Simultaneous analysis of monoclonal antibodies using a novel dual-channel UHPLC instrument and orthogonal chromatography

Application benefits

• The Dual LC workflow demonstrates the ability to employ two chromatography channels with different separation mechanisms at one time.
• Higher number of sample injections can be performed during analysis time resulting in efficient sample analysis and overall lower costs.
• Separate software modules for each LC system results in easy data processing.

Goal

To demonstrate the flexibility of the newly developed Thermo Scientific™ Vanquish™ Flex Duo UHPLC system for Dual LC. This study focused on the ability of the Dual LC workflow to employ two different chromatographic mechanisms at one time, without compromising data reproducibility and the quality of chromatography.

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