The AcroSeal system: performance, convenience, safety

AcroSeal packaging bottle showing sealing system

Chemical reactions often involve the use of air- and moisture-sensitive solvents, and pyrophoric or hazardous reagents. Our AcroSeal packaging is a packaging solution designed to enable safe handling of these types of materials which are used in a variety of research and development applications, including NMR analysis and studies in drug discovery, agrochemicals, flavors and fragrances, and more.

The AcroSeal cap

We keep improving our AcroSeal packaging. The redesigned gray portion of the sealing system makes it both easier and safer to remove the whole system and replace it back on the bottle securely. No special tool is required for removal or replacement. This facilitates access to larger volumes of product and packaging recycling after use.

If you are new to AcroSeal Packaging, please see "How to use AcroSeal packaging" below.

Your feedback is appreciated. Please take a moment to share your experience with the new AcroSeal packaging by completing our survey.


Frequently asked questions

Why are we making these changes?

The redesigned gray portion of the sealing system makes it both easier to remove the whole system and replace it back on the bottle. No special tool is required for removal or replacement. It also makes it more difficult to accidentally unscrew the whole sealing system.

Why is it important that the whole sealing system can be removed?

In use, removal of the whole system allows access to higher volumes of dry solvent than the usual method of multiple needle and syringe extractions. Simply decant from the bottle in dry conditions (i.e., in the fume hood). It is essential that the complete system be securely replaced if material remains for later use.

After use, the new design simplifies recycling that requires separation of the glass bottle from the plastic cap.

How has it been made more difficult to accidentally remove the whole system from the bottle?

There is now a clear distinction in the system between the red cap to be removed for ‘regular’ use and the gray collar.

A second tamper-evident ring has been added to protect against accidental removal as the second seal must be deliberately broken to remove the whole gray collar and red cap together.

Is there a change to the septum?

No, the septum is not changing.


How to use AcroSeal packaging

top view of bottle

To get the best results using AcroSeal packaging, we recommend the following process:

  1. Puncture the septum
  2. Withdraw the required amount
  3. Replace the nitrogen blanket
  4. Store upright to prevent prolonged product contact with the seal

Advanced tips:

  1. Prepare the nitrogen balloon in advance and use two balloons, one inside the other
  2. Purge the doubled balloons with nitrogen three times before use
  3. Bend the needle as it makes it easier to use and control
  4. Flush each needle and syringe with nitrogen three times before use
  5. Use the reaction flask to flush the syringe and needle prior to use

To get the best results from the septum, we recommend you use 18 to 21 gauge needles and puncture in a clock face pattern to avoid piercing the septum in the same place.

If you require a large amount of solvent, remove the whole cap under an inert atmosphere and decant the desired amount of product from the bottle.


25 years of AcroSeal packaging

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.