Affinity Chromatography Resins—Antibody Therapeutics

Antibody purification by affinity chromatography

CaptureSelect affinity chromatography resins, specifically developed to bind antibody-subdomain regions are a key solution for the purification of novel antibody therapeutics, such as bi-specific monoclonal antibodies, Fab fragments, and Fc-fusion proteins. These resins are based on the CaptureSelect technology, enabling increased purity and yield in a single purification step.

Due to the unique selectivity of each resin, a broad range of antibody modalities can be captured. The antibody-subdomain-specific resins help to improve downstream processing of monoclonal antibodies and antibody fragments, and serve as an alternative solution when Protein A does not yield optimal results.

CaptureSelect affinity resins are scalable platform purification solutions, non-animal derived, and suitable for cGMP manufacturing.

Benefit from:

• High capacity, addressing process demand and high-titer feedstocks
• Mild elution conditions for successful purification of pH-sensitive modalities
• Efficient antibody fragment purification, without co-purification of light chains
• Alternative purification solutions when Protein A doesn't yield desired results

Learn how our affinity resins interact with antibodies to help optimize your downstream process. Explore the Affinity Resins for Antibody Purification 3D Tour.

IgE purification

In addition to our subdomain-specific IgG resins, we offer a highly specific resin for when you are working on IgE drug development. The CaptureSelect IgE affinity matrix  helps provide efficient purification of IgE from plasma and recombinant sources.

Find your desired antibody affinity matrix 

All CaptureSelect antibody purification resins are available as loose resin in different unit sizes. For your process development needs, the resins are available in pre-packed columns in high-throughput screening format and for bench-scale screening purposes. Additionally, when your unique purification needs cannot be met with off-the-shelf resins, our custom chromatography resin service can help with solving your specific challenge. Click on the product table below to see all available resins.

Products incorporating CaptureSelect technology are used for clinical and commercial manufacturing of a variety of biologics. To complement each affinity resin, we offer product specific ELISAs to measure ligand potentially leaching from the column. Click on the product table below to see all available ELISAs.

For Research Use or further manufacturing, not for diagnostic use or direct administration in humans or animals.