Expect and receive high quality cellular profiling data in days and accelerate your lead discovery projects with SelectScreen Cell-based Pathway Profiling Services from Thermo Fisher Scientific.

Labs from pharmaceutical, biotech, consumer goods, and academic institutions have utilized SelectScreen Cell-based Pathway Profiling Service since their initiation in 2006. To date, our SelectScreen team has completed more than 500 cell-based pathway profiling projects – with an on-time delivery rate higher than 99%.

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Why do scientists trust the SelectScreen Services team?

  • Access your data in real-time – as soon as it’s available – through our secure online portal!
  • Projects completed in an average of 7 days
  • All assays and reagentsused in the service can be purchased from Thermo Fisher Scientific – allowing you to utilize the same cellular assays in your follow-up studies that our team uses in the service
  • Broad panel of more than 118 cellular assays available
  • State-of-the-art compound management system ensures consistently high quality data is delivered for every project
  • Complete Lab Information Management System (LIMS) ensures project traceability and consistency

Customize your cell-based profiling project to get the right data for your research.

Standard service options include:

  • Targets – 38 Pathways (72 assays)  and 13 LanthaScreen cell lines (46 assays) available
  • Mode – IC50 and/or EC50 determinations

Biochemical kinase profiling services are also available for clients seeking both biochemical and cellular data.

To discuss your cell-based profiling project requirements, send us an inquiry.

Currently, two different assay platforms are available for profiling - CellSensor reporter gene assays and LanthaScreen cellular TR-FRET assays.

Overview of available formats

CellSensor cell linesTechnology OverviewProtocol and Assay Conditions
LanthaScreen cellular assaysTechnology OverviewProtocol and Assay Conditions

A stringent validation process ensures the highest quality data possible with each data point performed in duplicate.  Strict quality control protocols ensure that any assay results not meeting set specifications will be automatically repeated, this includes a control inhibitor titration for each cell-based assay on every plate.

To discuss your cell-based profiling project requirements, send us an inquiry. 

If your target of interest is not on the list below, additional CellSensor Cell Lines may be profiled using our Custom Services. View the entire list of CellSensor Cell Lines available.

PathwayCell LineActivatorInhibitorAntibodyCellSensor Cell LinesLanthaScreen Cellular Assay
Anti-oxidant ResponseARE-bla HepG2tBHQRo-31-8220N/A

 

 
B cell receptorNFAT-bla RA-1Goat anti-Human IgMSyk Inhibitor II

N/A

 

 
cAMP/PKACRE-bla HEK 293TForskolinH-89

N/A

 

 
cAMP/PKACRE-bla JurkatForskolinH-89

N/A

 

 
DNA damage/p53 Responsep53RE-bla HCT-116MitomycinN/A

N/A

 

 
ER Stress ResponseESRE-bla HeLaTunicamycinN/A

N/A

 

 
Glucocorticoid ReceptorMMTV-bla HeLaDexamethasoneRU-486

N/A

 

 
Heat Shock ResponseHSE-bla HeLa17-AAGQuercetin

N/A

 

 
HypoxiaHRE-bla ME-120CoCl2Chetomin

N/A

 

 
Interleukin 4/STAT6STAT6-bla RA1IL-4JAK Inhibitor I

N/A

 

 
JAK/STATirf1-bla HELN/AJAK Inhibitor I

N/A

 

 
JAK/STATISRE-bla HEK 293TIFN-alphaJAK Inhibitor I

N/A

 

 
JAK/STATISRE-bla JurkatIFN-alphaJAK Inhibitor I

N/A

 

 
JAK/STATSIE-bla HEK 293TIFN-gammaJAK Inhibitor I

N/A

 

 
JAK/STATSIE-bla HEK 293TIL-6JAK Inhibitor I

N/A

 

 
JAK/STATSIE-bla ME-120IL-6JAK Inhibitor I

N/A

 

 
JAK/STATSIE-bla ME-120IFN-gammaJAK Inhibitor I

N/A

 

 
JAK2/STAT5irf1-bla TF1GM-CSFJAK Inhibitor I

N/A

 

 
JAK2/STAT5irf1-bla TF1EPOJAK Inhibitor I

N/A

 

 
MAPKc-fos-bla HEK 293TPMAU0126

N/A

 

 
MAPKc-fos-bla ME-120

EGF		PD153035

N/A

 

 
MAPK/EGFR/Ras/RafAP1-bla ME-120EGFPD153035

N/A

 

 
MAPK/MEK/B-rafAP1-bla A375N/ARaf1 Kinase Inhibitor

N/A

 

 
NFkBNFkB-bla JurkatTNF-alphaWithaferin A

N/A

 

 
NFkBNFkB-bla ME-120TNF-alphaWithaferin A

N/A

 

 
NFkBNFkB-bla ME-120IL-1 betaWithaferin A

N/A

 

 
NFkBNFkB-bla THP-1TNF-alphaWithaferin A

N/A

 

 
PI3K/AKT/FOXO3TREx FOXO3-DBE-bla HeLaInsulinTriciribine

N/A

 

 
PKC & Ca2+TrkA-NFAT-bla CHO-K1NGF-2.5SK252a

N/A

 

 
PKC & Ca2+TrkB-NFAT-bla CHO-K1BDNFK252a

N/A

 

 
PKC & Ca2+TrkC-NFAT-bla CHO-K1Neurotrophin-3

K252a

N/A

 

 
PKC/Ca2+NFAT-bla JurkatThapsigargin

Ro-31-8220

N/A

 

 
T Cell ReceptorNFAT-bla Jurkatanti-CD3:CD28Ro-31-8220

N/A

 

 
TGF-betaSBE-bla HEK 293TTGF-betaTGF-beta R1 Kinase Inhibitor

N/A

 

 
TNF-alpha/JNKAP1-bla ME-120TNF-alphaJNK Inhibitor II

N/A

 

 
Toll-Like Receptor (TLR4)NFkB-bla THP-1LPSWithaferin A

N/A

 

 
Wnt/Beta-CateninLEF/TCF-bla HCT-116Wnt-3AICG-001

N/A

 

 
Wnt/Beta-Catenin (APC-/-)LEF/TCF-bla SW 420NoneICG-001

N/A

 

 
NFkBIkB GripTite (293)TNF-alphaBMS345541Tb-anti-plkB[pSer32] 

 

MAPKc-Jun (1-79) HeLaTNF-alpha or AnisomycinJNK Inhibitor IITb-anti-c-Jun[pSer73] 

 

MAPKATF2 (19-106) A549TNF-alpha or AnisomycinJNK Inhibitor IITb-anti-AFT2[pThr71] 

 

MAPK*ERK2 U2OSEGF or PDGFU0126Tb-anti-ERK2[pThr185/Tyr187] 

 

MAPKERK2 A375 (B-RAF V600E)NoneRaf1 Kinase InhibitorTb-anti-ERK2[pThr185/pTyr187] 

 

PI3K/AKTPRAS40 HEK 293EInsulin or IGF-1PI-103Tb-anti-PRAS40[pThr246] 

 

PI3K/AKTPRAS40 HEK 293EInsulin or IGF-1PI-103Tb-anti-PRAS40[pSer183] 

 

PI3K/AKTPDCD4 HEK 293EInsulin or IGF-1RapamycinTb-anti-PDCD4[pSer457] 

 

PI3K/AKTAKT HEK 293EIGF-1PI-103Tb-anti-AKT[pSer473] 

 

PI3K/AKTAKT HEK 293EIGF-1PI-103

Tb-anti-AKT (pThr308)		 

 

PI3K/AKTIGF-1R GripTite (293)IGF-1PQ401

Tb-PY20		 

 

JAK/STATSTAT1 U2OSIFN-gamma or IFN-alphaJAK Inhibitor ITb-STAT1[pTyr701] 

 

JAK/STATSTAT3 GripTiteIL-6 or IFN-alphaJAK Inhibitor ITb-STAT3[pTyr705] 

 

JAK/STATSTAT5 TF-1GM-CSF or EPOJAK Inhibitor IAnti-STAT5 A/B[pTyr694/699] 

 

     JAK/STATSTAT5 U2OS (JAK2 V617F)NoneJAK Inhibitor IAnti-STAT5 A/B[pTyr694/699] 

 

Choose the right reagents, assays and services for your cell-based pathway profiling project. In addition to our SelectScreen Cell-Based Pathway Profiling Services, we offer a broad selection of tools for “do it yourself” projects.

Project Options

Customize your cell-based profiling project to get the right data for your research.

Standard service options include:

  • Targets – 38 Pathways (72 assays)  and 13 LanthaScreen cell lines (46 assays) available
  • Mode – IC50 and/or EC50 determinations

Biochemical kinase profiling services are also available for clients seeking both biochemical and cellular data.

To discuss your cell-based profiling project requirements, send us an inquiry.

Technology Overview

Currently, two different assay platforms are available for profiling - CellSensor reporter gene assays and LanthaScreen cellular TR-FRET assays.

Overview of available formats

CellSensor cell linesTechnology OverviewProtocol and Assay Conditions
LanthaScreen cellular assaysTechnology OverviewProtocol and Assay Conditions

A stringent validation process ensures the highest quality data possible with each data point performed in duplicate.  Strict quality control protocols ensure that any assay results not meeting set specifications will be automatically repeated, this includes a control inhibitor titration for each cell-based assay on every plate.

To discuss your cell-based profiling project requirements, send us an inquiry. 

Broad Assay Panel

If your target of interest is not on the list below, additional CellSensor Cell Lines may be profiled using our Custom Services. View the entire list of CellSensor Cell Lines available.

PathwayCell LineActivatorInhibitorAntibodyCellSensor Cell LinesLanthaScreen Cellular Assay
Anti-oxidant ResponseARE-bla HepG2tBHQRo-31-8220N/A

 

 
B cell receptorNFAT-bla RA-1Goat anti-Human IgMSyk Inhibitor II

N/A

 

 
cAMP/PKACRE-bla HEK 293TForskolinH-89

N/A

 

 
cAMP/PKACRE-bla JurkatForskolinH-89

N/A

 

 
DNA damage/p53 Responsep53RE-bla HCT-116MitomycinN/A

N/A

 

 
ER Stress ResponseESRE-bla HeLaTunicamycinN/A

N/A

 

 
Glucocorticoid ReceptorMMTV-bla HeLaDexamethasoneRU-486

N/A

 

 
Heat Shock ResponseHSE-bla HeLa17-AAGQuercetin

N/A

 

 
HypoxiaHRE-bla ME-120CoCl2Chetomin

N/A

 

 
Interleukin 4/STAT6STAT6-bla RA1IL-4JAK Inhibitor I

N/A

 

 
JAK/STATirf1-bla HELN/AJAK Inhibitor I

N/A

 

 
JAK/STATISRE-bla HEK 293TIFN-alphaJAK Inhibitor I

N/A

 

 
JAK/STATISRE-bla JurkatIFN-alphaJAK Inhibitor I

N/A

 

 
JAK/STATSIE-bla HEK 293TIFN-gammaJAK Inhibitor I

N/A

 

 
JAK/STATSIE-bla HEK 293TIL-6JAK Inhibitor I

N/A

 

 
JAK/STATSIE-bla ME-120IL-6JAK Inhibitor I

N/A

 

 
JAK/STATSIE-bla ME-120IFN-gammaJAK Inhibitor I

N/A

 

 
JAK2/STAT5irf1-bla TF1GM-CSFJAK Inhibitor I

N/A

 

 
JAK2/STAT5irf1-bla TF1EPOJAK Inhibitor I

N/A

 

 
MAPKc-fos-bla HEK 293TPMAU0126

N/A

 

 
MAPKc-fos-bla ME-120

EGF		PD153035

N/A

 

 
MAPK/EGFR/Ras/RafAP1-bla ME-120EGFPD153035

N/A

 

 
MAPK/MEK/B-rafAP1-bla A375N/ARaf1 Kinase Inhibitor

N/A

 

 
NFkBNFkB-bla JurkatTNF-alphaWithaferin A

N/A

 

 
NFkBNFkB-bla ME-120TNF-alphaWithaferin A

N/A

 

 
NFkBNFkB-bla ME-120IL-1 betaWithaferin A

N/A

 

 
NFkBNFkB-bla THP-1TNF-alphaWithaferin A

N/A

 

 
PI3K/AKT/FOXO3TREx FOXO3-DBE-bla HeLaInsulinTriciribine

N/A

 

 
PKC & Ca2+TrkA-NFAT-bla CHO-K1NGF-2.5SK252a

N/A

 

 
PKC & Ca2+TrkB-NFAT-bla CHO-K1BDNFK252a

N/A

 

 
PKC & Ca2+TrkC-NFAT-bla CHO-K1Neurotrophin-3

K252a

N/A

 

 
PKC/Ca2+NFAT-bla JurkatThapsigargin

Ro-31-8220

N/A

 

 
T Cell ReceptorNFAT-bla Jurkatanti-CD3:CD28Ro-31-8220

N/A

 

 
TGF-betaSBE-bla HEK 293TTGF-betaTGF-beta R1 Kinase Inhibitor

N/A

 

 
TNF-alpha/JNKAP1-bla ME-120TNF-alphaJNK Inhibitor II

N/A

 

 
Toll-Like Receptor (TLR4)NFkB-bla THP-1LPSWithaferin A

N/A

 

 
Wnt/Beta-CateninLEF/TCF-bla HCT-116Wnt-3AICG-001

N/A

 

 
Wnt/Beta-Catenin (APC-/-)LEF/TCF-bla SW 420NoneICG-001

N/A

 

 
NFkBIkB GripTite (293)TNF-alphaBMS345541Tb-anti-plkB[pSer32] 

 

MAPKc-Jun (1-79) HeLaTNF-alpha or AnisomycinJNK Inhibitor IITb-anti-c-Jun[pSer73] 

 

MAPKATF2 (19-106) A549TNF-alpha or AnisomycinJNK Inhibitor IITb-anti-AFT2[pThr71] 

 

MAPK*ERK2 U2OSEGF or PDGFU0126Tb-anti-ERK2[pThr185/Tyr187] 

 

MAPKERK2 A375 (B-RAF V600E)NoneRaf1 Kinase InhibitorTb-anti-ERK2[pThr185/pTyr187] 

 

PI3K/AKTPRAS40 HEK 293EInsulin or IGF-1PI-103Tb-anti-PRAS40[pThr246] 

 

PI3K/AKTPRAS40 HEK 293EInsulin or IGF-1PI-103Tb-anti-PRAS40[pSer183] 

 

PI3K/AKTPDCD4 HEK 293EInsulin or IGF-1RapamycinTb-anti-PDCD4[pSer457] 

 

PI3K/AKTAKT HEK 293EIGF-1PI-103Tb-anti-AKT[pSer473] 

 

PI3K/AKTAKT HEK 293EIGF-1PI-103

Tb-anti-AKT (pThr308)		 

 

PI3K/AKTIGF-1R GripTite (293)IGF-1PQ401

Tb-PY20		 

 

JAK/STATSTAT1 U2OSIFN-gamma or IFN-alphaJAK Inhibitor ITb-STAT1[pTyr701] 

 

JAK/STATSTAT3 GripTiteIL-6 or IFN-alphaJAK Inhibitor ITb-STAT3[pTyr705] 

 

JAK/STATSTAT5 TF-1GM-CSF or EPOJAK Inhibitor IAnti-STAT5 A/B[pTyr694/699] 

 

     JAK/STATSTAT5 U2OS (JAK2 V617F)NoneJAK Inhibitor IAnti-STAT5 A/B[pTyr694/699] 

 

Pathway Biology Tools

Choose the right reagents, assays and services for your cell-based pathway profiling project. In addition to our SelectScreen Cell-Based Pathway Profiling Services, we offer a broad selection of tools for “do it yourself” projects.

Personalized Support

Drug Discovery Services team

From project beginning to end, you can rely on our Drug Discovery Services project management team to provide frequent project communication via a single point of contact.

Watch this two-minute video to see how our project managers and technical specialists create an exceptional experience for our customers. Submit order

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