Antigenic T-cell Response Profiling in COVID-19 Using Single-Cell Proteomics and Transcriptomics

Single-cell multi-omics of SARS CoV-2 antigen-specific T-lymphocytes reveals population diversity

Available on demand

Immunity against SARS-CoV-2 has been studied predominantly regarding antibody responses. However, the T-lymphocyte response against immunodominant viral nucleocapsid protein (NP) derived antigens represents a critical constituent responsible for the elimination of virus infected cells.

This webcast will present work looking at these responses more closely, employing both proteomics and transcriptomics to analyze NP-specific T-cells from acute SARS-CoV-2 patients.

You will learn:

How to conduct a single-cell MS (scMS) proteomics study using TMT multiplexing to maximize throughput with high resolution accurate mass (HRAM) Orbitrap mass spectrometry
Best practices in designing, executing, and interpreting a multi-omics experiment
What is the most critical element to be aware of in single-cell experiments?

About the presenter

Dr. Benedikt Kessler

Professor of Biochemistry and Life Science Mass Spectrometry
Nuffield Department of Medicine University of Oxford

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