Resources for Structure Based Drug Design with Cryo-EM

Resources to get a jump start in accelerating your pipelines with cryo-electron microscopy

At Thermo Fisher Scientific, we are here to help accelerate your drug discovery pipeline with powerful cryo-electron microscopes. Discover how cryo-EM can help your research with our curated white papers, eBooks, and on-demand webinars below.

Featured webinars

Structural biology is advancing biotherapeutics design

Explore the evolution of X-ray crystallography (XRC) and cryo-electron microscopy (cryo-EM) in biotherapeutics. Learn how AI and ML advancements are revolutionizing protein structural analysis and accelerating the design of next-generation biologics.

Quantitative analysis of full and empty particles in AAV vectors for gene therapy

In this webinar, Professor Susumu Uchiyama will explain how combining cryo-electron microscopy with deep learning classification of particle images delivers a powerful approach for quantitative analysis.

 

Watch on demand to:

  • Gain valuable insights into the importance of accurately quantifying the ratio of complete to empty particles in AAV vectors to ensure optimal efficacy and safety
  • Explore gold standard methods like analytical ultracentrifugation (AUC) and discover emerging techniques such as mass photometry and cryo-electron microscopy with deep learning classification
  • Understand the impact of impurities and the significance of precise quantification in AAV vector analysis
  • Stay ahead in AAV vector research and development by learning about the latest advancements and techniques

Shaping the future of therapeutics with AI

By delivering greater insight into protein sequence, structure, and function, artificial intelligence and machine learning make it possible to program novel medicines that can treat a variety of diseases.

 

In this webinar, Dr. Alex Snyder from Generate: Biomedicines covers:

  • How generative AI is being leveraged to fill critical gaps in medical treatments by identifying and developing new drug targets
  • The synergistic integration of computational (dry-lab) and experimental (wet-lab) approaches to accelerate the drug development pipeline, leading to more personalized and efficacious medical solutions

Cryo-electron microscopy is revolutionizing rational drug discovery pipelines

Rational design leveraging routine, high resolution protein structure determination is driving the discovery and development of diverse biologic and small molecule therapies. Cryo-EM delivers rapid epitope mapping on the atomic scale for antibody therapeutics and immune response profiling, supports elucidation of mechanism of action and is also enabling more therapeutic targets than ever before for Structure-Based Drug Design. Whether to modulate binding affinities or to optimize drug stability, all of these questions can be answered in just one day of data collection.

 

Watch the webinar to hear experts from Sanofi to discuss:

  • An overview of how to quickly go from protein to structure
  • Key examples of multi-specific drugs and structural insights of a CEACAM5-targeting antibody drug conjugate (ADC)
  • How the adoption of Cryo-EM has significantly increased the number of the targets that can be identified for clinical trials in both biopharma and biotech

Generative AI: Turning drug discovery into a technological pursuit

Hear from Generate: Biomedicines to learn how generative AI has the capability to ultimately deliver medicines better tailored to specific patient conditions and unmet medical needs faster and cheaper than ever before.

Incorporating cryo-EM into your current workflows

Learn how Embedded CryoSPARC Live can support your single particle analysis by seamlessly integrating with your workflow to simplify operation, feeding Smart Plugins to automatically adjust data collection settings on the fly for higher data quality, providing real-time image analysis, and facilitating post processing.

Cryo-EM processing at the pace of medicinal chemistry on AWS

Instrumentation and resources for the preparation of single particle cryo-EM samples

Cryo-EM trends for drug discovery

Find a selection of case studies supported by cryo-EM

  • Antibody neutralization of Zika and Dengue
  • Coronavirus SARS-CoV-2 spike protein, from sequence to structure in 4 weeks
  • Structure-based drug design with cryo-EM
  • And more

GPCRs and membrane proteins

Cryo-EM approaches for active-state and inactive-state GPCRs

Grid preparation for detergent-solubilized GPCR samples

De novo inactive GPCR cryo-EM structure and epitope mapping

Small molecule drug design

Revolutionizing Small Molecule Drug Discovery Pipelines with Cryo-EM: A Workflow for High-Throughput Screening and High-Resolution Data Collection

Routine high-throughput screening and high-resolution data collection workflow using 200 kV and 300kV TEMs

Epitope mapping

Cryo-EM as a powerful tool for epitope mapping of difficult targets

Leveraging cryo-electron microscopy for innovative vaccine development

Accelerating discovery and rational engineering of antibody modalities using Cryo-EM

Cryo-EM structure of AAV8 and epitope mapping of CaptureSelect AAVX

High-throughput cryo-EM epitope mapping of SARS-CoV-2 spike protein antibodies

Explore available courses and additional cryo-EM resources

Getting started in cryo-EM

Learn tips and tricks and hear practical advice to getting started in single particle cryo-EM—from sample preparation to data collection.

Cryo-EM University

Full single particle cryo-EM course alternating theory and practical demonstration videos covering all aspects from sample preparation, microscope design, cameras, to data acquisition. 

Live virtual webinars

Watch and join in live virtual seminars or watch on-demand to receive firsthand knowledge of the latest technologies and scientific breakthroughs for electron microscopy

Cryo-EM Service and Support

Whether you are purchasing a new system, or need services for an existing system, we have a variety of support options and plans.

For Research Use Only. Not for use in diagnostic procedures.