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Discover available B·R·A·H·M·S Biomarker Assays
Thermo Scientific B·R·A·H·M·S Biomarkers provide an outstanding long-term lot-to-lot stability and highest precision for the most reliable results in prenatal screening.1 With our biomarker portfolio, we provide solutions from first trimester trisomy to second trimester trisomy and neural tube defect screening.
B·R·A·H·M·S AFP KRYPTOR
Intended uses
| First trimester screening/risk assessment | Second trimester screening/risk asessment | Second trimester diagnosis | ||
| Trisomy 21 | Trisomy 21 | Trisomy 18 | NTD* in serum and plasma (heparin) | NTD* in amniotic fluid |
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* Neural Tube Defect
US Only: Product is not FDA cleared in US.
Product specifications
| Sample volume | 14 µL |
| Sample type | Serum, heparin plasma, amniotic fluid |
| Incubation time | 9 min |
| Linear direct measuring range | 1.91 to 700 ng/mL |
| Upper measuring range with automatic dilution | up to 500 000 ng/mL |
| Limit of detection | 0.21 ng/mL |
| Limit of quantification | 1.91 ng/mL |
| Kit stability on board | 15 days |
| Calibrator | 1 point |
| Calibration stability | 15 days |
B·R·A·H·M·S AFP KRYPTOR kit and accessories
| Article number | Description |
| 816075N | B·R·A·H·M·S AFP KRYPTOR Kit, reagents for 75 determinations |
| 081691N | B·R·A·H·M·S AFP KRYPTOR CAL Calibrator kit, 6 vials |
| 081693N | B·R·A·H·M·S AFP KRYPTOR Diluent Diluent AFP for amniotic fluid samples, 5 vials |
| 088192N | B·R·A·H·M·S GM KRYPTOR QC Control kit prenatal screening, 3 levels (2 vials per level) |
B·R·A·H·M·S Free βhCG KRYPTOR
Intended uses
| First trimester screening | Second trimester screening | |||
| Trisomy 21 | Trisomy 18 | Trisomy 13 | Trisomy 21 |
Trisomy 18 |
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US Only: Product is not FDA cleared in US.
Product specifications
| Sample volume | 26 µL |
| Sample type | Serum |
| Incubation time | 19 min |
| Linear direct measuring range | 0.74 to 150 IU/L |
| Upper measuring range with automatic dilution | up to 50 000 IU/L |
| Limit of detection | 0.09 IU/L |
| Limit of quantification | 0.74 IU/L |
| Kit stability on board | 29 days |
| Calibrator | 1 point |
| Calibration stability | 15 days |
B·R·A·H·M·S Free βhCG KRYPTOR kit and accessories
| Article number | Description |
| 809075N | B·R·A·H·M·S Free βhCG KRYPTOR Kit, reagents for 75 determinations |
| 080991N | B·R·A·H·M·S Free βhCG KRYPTOR CAL Calibrator kit, 6 vials |
| 088192N | B·R·A·H·M·S GM KRYPTOR QC Control kit prenatal screening, 3 levels (2 vials per level) |
B·R·A·H·M·S hCG+β KRYPTOR
Intended uses
| Second trimester screening | |
| Trisomy 21 | Trisomy 18 |
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US Only: Product is not FDA cleared in US.
Product specifications
| Sample volume | 26 µL |
| Sample type | Serum |
| Incubation time | 14 min |
| Linear direct measuring range | 5.0 to 2 000 IU/L |
| Upper measuring range with automatic dilution | up to 1 000 000 IU/L |
| Limit of detection | 2.0 IU/L |
| Limit of quantification | 5 IU/L |
| Kit stability on board | 29 days |
| Calibrator | 1 point |
| Calibration stability | 15 days |
B·R·A·H·M·S Inhibin A KRYPTOR
Intended uses
| Second trimester screening |
| Trisomy 21 |
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US Only: Product is not FDA cleared in US.
Product specifications
| Sample volume | 70 µL |
| Sample type | Serum |
| Incubation time | 39 min |
| Linear direct measuring range | 53.3 to 5000 pg/mL |
| Limit of detection | 20.9 pg/mL |
| Limit of quantification | 53.3 pg/mL |
| Kit stability on board | 15 days |
| Calibrator | 1 point |
| Calibration stability | 7 days |
B·R·A·H·M·S PAPP-A KRYPTOR
Intended uses
| First trimester screening/risk assessment | ||
| Trisomy 21 |
Trisomy 18 | Trisomy 13 |
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US Only: Product is not FDA cleared in US.
Product specifications
| Sample volume | 50 µL |
| Sample type | Serum |
| Incubation time | 19 min |
| Linear direct measuring range | 0.010 to 6 IU/L |
| Upper measuring range with automatic dilution | up to 90 IU/L |
| Limit of detection | 0.0054 IU/L |
| Limit of quantification | 0.01 IU/L |
| Kit stability on board | 29 days |
| Calibrator | 1 point |
| Calibration stability | 15 days |
B·R·A·H·M·S PAPP-A KRYPTOR kit and accessories
| Article number | Description |
| 866075N | B·R·A·H·M·S PAPP-A KRYPTOR Kit, reagents for 75 determinations |
| 086691N | B·R·A·H·M·S PAPP-A KRYPTOR CAL Calibrator kit, 6 vials |
| 088192N | B·R·A·H·M·S GM KRYPTOR QC Control kit prenatal screening, 3 levels (2 vials per level) |
B·R·A·H·M·S PlGF plus KRYPTOR
Intended uses
| First trimester screening/risk assessment |
| Trisomy 21 |
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US Only: Product is not FDA cleared in US.
Product specifications
| Sample volume | 70 µL |
| Sample type | Serum, EDTA plasma |
| Incubation time | 29 min |
| Linear direct measuring range | 7.7 to 7 000 pg/mL |
| Limit of detection | 4.91 pg/mL |
| Limit of quantification | 7.7 pg/mL |
| Kit stability on board | 29 days |
| Calibrator | 1 point |
| Calibration stability | 15 days |
B·R·A·H·M·S uE3 KRYPTOR
Intended uses
| Second trimester screening |
| Trisomy 21 |
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US Only: Product is not FDA cleared in US.
Product specifications
| Sample volume | 50 µL |
| Sample type | Serum |
| Incubation time | 19 min |
| Linear direct measuring range | 0.52 to 17 nmol/L |
| Limit of detection | 0.2 nmol/L |
| Limit of quantification | 0.52 nmol/L |
| Kit stability on board | 15 days |
| Calibrator | 2 point |
| Calibration stability | 7 days |
References
1. Monthly UK NEQAS reports, February 2003 - December 2023.
Thermo Fisher Scientific products are distributed globally and their uses, applications, indications, claims and availability of products in each country depend on local regulatory marketing authorization status, please consult the Instructions For Use (IFU) available in your country.
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KRYPTOR and TRACE are trademarks of Cisbio Bioassays, licensed for use by B·R·A·H·M·S GmbH, a part of Thermo Fisher Scientific. Nobel Prize is a registered trademark of the Nobel Foundation.