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Animal Serum Alternatives to FBS |
Animal serum provides proteins, nutrients, attachment factors, trace elements, growth factors, and hormones, which aid in the growth of the cells. Although FBS is the most used serum for cell culture, other animal sera are available as lower-cost alternatives for cell culture and serological applications.
Gibco non-FBS animal sera are sourced from New Zealand (except for rabbit), which is recognized as the world’s premier source of animal sera and protein products. Because of the country’s protected environment, strict agricultural regulations, and high standards of husbandry and care, animals are spared many significant diseases that affect herds elsewhere. New Zealand is considered free from all OIE diseases .
Thermo Fisher Scientific offers more than 60 years of experience in serum manufacturing. We possess the sourcing capabilities, technology, manufacturing know-how, and the widest range of options. Collaborate with Thermo Fisher scientists and engineers to obtain solutions that are best for your needs.
Choose from a range of viable FBS alternatives, formulated to support cell culture in your lab.
Country of origin | Cell attachment and proliferation tested in | Applications | |
---|---|---|---|
Horse serum | New Zealand | Sp2/O-Ag14 (murine myeloma) cells | Cell culture (e.g., cell differentiation, neural cell growth), IHC, serology assays |
Newborn calf/bovine calf/adult bovine serum | New Zealand | Vero cells | Cell culture, IHC, serology assays |
Rabbit serum | US | Sp2/O-Ag14 (murine myeloma) cells | Cell culture, IHC, serology assays |
Chicken serum | New Zealand | 3 adherent cell lines | Cell culture, IHC, serology assays |
Goat serum | New Zealand | 3 adherent cell lines | Cell culture, IHC, serology assays |
Sheep/lamb serum | New Zealand | 3 adherent cell lines | Cell culture, IHC, serology assays |
Pig/porcine serum | New Zealand | 3 adherent cell lines | Cell culture (e.g., epithelial cell growth), IHC, serology assays |
Chicken serum is collected in New Zealand from healthy birds slaughtered for human consumption and can be used as an FBS alternative in some cell culture applications.
Chicken serum can be used as an FBS alternative for the support of cells in culture and contains factors such as proteins, hormones, and nutrients important for cell growth. A specific use for chicken serum is in radioisotope dilution assay of serum vitamin B12 [1].
Chicken serum is also available in custom formats; call your local representative for more details.
Goat serum, a viable FBS alternative in certain applications, is donor-herd collected, processed, and manufactured in New Zealand.
Goat serum can be used as a cell culture supplement, providing nutrients, hormones, and enzymes important to cell growth. In addition, Thermo Fisher Scientific offers 10% normal goat serum, which can be used as a blocking solution for immunohistochemical studies.
There are also several common and more specific uses for goat serum:
Goat serum is also available in custom formats; call your local representative for more details.
Sheep serum, which is collected, processed, and manufactured in New Zealand, can be used as an alternative to FBS in certain cell culture applications.
As a cell culture supplement, sheep serum can provide an array of nutrients, proteins, and other factors necessary for cell growth and viability. In addition, a specific suggested use for sheep serum is in antibody production [1].
Sheep serum is also available in custom formats; call your local representative for more details.
Porcine serum, collected from animals in New Zealand that are typically less than one year of age, can serve as a viable alternative to FBS for certain cell culture applications.
As a cell culture media supplement, porcine serum can provide nutrients, proteins, and other factors necessary for supporting cell growth and proliferation.
In addition, porcine serum has been used in several specific applications:
Thermo Fisher Scientific also offers normal porcine serum, which can be used as a blocking solution for immunohistochemical studies.
Fetal Bovine Serum Basics
Learn the basics of FBS for cell culture, including information on the FBS uses, components, and the market dynamics driving this industry.
Cell Culture Basics
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For Research Use or Further Manufacturing Use only. Serum and blood proteins are not for direct administration into humans or animals.