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Custom antibody services include competitively priced packages and purification options for antibody production. We provide complete support for all types and steps of antibody production—from peptide design, synthesis, and carrier protein conjugation to animal immunization, serum collection, hybridoma fusion, titer analysis, and final antibody purification. We can also immunize with recombinant proteins or protein fragments provided by you or expressed and purified in our lab to generate antibodies in rabbits, chickens, goats, guinea pigs, mice, or rats.
Our detailed knowledge of antigen-determining factors (e.g., size, localized secondary structure, and antigenicity) allows us to produce custom antibodies with unmatched specificity, affinity, and assay utility. Our expertise helps increase the probability that you will obtain a polyclonal or monoclonal antibody capable of distinguishing among even highly related proteins within complex mixtures to characterize protein expression patterns using IHC, ICC, IF, FACS, ELISA, western blotting, or immunoprecipitation (IP, Co-IP, ChIP).
We offer eight protocol packages (immunization schedules for rabbits, goats, etc.) for producing custom polyclonal antibodies to peptide and protein antigens.
Custom antibody services for the production and purification of phosphospecific and post-translational-modification-specific antibodies.
Rat and mouse hybridoma development options for producing custom monoclonal antibodies from synthesized peptides or recombinant protein antigens.
Three-step purification procedure as well as specialized purification options for obtaining monospecific antibodies.
ELISA and additional screening and method validation procedures for custom antibodies.
The Thermo Scientific Antigen Profiler is a bioinformatics protein sequence analysis tool and custom peptide design algorithm for designing and creating superior peptide antigens. The platform incorporates an exclusive set of powerful bioinformatics algorithms for analyzing and designing peptide and protein antigens to ensure high-titer custom production of highly-specific antibodies. The analysis is offered as a service for researchers who wish to design and synthesize effective peptide antigens for custom antibody development using our comprehensive custom antibody production service.
Is this your first time considering custom antibody production? No problem!
The following tables summarize some of our more popular custom antibody production packages, options, and corresponding features.
Recombinant Protein Antibody | Standard Anti-Peptide Antibody | Modification Specific Antibody† | |
---|---|---|---|
Antigen Design with Antigen Profiler | ✓ | ✓ | ✓ |
Peptide Antigen Synthesis | N/A | ✓ | ✓ |
Depleting Peptide Synthesis | N/A | N/A | ✓ |
Protein Expression (vs. you supply) | Optional | N/A | N/A |
Animal Immunization (8 protocol options) | ✓ | ✓ | ✓ |
Bleeds, Serum Prep, ELISA Screening and Titration | ✓ | ✓ | ✓ |
Affinity Purification and Depletion (several options) | Optional | Optional | ✓ |
Specific Assay Validation or Antibody Labeling | Optional | Optional | Optional |
† Modification specific antibodies are phosphospecific antibodies or monospecific antibodies against peptides with other post-translational modifications or specific states (phosphorylation, sumoylation, myristoylation, acetylation, polymorphisms, drug binding, ubiquitination, glycosylation, isoforms, splice variants, ligand binding, prenylation, protein cleavage neo-epitopes, mutations, species cross-reactivity).
Modification Specific Antibody† | Standard Anti-Peptide Antibody | Recombinant Protein Antibody | |
---|---|---|---|
Antigen Design with Antigen Profiler | ✓ | ✓ | ✓ |
Peptide Antigen Synthesis | ✓ | ✓ | N/A |
Control Peptide Synthesis | ✓ | N/A | N/A |
Protein Expression (vs. you supply) | N/A | N/A | Optional |
Animal Immunization (3 protocol options) | ✓ | ✓ | ✓ |
Hybridoma Fusion, Cloning, Screening and ELISA Titration | ✓ | ✓ | ✓ |
Culture, Production and Purification (several options) | Optional | Optional | Optional |
Specific Assay Validation or Antibody Labeling | Optional | Optional | Optional |
Complete Online Project Tracking | Coming Soon | Coming Soon | Coming Soon |
† Modification specific antibodies are phosphospecific antibodies or monospecific antibodies against peptides with other post-translational modifications or specific states (phosphorylation, sumoylation, myristoylation, acetylation, polymorphisms, drug binding, ubiquitination, glycosylation, isoforms, splice variants, ligand binding, prenylation, protein cleavage neo-epitopes, mutations, species cross-reactivity).
Recombinant Protein Antibody | Standard Anti-Peptide Antibody | Modification Specific Antibody† | |
---|---|---|---|
Antigen Design with Antigen Profiler | ✓ | ✓ | ✓ |
Peptide Antigen Synthesis | N/A | ✓ | ✓ |
Depleting Peptide Synthesis | N/A | N/A | ✓ |
Protein Expression (vs. you supply) | Optional | N/A | N/A |
Animal Immunization (8 protocol options) | ✓ | ✓ | ✓ |
Bleeds, Serum Prep, ELISA Screening and Titration | ✓ | ✓ | ✓ |
Affinity Purification and Depletion (several options) | Optional | Optional | ✓ |
Specific Assay Validation or Antibody Labeling | Optional | Optional | Optional |
† Modification specific antibodies are phosphospecific antibodies or monospecific antibodies against peptides with other post-translational modifications or specific states (phosphorylation, sumoylation, myristoylation, acetylation, polymorphisms, drug binding, ubiquitination, glycosylation, isoforms, splice variants, ligand binding, prenylation, protein cleavage neo-epitopes, mutations, species cross-reactivity).
Modification Specific Antibody† | Standard Anti-Peptide Antibody | Recombinant Protein Antibody | |
---|---|---|---|
Antigen Design with Antigen Profiler | ✓ | ✓ | ✓ |
Peptide Antigen Synthesis | ✓ | ✓ | N/A |
Control Peptide Synthesis | ✓ | N/A | N/A |
Protein Expression (vs. you supply) | N/A | N/A | Optional |
Animal Immunization (3 protocol options) | ✓ | ✓ | ✓ |
Hybridoma Fusion, Cloning, Screening and ELISA Titration | ✓ | ✓ | ✓ |
Culture, Production and Purification (several options) | Optional | Optional | Optional |
Specific Assay Validation or Antibody Labeling | Optional | Optional | Optional |
Complete Online Project Tracking | Coming Soon | Coming Soon | Coming Soon |
† Modification specific antibodies are phosphospecific antibodies or monospecific antibodies against peptides with other post-translational modifications or specific states (phosphorylation, sumoylation, myristoylation, acetylation, polymorphisms, drug binding, ubiquitination, glycosylation, isoforms, splice variants, ligand binding, prenylation, protein cleavage neo-epitopes, mutations, species cross-reactivity).
For Research Use Only. Not for use in diagnostic procedures.
For Research Use Only. Not for use in diagnostic procedures.