without cross-binding to mouse, rat, rhesus and cynomolgus monkey IgG, thereby making it extremely suitable for setting up pharmacokinetics (PK) assays. |
Review our list of biotinylated ligands directed against different proteins and virus particles. Find more detailed information on selectivity and use of these products in the product information sheets available for download on the specific product pages:
Binds the short C-tag sequence E-P-E-A (glutamic acid - proline - glutamic acid – alanine) when this affinity tag is fused at the C-terminus of a target protein. | |
Binds the short C-tag sequence E-P-E-A (glutamic acid - proline - glutamic acid – alanine) when this affinity tag is fused at the C-terminus of a target protein. | |
Biotin Anti-FX | Binds to human Factor X and its activated form Factor Xa from plasma and recombinant sources |
Binds recombinant as well as plasma derived human Factor IX (FIX) | |
Binds recombinant (full length and B-domain deleted) as well as plasma derived human Factor VIII (FVIII), through recognition of the FVIII light chain. | |
Biotin anti-FVII | Binds recombinant as well as plasma derived human Factor VII (FVII) |
Biotin Anti-Gonadotropin | Binds to the alpha chain of recombinant as well as natural sourced hCG (human chorionic gonadotropin), LH (luteinizing hormone), TSH (Thyroid-stimulating hormone) and FSH (follicle-stimulating hormone) |
Biotin Anti-Human Albumin | Binds recombinant as well as natural sourced human serum albumin (HSA) including HSA-fusion proteins |
Biotin Anti-AAT | Binds recombinant as well as natural sourced human α1-Antitrypsin (AAT) |
Biotin Anti-C1-Inhibitor | Binds recombinant as well as natural sourced human C1-Inhibitor (C1-inh, C1 esterase inhibitor) |
Biotin Anti-Fibrinogen | Binds recombinant as well as natural sourced human Fibrinogen (coagulation factor I, FI) |
Biotin Anti-Transferrin | Binds recombinant as well as natural sourced human Transferrin |
Biotin Anti-α1-Acid Glycoprotein | Binds recombinant as well as natural sourced human α1-Acid Glycoprotein (AGP) or Orosomucoid (ORM) |
Biotin Anti-Haptoglobin | Binds recombinant as well as natural sourced human Haptoglobin (Hp) |
Biotin Anti-C3 | Binds recombinant as well as natural sourced human Complement Component 3 (C3) |
Biotin Anti-vWF | Binds recombinant as well as natural sourced human von Willebrand Factor (vWF) |
Biotin Anti-ApoA1 | Binds recombinant as well as natural sourced human Apolipoprotein A1 (ApoA1) |
Biotin Anti-α2-Macroglobulin | Binds recombinant as well as natural sourced human α2-Macroglobulin (A2M) |
Biotin Anti-Antithrombin III | Binds recombinant as well as natural sourced human Antithrombin III (ATIII) |
Biotin Anti-Prothrombin | Binds recombinant as well as natural sourced human Prothrombin (coagulation factor II, FII) |
Binds recombinant as well as natural sourced human Growth Hormone (hGH). | |
Binds recombinant as well as natural sourced human Granulocyte-Colony Stimulating Factor (G-CSF) | |
Binds recombinant as well as natural sourced human Follicle Stimulating Hormone (FSH), through recognition of an epitope specific for intact FSH only. | |
Biotin Anti-Insulin | Binds recombinant and natural-sourced human insulin and shows similar binding reactivity towards porcine- and bovine-sourced insulin. It also binds to human proinsulin, the precursor of insulin that still contains the C-peptide. |
Biotin Anti-EPO | Binds recombinant and natural-sourced human Erythropoietin (EPO). |
Biotin anti-AAV8 | Binds with high affinity to Adeno-associated virus particles of serotype 8 (AAV8). Note that it may cross-bind towards other AAV serotypes. |
Biotin anti-AAV9 | Binds with high affinity and selectivity to Adeno-associated virus particles of serotype 9 (AAV9) |
Biotin anti-AAVX | Binds with high affinity and selectivity to adeno-associated viral (AAV) particles of a wide variety of serotypes. |
Biotin anti-Adv5 | Binds with high affinity and selectivity to recombinant hexon capsomeres of Adenovirus serotype 5 (AdV5) particles as well as free hexon proteins thereof |
Review our list of biotinylated ligands directed against several tetraspanin family member exosome surface molecules. Find more detailed information on selectivity and use of these products in the product information sheets available for download on the specific product pages:
Binds the tetraspanin molecule CD81 (Cluster of Differentiation 81; TAPA1 or TSPAN28) expressed on extracellular vesicles (EVs) like exosomes. | |
Binds the tetraspanin molecule CD63 (Cluster of Differentiation 63; LAMP3 or LIMP1) expressed on extracellular vesicles (EVs) like exosomes. | |
Binds the tetraspanin molecule CD9 (Cluster of Differentiation 9; MIC3, MRP1 or TSPAN29) expressed on extracellular vesicles (EVs) like exosomes. |
Review our list of biotinylated ligands directed against antibodies and related derivatives. Find more detailed information on selectivity and use of these products in the product information sheets available for download on the specific product pages:
Binds human IgG and all Fab fragments thereof, through recognition of the CH1 domain on all four human IgG subclasses. | |
Binds human IgG, through recognition of the Fc region (CH3 domain) on all four human IgG subclasses. | |
Binds IgG through recognition of the Fc region on IgG of multiple species. View product sheet for species coverage. | |
Biotin Anti-IgG-Fc (Rabbit) | Binds to rabbit IgG (immunoglobulin G) from recombinant and plasma sources. The ligand shows no cross-binding to bovine, horse, sheep, goat, mouse, rat, and human IgG. Moderate cross-binding was observed towards swine IgG. |
Binds human IgA, IgA-dimers and secretory IgA (sIgA), through recognition of the Fc region on both human IgA subclasses. | |
Binds human, mouse and rat IgM. | |
Biotin Anti-IgE | binds to human IgE (immunoglobulin E) from recombinant and plasma sources, through recognition of the Fc region (CH4 domain) |
Binds all human lambda light chains (LC), through recognition of the constant domain (CL-lambda) on any human antibody, Fab fragment or free light chain. | |
Binds all human kappa light chains (LC), through recognition of the constant domain (CL-kappa) on any human antibody, Fab fragment or free light chain. | |
Binds all mouse - and rat kappa light chains (LC), through recognition of the constant domain (CL-kappa) on any mouse and rat antibody, Fab fragment or free light chain. | |
Biotin Anti-LC-lambda (Mouse) | Binds all mouse lambda light chains (LC), through recognition of the constant domain (CL-lambda) on any mouse antibody, Fab fragment or free light chain |
Biotin Anti-LC-lambda (Rat) | Binds all rat lambda light chains (LC), through recognition of the constant domain (CL-lambda) on any rat antibody, Fab fragment or free light chain |
Binds human IgG3 without any cross-binding to other human IgG subclasses or antibody isotypes. | |
Binds human IgG4 without any cross-binding to other human IgG subclasses or antibody isotypes. | |
High affinity capture of human IgG Fab fragments that possess a kappa light chain. Extreme low off-rates are achieved through avidity by targeting the CL-kappa domain of the Fab (light chain) and its IgG CH1 domain (heavy chain) simultaneously, thereby enabling Fab screening on target binding kinetics. | |
High affinity capture of human IgG Fab fragments that possess a lambda light chain. Extreme low off-rates are achieved through avidity by targeting the CL-lambda domain of the Fab (light chain) and its IgG CH1 domain (heavy chain) simultaneously, thereby enabling Fab screening on target binding kinetics. | |
Binds highly selective to free human kappa light chains and dimers thereof, through recognition of an epitope on the human CL-kappa domain that is masked in intact antibodies and Fab fragments, thereby providing a unique tool for specific detection and quantitation of free kappa light chains in (crude) antibody preps. | |
Binds highly selective to human IgG, through recognition of the Fc region on all four human IgG subclasses without cross-binding to mouse, rat, rhesus and cynomolgus monkey IgG, thereby making it extremely suitable for setting up pharmacokinetics (PK) assays. |
Review our list of biotinylated ligands directed against different proteins and virus particles. Find more detailed information on selectivity and use of these products in the product information sheets available for download on the specific product pages:
Binds the short C-tag sequence E-P-E-A (glutamic acid - proline - glutamic acid – alanine) when this affinity tag is fused at the C-terminus of a target protein. | |
Binds the short C-tag sequence E-P-E-A (glutamic acid - proline - glutamic acid – alanine) when this affinity tag is fused at the C-terminus of a target protein. | |
Biotin Anti-FX | Binds to human Factor X and its activated form Factor Xa from plasma and recombinant sources |
Binds recombinant as well as plasma derived human Factor IX (FIX) | |
Binds recombinant (full length and B-domain deleted) as well as plasma derived human Factor VIII (FVIII), through recognition of the FVIII light chain. | |
Biotin anti-FVII | Binds recombinant as well as plasma derived human Factor VII (FVII) |
Biotin Anti-Gonadotropin | Binds to the alpha chain of recombinant as well as natural sourced hCG (human chorionic gonadotropin), LH (luteinizing hormone), TSH (Thyroid-stimulating hormone) and FSH (follicle-stimulating hormone) |
Biotin Anti-Human Albumin | Binds recombinant as well as natural sourced human serum albumin (HSA) including HSA-fusion proteins |
Biotin Anti-AAT | Binds recombinant as well as natural sourced human α1-Antitrypsin (AAT) |
Biotin Anti-C1-Inhibitor | Binds recombinant as well as natural sourced human C1-Inhibitor (C1-inh, C1 esterase inhibitor) |
Biotin Anti-Fibrinogen | Binds recombinant as well as natural sourced human Fibrinogen (coagulation factor I, FI) |
Biotin Anti-Transferrin | Binds recombinant as well as natural sourced human Transferrin |
Biotin Anti-α1-Acid Glycoprotein | Binds recombinant as well as natural sourced human α1-Acid Glycoprotein (AGP) or Orosomucoid (ORM) |
Biotin Anti-Haptoglobin | Binds recombinant as well as natural sourced human Haptoglobin (Hp) |
Biotin Anti-C3 | Binds recombinant as well as natural sourced human Complement Component 3 (C3) |
Biotin Anti-vWF | Binds recombinant as well as natural sourced human von Willebrand Factor (vWF) |
Biotin Anti-ApoA1 | Binds recombinant as well as natural sourced human Apolipoprotein A1 (ApoA1) |
Biotin Anti-α2-Macroglobulin | Binds recombinant as well as natural sourced human α2-Macroglobulin (A2M) |
Biotin Anti-Antithrombin III | Binds recombinant as well as natural sourced human Antithrombin III (ATIII) |
Biotin Anti-Prothrombin | Binds recombinant as well as natural sourced human Prothrombin (coagulation factor II, FII) |
Binds recombinant as well as natural sourced human Growth Hormone (hGH). | |
Binds recombinant as well as natural sourced human Granulocyte-Colony Stimulating Factor (G-CSF) | |
Binds recombinant as well as natural sourced human Follicle Stimulating Hormone (FSH), through recognition of an epitope specific for intact FSH only. | |
Biotin Anti-Insulin | Binds recombinant and natural-sourced human insulin and shows similar binding reactivity towards porcine- and bovine-sourced insulin. It also binds to human proinsulin, the precursor of insulin that still contains the C-peptide. |
Biotin Anti-EPO | Binds recombinant and natural-sourced human Erythropoietin (EPO). |
Biotin anti-AAV8 | Binds with high affinity to Adeno-associated virus particles of serotype 8 (AAV8). Note that it may cross-bind towards other AAV serotypes. |
Biotin anti-AAV9 | Binds with high affinity and selectivity to Adeno-associated virus particles of serotype 9 (AAV9) |
Biotin anti-AAVX | Binds with high affinity and selectivity to adeno-associated viral (AAV) particles of a wide variety of serotypes. |
Biotin anti-Adv5 | Binds with high affinity and selectivity to recombinant hexon capsomeres of Adenovirus serotype 5 (AdV5) particles as well as free hexon proteins thereof |
Review our list of biotinylated ligands directed against several tetraspanin family member exosome surface molecules. Find more detailed information on selectivity and use of these products in the product information sheets available for download on the specific product pages:
Binds the tetraspanin molecule CD81 (Cluster of Differentiation 81; TAPA1 or TSPAN28) expressed on extracellular vesicles (EVs) like exosomes. | |
Binds the tetraspanin molecule CD63 (Cluster of Differentiation 63; LAMP3 or LIMP1) expressed on extracellular vesicles (EVs) like exosomes. | |
Binds the tetraspanin molecule CD9 (Cluster of Differentiation 9; MIC3, MRP1 or TSPAN29) expressed on extracellular vesicles (EVs) like exosomes. |
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