Protein Modification

We offer a wide range of reagents to modify proteins by crosslinking, fragmenting, cleaving, denaturing, reducing disulfides, or attaching functional groups to study protein function and interactions.

Use our helpful Bioconjugation Technical Handbook to help improve your protein modification results.

Chemical agents to modify amino acid side chains on protein or peptides in order to alter charges, block or expose reactive binding sites, inactivate functions, or change functional groups to create targets for crosslinking and labeling.

View all modification agents

Purified powders, convenient solutions, and solid-phase resins for protein denaturation (Urea, Guanidine) or reducing agents (DTT, TCEP) for stabilizing free sulfhydryls (cysteines) and disrupting disulfide bonds.

View all denaturing and reducing agents

Purified and agarose-immobilized proteases for the enzymatic cleavage or digestion of proteins to facilitate amino acid sequencing, peptide analysis, and polypeptide structural characterization.

View all proteases and peptide-cleaving reagents

Free download

Bioconjugation and crosslinking technical handbook

Everything you need to bioconjugate, crosslink, biotinylate, and modify proteins and peptides.

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Bulk or custom product request

Need larger quantities of our protein labeling, crosslinking or modification reagents? We offer bulk and custom fill sizes.

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Resources

For Research Use Only. Not for use in diagnostic procedures.