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Angiogenesis is the process by which new blood vessels are formed. It is important in growth and development as well as in wound healing, but it also plays a significant role in tumorigenesis. Several angiogenesis pathways include angiopoietin-TIE2 signaling and the VEGF family of ligands and receptor interactions.
The angiopoietins are a new family of growth factor ligands that bind to TIE2/TEK RTK (Receptor Tyrosine Kinase).
Vascular endothelial growth factor (VEGF) is a highly-conserved genetic pathway that has evolved from simple to complex systems.
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