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CRTAC1 encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants.
2810454P21Rik; 68 kDa chondrocyte-expressed protein; acidic secreted protein in cartilage; ASPIC; ASPIC1; AW047536; cartilage acidic protein 1; Cep68; CEP-68; chondrocyte expressed protein 68 kDa CEP-68; Crtac1; Crtac1B; FLJ10320; Lotus; Protein CRTAC1-B; W307
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